Digital Commons Network^™

Phase Ii Trial Of Cdx-3379 And Cetuximab In Recurrent/Metastatic, Hpv-Negative, Cetuximab-Resistant Head And Neck Cancer, Julie E Bauman, Ricklie Julian, Nabil F Saba, Trisha M Wise-Draper, Douglas R Adkins, Paul O'Brien, Mary Jo Fidler, Michael K Gibson, Umamaheswar Duvvuri, Margo Heath-Chiozzi, Diego Alvarado, Richard Gedrich, Philip Golden, Roger B Cohen

Open Access Publications

In phase I development, CDX-3379, an anti-ErbB3 monoclonal antibody, showed promising molecular and antitumor activity in head and neck squamous cell carcinoma (HNSCC), alone or in combination with cetuximab. Preliminary biomarker data raised the hypothesis of enhanced response in tumors harboring

Novel Mobility Index Tracks Covid-19 Transmission Following Stay-At-Home Orders, Peter Hyunwuk Her, Sahar Saeed, Khai Hoan Tram, Sahir R Bhatnagar

Open Access Publications

Considering the emergence of SARS-CoV-2 variants and low vaccine access and uptake, minimizing human interactions remains an effective strategy to mitigate the spread of SARS-CoV-2. Using a functional principal component analysis, we created a multidimensional mobility index (MI) using six metrics compiled by SafeGraph from all counties in Illinois, Ohio, Michigan and Indiana between January 1 to December 8, 2020. Changes in mobility were defined as a time-updated 7-day rolling average. Associations between our MI and COVID-19 cases were estimated using a quasi-Poisson hierarchical generalized additive model adjusted for population density and the COVID-19 Community Vulnerability Index. Individual mobility metrics …

Metal Droplet Generator For Studying Impact Dynamics, Xitong Xu

Mechanical Engineering and Materials Science Independent Study

This report outlines the fabrication and improvement of a metal-droplet generator, which is used to conduct research to enhance the knowledge in the field of additive manufacturing. In this report, the droplet generator was tested and optimized in four parts. Finally, two types of high-speed cameras are used to record impact dynamics. However, more work and analyses es are needed in the future.

Development Of Passive And Compact Solid Metal Heat Switch, Steve Park

Mechanical Engineering and Materials Science Independent Study

The main purpose of the independent study was to design and validate a passive solid metal thermal heat switch, which is an alternative approach for a current project in Dr. Weisensee’s lab entitled “Development of Passive and Compact Liquid Metal Heat Switch”. Based on an initial wooden prototype and an analytical tip angle analysis, prototypes were generated using a polymer 3D printer. Multiple thermal actuation tests were conducted for each prototype. The actuation of the final polymer prototype was fully functional – the plug exits the gap without blockage when heated. It was found that a cold plate should be …

Iel Isolation And Image Processing In Matlab, Helena Teixeira-Dasilva

Mechanical Engineering and Materials Science Independent Study

The purpose of this study was to create a streamlined image processing protocol which isolates the internal elastic laminae (IEL) from an image stack taken on a confocal microscope. The projection of the isolated IEL can be used to investigate structural changes to the elastic laminae. Specifically, this process will be used in image analysis for a study on the effects of elastic laminae structure changes on mass transport.

Precursor And Pgg Concentration Affects The Tropoelastin Coacervation Peak Absorbance, Zhuangyu Zhang

Mechanical Engineering and Materials Science Independent Study

This project investigates the effects of the precursor and PGG concentration on the coacervation kinetics for three different types of polypeptides: Elastin ES12, Alpha-Elastin AE17, and Elastin-Opcein E154. The objects of this set of experiments are 1) to compare the coacervation kinetics for different concentrations of tropoelastin proteins; 2) to compare the coacervation kinetics with the PGG addition in different concentrations.

Independent - May 10, 2022, Monty Stites

The Independent (1988-present)

No abstract provided.

Sustainable Rural Development: Is It Possible To Boost Rural Economies While Protecting The Environment?, Jack M. Hempleman

Undergraduate Theses, Capstones, and Recitals

Amidst rapid depletion of our carbon budget, the need to change our practices to be more in line with Earth’s limits has become important in every sector of our economy. From advances in renewable energy generation to the growth of urban gardening, people around the world are taking action to change the way they interact with our planet. However, growing concerns have been raised that protections for the environment will disproportionately harm struggling communities. For instance, rural communities in the United States already exhibit disproportionately high poverty rates, income inequality, and unemployment, as well as lower quality healthcare and public …

Inclusion And Deliberative Dialogues: Exploring Outcomes Of Transformative Experiences For Adolescents, Hadley Robertson

