Digital Commons Network^™

110 Assets Llc V. Patel

All Decisions

No abstract provided.

Visual Communication In A Time Of Crisis: Insights Into The Relationship Between Visual Communication And Health, V Squire

School of Art, Design and Architecture

The impact of Covid-19 has taken numerous forms. It will continue to affect individuals and groups in a multitude of ways, due to the ever adapting, ever changing uncertain world. A shift has taken place in our perspectives, knowledge and understanding of health crises, with visual communication being integral to this process; through the visualization of health data, communication of scientific knowledge, and as a crucial force for knowledge mobilization. This paper will outline a research study of visual communicators’ experiences and visual manifestations of the Covid-19 pandemic, bringing greater insight into the relationship between visual communication and the Covid-19 …

Roberts V. Howell

All Decisions

ERAP Case.

Maternal Adipocyte Connexin43 Gap Junctions Affect Breastmilk Lactose Levels And Neonate Growth In Mice, Mingyang Huang, Anying Song, Xi Chen, Sarah Ishtiaq, Chunmei Wang, Darryl L Hadsell, Qiong A Wang, Yi Zhu

Faculty, Staff and Students Publications

Simple Summary

Breastfeeding offers many health benefits for both mothers and infants. However, overnutrition and a steady increase in obesity in the U.S. has made it harder for many mothers to produce and express breastmilk. Moreover, the quality of breastmilk from obese mothers is frequently compromised in that it contains fewer nutrients and more inflammatory components. In this study, we used mice to model this phenomenon. We found that short-term high-fat feeding at the start of breeding reduces litter size and pups’ body weight. It also impairs adipocyte remodeling during lactation. Connexin43 is the primary building block for gap junctions …

Long-Term Follow-Up For The Development Of Subsequent Malignancies In Patients Treated With Genetically Modified Iecs, David H M Steffin, Ibrahim N Muhsen, Laquisa C Hill, Carlos A Ramos, Nabil Ahmed, Meenakshi Hegde, Tao Wang, Mengfen Wu, Stephen Gottschalk, Sarah B Whittle, Premal D Lulla, Maksim Mamonkin, Bilal Omer, Rayne H Rouce, Andras Heczey, Leonid S Metelitsa, Bambi J Grilley, Catherine Robertson, Virginia Torrano, Natalia Lapteva, Adrian P Gee, Cliona M Rooney, Malcolm K Brenner, Helen E Heslop

Faculty, Staff and Students Publications

Subsequent malignancies are well-documented complications in long-term follow-up of cancer patients. Recently, genetically modified immune effector (IE) cells have shown benefit in hematologic malignancies and are being evaluated in clinical trials for solid tumors. Although the short-term complications of IE cells are well described, there is limited literature summarizing long-term follow-up, including subsequent malignancies. We retrospectively reviewed data from 340 patients treated across 27 investigator-initiated pediatric and adult clinical trials at our center. All patients received IE cells genetically modified with γ-retroviral vectors to treat relapsed and/or refractory hematologic or solid malignancies. In a cumulative 1027 years of long-term follow-up, …

Extracellular Domain Of Pept1 Interacts With Tm1 To Facilitate Substrate Transport, Jiemin Shen, Miaohui Hu, Xiao Fan, Zhenning Ren, Corinne Portioli, Xiuwen Yan, Mingqiang Rong, Ming Zhou

Faculty, Staff and Students Publications

Mammalian peptide transporters, PepT1 and PepT2, mediate uptake of small peptides and are essential for their absorption. PepT also mediates absorption of many drugs and prodrugs to enhance their bioavailability. PepT has twelve transmembrane (TM) helices that fold into an N-terminal domain (NTD, TM1–6) and a C-terminal domain (CTD, TM7–12), and has a large extracellular domain (ECD) between TM9–10. It is well-recognized that peptide transport requires movements of the NTD and CTD, but the role of the ECD in PepT1 remains unclear. Here we report the structure of horse PepT1 encircled in lipid nanodiscs and captured in the inward-open apo …

Factors Associated With Racial And Ethnic Minority Youths' Mental Health Help-Seeking At School, Sam Allouche

LSU Doctoral Dissertations

Despite the high prevalence and associated consequences of mental health problems in youth, adolescents with these problems are often left untreated. This service gap is even greater in racial and ethnic minority youth who not only engage in treatment less frequently, but also experience far greater discrimination and systemic inequality than non-ethnic or racial minority students; factors further contributing to a need for service. Schools may provide an ideal location to treat mental health problems in youth, in part because schools eliminate structural barriers, but also because school staff have an opportunity to observe students across a range of functioning. …

