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Math Musicians: Exploring The Impact Of Content Integrated Pop Music On Students’ Attitudes And Engagement During Math Instruction, Megan Hook

Departmental Honors & Graduate Capstone Projects

Traditional methods of math instruction have been consistently linked to students having negative feelings about math, as well as decreased motivation and engagement during math instruction. This study investigated how arts integration, specifically integrating pop music, impacted students’ attitudes about math and students’ motivation and engagement during math instruction in a fifth-grade classroom. This study was mixed methods, with quantitative data collected through an adapted version of a student dispositions survey to assess students’ attitudes, motivation, and engagement, and qualitative data collected through a short response question about how students feel music impacted their math experiences. Results indicated that the …

“The Battle Against Sameness”: Queer Marriages In Forster And Woolf, Lindsey Hatton

Departmental Honors & Graduate Capstone Projects

The Bloomsbury Group was known for unconventionality, both in their lives and in their writing. This holds especially true for E.M. Forster and Virginia Woolf, whose novels uniquely depict queer relationships as an alternative to traditional, rigid, heterosexual marriages. This paper looks at Clarissa and Richard from Mrs. Dalloway, Margaret and Henry from Howards End, and Maurice and Alec from Maurice and how each of these couples subvert the societal conventions of the Victorian era in different ways. A close reading of these texts and characters allows for a nuanced understanding of Woolf and Forster’s revolutionary visions and demonstrates how …

Coronavirus Disability Survey: Assessing The Impact Of Covid-19 On Young Adults With Disabilities, Hena Rashid

Departmental Honors & Graduate Capstone Projects

This paper seeks to inform individuals of the importance of digital inclusivity, diminish the digital divide, and accessibility to technological services of college students who experience a form of disability. The United States has conducted minimal research on the digital disability rhetoric, promoted minimal disability-inclusive measures to protect the rights and well-being of college students, and minimal assistance to mitigate Coronavirus (COVID-19) impacts to this population subgroup. This subject can have a big impact on individuals who suffer from disability stigma, low accessibility issues, and who have been disproportionately impacted by the pandemic. Furthermore, this subject will benefit college students …

Teacher Work Sample: Telling Time, Courtney R. Hallam

Honors Theses

Three local elementary students were identified as performing below grade-level and receiving special education services, using direct instruction with a scripted program. The students cannot tell time using classroom clocks. The teacher created a five-day unit to teach telling time to the nearest hour and half-hour. Lesson plans were created and implemented using evidence-based practices (EBPs), including explicit instruction, modeling, and response cards. Students were able to successfully complete formative and summative assessments with scores indicating mastery. Implications and suggestions for future teaching are presented.

Bare: The Modern Female Nude Uncovered, Tasha A. Determan

Honors Thesis

My honors thesis criticizes representations of the female nude and advocates for diverse expression of the female body. The research encompasses two series of artwork and a written component examining and reflecting upon the artwork. The first series is Venus of Fruit, which assesses past depictions and associations of the female nude specifically objectification and sexualization in western art. The sculptures are four cast bronze nude figures within an apple, a banana, and a pineapple. The figures are Venuses trapped within nature, beauty, fertility, and sexualization. The second series is Venus Anew, which examines the naked and the …

Reno-Protective And Immune Effects Of Growth Differentiation Factor 15 In Obesity-Related Kidney Disease, Jessie T. Sullivan

Honors Thesis

According to the World Health Organization, worldwide obesity has tripled since 1975 and is still on the rise, putting people at a higher risk of some cardiovascular diseases and kidney disease. Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has been studied recently for its role in multiple biological processes and diseases. The member of the transforming growth factor beta (TGF-b) family has been investigated as a therapeutic agent and biomarker for obesity and associated cardiovascular diseases, stroke, diabetes, osteoarthritis, cancer, and kidney disease. Studies have shown the anti-inflammation, anti-obesity, and anti-diabetic effects of GDF15, but few have …

Bilingual Behaviors: Learning Context In Second Language Acquisition, Sydney M. Fulton

