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Characterization Of Mef2c-Related Disorders: Genotype, Phenotype, And Gene Pathway Dysregulation, Jessica Ann Cooley Coleman

All Dissertations

MEF2C­-related disorders are characterized by intellectual disability, developmental delay, lack of speech, seizures, stereotypic movements, hypotonia, and brain abnormalities and are caused by pathogenic alterations involving the MEF2C gene. Despite published cases, MEF2C­-related disorders are difficult to recognize clinically. These studies sought to further characterize MEF2C­-related disorders by investigating the genotypes, phenotypes, and gene functions (or dysfunctions) associated with the disorder.

Tremors have been reported in some patients with MEF2C­-related disorders, but the concept of tremors has been complicated by vague definitions and numerous categorization methods. We performed a concept analysis following the Walker and Avant …

Integrating Fire Responses To Combat Wildfires, Jonathan Leonard Badal

Electrical Engineering

Each year wildfires cause significant loss of property, worsen people’s health, and destroy multiple ecosystems. On average, a wildfire season costs anywhere from 7.6-62.8 billion dollars due to fire containment, repair, and restoration [1]. It can take decades to recover from the crippling loss of land and take even longer to fully restore it. However, with the implementation of a robust early detection system, these losses can be significantly reduced. The current process for identifying wildfires involves visual identification, phone call alerts, and media tools primarily driven by park rangers and public reporting. Unfortunately, this system is not preventative and …

My Body Is A Question Mark Lit From Within, Lisa Marie Schrad

Graduate Thesis Collection

In her MFA thesis “My Body Is a Question Mark Lit from Within,” Lisa Marie Schrad explores through poetry the body and its different appetites—hunger for justice, for healing, for God, for home, for wonder. Along the way, the poems also make clear that the path toward fullness and satisfaction must inevitably pass through a deep, brave commitment to knowing the full truth about ourselves. When a light shines out from inside the body, what shortcomings are exposed? What goodness is revealed? And how do we live in the world responsibly, kindly, from the space in-between our questions and their …

Humor Writer Of The Month: David Misch, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Our Humor Writer of the Month is David Misch, a comic folksinger, stand-up comedian and screenwriter whose credits include Mork and Mindy, Saturday Night Live and The Muppets Take Manhattan.

Vicarious Trauma And Doctoral-Level Trainees: Self-Care Practices, Elisabeth B. Gibson

Doctor of Psychology (PsyD)

Research reflects correlations between trauma history and motivation to pursue a career in clinical psychology and mental health professions. Professional longevity is a concern for clinicians in general, especially for clinicians with a trauma history who work with people suffering with trauma conditions. Trauma histories measured by adverse childhood experiences (ACEs), are likely to be present within students of doctor of psychology training programs, and may influence doctoral trainee readiness and ability to engage clients in clinical work. Self-care is thought to not only support overall well-being, but to also mitigate the negative consequences of stress associated with clinical work. …

Resilience, Spirituality And Cultural Connectiveness Within The Native American/American Indian Indigenous Population, Lindsay Price

Doctor of Psychology (PsyD)

Native Americans, also known as the American Indian or Indigenous population, were colonized over four centuries ago by Europeans who brought many diseases which decimated this population. This immense trauma continued for generations as the settlers continued to violate Native American life and identity on every level. Hundreds of indigenous tribes endured massacre, annihilation of traditional culture, forced religious assimilation, stolen land, broken treaties, betrayal of rights, removal of identity, neglect, and constant abuse without any recompense. These violations still widely occur, yet the strength and flourishing of Native Americans remain ever-present. Their deep-rooted protective factors within resilience, like cultural …

Personality And Behavioral Characteristics: A Study Of Court Populations, Markayla Shattuck

Doctor of Psychology (PsyD)

Despite the growing body of research for Fetal Alcohol Spectrum Disorder (FASD) within adults, there remains a lack of research addressing the prevalence of FASD in the legal system. Over the last several decades it has become apparent that alcohol consumption during pregnancy can have devastating long term impacts on the developing fetus including facial abnormalities, cognitive deficits, adverse life outcomes, and behavioral challenges (Brintnell et al., 2019; O’Neil, 2011; Sarman, 2018; Streissguth et al., 2004). Within the legal system, FASD is about 30 times higher than the general population (Lange et al., 2017). Initially, the prevalence of FASD was …

High Spatial And Temporal Resolution Census Data Reveals Communities At Risk Along The Wildland-Urban Interface (Wui) In California, Usa, Jessica E. Viner, Slade T. Laszewski, Wesley Ho, Justin Ewoldt, Pionnah Gregorio, Liz Lyon, Brian Hoover, Shenyue Jia

Mathematics, Physics, and Computer Science Faculty Articles and Research

We tracked census tract level population change along California's wild land-urban interface (WUI) during the past decade (2010-2019), an ecological sensitive region transitioning from developed land to wilderness. Our results from Mann-Kendall analysis, a method employed for monotonic trend detection showed that about one-third (29.1%) of census tracts in California’s WUI have seen a significant population increase from 2010 to 2019, affecting 12.7% population in California.

