Digital Commons Network^™

Characterizing The Expression Pattern And Function Of Tartan During Drosophila Development, Alaina Baggett

Biomedical Engineering Undergraduate Honors Theses

The development of complex structures and organs by multicellular organisms relies on the ability of epithelial cells to self-organize. Epithelia are sheets of connected cells, and compartment boundaries are formed between certain epithelial cells to create distinct tissue compartments. Compartment boundaries are specialized cell-cell interfaces that are enriched for the cytoskeletal proteins actin and myosin, leading to straight cell edges under relatively high tension that act as fences keep cells from moving between compartments. In the model organism Drosophila melanogaster (fruit fly), compartment boundaries in the early embryo are established in response to the non-uniform striped expression of the cell-surface …

Librarians’ Attitudes Toward Providing Environmental Education Services In Georgia, Xiaoai Ren

Georgia Library Quarterly

This article reports on the findings from a survey of the Georgia Library Association (GLA) members on their attitudes toward providing environmental education services in libraries, and their perceptions of the role libraries should play in developing environmentally sustainable community. Information on the environmentally sustainable practices within libraries was also collected, along with the libraries' environmental education services. Most respondents agreed that it is vital to integrate environmentally sustainable practices into library operations and provide environmental education services. However, the study also identified a gap between librarians’ attitudes and the actual environmentally sustainable practices and environmental education services in their …

Kennesaw State University's Adobe Creative Jam, Ellie Burell

Georgia Library Quarterly

The Kennesaw State University Library System had the honor of partnering with the Norman J. Radow College of Humanities and Social Science for this year's Adobe Creative Jam. As Georgia's only Adobe Creative Campus, Kennesaw State University offers an annual Adobe Creative Jam to raise awareness of Adobe's Creative Cloud software that is offered to all KSU students, faculty, and staff through a friendly, informative, yet competitive event. This year's Adobe Creative Jam broke records for the university and for Adobe.

Validation Of The Kiswahili Version Of The Migraine Disability Assessment Scale In Dar Es Salaam, Tanzania, Aliasger Nagri

Master of Internal Medicine

Background: Migraine is a chronic paroxysmal neurological disorder characterized by multiphase attacks of head pain and many neurological symptoms. The MIDAS is a five (5) question-based questionnaire used in clinical practices to identify the disability caused by migraine at work, school, household or social life; with a score indicating little or no disability (0-5), mild disability (6-10), moderate disability (11-20), and severe disability (21+). Translated versions of the MIDAS scale in a number of languages has been validated. Translating and validating the Kiswahili version of the MIDAS questionnaire is essential and needed to ensure its comparability to the original English …

Designing Autonomous Drone For Food Delivery In Gazebo/Ros Based Environments, Hrishitva Patel

Computer Science and Engineering Research

There has been a growing global trend towards convenience, speed, and ease in delivery services, and this has been further accelerated by the COVID pandemic. With the everincreasing demand for easily accessible deliveries and expanded delivery service coverage, it has become critical that innovations in this space be developed to further ensure the industry’s smooth operation. With the emergence of the COVID-19 pandemic, the inadequacies became more apparent, emphasizing the need to revolutionize and accelerate the trend in order to meet the increased demand. Drone delivery systems are of particular interest in this context because they can enable faster and …

Incorporating Climate Change In Nepa Reviews: Recommendations For Reform, Michael Burger, Romany M. Webb, Jessica A. Wentz

Sabin Center for Climate Change Law

The National Environmental Policy Act (“NEPA”) requires federal agencies to conduct an environmental review prior to moving ahead with any major federal project, plan, or program that could significantly affect the environment. As part of the environmental review, agencies must share information with, and solicit feedback from, the public. The goal is to improve federal decision-making by ensuring that agencies take a hard look at the environmental effects of their actions and fully inform the public about those effects.