Honors Thesis

Language separates human beings from other species in the animal kingdom. Not only does language provide humans with a means to communicate, but it represents one’s family, cultural identity, and personality. There are over six thousand spoken languages in the world today, and around half of the earth’s inhabitants speak more than one language. First language acquisition is a natural process for all humans that begins before birth. The human brain can acquire multiple languages during infancy, but many people acquire a second language after the brain has fully developed. Knowledge of more than one language allows one to make …

The Well-Being Outcomes Of Sexual Assault Survivors After Sexual Assault Kit Examinations, Brianna N. Zimmer

Honors Thesis

This study examined how the quality of a sexual assault medical forensic exam, or SAMFE, affects the well-being outcomes of sexual assault victims. A SAMFE is used to collect forensic evidence and provide comprehensive care to victims. Furthermore, SAMFEs are typically collected by a specially trained Sexual Assault Nurse Examiner (SANE) or medical practitioner. It was hypothesized that a more trauma-informed and victim-centered SAMFE allowed victims to have better physical, psychological, and social well-being outcomes. In this study, a victim’s well-being outcomes were measured through the dependent variables of the TSC-40, Brief-COPE, and Posttraumatic Growth Inventory scales. Furthermore, the quality …

Antitrust Philosophy And Its Impact On Rural Industry, Logan Gary Johnson

Honors Thesis

The United States is a nation steeped in values, and tradition. One of these values has always been the preservation of competition in the pursuit of liberty. The philosophical backing of America’s founding can be traced back to a handful of European thinkers, most notably John Locke. The connection between Locke, America’s founding, and continued struggles with antitrust enforcement are worthy of exploration. Though likely unintentional, rural communities have been left to deal with the impacts of weak antitrust enforcement in a number of key sectors. Chief of which is Agriculture. Consolidation is the new norm, with each stage of …

Operational Details Of Usd 1 Billion Credit Line, High Commission Of India (Goi)

Documents

No abstract provided.

The Development Of Polymeric Dexamethasone Prodrug Nanomedicines For The Treatment Of Lupus Nephritis, Zhifeng Zhao

Theses & Dissertations

Lupus nephritis (LN) is a significant cause of morbidity and mortality among lupus patients. Glucocorticoids (GCs) are uniformly used in clinical LN management. Their notorious toxicities, however, have hampered the long-term clinical application. To circumvent GCs’ adverse effects while maintaining their potent therapeutic efficacy, we have developed a micelle-forming polyethylene glycol (PEG)-conjugated dexamethasone prodrug (ZSJ-0228), which could passively target the inflamed kidney in NZB/W F1 lupus-prone mice. It was found that monthly ZSJ-0228 treatment for five months significantly reduced the incidence of nephritis in NZB/W F1 mice with an improved survival rate. Unlike the dose equivalent daily dexamethasone treatment, long-term …

Feasibility And Efficacy Of Bisphosphonate Use For The Prevention Of Bone And Muscle Loss, Laura E. Flores

Theses & Dissertations

Loss of bone and muscle mass often occurs in tandem, increasing the risk of fragility fractures. Whereas many drugs are approved for the treatment of bone loss, there are few treatments available for the concomitant loss of bone and muscle. Identification of a treatment to mitigate pathologic bone and muscle atrophy has the potential to impact countless populations and influence approaches for healthy aging. Bisphosphonates have emerged as a potential treatment for both bone and muscle loss in cellular, murine, and observational human studies. Our findings of modest weight maintenance in postmenopausal women treated with 12-months of risedronate, relative to …

Modulation Of Immune Homeostasis In Neurodegenerative Diseases, Pravin Yeapuri

Theses & Dissertations

Modulating the immune system via. transformation of CD4+ T cell effector to regulatory (Teff to Treg) or promoting microglial clearance of abnormal disease proteins are attractive therapeutic strategies to restore immunological balance in neurodegenerative diseases like Parkinson’s disease (PD) and Alzheimer’s disease (AD). In the past decade, we defined a safe and effective pathway for Treg induction through the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF was developed in PD animal models and early phase I human studies demonstrating proof-of-concept efficacy for ameliorating disease signs and symptoms. Despite the recorded efficacy, the medicine’s short half-life, limited bioavailability, and injection site reactions …

