Digital Commons Network^™

Effect Of Ginseng On Obesity And Neurogenesis, Hayden L. Withers, Claudia A. Grillo, Lawrence P. Reagan, Natalia Maciejewska, Sai V. Nallu, Jennifer L. Woodruff

Senior Theses

Obesity and major depressive disorder are two conditions with high comorbidity as well as overlapping pathophysiological mechanisms, including neuroinflammation, metabolic/endocrine dysfunction, and impaired hippocampal neurogenesis. Panax ginseng, a medicinal herb, is known to demonstrate anti-inflammatory and metabolic regulatory properties. Ginseng has demonstrated its effective antidepressant-like effects within preclinical studies, but its potential to restore neurogenesis in the context of obesity-induced depression is not clear. Within this study, male Sprague-Dawley rats were tested in either a high fat diet (HFD) or control diet (Cont) for 12 weeks and then was treated subsequently with daily intraperitoneal injections of either ginseng or saline …

Eating Disorder Prevention And Early Intervention In U.S. Higher Education – A Comparative Benchmarking Study, Jake R. Arcement

Senior Theses

Eating disorders (EDs), including anorexia nervosa, have the highest mortality rate of any psychiatric illness, yet remain underrecognized relative to their severity and treatment burden. Because the period of peak onset aligns with the college years, institutions of higher education are uniquely positioned to play an important role in prevention, early identification, and referral to specialized care. However, limited research has examined how colleges and universities structure ED prevention and treatment resources. This thesis applies a comparative benchmarking framework to assess current institutional practices across U.S. colleges and universities. A national survey of student health and counseling centers examined staffing, …

Long Term Effects Of Gestational Stress On Postpartum Cardiovascular Health In Female Rats, Arshaam Kordamiri

Senior Theses

Approximately 15% of women experience postpartum cardiovascular complications, including hypertension, cardiomyopathy, and heart failure. These conditions can impair maternal functioning and maternal-infant bonding, while increasing long-term health risks. Despite their severity, the underlying causes remain unclear. Stress is a known risk factor for cardiovascular disease (CVD), and gestation represents a period of heightened vulnerability. As CVD is a leading cause of maternal mortality, identifying contributing factors is critical.

Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and troponin I are cardiac biomarkers involved in fluid regulation, blood pressure, and myocardial injury. We hypothesized that gestational stress alters cardiovascular function, geometry, …

Searching For Temporal Variations In The Fine-Structure Constant Using Espresso Spectrograph Data, David Hoffman Iv

Senior Theses

The fine-structure constant α is a dimensionless constant, defined as e²/(4πε₀ℏc) ≈ 1/137. On the order of human timescales, its value is very much unchanging, however, in recent years there has been extensive debate over whether or not the value of α has remained constant over cosmological timescales. With the natural corollary to a changing α being that either one or multiple of its constituent physical constants have also changed in value, observing a variation in the fine-structure constant would have vast ramifications for our understanding of the nature of the early universe and how it has evolved. While past …

Reevaluating Pediatric Concussion Recovery: The Need For Comprehensive Psychological Assessments, Jolie L. Slobodin

Senior Theses

Pediatric concussions represent a significant public health concern due to their complex and often long-lasting effects on the developing brain. Although concussion is classified as a mild traumatic brain injury (mTBI), growing evidence indicates that children and adolescents experience psychological, cognitive, and academic difficulties that extend beyond physical symptom resolution. While somatic and cognitive symptoms often predominate in the acute phase of recovery, emotional and behavioral concerns frequently emerge or persist later, yet remain inconsistently evaluated in standard concussion care. This thesis examines the psychological, cognitive, and academic outcomes of pediatric concussion and evaluates whether current assessment practices capture the …

Crystallization And Utility Of Brominated Phenylethynylene Bis-Urea Macrocycles, Paras Srivastava

Senior Theses

Macrocycles are large, cyclic molecules with central cavities that can encapsulate other molecules and that have uses in supramolecular chemistry. The Shimizu group has previously synthesized Macrocycle 1, a phenylethynylene bis-urea macrocycle that crystallizes in a columnar form, enabling its utility as a host in host-guest systems. Reactions within these systems can be used to modify stereospecificity, kinetics, and other physical properties. Previously, photodimerization reactions between coumarins and chromones have been studied in systems of Macrocycle 1, resulting in the improved specificity of photodimerization products. Herein, we apply a dynamic covalent chemistry (DCC) strategy to synthesize Macrocycle 1 and its …