Undergraduate Honors Theses

The purpose of this study was to explore outcomes of participating in a deliberative dialogue for adolescents. Participants attended a deliberative dialogue facilitated by the primary researcher. After the dialogue, participants completed journal prompts that asked about their experience participating in the dialogue. Results indicated that participation in the dialogues impacted adolescents’ confidence and open-mindedness. Findings also indicated components of atmosphere that contributed to willingness to engage, and strategies participants can use in future conversations. Deliberative dialogues are an avenue for transformative experiences and the data from this study can help experience designers understand these types of experiences for adolescents. …

Eskape Pathogens: The Clinical Prevalence And Molecular Mechanisms Of Antibiotic Resistance, Anusha Attre

Honors Scholar Theses

The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are the leading cause of all nosocomial, or healthcare-associated (HAI), infections (Navidinia, 2016). The purpose of this research study is to determine the burden of ESKAPE infections on healthcare and study the antibiotic resistance in these high-risk pathogens to provide direction for researchers to develop new antimicrobial innovations to reduce ESKAPE infectivity and improve patient outcomes. To study the burden of ESKAPE infections, this review analyzes the current statistics explaining the clinical prevalence of each pathogen in causing HAIs. Additionally, each pathogen is …

St. Norbert College Students Commissioned As Second Lieutenants In The United States Army, St. Norbert College

Press Releases 2022

No abstract provided.

Optimization Of Paper-Based Substrates For Surface Enhanced Raman Spectroscopic Biosensor Development, Kaylee M. Cappuccio

Undergraduate Honors Theses

Advancements in the field of analytical chemistry have greatly expanded the development of biosensors for the detection of a wide array of diseases. This study aims to optimize an affordable paper-based nanocomposite biosensor that utilizes surface-enhanced Raman spectroscopy (SERS). Specifically, it investigates the preparation parameters for a paper-based SERS substrate, including nanoparticle administration and drying procedures. A particular focus of this work is to assess how the wax-defined paper channels can effectively enhance SERS intensity. The results revealed that while the wax-printed wells can define the nanoparticle administration for SERS detection, wax backing may reduce the sensitivity of SERS by …

Regulation Of Oxidative Phosphorylation Of Liver Mitochondria In Sepsis, Pierre Eyenga, Benjamin Rey, Lilia Eyenga, Shey-Shing Sheu

Center for Translational Medicine Faculty Papers

The link between liver dysfunction and decreased mitochondrial oxidative phosphorylation in sepsis has been clearly established in experimental models. Energy transduction is plastic: the efficiency of mitochondrial coupling collapses in the early stage of sepsis but is expected to increase during the recovery phases of sepsis. Among the mechanisms regulating the coupling efficiency of hepatic mitochondria, the slipping reactions at the cytochrome oxidase and ATP synthase seem to be a determining element, whereas other regulatory mechanisms such as those involving proton leakage across the mitochondrial membrane have not yet been formally proven in the context of sepsis. If the dysfunction …

Burnout And Psychological Capital In Baccalaureate Nursing Students Enrolled In Clinical Rotations, Kathleen Horan

Seton Hall University Dissertations and Theses (ETDs)

Nursing students who will successfully transition to practice as registered nurses are a crucial resource, especially now with the current nursing shortage. Using Meleis’ Transition Theory as a framework, the purpose of this descriptive correlational study was to examine specific intrapersonal factors in nursing students enrolled in clinical rotations. The convenience sample consisted of 129 BSN students with a mean age of 24. Their levels of burnout (exhaustion, cynicism and inefficacy) and psychological capital (hope, efficacy, resilience and optimism), also called PsyCap, were measured using the Maslach Burnout Inventory-General Survey and the Psychological Capital Questionnaire. Findings demonstrated moderate levels of …

Hate Speech Detection In A Mix Of English And Hindi-English (Code-Mixed) Tweets, Mohamed Sameer

Theses

With the increasing usage of social networking platforms seen over recent years, there has been an extensive rise in hate speech usage between the users. Hence, Government and social media platforms face lots of responsibility and challenges to control, detect and eliminate massively growing hateful content as early as possible to prevent future criminal acts such as cyber violence and real-life hate crimes. Since Twitter is used globally by people from various backgrounds and nationalities, the platform contains tweets posted in different languages, including code-mixed language, namely Hindi-English. Due to the informal format of tweets with variations in spelling and …

Predictive Policing, Amna Ali Al Boom, Shaikha Khalid Bin Thani

Theses

UAE is one of the safest countries to live in, but that does not indicate that the country does not witness crimes, During the COVID-19 pandemic, the country saw an increase in cyber and digital crimes. Apart from cybercrime, there are other types of crimes, such as street crimes and violent crimes. Data analytics aids Dubai Police to predict crimes. Criminal investigation is one of the fields that is very interesting and is taught in colleges and academies. Data analytics opens the door for studying the details of each crime. Data mining tools consist of a variety of techniques that …

