Digital Commons Network^™

Trafficking In Persons: The Reliability Of The Tier Ranking System And Its Ability To Influence Global Policy Decisions, Zoe Storck

Honors Theses

This research investigates the Trafficking in Persons (TIP) report published annually by the United States. Specifically, this research examines both the role that the Trafficking in Persons report plays in pushing specific human rights policy decisions throughout the world and its overall effectiveness in creating governmental response. The tier rankings and country narratives included in the report are essential for identifying specific government responses to recommendations made in the TIP report, and the tier rankings specifically have created a system that pressures countries to pursue steps toward combatting human trafficking. The data collection method utilized throughout this research consists primarily …

A Study Of Public Accounting And Related Economic Concepts, Seth Gerus

Honors Theses

This thesis consists of several case studies relating to different topics within the world of accounting. These cases were completed as assignments within the thesis practicum class taught by Dr. Victoria Dickinson. Each case pertains to a different accounting-related topic, and topics include the fundamentals of accounting as well as recent events in the business world. The thesis also includes a five-week long case competition in which students were put into groups to present Audit, Tax, and Advisory strategies for companies headquartered in the United States. Each of these cases were completed during the course of the Fall 2020 and …

Practicum In The Study Of Financial Accounting, Laine Keel

Honors Theses

This paper was intended to be a practicum in the study of financial accounting. The different sections encompass many distinct aspects of the field and was completed over two semesters. Each section had a goal to investigate a specific area related to accounting, and my mission was to focus on this area and express my thoughts on the section. To do this, I would explain how each topic was related to accounting and how that would affect me in my future positions – often alone but sometimes as a part of a group. Additionally, this deep dive into the various …

Effects Of Waterborne Benzo[A]Pyrene Embryonic Exposure On Development, Behavior, Reproduction, And Mitochondrial Bioenergetics In Zebrafish, Megha Patel

Honors Theses

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is a known carcinogen leading to adverse effects in the development of both humans and animals. BaP is also continuously present in the environment leading to regular exposure via inhalation or ingestion. Because organisms’ early life stages can be more susceptible to contaminant exposure, our focus was on BaP’s adverse impacts on survival, length, weight, behavior, bioenergetic state, and fecundity following developmental exposures. To study BaP’s impacts, zebrafish (Danio rerio) were used as a model organism. BaP is a ligand for the aryl hydrocarbon receptor (AHR in humans; Ahr in …

Investigating The Effect Of Meaningful Relationships On Team Chemistry, Isabel N. Fairbanks

Honors Thesis

Team chemistry in sports is one of the more vital factors that potentially impacts the overall success of a team. There is increasing growth in the school of thought surrounding the use of team building in sports to develop the best teams built for success. Many programs exist in athletics and other environments that strive to promote strong team culture. This literature review examines the influence sports psychology has on the success of a sports team and current programs that exist in both the business environment and athletics, intending to improve team culture. Furthermore, the book containing the experiment on …

Trophish: Building A Global Database Of Freshwater Trophic Interactions, Jacob M. Ridgway

Honors Thesis

Freshwater management and research frequently use the trophic data of freshwater fishes. Despite this fact, it is difficult to perform a simple search of dietary information for any one fish species. FishBase represents, to our knowledge, the largest compilation of freshwater dietary information to date. However, it excludes a large portion of the ecological literature due to its development taking place prior to the creation of most modern scientific search engines. Our project (TroPhish) is building upon FishBase by digitizing approximately 130 years of data from the fish predation literature. Data from the primary and grey (e.g. theses, dissertations, reports) …

Mechanical Characterization Of 3d Printed Hydrogel Lattices, Annabella Mascot

Mechanical Engineering and Materials Science Independent Study

White matter brain tissue is largely inaccessible and is therefore difficult to mechanically characterize although this would be useful in understanding injuries and injury prevention. Thus, soft gels and 3D bioprinted materials allow for the estimation of the mechanical properties of brain tissue through non-invasive means. Through previous studies, it is determined that brain tissue is inherently anisotropic. To properly model it, the use of anisotropic cubic, diamond, and vintile type lattice 10 x 10 x 10 cm cube structures were used in compression testing to determine the elastic modulus of each lattice type in each of its orientations. Each …

Gut Commensals Modulate Siv/Shiv Pathogenesis And Therapeutics, Samuel Johnson

Theses & Dissertations

Despite significant advancements in combination antiretroviral therapy (cART), ongoing inflammation in the brain and gut remain two of the most significant hurdles in the health of people living with human immunodeficiency virus (HIV). Additionally, a viral reservoir in each compartment inhibits cure efforts by allowing rapid viral rebound following cART interruption. Emerging understanding of the gut-brain axis (GBA) implicates each compartment in the modulation of the other in a complex bi-directional interaction mediated by vagus innervation, circulating lymphocytes, and microbiome composition and biproducts. Using multiple models of the simian (and simian-human) immunodeficiency virus (SIV/SHIV) and therapeutic intervention, I present how …