Modulating Cellular Senescence To Improve Age-Associated Wound Healing Impairment, Upasana Niyogi

Theses & Dissertations

Impaired tissue repair and regenerative ability in the aged is a major socio-economic and clinical problem. One of the likely factors associated with poor wound healing is the presence of lingering senescent cells in the wound sites. Failure to eliminate these cells has been associated with inadequate healing, excessive scarring, and abnormal skin stiffening. Thus, the objective of our study was to test interventional strategies to mitigate the negative effect of senescent cells. We hypothesized that reducing senescent cell burden and promoting non-senescent cell functionality will improve wound healing with age.

We developed a 3D in vitro senescent fibroblast populated …

Modulating Cardiac Remodeling After Myocardial Infarction, Upendra Chalise

Theses & Dissertations

Cardiac remodeling after myocardial infarction (MI) is indicated by infarct wall thinning, reduced ejection fraction, and dilation of the left ventricle (LV). Inflammation presides in the early days of MI as a key event in cardiac wound healing. Infiltration of inflammatory cells, predominantly neutrophils and macrophages, is stimulated by ischemic cardiomyocytes that secrete inflammatory cues. This dissertation focused on identifying factors that influence cardiac remodeling after MI. S100A9 is a neutrophil-derived factor identified that exacerbated infarct wall thinning and cardiac dilation by increasing neutrophil and macrophage infiltration. Similarly, murinoglobulin 1 (Mug1) and galectin (Lgals)3 were macrophage-derived factors identified that regulate …

Visceral Adipose Tissue Remodeling In Pancreatic Ductal Adenocarcinoma Cachexia: The Role Of Activin A Signaling, Pauline Xu

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer death in the United States and is projected to become the second leading cause by the year 2030. Prognosis for patients with metastatic disease remains dismal, with cachexia as a main contributor to the low survival rate. Emerging reports indicate that PDAC patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. While muscle wasting has been the most frequently studied mechanism in cachexia research, changes in adipose tissue are increasingly understood as important components of …

Sox2 Dosage Governs Tumor Cell Identity And Proliferation, Ethan P. Metz

Theses & Dissertations

The stem cell transcription factor SOX2 has been widely recognized for its critical roles during mammalian development. SOX2 expression has also been implicated in more than 20 types of human cancers. Importantly, the expression of SOX2 is regulated at multiple levels, which enables the tight regulation of SOX2 levels. Previous work from our laboratory has shown that elevating SOX2 from an inducible promoter inhibits the proliferation of several human tumor cell types. Other studies have reported that high levels of SOX2 are necessary to maintain lineage plasticity in advanced tumors. Thus, the dosage of SOX2 plays a critical role in …

Exploring Host-Pathogen Interactions Of The Ebola Virus Ribonucleoprotein Complex, M. Jane Morwitzer

Theses & Dissertations

Ebola virus (EBOV) causes a severe hemorrhagic fever in humans that is oftentimes lethal, emerging as a global public health threat in recent years. Understanding the host factors that contribute to the dynamic states and functions of the EBOV ribonucleoprotein (RNP) complex could potentially advance the development of therapeutics. The viral architecture of the EBOV RNP complex has been defined but host protein interactions that modulate viral replication have largely gone unaddressed. EBOV nucleoprotein (NP) and viral protein 35 (VP35) play critical roles in viral replication and capsid assembly, comprising two major components of the RNP complex. Elucidation of host …

Extracellular Mechanotransduction In Marfan Syndrome: An Equivalence Principle, Stephen Haller

Theses & Dissertations

Biological tissues continuously experience mechanical stress and have evolved sophisticated mechanisms to sense mechanical stimuli. While traditional viewpoints regard cells as the ultimate sensors and processors of mechanical information, compounding evidence demonstrates that extracellular matrix, the structural component of tissues, also exhibits evolved molecular responses to force. This led us to propose a new paradigm termed extracellular mechanotransduction, in which matrix orchestrates a complementary form of force integration distinct from traditional cellular and extracellular viewpoints. We thus propose that force-sensitive signaling mechanisms evolved within the extracellular space to help cells maintain mechanical homeostasis in tissues. In this dissertation, we apply …