Exploring Digital Checking: Evolution, Technology, And Future Directions, Mohammed Hasan Saleh Bamasood

Theses

This capstone project sought to explore the evolution of digital/electronic checking, assess how technology and other factors fueled the development of digital electronic checking, evaluate if the sampled research literature indicate that the desirable attributes of a payment instrument have been fully addressed; and analyze issues that deter the digital/electronic checking system to fully integrate the six most desirable attributes for a payment instrument in order to recommend possible directions for future research and design implementation. The project utilized integrative review as its methodology and adopted a theoretical framework based on the input-process-output model to guide the analysis and presentation …

The Power Of Mind Control, Ali Adnan Majed

Theses

Electroencephalogram (EEG) is a technology that has been used for so long to read and record neurological activity in the brain. EEG recordings are widely used nowadays for different neurological applications. Emerging technologies that can detect and analyze eye focus using EEG based technology are now are developing quickly. At a relatively affordable cost one can own an EEG kit. With the help of predisposed algorithms or the help of developers, new algorithms for different commands are being worked on. Along with other technologies EEG eye tracking can be beneficial in many domains such as, psychology, marketing, automotive industry, and …

“Subestimamos Las Habilidades De Los Estudiantes:” Bilingual Teacher Candidates Building On Multilingual Assets, Allison Briceño, Emily Zoeller

Faculty Research, Scholarly, and Creative Activity

Teaching for equity with bilingual learners means building on students’ linguistic strengths. This critical qualitative self-study explored how pre-service bilingual teachers developed ideology and pedagogy through a structured, holistic approach to writing instruction. Seven bilingual teacher candidates implemented a strategic Transliteracy approach to writing instruction, observing student assets and teaching cross-linguistically. Data includes semi-structured interviews and coursework. Findings showed teachers’ ideological and pedagogical clarity co-developed as they implemented a holistic biliteracy practice. Implications for bilingual teacher education include (1) providing opportunities for teacher candidates to practice assets-based formative assessment and instruction; (2) employing a holistic biliteracy orientation; and (3) creating …

Systemic Opportunities To Improve Older Pedestrian Safety: Merging Crash Data Analysis And A Stakeholder Workshop, Jason C. Anderson, Sirisha Kothuri, Christopher M. Monsere, David S. Hurwitz

Civil and Environmental Engineering Faculty Publications and Presentations

This paper presents a framework for improving older pedestrian safety in regard to serious (fatal and incapacitating) crashes, using Oregon as a case study. On review of state and federal practices pertaining to older pedestrian safety, 4 years of crash data identified 112 older (≥ 65 years) pedestrian serious injury crashes. These data were explored for factors that might be addressed systemically using two methods. First, raw frequencies in the crash data were assessed to determine trends and crash-related factors that are overrepresented. Second, a random forest analysis was conducted to determine important variables for predicting older pedestrian serious injury …

Transitioning Eating Practices Of Older Adults, Michelle Lajoy Jackson

Dissertations

Purpose: The purpose of this descriptive qualitative study was to explore what factors may have influenced the transition of an individual older adult’s eating practices over a lifespan and the impact participants perceived those factors currently had upon their nutritional health in older adulthood.

Background: The older adult population is recognized as one of the fastest growing populations in the United States. One of many growing concerns for this population is the impact of dietary practices on the morbidity and mortality of this aging population. There is limited research to date that has explored the transitioning of appetite …

Multifunctional Carbon-Supported Cobalt-Nickel Compounds For Water Splitting And Energy Storage Applications, Wang Lin

Electronic Theses & Dissertations

In order to effectively reduce carbon emission and achieve the goal of mitigating climate change, hydrogen energy has high hopes as a representative of green energy. According to the most current and updated research, compounds of cobalt and nickel have been widely studied as alternatives instead noble metal materials as catalysts for the electrolysis of water. Based on some other research reports, a hydrothermal method to grow cobalt-nickel hydroxide on nickel foam that has been carbonized in advance was proposed. To compare the modification results of these materials by different activation methods, calcination, sulfidation, and phosphating were performed on the …

Biophysical Insight Into The Sars-Cov2 Spike–Ace2 Interaction And Its Modulation By Hepcidin Through A Multifaceted Computational Approach, Hamid Hadi-Alijanvand, Luisa Di Paola, Guang Hu, David M. Leitner, Gennady M. Verkhivker, Peixin Sun, Humanath Poudel, Alessandro Giuliani