Implementing High-Intensity Trauma-Informed Sexual Behavior Risk Reduction In Justice-Involved Women, Lakisha M. Holton

Doctoral Projects

Sexually transmitted infections continue to be a source of significant morbidity in people with a history of incarceration, particularly women. Justice-involved women are at exceptionally high risk of long-lasting and severe health consequences of contracting an STI. This evidence-based practice implementation project used a repeated measures design to compare sexually transmitted infection knowledge acquisition and condom use self-efficacy in a group of incarcerated women before, immediately after, and three weeks following participation in the Safer Sex Self-Efficacy Workshop. Of the participants (N= 21), 100% demonstrated a significant increase in sexually transmitted infection knowledge and condom use self-efficacy between pre- and …

High-Quality Parent Teacher Relationships: Collaboration That Creates Culturally Relevant Educational Experiences For Students Of Color, Kelly Kudla

Doctorate in Education

Effective parent teacher relationships (PTRs) have positive impacts on student academic and social achievement; however, families of color often face barriers which limit their access to these relationships. When barriers are removed and collaborative PTRs with families of color are established, teachers can more effectively create culturally relevant experiences for students. The purpose of this dissertation was to examine the experiences of teachers that have participated in collaborative PTRs, with a focus on experiences that contributed to teachers’ abilities to establish and maintain partnerships with families of color, and how teachers utilize the knowledge and skills of families to benefit …

Pendulums Of Personhood? Exploring The Multitudes Of Immigrant Womanhood In Spanish-Maghrebi Literature, Kaitlyn C. Sisco

Honors Theses

Often considered articulations of in-between-ness and bearers of fraught selfhoods, the work of Spanish-Maghrebi authors has been widely debated in literary fields, with academics arguing that it constitutes a largely homogenous set of texts about the standard immigrant experience. However, by placing these texts in a single category, such arguments end up erasing the immensely varied identities expressed and represented by Spanish-Maghrebi authors. This thesis seeks to address this issue by paying particular attention to how Spanish-Maghrebi authors negotiate different types of immigrant subjectivities in their writing. Specifically, I analyze the works of three contemporary Spanish-Maghrebi writers, Najat El Hachmi, …

Customized Sidearm Case: Leading A Cme Capstone Team From Concept To Production, Robert B. Sharp

Honors Theses

The goal behind this thesis is to document and analyze my performance as the project manager for the Customized Sidearm Case capstone team during the Center for Manufacturing Excellence’s senior capstone experience. The capstone experience begins the fall of students senior year where a select number of product ideas submitted by the students are chosen, and teams are built around these projects. The objective of the project is to walk a product from the concept phase through the entire design process resulting in a full-scale production run during the spring semester. My product pitch of a wooden sidearm case, customized …

Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner

Honors Theses

Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the crutch like …

Measles And Migration In Colombia And Brazil: Determinants Of Differential Disease Impact Resulting From The Venezuelan Crisis, Kaylen Hisle

Honors Theses

This thesis investigates the 2018 measles outbreaks that occurred in Colombia and Brazil as a result of importation from Venezuela, seeking to uncover underlying factors contributing to significantly greater case numbers in Brazil than in Colombia. It analyzes vaccination coverage, migrant integration, and migration policy, using a mixed-methods approach to compare the two countries. Qualitative analysis of the border zones, migration policies, health systems, and progression of the outbreaks in each country reveals that geographical and socioeconomic differences at the borders, heterogeneity of vaccination coverage, timeliness of policy responses, and disease tracing capabilities could all be possible contributors to greater …

The Impact Of Sleep On Athletic Performance: A Review Of The Literature, Rylan J. Pratt

Honors Thesis

This paper reviewed the literature regarding sleep and athletic performance, specifically identifying the problem of sleep debt in student athletes, the effects of sleep debt, and what factors negatively influence sleep, along with how to improve sleep. The literature revealed that it is common for athletes to not get adequate sleep. Sleep debt can have psychomotor and physiological effects on the body, which decreases optimal athletic performance. The many factors that negatively impact sleep include high intensity training sessions, travel, sleep disturbances, caffeine and/or alcohol consumption, and pre-competition anxiety. Recommendations for athletes that are struggling to achieve adequate sleep include, …

Paleopathological Analyses Of Maya Skeletal Samples To Reconstruct Childhood Health And Frailty, Kira J. Wilde

Honors Thesis

Nonadults are particularly sensitive and reactive to stress, illness, and injury and, as such, they are good proxies for examining health of past populations based on evidence of stress events recorded in their skeletal and dental remains. Skeletal data on childhood stress and frailty was derived from nineteen individuals sourced from the BVAR skeletal collection, which was excavated from Maya settlements in the Belize River Valley and dated from the Early and Late Classic (250-900 CE) periods of the ancient Maya kingdoms. Osteological analyses included age-at-death estimation for adults and nonadults, following the criteria of Buikstra and Ubelaker (1994) and …