In guidance issued in 2016, the Council on Environmental Quality (“CEQ”)—the federal body charged with implementing NEPA—identified climate change as a …

Helping New Jersey State Agencies And Departments Align Their Actions With Ghg Reduction Mandates And Environmental Justice Principles, Jennifer Danis, Zoe Makoul

Sabin Center for Climate Change Law

This white paper analyzes New Jersey’s implementation gap in both the climate and justice space. Its findings are potentially applicable to the many other states who have set climate and justice goals, without robustly embedding them into their existing legal and administrative landscapes. New Jersey already has GHG reduction targets, a plan, and mapped pathways. While more aggressive tactics and targets may be required to meet evolving scientific knowledge, and cost-effective technology and markets will evolve over time, New Jersey’s climate-alignment tools and pathways are clear. The EMP, the 2020 GWRA 80x50 Report, and EO-274, among other strong state initiatives, …

Facilitators And Barriers Of Reflective Learning In Postgraduate Medical Education: A Narrative Review, Catherine Gathu

Family Medicine, East Africa

Background: Reflection in postgraduate medical education has been found to aid in the development of professional skills, improve clinical expertise, and problem solving with the aim of advancing lifelong learning skills and self-awareness, leading to good medical practice among postgraduate residents. Despite the evidenced benefits, reflection remains underused as a tool for teaching and learning, and few trainee physicians regularly engage in the process. Factors that affect the uptake of reflective learning in residency training have not yet been adequately explored.

Objective: The purpose of this review is to demonstrate the factors that influence the adoption of reflective …

The Quality Of Primary Care Performance In Private Sector Facilities In Nairobi, Kenya: A Cross-Sectional Descriptive Survey, Gulnaz Mohamoud, Robert Mash

Family Medicine, East Africa

Background: Integrated health services with an emphasis on primary care are needed for effective primary health care and achievement of universal health coverage. The key elements of high quality primary care are first-contact access, continuity, comprehensiveness, coordination, and person-centredness. In Kenya, there is paucity of informa- tion on the performance of these key elements and such information is needed to improve service delivery. Therefore, the study aimed to evaluate the quality of primary care performance in private sector facilities in Nairobi, Kenya.

Methods: A cross-sectional descriptive study using an adapted Primary Care Assessment Tool for the Kenyan context …

Girls On The Map: Mapping For Program Planning And Social Change, Eva Roca

Adolescents and Young People

This guide explores ways in which maps can add depth to the learning process as practitioners design programs for girls. Mapping leads practitioners through a cycle of information collection and analysis. It supports decision-making about where, with whom, and when to work, and how programs can make a real difference in girls’ lives. Programs increasingly recognize the importance of household and community characteristics in shaping girls’ lives, yet it is relatively less common to measure or map community features as part of program planning. Mapping relevant populations of girls and the features of the communities they live in can inform …

The Effects Of Leadership Curricula With And Without Implicit Bias Training On Graduate Medical Education: A Multicenter Randomized Trial, Matt Hansen, Tabria Harrod, Nathan Bahr, Amanda Schoonover, Karen Adams, Josh Kornegay, Amy Stenson, Vivienne Ng, Jennifer Plitt, Tony Ogburn

School of Medicine Publications

Purpose: To determine whether a brief leadership curriculum including high-fidelity simulation can improve leadership skills among resident physicians.

Method: This was a double-blind, randomized controlled trial among obstetrics-gynecology and emergency medicine (EM) residents across 5 academic medical centers from different geographic areas of the United States, 2015-2017. Participants were assigned to 1 of 3 study arms: the Leadership Education Advanced During Simulation (LEADS) curriculum, a shortened Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS) curriculum, or as active controls (no leadership curriculum). Active controls were recruited from a separate site and not randomized to limit any unintentional …

Ulnar Nerve Palsy As Covid-19 Sequelae In 3 Patients, Cristina Terhoeve, Ryan Bliss, Rasheed Ahmad