Teaching Quality Improvement: The Use Of Education Theories Across The Medical Education Spectrum., Sugeet Jagpal, Abra Fant, Riccardo Bianchi, Andrew Kalnow

Medical Education Articles

It is well recognized that the principles and practices of patient safety and quality improvement (QI) need to be included in medical education. The implementation of patient safety and QI learning experiences at the undergraduate medical education (UME) and graduate medical education (GME) levels has been variable. Consistent teaching of QI across the UME-GME-continuing medical education (CME) spectrum may result in a systemic change of improved patient care and patient safety in clinical practice. We propose using education theories to frame the development of QI curricula for a longitudinal integration in medical education and clinical practice. The basic principles of …

Microbial Liberation Of N-Methylserotonin From Orange Fiber In Gnotobiotic Mice And Humans, Nathan D Han, Daniel Webber, Stacey Marion, Michael J Barratt, Andrew C Heath, Et Al.

2020-Current year OA Pubs

Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, plus in vitro studies, revealed liberation of N-methylserotonin from orange fibers by human gut microbiota members including Bacteroides ovatus. Functional genomic analyses of B. ovatus strains grown under permissive and non-permissive N-methylserotonin "mining" conditions revealed polysaccharide utilization loci that target pectins whose expression correlate with strain-specific liberation of this compound. N-methylserotonin, orally administered to germ-free mice, reduced adiposity, altered liver glycogenesis, shortened gut transit …

Lipid Absorption And Overall Intestinal Lymphatic Transport Are Impaired Following Partial Small Bowel Resection In Mice, Emily J Onufer, Rafael S Czepielewski, Yong-Hyun Han, Cathleen M Courtney, Stephanie Sutton, Anne Sescleifer, Gwendalyn J Randolph, Brad W Warner

2020-Current year OA Pubs

Short bowel syndrome (SBS) is associated with diminished levels of serum fats caused by unknown mechanisms. We have shown that mesenteric lymphatics remodel to a more primitive state one week after small bowel resection (SBR); therefore, this study focuses on the effect of chronic lymphatic remodeling and magnitude of resection on intestinal lipid uptake and transport. C57BL6 and Prox1 creER-Rosa26

Revised Draft Final Butte Priority Soils Operable Unit Butte Treatment Lagoons And Bpsou Subdrain Sampling And Monitoring Quality Assurance Project Plan, Nikia Greene, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Gender Equity And State-Mosque Relations In Middle East North Africa: A Case Study Of Tunisia, Joy Amarachi Agbugba

Dissertations and Theses

Why is the Middle East North Africa region consistently ranked the lowest on the gender equity scale? This question is quite perplexing and that has driven several scholarly researchers to investigate the situation of gender and women's rights within the states in the region. In this research, I explore the various theories explaining the cause of gender inequity in this region including the Islam thesis/social modernization theory, political-economic theory, and psychological/social structural theories, with an emphasis on the Islamic thesis theory. I argue that the state's support and prioritization of Muslim/sharia law over federal law is a major contributor to …

Tp53 Copy Number And Protein Expression Inform Mutation Status Across Risk Categories In Acute Myeloid Leukemia, Mehrnoosh Tashakori, Tapan Kadia, Sanam Loghavi, Naval Daver, Rashmi Kanagal-Shamanna, Sherry Pierce, Dawen Sui, Peng Wei, Farnoosh Khodakarami, Zhenya Tang, Mark Routbort, Carol A Bivins, Elias J Jabbour, L Jeffrey Medeiros, Kapil Bhalla, Hagop M Kantarjian, Farhad Ravandi, Joseph D Khoury

Faculty, Staff and Student Publications

Mutant TP53 is an adverse risk factor in acute myeloid leukemia (AML), but large-scale integrated genomic-proteomic analyses of TP53 alterations in patients with AML remain limited. We analyzed TP53 mutational status, copy number (CN), and protein expression data in AML (N = 528) and provide a compilation of mutation sites and types across disease subgroups among treated and untreated patients. Our analysis shows differential hotspots in subsets of AML and uncovers novel pathogenic variants involving TP53 splice sites. In addition, we identified TP53 CN loss in 70.2% of TP53-mutated AML cases, which have more deleterious TP53 mutations, as well as …

Lncrna-Associated Genetic Etiologies Are Shared Between Type 2 Diabetes And Cancers In The Uae Population, Roberta Giordo, Rida Gulsha, Sarah Kalla, George A Calin, Leonard Lipovich