The population increase along WUI is largely driven by the sixteen counties in the San Francisco Bay Area (10) and Southern California (6). We also found that higher proportion of WUI residents in Bay …

Transformative Pedagogy And Science Identity In Undergraduate Anatomy And Physiology, Emily Ann Royse

Dissertations

Anatomy and Physiology (A&P) courses are undergraduate biology prerequisite courses that cover many topics about human biology, including anatomy, histology, organ systems, and homeostasis. The purpose of the course is to equip students aiming to enter nursing and allied health education programs with an understanding of basic biological principles relevant to human biology and pharmacology. However, these courses have a high incidence of failure, and many students need to retake the course to progress in their competitive academic programs. Students tend to rely on memorization techniques to learn the course content, and given the nature of A&P as a discipline, …

Variation In Ampicillin Dosing For Lower Respiratory Tract Infections And Neonatal Bacterial Infections In Us Children's Hospitals., Elizabeth A. Daniels, Christopher C. Mcpherson, Jason G. Newland, Brian R. Lee

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: We examined ampicillin dosing in pediatric patients across 3 conditions: (1) bacterial lower respiratory tract infections (LRTIs) in infants and children >3 months, (2) neonates with suspected or proven sepsis, and (3) neonates with suspected central nervous system (CNS) infections. We compared our findings to dosing guidance for these specific indications.

DESIGN: Retrospective cohort study.

SETTING: The study included data from 32 children's hospitals in the United States.

METHODS: We reviewed prescriptions from the SHARPS study of antimicrobials, a survey of antibiotic prescribing from July 2016 to December 2017. Prescriptions were analyzed for indication, total daily dose per kilogram, …

Teaching Programmable Microcontrollers To Novice Users In A College Of Agriculture: Effects On Attitude, Self-Efficacy, And Knowledge, Grant T. Hood

Graduate Theses and Dissertations

This thesis consists of two articles that examined an instructional treatment based on the use of Arduino UNO R3 programmable microcontrollers in a fundamentals of agriculture systems technology course at the University of Arkansas. The first article examined students’ breadboarding and programming self-efficacy and knowledge of Arduino. The treatment consisted of a three-class-period instructional treatment, starting with a pretest before instruction to measure students’ baseline interest, knowledge, and self-efficacy of breadboarding and programming Arduino. This was followed with a short 30-minute instructional video explaining basic Arduino programming and breadboarding. Next a hands-on laboratory activity requiring students to breadboard and program …

Benchmarking Challenging Small Variants With Linked And Long Reads., Justin Wagner, Nathan D. Olson, Lindsay Harris, Ziad Khan, Jesse Farek, Medhat Mahmoud, Ana Stankovic, Vladimir Kovacevic, Byunggil Yoo, Neil Miller, Jeffrey A Rosenfeld, Bohan Ni, Samantha Zarate, Melanie Kirsche, Sergey Aganezov, Michael C. Schatz, Giuseppe Narzisi, Marta Byrska-Bishop, Wayne Clarke, Uday S. Evani, Charles Markello, Kishwar Shafin, Xin Zhou, Arend Sidow, Vikas Bansal, Peter Ebert, Tobias Marschall, Peter Lansdorp, Vincent Hanlon, Carl-Adam Mattsson, Alvaro Martinez Barrio, Ian T. Fiddes, Chunlin Xiao, Arkarachai Fungtammasan, Chen-Shan Chin, Aaron M. Wenger, William J. Rowell, Fritz J. Sedlazeck, Andrew Carroll, Marc Salit, Justin M. Zook