Interview With Helen (Jim’S Chinese Restaurant), Lucas Bugarin, Jasmine Venegas

Pacific Food Empires

Helen is a first generation Chinese immigrant who originated in Guangzhou China. Helen is one of the main owners of Jim’s Chinese restaurant in Seaside, CA along with her husband. Helen specializes in cooking authentic Chinese food based on her cultural background and has continuously worked in the food industry for over 20 years. She begun working on restaurants in San Francisco, CA but eventually opened up her own restaurant in Seaside and has kept a steady amount of loyal clientele ever since.

Development Of A Patient Educational Resource On Carrier Screening, Katelyn Watkin, Kristen Fishler Malone, Sara Fisher

Capstones: Genetic Counseling

Objective: Previous studies suggest carrier screening is not consistently offered to all patients meeting national guidelines. Introducing basic carrier screening options prior to an appointment could potentially decrease the time providers spend discussing this screening, while increasing patient awareness. Our goal was to create an educational handout that was a source of baseline knowledge on carrier screening, accessible, and non-directive.

Methodology: We developed this educational handout in four phases: preliminary research, resource development, stakeholder feedback, and revision. Preliminary research involved compiling existing guidelines published by professional organizations such as the American College of Obstetricians and Gynecologists, the American …

Visceral Adipose Tissue Remodeling In Pancreatic Ductal Adenocarcinoma Cachexia: The Role Of Activin A Signaling, Pauline Xu

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer death in the United States and is projected to become the second leading cause by the year 2030. Prognosis for patients with metastatic disease remains dismal, with cachexia as a main contributor to the low survival rate. Emerging reports indicate that PDAC patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. While muscle wasting has been the most frequently studied mechanism in cachexia research, changes in adipose tissue are increasingly understood as important components of …

Mechanisms Of Sorting And Fission At The Endosomes, Kanika Dhawan

Theses & Dissertations

Endocytic trafficking is a fundamental cellular process that regulates the transport of lipids and proteins. Our lab focuses on the intracellular trafficking of receptors involved in cellular processes such as cell division, migration, and proliferation. Accordingly, the regulation of these trafficking pathways is tightly controlled, involving a complex series of events, of which a key step is the endosomal fission. Perturbations in the endosomal network can eventually lead to impaired receptor recycling to the plasma membrane (PM) and, therefore, have pathological consequences like Alzheimer’s disease and multiple cancers. Upon internalization, cargo-laden vesicles released from the PM fuse with the sorting …

Contextual Factors And Sti/Hiv Sexual Risk Behaviors Among Hispanic Youths Aged 13 To 24 Years, Mariam Taiwo

Theses & Dissertations

Despite the growing population of Hispanics and several efforts to combat the high STI/HIV rates among Hispanic youths aged 13 to 24 years in the United States, this population continues to experience stark disparities in STI/HIV and is underrepresented in STI/HIV research relative to their White peers. This dissertation consists of three distinct studies designed to identify and understand the contextual factors of STI/HIV sexual risk behaviors across the social-ecological model that are pertinent to Hispanic youths.

Results from the first study showed that STI/HIV sexual risk behavior varied by Hispanic youths’ acculturation types and moderated by gender. We found …

Extracellular Mechanotransduction In Marfan Syndrome: An Equivalence Principle, Stephen Haller

Theses & Dissertations

Biological tissues continuously experience mechanical stress and have evolved sophisticated mechanisms to sense mechanical stimuli. While traditional viewpoints regard cells as the ultimate sensors and processors of mechanical information, compounding evidence demonstrates that extracellular matrix, the structural component of tissues, also exhibits evolved molecular responses to force. This led us to propose a new paradigm termed extracellular mechanotransduction, in which matrix orchestrates a complementary form of force integration distinct from traditional cellular and extracellular viewpoints. We thus propose that force-sensitive signaling mechanisms evolved within the extracellular space to help cells maintain mechanical homeostasis in tissues. In this dissertation, we apply …

Evaluating Targets And Therapeutics For The Treatment Of Pancreatic Cancer, Shelby M. Knoche

Theses & Dissertations

Pancreatic cancer has a dismally low survival rate, due to inadequate understanding of the processes that are involved in disease development and progression. Despite the identification of oncogenic drivers such as KRAS and p53, there is a need for the identification of molecular targets to improve and develop novel therapeutic approaches for the treatment of pancreatic cancer. Studies from our laboratory have identified and evaluated targets and therapeutic approaches that can aid in our understanding of pancreatic cancer disease progression and improve patient outcomes. Through the use of epidermal growth factor receptor (EGFR) ligands (EGF and TGF-α) and small molecule …