School of Medicine Faculty Publications

The pathophysiology and treatment of COVID-19 have been at the forefront of medical research this past year. While great strides have been made in our knowledge of the disease, there is still much that is unknown. More than one-third of patients with COVID-19 present with symptoms involving the nervous system. The reason for this is unclear, although several theories have been postulated. In this case study, we present 3 patients with severe ulnar nerve dysfunction following treatment for COVID-19 in the intensive care unit. We discuss reasons why this may have occurred, the etiology of which is likely multifactorial. We …

Cu And Ni Co-Sputtered Heteroatomic Thin Film For Enhanced Nonenzymatic Glucose Detection, Brianna Barbee, Baleeswaraiah Muchharla, Adetayo Adedeji, Abdennaceur Karoui, Kishor Kumar Sadasivuni, Mizaj Shabil Sha, Aboubakr M. Abdullah4, Gymama Slaughter, Bijandra Kumar

Bioelectrics Publications

In this work, we report a wafer-scale and chemical-free fabrication of nickel (Ni) and copper (Cu) heteroatomic Cu–Ni thin films using RF magnetron sputtering technique for non-enzymatic glucose sensing application. The as-prepared wafer-scale Cu–Ni thin films exhibits excellent electrocatalytic activity toward glucose oxidation with a 1.86 μM detection limit in the range of 0.01 mM to 20 mM range. The Cu–Ni film shows 1.3- and 5.4-times higher glucose oxidation activity in comparison to the Cu and Ni electrodes, respectively. The improved electrocatalytic activity is attributed to the synergistic effect of the bimetallic catalyst and high density of grain boundaries. The …

Flow Characteristics Through Granular Soil Influenced By Saline Water Intrusion: A Laboratory Investigation, Sudip Basack, Ghritartha Goswami, Hadi Khabbaz, M Karakouzian

Civil and Environmental Engineering and Construction Faculty Research

The coastal geoenvironment initiates saline water intrusion into the freshwater aquifers, producing a geohydraulic problem. Such intrusion not only contaminates the fresh groundwater resources, making them unsuitable for human use, but also alters the hydraulic conductivity of the aquifer materials, which affects the coastal groundwater flow, influencing the water resources planning and management. Past investigations reveal that the groundwater flow can be linear or nonlinear depending upon the hydraulic gradient. Thus, the coefficients of nonlinear hydraulic conductivities are affected by saltwater intrusion. The present study focuses on an in-depth laboratory investigation into the influence of saltwater submergence on the nonlinear …

Corruption In Uganda, Jared Saxton

Ballard Brief

Corruption in Uganda accounts for ½ of government expenditure and mainly benefits the rich and well connected. Due to weak and unspecific laws, corruption is often not enforced in the nation. Additionally, when there are adequate laws in place, enforcement agencies often benefit from corruption and are therefore unmotivated to take action against it. Cultural factors mean that corruption is socially acceptable in many cases and is common throughout the nation. Foreign aid props up corrupt government expenditure because funding comes from an external source, and thus, the government feels less accountable to its citizens. Corruption results in poor service …

Inadequate Wash Infrastructure Among Rural Populations In The Pacific Islands, Olivia Wallgreen

Ballard Brief

Water, Sanitation, and Hygiene (WASH) are key aspects for development that allows families to five clean and healthy lives. However. many regions of the world. including the Pacific Islands Region. do not have proper facilities and funding to build or maintain WASH infrastructure. especially in rural areas. About 45% of rural Pacific Islanders lack access to adequate sanitation and 13% lack access to basic drinking water. Natural disasters. climate change, insufficient government action. and difficult geographic features make developing WASH infrastructure challenging. Inadequate WASH infrastructure increases the prevalence of disease and negatively affects the ecosystems of the islands. While these …

Inadequate Maternal Health Care For Women In The United States, Rebecca Stull Zundel

Ballard Brief

Although insufficient maternal health care has seen improvements in most developed countries, it is still a rising issue in the United States. This insufficiency may partly be due to the accessibility barriers that both rural and urban women face in reaching adequate care. Additionally, the expenses of maternal care or gender discrimination within medical establishments may dissuade women from seeking the care that they need. Women who receive inadequate care are at a higher risk for maternal mortality, the death of their unborn or newly born infant, and having a low-birth weight child, which comes with many issues of its …

Mission Statement

Seattle Journal for Social Justice

No abstract provided.