A Guide To Environmentally Sustainable Filmmaking In South Carolina, Christina Vera Dobrowolski

Senior Theses

The entertainment industry has a massive environmental impact. This information is not new in the filmmaking world, as multiple mainstream efforts exist to curb the material-intensive production of live action films and TV. One of these efforts is the use of voluntary sustainable guidelines, which serve as tools that outline sustainable best practices and resources that can help achieve them. However, current guidelines often lack practicality— focusing more on altruism rather than core economic factors that ultimately drive filmmaking. This project aims to address that gap for filmmakers in South Carolina by offering a website featuring attainable, state-specific resources for …

Exploring Synthesized Cbd Derivatives: Implications Of Therapeutic Strategies For Neuroinflammation, Josephine Mosser

Senior Theses

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid derived from Cannabis Sativa with well-documented antioxidant and anti-inflammatory properties, yet its clinical utility is limited by moderate receptor selectivity, rapid hepatic metabolism, and broad pharmacological activity on the central nervous system (CNS). This thesis describes the design and partial execution of a multi-step synthetic route aimed at generating CBD/CBD-derived chalcone intermediates for potential therapeutic applications for neuroinflammation. The steps encompass an O-methylation, O-acetylation, and a Fries rearrangement. The first three steps were completed successfully and reproducibly shown through 1H-NMR and 12C-NMR; however, purification of the fourth step was not successful within the available …

Main Concept Analysis As A Predictor Of Aphasia Severity: Semantic, Phonological, And Executive Influences On Main Concept Performance, Chathurvedi Ganguru

Senior Theses

Main Concept Analysis is a discourse-based measure that captures the essential information conveyed during narrative speech and may serve as a functional indicator of communication ability in aphasia. This study will examine whether Main Concept composite scores derived from the Cinderella narrative task are associated with aphasia severity and identify the linguistic and cognitive factors that influence Main Concept performance. Participants will be drawn from the baseline cohort of the POLAR study and will include approximately 100 individuals with chronic post-stroke aphasia. Baseline measures include Western Aphasia Battery Aphasia Quotient, Pyramids and Palm Trees Test, Philadelphia Repetition Test, and Wechsler …

Increased Backbone Rigidity Of Artificial Transcription Factors, Jasmine Glover, Emma Otey, Joanna K. Kwao, Nicholas Truex

Senior Theses

Programming DNA-binding proteins is an effective strategy for developing therapeutics that regulate gene expression. These proteins can directly bind to DNA to activate or repress transcription of specific genes. Zinc finger proteins are a class of DNA-binding proteins commonly found in eukaryotic organisms. Their DNA-binding function is derived from unique amino acid sequences within each domain that recognizes specific nucleotides, allowing each finger to selectively recognize three DNA base pairs. Adjoining of multiple domains in tandem allows recognition of a specific DNA sequence. Artificial transcription factors can be made of multiple zinc finger domains arranged in tandem and engineered to …

Breaking The Cycle: Implementing Journal-Based Emotional Regulation Workshops At South Carolina’S Department Of Juvenile Justice, Sarah Hobson

Senior Theses

Incarcerated youth experience disproportionately high rates of trauma exposure, estimated at 70% to 90%, which significantly impacts emotional regulation and behavior, keeping them in a cycle of repeated offense and increased recidivism rates (Branson et al., 2017). Despite the prevalence of these psychological needs, juvenile justice systems often lack consistent, trauma-informed programming that addresses the underlying causes of delinquent behavior. This study examines the implementation and impact of a structured, eight-week trauma-informed journaling intervention conducted as a pilot program within the South Carolina Department of Juvenile Justice. This program was implemented among a small cohort of participants at the Juvenile …

Emotion Regulation As A Moderator Of The Association Between Stressful Life Events And Changes In Religiosity, Catharine Mann