Development Of Perfluorocarbon Nanoemulsions For Delivery Of Therapeutic Nucleic Acids, Ling Ding

Theses & Dissertations

Local pulmonary administration of therapeutic siRNA represents a promising approach to the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Pancreatic cancer (PC) is a fatal human cancer whose progression is highly dependent on the nervous tumor microenvironment. siRNA delivery has been well studied as a promising therapeutic agent for several disease, including the pulmonary fibrosis and cancer. Perfluorocarbon nanoemulsions have been studied in the treatment of various diseases as drug delivery systems. We report development of perfluorooctylbromide (PFOB) nanoemulsions as a platform to facilitate delivery and penetration of a therapeutic siRNA to pulmonary fibrosis lung and …

Characterization Of 1,1-Diarylethylene Foxm1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells, Cassie Liu

Theses & Dissertations

Forkhead box M1 (FOXM1) is a member of the conserved forkhead box (FOX) transcription factor family. Over the last two decades, FOXM1 has emerged as a multifunctional oncoprotein and a robust biomarker of poor prognosis in many human malignancies. FOXM1 and its associated oncogenic transcriptional signature are enriched in >85% of ovarian cancer cases, and FOXM1 expression and activity can be enhanced by a plethora of genomic, transcriptional, post-transcriptional, and post-translational mechanisms. As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell …

Biologically-Inspired Nanoparticles For Oncology Applications, Aishwarya Bapat

Theses & Dissertations

Cancer is the leading cause of death in the United States and its high mortality rate can be attributed towards poor diagnosis methods and less effective therapeutic treatments. Many nanotechnology-based diagnostics and therapeutics are being developed to improve cancer patient outcomes. In this work, we have studied nanoparticles for diagnostic and therapeutic applications in cancer treatment.

In the first work, novel fluorescent NPs loaded with indocyanine green (ICG) were developed for bioimaging applications of pancreatic cancer. Targeted fluorescent nanoparticles (NPs) are being developed to image a range of cancer types with the goal to improve patient outcomes by utilizing in …

Leukocyte Subsets In The Peripheral Blood And Spleen Of Gastrointestinal Cancer Patients, Kathryn E. Cole

Theses & Dissertations

In 2022, an estimated 62,210 people will be diagnosed with pancreatic ductal adenocarcinoma (PDAC) and approximately 49,830 will die from the disease. Current treatment strategies for gastrointestinal (GI) cancer patients, such as PDAC, have shown limited benefit, suggesting the need to develop novel, multimodality therapeutic approaches. Adoptive cellular therapy (ACT) using autologous tumor infiltrating lymphocytes (TILs) has shown efficacy in patients with melanoma; however, this approach is costly and requires extensive cell culture for sufficient numbers of T-cells for infusion. GI cancer patients with borderline resectable disease, whose primary tumor is adjacent to the splenic vasculature, can sometimes undergo a …

Design, Synthesis, And Biological Investigation Of Pyridine Sulfones As Anti-Chlamydia Trachomatis Agents, Mohamed A. Seleem

Theses & Dissertations

Chlamydia trachomatis is the most prominent cause of sexually transmitted bacterial infections worldwide, with around 128 million reported cases annually. This pathogen can cause severe urogenital and ocular consequences, resulting in infertility and trachoma. In its unique developmental cycle, Chlamydia fluctuates between two distinct forms, elementary bodies (EBs) and reticulate bodies (RBs). We hypothesized that caseinolytic protease P (ClpP), a conserved protease among bacterial species, drives the Chlamydia developmental cycle. Earlier work by the Ouellette group demonstrated that Chlamydia relies on its ClpP2 paralogue (ctClpP2) to differentiate between its developmental forms. Dysregulation of ctClpP2 had a significant …

Building An Artificial Intelligence Framework For Hypertension Diagnosis: A Use Case Of The Problem List Curation, Ketemwabi Yves Shamavu