Manuscripts, Articles, Book Chapters and Other Papers

Genome in a Bottle benchmarks are widely used to help validate clinical sequencing pipelines and develop variant calling and sequencing methods. Here we use accurate linked and long reads to expand benchmarks in 7 samples to include difficult-to-map regions and segmental duplications that are challenging for short reads. These benchmarks add more than 300,000 SNVs and 50,000 insertions or deletions (indels) and include 16% more exonic variants, many in challenging, clinically relevant genes not covered previously, such as PMS2. For HG002, we include 92% of the autosomal GRCh38 assembly while excluding regions problematic for benchmarking small variants, such as …

Managing Stress Tolerance On Warm-Season Putting Greens In The Transition Zone, Thomas Edward Walton

Graduate Theses and Dissertations

The use of warm-season putting greens in the transition zone has increased in recent years. Ultradwarf bermudagrass (Cynodon dactylon (L.) Pers x C. transvaalensis Burtt-Davy) is the most prevalent warm-season putting green selection in the transition zone, however, newly developed greens-type zoysiagrass (Zoysia spp.) cultivars represent another potential selection for golf courses. The two major limitations of warm-season grasses in the transition zone are a general lack of cold- and shade-tolerance. Protective covers are essential to protect ultradwarf bermudagrass putting greens in the winter months. Unfortunately, golf courses can still experience winterkill underneath protective covers. Two field trials were conducted …

“Implacement”: The Importance Of Place And Community In Schooling, Emily Coady

Graduate Theses and Dissertations

This dissertation consists of three chapters exploring my overarching research question: How does sense of place shape a teacher’s orientation to their profession? My first chapter empirically answers the question: Is there a relationship between place attachment and measured aspects of teacher quality? In an attempt to qualify the strength of bond between a teacher and his or her community, I adapted a place attachment instrument developed by Raymond, Brown, and Weber (2010). Each teacher is given a place attachment score informed by their responses on the 21-item survey. Next, I correlated these scores to other aspects of teacher quality …

Imagining Communicative Success: How Imagined Interactions Affect Conflict Management In Romantic Relationships, Melinda Shaw

Graduate Theses and Dissertations

Currently, there are no bodies of research that examine the relationship between imagined interactions, relational maintenance, conflict management, and gender identity. Previous research has primarily relied on quantitatively measuring the functionality of imagined interactions and generating an understanding as to why individuals use them. However, this study qualitatively examined the connection between these concepts, specifically how gender identity affects how individuals use imagined interactions to manage conflict with their partner and maintain their relationship. Fifteen participants who are currently in long-term relationships were interviewed and then required to complete the Thomas-Kilmann (1974) conflict management mode survey. Afterward, the responses were …

Investigating Molecular Mechanisms Behind Bacterial Chondronecrosis With Osteomyelitis (Bco) Pathogenesis In Modern Broilers, Alison Ramser

Graduate Theses and Dissertations

Bacterial chondronecrosis with osteomyelitis (BCO), a leading cause of lameness in broiler chickens, is characterized by infection, inflammation, and bone attrition. There are currently no effective treatments and positive diagnosis is only possible through necropsy evaluations. Lameness is also a rising animal welfare and economic concern, making prevention and detection of BCO all the more critical. These challenges are exacerbated by a lack of mechanistic understanding of BCO’s etiology. The question I asked during my dissertation was how bacteria induce bone attrition in BCO pathology. My research has shown that mitochondrial dysfunction is characteristic of BCO conditions along with autophagy …

The Role Of Ccaat Binding Factor In The Regulation Of Catalase Gene Expression In Candida Albicans, Zahra Al-Rumaih

Graduate Theses and Dissertations

Candida albicans is a fungal opportunistic human pathogen. Its infections range from surficial infections like skin rash to fatal systemic infections. Filamentation growth mode is associated with C. albicans virulence because it helps penetration of the host’s epithelial cells. The CCAAT-binding factor (CBF) is a conserved heterooligomeric transcription factor found in 30% of eukaryotes genes. In C. albicans it is composed of 4 major subunits, including Hap2, Hap3, Hap4, and Hap5. Hap2 and Hap5 are essential for DNA binding and function. Hap4 has 3 homologous subunits: Hap41 and Hap42 are putative subunits of CBP. Hap43 is the only Hap4 subunit …

Supervised Representation Learning For Improving Prediction Performance In Medical Decision Support Applications, Phawis Thammasorn

Graduate Theses and Dissertations

Machine learning approaches for prediction play an integral role in modern-day decision supports system. An integral part of the process is extracting interest variables or features to describe the input data. Then, the variables are utilized for training machine-learning algorithms to map from the variables to the target output. After the training, the model is validated with either validation or testing data before making predictions with a new dataset. Despite the straightforward workflow, the process relies heavily on good feature representation of data. Engineering suitable representation eases the subsequent actions and copes with many practical issues that potentially prevent the …