Senior Theses

Previous research indicates that religion and spirituality can have a beneficial impact on the well-being of individuals, both promoting health and reducing poor mental and physical health outcomes. Religiosity often shifts across the lifespan, but some experiences can predict those changes. For example, stressful life events (SLEs; e.g., loss of a family member, serious illness) are often associated with a decrease in religiosity. Past research has shown that in adults, the experience of SLEs predicts less identification with previously held religious beliefs. This relation could be influenced by a number of factors, but many are likely related to the use …

Wharton's Duct Injury As A Complication Of Oral Surgery And Its Management: A Clinical Case Report, María Paulina Araneda, Zabiel A. Faundez, Martin A. Sanchez, Pablo Romero, Ramon A. Rivera

Journal of Dentomaxillofacial Science

Introduction: Oral surgery may be associated with intraoperative complications, such as nerve injury, hemorrhage, and other procedure-related adverse events. Wharton's duct laceration is an uncommon but significant complication involving the floor of the mouth. Owing to the region's anatomical complexity, unrecognized injuries may affect gland function and patient well-being.

Case Report: A 69-year-old female patient presented with left submandibular swelling associated with a prior Wharton's duct injury. Initial management included local interventions and marsupialization; however, clinical symptoms recurred, which required submandibulectomy. The postoperative course was favorable.

Discussion: Early diagnosis is key to managing submandibular duct injuries. Up to 32% of …

Nigella Sativa Oil-Loaded Treated Dentin Matrix Hydrogel As An Alternative Biomaterial For Direct Pulp Capping: A Systematic Review, Alfin R. Cahyadi, Ayu Annafi, Malika Q. Rahmalia, Adelisa D. Ryani, Tania Saskianti, Harly Prabowo, Nadia Kartikasari, Abil Kurdi, Agus Dahlan

Journal of Dentomaxillofacial Science

Objective: To assess evidence on Treated Dentin Matrix Hydrogel (TDMH) and Nigella sativa oil (NSO), individually or combined, as biomaterials for direct pulp capping (DPC) and their reparative dentin promotion ability. Methods: A systematic search of PubMed, EBSCO, ScienceDirect, and Wiley (January 1, 2018–December 31, 2023) was conducted using MeSH-based terms associated with ``treated dentin matrix hydrogel,'' ``Nigella sativa oil,'' and ``direct pulp capping.'' Eligible studies included in vitro, in vivo, and clinical research evaluating TDMH or NSO for DPC; studies with no outcome data were excluded. Risk-of-bias assessment was performed using ROB2 (clinical) and SYRCLE (animal). Because of …

Automated Classification Of Periodontal Bone Loss In Periapical Radiographs Using Convolutional Neural Networks, Ramadhan Hardani Putra, Eha Renwi Astuti, Alhidayati Asymal, Aga Satria Nurrachman, Afifah Salsabila, Nasywa Athaillah Safitri, Fatina Yasmin, Andrew Nalley

Journal of Dentomaxillofacial Science

Objective: Periodontal diseases, including periodontitis, affected approximately 951.3 million people worldwide in 2021. Early detection and accurate diagnosis are crucial for determining effective treatment plans. Radiographic examination, particularly periapical radiographs, is a valuable method for assessing periodontal bone loss (PBL). However, classification of PBL stages is often influenced by observer subjectivity due to the complexity of manual measurement. This study aimed to develop and evaluate convolutional neural network (CNN) models for automated PBL classification in periapical radiographs.

Material and Methods: A dataset of 600 periapical radiographs was used, consisting of 480 training images, 60 validation images, and 60 testing images. …

Caries Risk Assessment As The Strongest Predictor Of Oral Health–Related Quality Of Life: A Cross-Sectional Multivariate Study Of Adolescent Students, Fadil Abdillah Arifin, Mila Febriany, Husnah Husein, Eva Novawaty

Journal of Dentomaxillofacial Science

Objective: This study aimed to determine the factors associated with oral health–related quality of life (OHRQoL) among adolescent students, with a particular focus on identifying the strongest predictor using a multivariate analytical approach.