Ethical Sensitivity Of Padis Care Among Critical Care Nurses: A Mixed Methods Study, Denise Waterfield

Theses & Dissertations

Critically ill patients often experience distressful and impactful symptoms and conditions that include pain, agitation/sedation, delirium, immobility, and sleep disruption (PADIS). The presence of PADIS can affect recovery and long-term patient outcomes. An integral part of critical care nursing is PADIS prevention, assessment, and management. To better understand the complexities of PADIS care, two reviews of the literature were completed. The first is an integrative review of the use of PADIS assessment tools by critical care nurses. The second is a qualitative systematic review of the literature on the integration of care ethics and nursing workload. Ethical sensitivity of everyday …

Genome-Wide Distribution Of Acape1 And Its Implications In Dna Repair And Transcription, Mason Tarpley

Theses & Dissertations

Endogenous DNA damage can occur throughout the genome and is resolved through the Base Excision Repair (BER) pathway. The apurinic/apyrimidinic sites that result from endogenous DNA damage, called AP-sites, are created by DNA glycosylases removing oxidized or modified bases. These AP-sites are primarily repaired by AP endonuclease 1 (APE1) through the BER pathway. Modification of APE1 by acetylation of specific lysine residues in the proteins’ unstructured, N-terminal tail, have been shown to increase the residence time of APE1 (AcAPE1) at the AP-sites. It is unknown where AcAPE1 is binding to chromatin in the genome. Here, we are testing the hypothesis …

Strengthening Capacity For Clinical And Translational Science: A Multi-Method Assessment Of Research Capacity Development In A Regional Clinical And Translational Research Network, Lakaija Johnson

Theses & Dissertations

The National Institute of Health (NIH) has made significant investments to establish and maintain statewide and regional clinical and translational research (CTR) networks. These networks are designed to accelerate the translation of research discoveries from laboratory and clinical settings to improve community and population health. The National Institute of General Medical Science (NIGMS) Institutional Development Award (IDeA) Program Infrastructure for Clinical and Translational Research (CTR) [IDeA-CTR] initiative was initiated in 2012 to broaden participation in CTR in regions and territories with IDeA designation, having historically been funded by the NIH at lower levels. IDeA-CTR networks stimulate infrastructural investments in complex …

Phos-Tag-Based Screens Identify Novel Therapeutic Targets In Ovarian Cancer And Pancreatic Cancer, Renya Zeng

Theses & Dissertations

Multiple Phos-tag-based screens were conducted in anti-tubulin drug (paclitaxel and nocodazole)-treated cells to explore novel targets implicated in cell cycle regulation, resistance against paclitaxel, and yes-associated protein (YAP) nucleocytoplasmic transport. The Phos-tag-based screen of protein kinases identified that several proteins were degraded or phosphorylated in response to anti-tubulin drug treatment. A tyrosine kinase, fibroblast growth factor receptor 4 (FGFR4), was significantly degraded upon anti-tubulin drug treatment, suggesting its potential role in cell response to paclitaxel. Further functional investigations identified that FGFR4 mediated paclitaxel resistance in ovarian cancer, and specific inhibitors targeting FGFR4 could sensitize ovarian cancer cells to paclitaxel. Mechanistically, …

Paf1/Pd2 Augments Pancreatic Cancer Progression And Mediates Radiation And Chemoresistance, Sanchita Rauth

Theses & Dissertations

NA

Characterization Of 1,1-Diarylethylene Foxm1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells, Cassie Liu

Theses & Dissertations

Forkhead box M1 (FOXM1) is a member of the conserved forkhead box (FOX) transcription factor family. Over the last two decades, FOXM1 has emerged as a multifunctional oncoprotein and a robust biomarker of poor prognosis in many human malignancies. FOXM1 and its associated oncogenic transcriptional signature are enriched in >85% of ovarian cancer cases, and FOXM1 expression and activity can be enhanced by a plethora of genomic, transcriptional, post-transcriptional, and post-translational mechanisms. As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell …

Influence Of Stocks Intrinsic Valuation On Investment Decision Making: A Literature Review, Maxwell Okpoti Mensah, Williams Kwasi Peprah, Adu Bismark Qwusu-Selyere, Mensah Morris Ayaa, Bamfo Daniel

Faculty Publications

All over the world, investment decisions are regarded as critical decisions. Investors prior to the investment decision would like to know the possible risk and returns associated with the kind of investment to be undertaken. Investors make an excellent investment decision based on facts and figures. Since an investor cannot just by looking at a stock say whether it is overvalued, undervalued or at a fair value. This study is based on a literature review determining the intrinsic value of a stock using the Discounted Cash Flow model, with a particular emphasis on the Internal Rate of Return (IRR) and …