Theses & Dissertations

Hypertension is the world's leading factor in cardiovascular disease. Forty-seven percent or close to one in two Americans aged 18 and older are affected. It predicts approximately a thousand deaths per day. Based on recent statistics from the Centers for Disease Control and Prevention, one in three patients with hypertension does not know they are hypertensive. Seventy-five percent of hypertensive patients have uncontrolled hypertension - meaning that they are not treated to target. While there is extensive literature on hypertension diagnosis and management, there is an apparent gap in understanding and acknowledging that a person is hypertensive. Moreover, blood pressure …

Maternal Distress In The Neonatal Intensive Care Unit, Morgan A. Staver

Theses & Dissertations

Maternal distress in the NICU is a common and potentially harmful phenomenon for mothers with a sick infant. The overall purpose of this dissertation was to describe maternal distress and to examine maternal distress among mothers who have infants greater than or equal to 34 weeks of gestation at birth in the NICU. This was accomplished by first conducting a concept analysis of maternal distress in the NICU. Next, an integrative review of the literature was done to assess maternal distress and associated variables in response to infant hospitalization in the NICU. Finally, a mixed methods study was done to …

Tourniquet-Induced Ischemia-Reperfusion Injury, Junliang Qian

Theses & Dissertations

Ischemia-reperfusion (IR) is a pathological condition characterized by an initial restriction of blood supply to an organ followed by subsequent restoration of reperfusion associated with exacerbation of tissue damage. For pre-hospital emergency situations and surgical procedures, tourniquet or femoral artery ligation are widely used to stop extremity hemorrhage or create a bloodless operating field. To fully evaluate the underlying mechanisms in IR pathophysiology and potential therapeutic options, we compared tourniquet- and femoral artery ligation-induced IR injuries in the hindlimb of mice. We found that tourniquet/IR-induced acute hindlimb injuries are more severe than those induced by femoral artery ligation/IR, including alteration …

The Development Of Thermoresponsive Hydrogel-Based Drug Delivery Systems For The Treatment Of Musculoskeletal Diseases, Ningrong Chen

Theses & Dissertations

Water-soluble polymers are one of the most commonly used drug delivery vehicles for musculoskeletal diseases. During the past few decades, various biocompatible polymers have been employed in the development of thermoresponsive hydrogels as drug delivery systems for the treatment of local musculoskeletal pathologies. As part of our laboratory’s contribution to this field of study, I have successfully developed three thermoresponsive hydrogel-based formulations for the treatment of three different pathologies associated with the musculoskeletal system.

As my initial effort, I have developed a bone-targeting injectable hydrogel drug delivery system based on Pluronic 127 (Poloxamer 407), which is a Generally Recognized As …

Investigation Of Cumulative Genetic Risk And Cc16 In Adult Asthma And Copd Populations, Kelli C. Gribben

Theses & Dissertations

INVESTIGATION OF CUMULATIVE GENETIC RISK AND CC16 IN ADULT ASTHMA AND COPD POPULATIONS

Kelli C. Gribben, Ph.D.

University of Nebraska Medical Center, 2022

Supervisors: Paraskevi A. Farazi and Tricia D. LeVan, Ph.D.

Asthma and Chronic Obstructive Pulmonary Disease (COPD) have complex etiologies and lack biological predictors that can be used for primary prevention, early detection, progression, or monitoring. Genetic risk scores (GRS) aggregate genetic effects from GWAS-identified susceptibility variants associated with a trait. GRS may provide opportunities to improve disease prediction to inform public health and clinical interventions. Asthma GRS studies utilizing multi-ethnic populations are scarce and there is a …

Mobile, Biosensor Technology For Measuring Joint-Level Human Motion, Matthew Mcmanigal

Theses & Dissertations

The measurement of three-dimensional knee joint angles can predict both anterior cruciate ligament (ACL) injuries and the risk of developing early knee osteoarthritis. However, knee joint angle assessment is currently limited, due to the lack of validated wearable and untethered technologies that can be deployed in natural environments and rural or community settings. To address this challenge, this thesis project aimed to 1) develop a fully untethered, wearable electronic device to measure knee joint angles during natural human movement and 2) test the accuracy of the device to collect sagittal knee joint angles during dynamic activities of human movement. For …