Mathematics, Physics, and Computer Science Faculty Articles and Research

At the center of the SARS-CoV2 infection, the spike protein and its interaction with the human receptor ACE2 play a central role in the molecular machinery of SARS-CoV2 infection of human cells. Vaccine therapies are a valuable barrier to the worst effects of the virus and to its diffusion, but the need of purposed drugs is emerging as a core target of the fight against COVID19. In this respect, the repurposing of drugs has already led to discovery of drugs thought to reduce the effects of the cytokine storm, but still a drug targeting the spike protein, in the infection …

Cultural Change And Threat Perception: Casual Implications On White Nationalist Beliefs And Outgroup Restricting Policies, Andrea Bellovary

College of Science and Health Theses and Dissertations

Cultural change is an inevitable aspect of life; however, how people react to cultural change can dramatically vary. Of particular interest to this analysis is how White Americans react to cultural changes occurring in the nation. Across three studies, I examined how White Americans may see cultural change, in the form of demographic change, as threatening and how these threat perceptions may influence their endorsement of White nationalism beliefs and support for outgroup restricting policies. This investigation found that White participants who read about real demographic changes occurring in the nation endorsed more threat perceptions (Study 1). Furthermore, there was …

Apoyo Deseado: The Role Of Parental Support For Latinx First-Generation College Students, Grevelin Ulerio

College of Science and Health Theses and Dissertations

Underrepresented groups, including ethnic and racial minorities as well as first-generation college students (FGCS), are less likely to attain a four-year college degree than their white counterparts. This is particularly true for Latinx youth that are often the first in their family to go to college. Existing research on the role of parental support in promoting retention among Latinx college students is mixed. The current study used a qualitative, longitudinal method to examine the perceptions of parental support among nine (9) Latinx FGCS attending a medium-sized private university in the Midwest region of the United States. Interpretative Phenomenological Analysis (IPA) …

Comprehensive Investigation Of The Accounting Principles Through Case Studies, Mary Frances Williams

Honors Theses

The following thesis consist of thirteen accounting case studies that were presented as the curriculum followed in the Accounting 420 class. Each case covers a topic that relates to the basic accounting principles and the accounting industry. This thesis represents a deep analysis of accounting principles and demonstrates a well-rounded understanding of the topics covered. Each case study is completed under the direction of Victoria Dickinson in abides with all requirements for the Patterson School of Accountancy, Sally McDonnell Barksdale Honors College, and the University of Mississippi ACCY 420 course in the 2020-2021 academic year.

Competency And Work Environments Among Military And Civilian Perioperative Registered Nurses: A Predictive Model, James X. Stobinski

Dissertations

This study examined the self-assessed competency levels, work environments, sub-specialty training and selected demographic characteristics of two groups—civilian and military (United States Navy) perioperative nurses. The Nurse Competence Scale (NCS) was used to assess competency levels, and the Practice Environment Scale-Nursing Work Index (PES-NWI) was used to assess the nursing work environment. Demographic characteristics, including years of experience, educational level and type of sub-specialty training, were gathered, and comparisons were made between the groups.

A cross-sectional non-equivalent comparison group design was used. The research was conducted by mailed survey packets. All active duty Navy perioperative nurses (228) were surveyed, as …

Interview With The Tran And Yen Tran (Saigon Noodles), The Tran, Yen Tran, Alyssa Powell

Pacific Food Empires

The Tran is the owner of a Vietnamese restaurant in Salinas, California, called Saigon Noodles, located just a short distance away from the Northridge Mall. The Tran was born in Vietnam near the capital of Saigon, now called Ho Chi Min City, and later immigrated to the United States as a young adult. Growing up, The always ate Vietnamese food, and his favorite food was Vietnamese noodle soup, also called pho. About five years ago, in 2018, The opened Saigon Noodles with his brother and his wife, Yen Tran, who continues to help him at the restaurant. They named their …

Bnsf Strategic Analysis, Bella Tran

Honors Program: Senior Projects (Public)

Burlington Northern Santa Fe, LLC. (BNSF), is an American railroad that is concentrated in the western two-thirds of the U.S. This railroad has a history stretching back over a century that has led the company to now function as one of the leading Class I Railroad with over 30,000 employees and over 30,000 miles of laid track. Two methods of analysis were used to examine the competitive environment in which BNSF operates. The first is the PESTEL analysis which examines the macro-environment. The second is Porter’s Five Forces which analyzes the competitive environment of an industry. The analyses concluded that …

A Strategic Audit Of Seaworld, Thomas Wolfe

Honors Program: Senior Projects (Public)

A strategic audit of SeaWorld