Material and Methods: A cross-sectional study with 249 adolescent students in Sekolah Menengah Pertama Negeri 54 Makassar, Indonesia, was conducted. Clinical examinations were performed to assess dental caries experience using the Decayed, Missing, and Filled Teeth index (DMF-T), oral hygiene status using the Oral Hygiene Index–Simplified (OHI-S), Body Mass Index (BMI), sex, and caries risk level using the Caries Risk Assessment (CRA) tool, categorized into low, medium, …

Oral Health–Related Quality Of Life Following Complete Denture Rehabilitation In Diabetic Edentulous Patients: A 6-Month Prospective Study, Eri Hendra Jubhari, Edy Machmud, Mohammad Dharma Utama, Bahruddin Thalib, Stang Stang, Rifaat Nurrahma, Indah Tresnawati

Journal of Dentomaxillofacial Science

Objective: Edentulism and diabetes mellitus (DM) are associated with impaired oral function and diminished quality of life. Complete denture rehabilitation plays a pivotal role in the restoration of mastication, comfort, and self-confidence. This study aimed to examine changes in oral health–related quality of life (OHRQoL) after complete denture insertion in diabetic edentulous patients using the OHIP-14 and Geriatric Oral Health Assessment Index (GOHAI) questionnaires.

Materials and Methods: This prospective, longitudinal observational study included 25 completely edentulous diabetic patients. Their OHRQoL was evaluated at baseline and at 1, 2, and 6 months postdenture insertion using validated questionnaires, namely, OHIP-14 and GOHAI. …

Immediate Antibacterial Effect Of Sargassum Binderi-Based Mouthwash: A Randomized Controlled Trial, Andre K. Ruslim, Nisrina E. Nasrun, Muhammad I. Rasul, Nurlindah Hamrun, Lenni Indriani, Muhammad H. Chandha, Vera Julia, Muhammad Ruslin

Journal of Dentomaxillofacial Science

Objective: The current randomized controlled trial evaluated the immediate effect of a Sargassum binderi-based mouthwash on the reduction of cultivable oral bacteria compared with control.

Methods: In the current randomized controlled trial, 30 individuals were screened for eligibility, of whom 14 met the inclusion criteria and were randomly assigned to receive either a Sargassum binderi-based mouthwash or chlorhexidine 0.2%. Immediate post-rinse sampling was performed; however, residual antimicrobial carryover could not be entirely excluded. The total cultivable oral bacterial load was quantified at baseline and following intervention using standard culture-based techniques. Baseline bacterial composition was characterized using the analytical profile …

Determinants Of Toothbrushing Behavior Among 12-Year-Old Children: An Application Of The Health Belief Model, Fitri D. Oktadewi, Riski A. Hidayah, Ryana B. Purnama, Ananda P. Yuliani

Journal of Dentomaxillofacial Science

Objective: Effective toothbrushing behaviors in school-aged children play an important role in preventing dental and oral health problems. At the age of 12, the behaviors constitute a critical phase in the formation of healthy lifestyle habits. Therefore, this study aimed to analyze the factors that influence toothbrushing behaviors in 12-year-old children based on the Health Belief Model (HBM) theory.

Material and Methods: A total of 92 12-year-old children were selected by cluster sampling method at elementary schools in Banyumas, Central Java. The independent variables included perceived susceptibility, severity, barrier, and benefit in accordance with HBM. The dependent variable comprised toothbrushing …

Comparative Evaluation Of Mechanical And Chemo-Mechanical Methods Of Caries Excavation In Permanent Teeth: A Randomized Clinical Trial, Rahul Rao, Neha Pol, Ashish Jain, Pooja Shah, Amit Patil, Sanpreet S. Sachdev

Journal of Dentomaxillofacial Science

Objective: To compare excavation efficacy and pain perception among air-rotor (carbide bur), polymer bur, and chemo-mechanical excavation (Carie-Care™)  in adult permanent posterior teeth as a confirmatory, population-specific evaluation.

Materials and Methods: A single-center, single-blind, randomized split-mouth clinical trial was conducted in 29 adults with three permanent posterior teeth each (total = 87 teeth) presenting with occlusal caries and an ICDAS score of 4 or 5. The trial was registered with the Clinical Trials Registry of India (CTRI Ref No.: REF/2025/07/109637). Each participant received all three interventions in the same session under standardized conditions. Excavation efficacy was assessed using a caries …

Euphorbia Tirucalli L. Accelerates Mandibular Bone Healing: Analysis Of Pmns, Fibroblasts, Osteoblasts, And Osteoclasts In Wistar Rats, Florence Meliawaty, Juni Handajani, Heni Susilowati, Poerwati Soetji Rahajoe, Euis Reni Yuslianti, Rahmadaniah Khaerunnisa, Kertamaya Sundawan, Adzra Farah Fajrina, Lorintan Sitepu

Journal of Dentomaxillofacial Science

Objective: The present study aimed to elucidate the therapeutic potential of Euphorbia tirucalli L. stem extract in accelerating mandibular bone defect healing through the modulation of inflammatory and regenerative cellular responses, including polymorphonuclear cells, fibroblasts, osteoblasts, and osteoclasts in Wistar rats.