Children’S Social Judgments Of Others On The Basis Of Dialect-Specific Vocabulary, Madison Myers-Burg

Graduate Theses and Dissertations

Many studies suggest that young children prefer speakers who speak similarly to them. Children demonstrate social preferences for speakers of their own native language over speakers of a non-native language as well as for speakers of a familiar accent over speakers of an unfamiliar accent. Recent research suggests that young children will similarly show preference for speakers who use familiar dialect-specific vocabulary over speakers who use vocabulary specific to an unfamiliar dialect. The current study investigated potential motivations behind young children’s preferences for familiar dialect-specific vocabulary. Fifty participants ages fifty-one months to ninety-five months (Mage =72.6 months) viewed an animated …

Predicting The Likelihood And Scale Of Wildfires In California Using Meteorological And Vegetation Data, Matthew Walters

Graduate Theses and Dissertations

Wildfires have devastating ecological, environmental, economical, and public health impacts through the deterioration of water and air quality, CO2 emissions, property damage, and lung illnesses. The early detection and prevention of wildfires allow for the minimization of these risks. The use of Artificial Intelligence (AI) in wildfire detection and prediction has been highly researched as a tool to assist firefighters in stopping wildfires in its early stages. The three common wildfire prediction categories include image and video detection, behavior prediction, and susceptibility prediction. Data such as climate, weather, vegetation, satellite images, and historical wildfire data is most commonly used. Many …

“Young Adult Books Don’T Realize They Have That Power”: Reader Response To Ideology In Young Adult Dystopian Fiction, Zane Emīlija Sarma

Graduate Theses and Dissertations

The purpose of this research is to find out how readers interact with novels in the Young Adult dystopian genre. I will examine the ways in which readers resist the dominant patriarchal ideological discourses in the YA dystopian novel and how readers submit to this ideology. Through an interaction with the text, the reader produces oppositional, negotiated, or preferred meanings. I will argue that readers’ response to ideology in the YA dystopian novel is affected by their active participation in reader communities such as the Bookish community online.

YA dystopian fiction was highly popular in the early 2010s, but the …

Naphthalene And Anthracene Degrading Potentials Of Bacteria Isolated From Soil Samples With Evidence Of Polycyclic Aromatic Hydrocarbon(Pah) Contamination, Olatunde Clement Akinola

Theses (2016-Present)

Polycyclic Aromatic Hydrocarbon (PAH) from crude oil and other sources is one of the most serious environmental problems. PAH has an adverse effect on human health, water bodies and agricultural products. Removal of PAH through the physical and chemical methods are expensive and not environmentally friendly. Bioremediation, which is the use of microorganisms to degrade environmental pollutants like naphthalene and anthracene and render them less toxic, provides a cheaper and safer method. The objective of this research is to study the naphthalene and anthracene degrading potentials of bacteria isolated from soil samples with evidence of cude oil contamination. Another objective …

An Assessment Of The Transit System Connecting Low-Income Households To The International Airport: A Case Study Of Southwest Alief, Texas, Abayomi Mololuwa Bakare

Theses (2016-Present)

Public transportation is part of the economic and social fabric of metropolitan areas, especially to low-income individuals who are often totally dependent on these services for their daily activities. In Houston Texas, this is made possible through the region's system of highway transit centers and other transportation options such as MetroBus and MetroRail. The role that transits plays in the connection between residential locations and employment opportunities is crucial in creating and implementing programs that will improve and maintain transit and ownership options available to vulnerable segments of Metropolitan residents. This study proposes the use of qualitative research methodology to …

Analyzing Breastfeeding On Social Media, Kerri Barnes

Theses (2016-Present)

The study uses the feminist theory to discourse issues surrounding breastfeeding as articulated on Twitter. The research employed a mixed methodology approach in executing its goal. The study will begin by examining and presenting findings on a Twitter hashtag, #breastfeeding, a popular hashtag that mothers and experts use to articulate breastfeeding issues. The extensive examination of breastfeeding beyond its linguistic form was undertaken in this study based on the feminist guidelines considering bodies that protect mothers' welfare were integrated into the study. The study findings from the tweets analyzed, N= 2,818, indicate and confirm that breastfeeding is the mode of …