Table Of Contents

Seattle Journal for Social Justice

No abstract provided.

Essential Overlapping Functions Of Crk And Crkl In Glioblastoma And Diffuse Intrinsic Pontine Glioma Cells, Neka Large, Taeju Park

Research at Children's Mercy Month 2022

Background: The expression levels of CT10 regulator of kinase (Crk) and Crk-like (CrkL) are elevated in many human cancers, including glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG). GBM and DIPG are both highly aggressive brain tumors derived from glial cells. Elevation of Crk and CrkL contributes to poor prognosis, and they have been proposed as therapeutic targets for GBM. We recently demonstrated that Crk and CrkL play essential overlapping roles in GBM cell migration. Here we have investigated if Crk and CrkL play similar roles in GBM and DIPG cells.

Methods: We induced gene knockdown of Crk, CrkL, or …

The Sars-Cov-2 E Protein Induces Pro-Inflammatory Tlr Signaling, Lung Injury And Alveolar Remodeling In The Neonatal Lung, Heather Menden, Wei Yu, Sherry M. Mabry, Aparna Venkatraman, Venkatesh Sampath

Research at Children's Mercy Month 2022

Background: The delta variant of SARS-CoV-2 is reported to cause severe acute lung injury (ALI) in neonates. Neonates with COVID-19 can exhibit a hyper-inflammatory response with vascular injury. The mechanisms by which SARS-CoV-2 structural proteins induce ALI in neonates is unclear. Emerging data suggest that the envelope (E protein) of the SARS-CoV-2 activates Toll Like Receptor (TLR)-mediated immune hyperactivation and cytokine storm. We tested the hypothesis that SARS-CoV-2 E protein can induce TLR-mediated inflammation and ALI in a neonatal mouse model of ALI we developed.

Objectives: 1) To investigate the pathogenicity of E protein in causing neonatal ALI and alveolar …

Development Of Whole-Genome Crispr-Cas9 Screens To Discover Novel Immunotherapy Targets In Pediatric Leukaemia, Jacqelyn Nemechek, Kealan Schroeder, Jennifer Pace, Bradley C. Stockard, John C. Means, Scott T. Younger, John M. Perry

Research at Children's Mercy Month 2022

Treatment of pediatric leukaemia often involves the use of high doses of anthracyclines, which results in severe side-effects including cardiotoxicity and the development of secondary cancers. Based on previous studies showing that anthracyclines such as doxorubicin (DXR) can target therapy-resistant leukemia stem cells (LSCs) at low, generally non-toxic doses, we repurposed DXR as a targeted inhibitor rather than a broadly cytotoxic chemotherapy. In contrast to typical clinical usage, low-dose DXR treatment reduces expression of multiple immune checkpoint (IC) inhibitors, which exposes LSCs to elimination by cytotoxic T lymphocytes. In the laboratory, anthracyclines can also stimulate immunogenic cell stress/death (ICD). Unlike …

Budesonide Embedded Sodium Alginate Thin Films For Controlled Release To The Esophagus, Norah Almahbub, Jacob Vandervaart, Rachel Chevalier

Research at Children's Mercy Month 2022

BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease affecting children at an increasing rate leading to poor weight gain, vomiting, esophageal strictures and increased health care burden from repeated endoscopies. Oral budesonide is the only drug commercially available for treatment, but adverse effects and compliance limit its utility.

We seek to design a microscale, low-aspect ratio, biodegradable, dispersible form of budesonide with controlled release. Our first step is to fabricate thin films utilizing common mucoadhesive polymers (chitosan and sodium alginate) embedded with budesonide. Here we report on the release characteristics of these thin films.