Material and Methods: A laboratory-based experimental study with a randomized post-test only control group design was conducted using 40 male Wistar rats. Standardized mandibular defects were created in the symphysis region utilizing a low-speed round bur. The animals were randomly assigned into four groups, including a negative control and three treatment groups receiving topical Euphorbia tirucalli L. stem extract …

Role Of Notch Intracellular Domain 1 In Lung Metastasis Of Salivary Gland Adenoid Cystic Carcinoma, Hermin Aminah Usman, Rakhmiana Rakhmiana, Birgitta Maria Dewayani, Seto A. Sadputranto, Bethy Suryawati Hernowo, Hasrayati Agustina, Anglita Yantisetiasti, Etis Primastari, Okky Husain, Nia Nuraeni

Journal of Dentomaxillofacial Science

Background: Adenoid cystic carcinoma (AdCC) is a malignant salivary gland tumor characterized by a high rate of metastasis. One of the recurrent genetic alterations in AdCC involves NOTCH1, leading to the activation and release of NOTCH intracellular domain 1 (NICD1). The epithelial–mesenchymal transition (EMT), a key process in tumor metastasis, is regulated by NICD1 and Snail. This study aimed to investigate the association between NICD1 expression, Snail expression, and pulmonary metastasis in AdCC.

Methods: This analytical observational case–control study included AdCC samples with and without pulmonary metastasis. NICD1 and Snail immunoexpression levels were assessed using histoscore and analyzed using …

Effects Of Ethanol On Opg Expression, Osteoclasts, And Osteoblasts During Orthodontic Tooth Movement In Wistar Rats: An Experimental Study, Nadia Setiawati Widjaja, Ardiansyah S. Pawinru, Nasyrah Hidayati, Eddy Heriyanto Habar, Eka Erwansyah, Baharuddin M. Ranggang, Ita Purnama Alwi

Journal of Dentomaxillofacial Science

Objective: This research sought to assess how ethanol influences the expression of osteoprotegerin (OPG) and the number of osteoclasts and osteoblasts during alveolar bone remodeling associated with orthodontic tooth movement.

Materials and Methods: A laboratory-based experimental study was conducted using 30 male Wistar rats. Palatal movement of the maxillary incisors was induced using a nickel–titanium (NiTi) closed coil spring applied to the maxillary arch. Rats were randomly divided into two groups: a control group (CG) receiving orthodontic force only, and an experimental group (EG) receiving both orthodontic force and ethanol administration. Observations were conducted on days 0, 3, and 14. …

Advancing Dental Research: From Biomaterials And Precision Dentistry To Population-Based Oral Health And Service Delivery, Acing H. Mude, H. Hasanuddin, Nisrina E. Nasrun, Muhammad Ikbal

Journal of Dentomaxillofacial Science

Objective: This editorial review aims to synthesize the thematic contributions of 14 manuscripts published in Journal of Dentomaxillofacial Science Volume 11 Issue 1, and to identify emerging scientific trends across contemporary dental research.

Methods: A descriptive thematic review was conducted by systematically analyzing the titles, abstracts, study objectives, methodologies, and key findings of all included manuscripts. Articles were grouped through qualitative synthesis into major thematic categories to capture the shared scientific directions and methodological patterns.