Identifying Genetic Differences Among African American And Caucasian Triple Negative Breast Cancer Genotypes, Christopher Jordan Dixon

Theses (2016-Present)

Triple negative breast cancers (TNBC) are closely related to basal-like cancers and classified based on their molecular signatures and their progenitor cell type. TNBCs lack the presence of three common types of receptors known to fuel breast cancer growth: estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptors 2 (HER2neu). TNBC represent 10-20% of all molecular breast cancer subtypes. Even though genomic and transcriptome analyses show that many of the molecular signatures associated with TNBC are not related to ethnicity, clinicians and researchers find that African American (AA) TNBC women have higher mortality rates compared to Caucasian …

Characterization Of The Cell Cycle Dependent Kinase Inhibitor P27kip1 In The Stem-Like Properties Of Breast Cancer Stem Cells, Jaz-Mine Mccovins

Theses (2016-Present)

Breast cancer is the second leading cause of cancer death among American women. Traditional therapies, such as chemotherapy and radiation therapy, target proliferative cells within the tumor bulk. However, these treatments do not provide long-term disease survival because they fail to eliminate a small population of long-lived tumor initiating cells known as breast cancer stem cells (CSCs). Two features of CSCs are that they slowly divide and are more resistant to conventional anti-cancer treatments due to altered cellular machinery. It is the breast CSC subpopulation that develops new tumors which have the potential to lead to recurrence. However, the mechanism …

Analysis Of Polychlorinated Biphenyls In Electric Transformer Oil Using Gas Chromatography With Electron Capture Detector., Vivek Mann

Theses (2016-Present)

Polychlorinated biphenyls (PCB’s) are a group of synthetic chemicals which are environmentally insistent that were once used as coolants and lubricants in paints, heat transfer fluids, transformers, capacitors, caulking materials and other electrical materials owning to their property of good insulators. PCBs are persistent organic pollutants since they are persistent, resistant to biodegradation, bioaccumulate and have shown to cause a variety of deleterious effects on human health and the environment. Due to this the manufacturing of PCBs was banned in the United States in 1977. Although, production of PCBs has reportedly stopped, the potential or actual release of PCBs into …

Multi Elemental Analysis Of Cannabis Oil Based Products Using Icpms And Microwave Assisted Digestion., Kevin Trevon Marchbanks-Owens

Theses (2016-Present)

Due to the presence of CBD-(cannabidiol), bioavailable elements as well as industry versatility and relatively low levels of toxicity to the environment. CBD oils have driven the overall demand for Cannabis based plant products in the commercial and medical sector. However, dependent upon the environmental circumstances upon which these plants are grown can leave them susceptible to toxic heavy metal exposure. In fact, the natural metabolism of Cannabis plants makes them a hyperaccumulator of trace metals. This creates a severe health risk for CBD product consumers especially for more vulnerable populations with pre-existing conditions. Furthermore, the risk of heavy metal …

Experimental Validation Of Gene Expression Of Mybl1, Mybl2, Ubxn8, And Adrm1 Genes In Triple Negative Breast Cancer Cell Lines, Esther Jensinne Nsende

Theses (2016-Present)

A previous study conducted in our laboratory demonstrated V-Myb Avian Myeloblast Viral Oncogene Homolog Like 1 (MYBL1) gene over-expression in triple negative breast cancer (TNBC) compared to normal, some luminal, and a subpopulation of other TNBC. The MYBL1 gene belongs to the Avian myeloblastosis virus (MYB) family and is classified as proto-oncogene that functions as a strong transcription factor. The MYBL1 gene is related to cancer progression which involves dysregulation of cell cycle signaling, apoptosis and differentiation processes. A primary goal of our laboratory is to further characterize MYBL1 gene expression in TNBC samples. To achieve this goal, we performed …

Adaptive Task Planning For Large-Scale Robotized Warehouses, Dingyuan Shi, Yongxin Tong, Zimu Zhou, Ke Xu, Wenzhe Tan, Hongbo Li

Research Collection School Of Computing and Information Systems

Robotized warehouses are deployed to automatically distribute millions of items brought by the massive logistic orders from e-commerce. A key to automated item distribution is to plan paths for robots, also known as task planning, where each task is to deliver racks with items to pickers for processing and then return the rack back. Prior solutions are unfit for large-scale robotized warehouses due to the inflexibility to time-varying item arrivals and the low efficiency for high throughput. In this paper, we propose a new task planning problem called TPRW, which aims to minimize the end-to-end makespan that incorporates the entire …