METHODS: Budesonide is suspended in …

Pediatric Covid-19 Involving Complicated Sinusitis With Intracranial Extension And Lemierre’S Syndrome: A Case Report, Rohit Nallani, Srivats Narayanan, Meghan Tracy, Jill M. Arganbright

Research at Children's Mercy Month 2022

Introduction: Pediatric COVID-19 has been associated with various complications including chronic respiratory disease and multisystem inflammatory syndrome (MIS-C). Otolaryngologic symptoms are common and include sore throat, nasal congestion, and taste/smell disturbances; few cases of complicated sinusitis have been reported. We present a patient with recent COVID-19 who developed complicated sinusitis with intracranial extension and Lemierre’s syndrome.

Case Description: A 16-year-old female presented to the Emergency department with history of COVID-19 diagnosis 17 days prior. She reported worsening symptoms including headache, visual changes, and neck stiffness. Initial concerns for MIS-C prompted admission to the PICU. Exam showed left proptosis, Cranial nerve …

Characteristics Of Hospitalized Children Associated With Restraint Use At A Free-Standing Children’S Hospital, Adrienne Deporre, Vincent S. Staggs, Ingrid Larson, Ashley Daly, Cy Nadler

Research at Children's Mercy Month 2022

Introduction:Hospitalized children are at risk for agitation and behavioral dysregulation, which may escalate to unsafe behaviors. If less restrictive de-escalation strategies fail to mitigate serious safety risks to self or others, mechanical restraints may be used on a limited basis. Restraint use, however, is problematic due to associated negative child mental health outcomes and injury risk. Pediatric studies of restraint use outside of dedicated psychiatric facilities are lacking. Specifically, clinical and demographic features associated with restraint use are poorly described. A broader understanding of restraint use among hospitalized children can guide alternative strategies for management and restraint mitigation efforts. …

The Cellular Dynamics Of Early And Transitional Human Breast Milk, Cas Lemaster, Stephen Pierce, Eric S. Geanes, Santosh Khanal, Staci Elliott, Allison Scott, Daniel A. Louiselle, Rebecca Mclennan, William E. Truog, Devika Maulik, Tamorah Lewis, Tomi Pastinen, Todd Bradley

Research at Children's Mercy Month 2022

Breast milk (BM) is a complex fluid containing factors essential for infant nutrition and immunity. Breastfeeding has been shown to be protective against infections and other immune-mediated diseases during the lacation period and beyond in later childhood. This suggests that BM also imprints the neonatal immune system and influences long-term health. BM also contains populations of maternal-derived cells. Which factors in BM that are important for neonatal health and how they change during lactation have not been well-defined. In this study, we used a single-cell transcriptomic approach to identify and define cell types of early and transitional milk. We collected …

Volcano Infrasound: Progress And Future Directions, Jacob F. Anderson, Jeffrey B. Johnson

Geosciences Faculty Publications and Presentations

Over the past two decades (2000–2020), volcano infrasound (acoustic waves with frequencies less than 20 Hz propagating in the atmosphere) has evolved from an area of academic research to a useful monitoring tool. As a result, infrasound is routinely used by volcano observatories around the world to detect, locate, and characterize volcanic activity. It is particularly useful in confirming subaerial activity and monitoring remote eruptions, and it has shown promise in forecasting paroxysmal activity at open-vent systems. Fundamental research on volcano infrasound is providing substantial new insights on eruption dynamics and volcanic processes and will continue to do so over …

May 2022 Library News, University Libraries

Library News

No abstract provided.

Doing Less With More: Why The Fourth Circuit Missed Its Chance To Raise The Floor Of Mental Health Care For Detained Persons, Joshua Philip Elmets

North Carolina Law Review

No abstract provided.

Managing The Police Emergency, Adam A. Davidson

North Carolina Law Review

No abstract provided.