Results: The analysis identified six major thematic clusters: (1) biomaterials and oral tissue regeneration, (2) oral hygiene, saliva, microbiology, and vulnerable populations, (3) oral pathology …

Evolution Of Antibiotic Responses During Chronic P. Aeruginosa Infections In The Human Lung, David Frank Ritz

Dartmouth College Ph.D Dissertations

Typical antibiotic susceptibility testing (AST) of microbial samples is performed in homogeneous cultures in batch environments, which does not account for the highly heterogeneous and dynamic nature of antibiotic responses. The most common mutation found in P. aeruginosa lineages evolved during chronic cystic fibrosis infections in the human lung, a loss of function of repressor MexZ, increases basal levels of multidrug efflux MexXY, but does not increase resistance by traditional minimal inhibitory concentration (MIC) assays. Here, we use single cell microfluidics to show that P. aeruginosa’s response to aminoglycosides is highly heterogeneous, with only a subpopulation of cells surviving exposure. …

Electron Microburst Precipitation In Earth's Upper Atmosphere, Kelly Cantwell

Dartmouth College Ph.D Dissertations

Electron microburst precipitation can be a significant and prevalent source of electron loss from Earth's radiation belts into the upper atmosphere. This precipitation has been of interest since its discovery in the 1960's, and the continued progression of experimental capabilities has allowed for new and comprehensive analysis to be conducted on this phenomenon. The \af{barrel} mission was able to remotely sense microburst precipitation in both Northern and Southern hemispheres. In this thesis, I have written an automated detection algorithm with which 38 microburst events (with each event containing tens to tens of thousands of individual microbursts) were detected in the …

Mitochondria Dynamics In Microglia During Health, Inflammation, And Aging, Alicia Nicole Pietramale

Dartmouth College Ph.D Dissertations

Microglia continually surveil the brain, allowing for rapid detection of tissue damage or infection. Microglial metabolism is linked to tissue homeostasis, yet how mitochondria are subcellularly partitioned in microglia and dynamically reorganize during surveillance, injury responses, and phagocytic engulfment in the intact brain has remained unclear. In this dissertation, I combine intravital imaging, ultrastructural analyses, and metabolic and cytoskeletal markers to investigate how mitochondrial organization relates to microglial function across health, inflammation, and aging.

I first show that microglial processes diverge in their mitochondrial content, with some containing multiple mitochondria while others are completely void. This heterogeneous partitioning is conserved …

Behavioral-Centric Team Evaluation Via Consistent Rewards, Clement Kudakwashe Nyanhongo

Dartmouth College Ph.D Dissertations

Across human domains ranging from sports to business and organizational settings, complex tasks are often solved by teams rather than individuals, leveraging benefits such as interaction, mutual support, complementary skills, cohesion, and task allocation. Evaluating team effectiveness, however, is inherently challenging due to the subjectivity of many existing techniques and the limitations of outcome-driven metrics that primarily focus on performance scores while overlooking the team processes that generated the scores. To address these challenges, this dissertation proposes a behavioral-centric, end-to-end framework for team evaluation grounded in reward functions that model sequential team behavior. Reward functions offer compact and interpretable representations …

Advancement And Characterization Of Next-Generation Solid-State Photon-Counting Image Sensors For Astrophysics Applications, Nicholas R. Shade

Dartmouth College Ph.D Dissertations

Astronomers’ pursuit of detecting light from increasingly faint and distant objects in the expanse of space necessitates continuous improvement in signal-to-noise ratio of camera technology. Recent advancements in solid-state detector technologies have enabled the determination of photon-number, including single photon events, enabling observations at the fundamental limits of physics. These developments are instrumental not only for standard two-dimensional imaging but also for advanced spectroscopy, which increasingly drives future astrophysical applications. This thesis presents an evaluation of three next-generation silicon-based detectors capable of photon-counting with deep-sub-electron input-referred read noise: the electron-multiplying charge-coupled device (EMCCD), the single-photon avalanche diode (SPAD), and the …

From Attention To Reasoning: Beyond Accuracy In Multimodal Ai, Wayner Barrios

Dartmouth College Ph.D Dissertations

Multimodal large language models have achieved impressive performance on vision-language benchmarks by integrating visual encoders with large language models. Yet a critical gap persists between benchmark accuracy and genuine multimodal understanding: current evaluation frameworks assess performance by final answers alone, rewarding confident predictions while leaving systematic reasoning failures undetected.

This thesis addresses this gap through a unified framework that progresses from understanding to reasoning, using video as the most comprehensive multimodal testbed. Video inherently combines vision, audio, and language with temporal dynamics and massive token redundancy; techniques developed for video's comprehensive challenges transfer naturally to simpler multimodal tasks.

On understanding …