Faculty, Staff and Student Publications

Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, the biological mechanisms linking the two diseases remain largely unknown. The advent of genome wide association studies (GWAS) revealed large numbers of genetic variants associated with both T2D and cancer. Most significant disease-associated variants reside in non-coding regions of the genome. Several studies show that single nucleotide polymorphisms (SNPs) at or near long non-coding RNA (lncRNA) genes may impact the susceptibility to T2D and cancer. Therefore, the …

Dissecting The Treatment-Naive Ecosystem Of Human Melanoma Brain Metastasis, Jana Biermann, Johannes C Melms, Amit Dipak Amin, Yiping Wang, Lindsay A Caprio, Alcida Karz, Somnath Tagore, Irving Barrera, Miguel A Ibarra-Arellano, Massimo Andreatta, Benjamin T Fullerton, Kristjan H Gretarsson, Varun Sahu, Vaibhav S Mangipudy, Trang T T Nguyen, Ajay Nair, Meri Rogava, Patricia Ho, Peter D Koch, Matei Banu, Nelson Humala, Aayushi Mahajan, Zachary H Walsh, Shivem B Shah, Daniel H Vaccaro, Blake Caldwell, Michael Mu, Florian Wünnemann, Margot Chazotte, Simon Berhe, Adrienne M Luoma, Joseph Driver, Matthew Ingham, Shaheer A Khan, Suthee Rapisuwon, Craig L Slingluff, Thomas Eigentler, Martin Röcken, Richard Carvajal, Michael B Atkins, Michael A Davies, Albert Agustinus, Samuel F Bakhoum, Elham Azizi, Markus Siegelin, Chao Lu, Santiago J Carmona, Hanina Hibshoosh, Antoni Ribas, Peter Canoll, Jeffrey N Bruce, Wenya Linda Bi, Praveen Agrawal, Denis Schapiro, Eva Hernando, Evan Z Macosko, Fei Chen, Gary K Schwartz, Benjamin Izar

Faculty, Staff and Student Publications

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant …

Health Literacy-Based Heart Failure Self-Care Intervention (H2lit), Maan Isabella Cajita, Karen M. Vuckovic, Spyros Kitsiou, Nathan Tintle, Susan L. Dunn

Sigma Foundation for Nursing Research Grant Reports

The purpose of the project was to develop the web-based H2Lit intervention and test the usability of the H2Lit intervention using an iterative user-centered approach.

The Paratexts Of Audience Engagement: Cover Matter That Draws In And Keeps Readers, Athena L. Edwards

All HCAS Student Capstones, Theses, and Dissertations

Within the book publishing industry, purchase statistics often determine a book’s success. This metric neglects crucial factors of reader engagement (i.e., reception and anticipation of current and future work) such as level of interest and appreciation. By blending key concepts from work on assemblage, ecology, reader-response, audience invoked, and media studies, this thesis attempts to (re)invigorate the discourse of book paratexts’ role in inspiring reader engagement. As a manifestation of various voices performing and contextualizing a core text for readers, paratexts are a key component to the discursive uptake of books by readers and their publics. Book covers, specifically, are …

Antibody Response To Sars-Cov-2 Vaccination In Patients With Lymphoproliferative Disorders And Plasma Cell Dyscrasias: Anti-Lymphoma Therapy As A Predictive Biomarker Of Response To Vaccination, Carol Gung, Regina Mcguire, Mercy George, Abdullateef Abdulkareem, Katherine A Belden, Pierluigi Porcu, Ubaldo Martinez-Outschoorn, Adam F Binder, Inna Chervenova, Onder Alpdogan

Department of Medical Oncology Faculty Papers

We retrospectively analyzed SARS-CoV-2 vaccination antibody responses in a cohort of 273 patients with lymphoproliferative disorders or plasma cell dyscrasias who were seen at a single tertiary cancer center. Semi-quantitative anti-spike protein serologic testing was performed with enzyme immunoassay method. We found that the antibody response rate to SARS-CoV-2 vaccination was 74.7% in our patient cohort with no difference based on gender, age or race. The highest response rate was found in patients with Multiple Myeloma (MM) (95.5%). The response rates found in Diffuse Large B-Cell Lymphoma (DLBCL), Chronic Lymphocytic Leukemia (CLL), and Low-Grade Non-Hodgkin Lymphoma (LG-NHL) were 73.2%, 61.5% …

Microfluidic Device For Localized Electroporation, Justin Brooks, Arian Jaberi, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Electroporation is a common method of transfection due to its relatively low risk and high transfection efficiency. The most common method of electroporation is bulk electroporation which is easily performed on large quantities of cells yet results in variable levels of viability and transfection efficiency across the population. Localized electroporation is an alternative that can be administered on a similar scale but results in much more consistent with higher quality transfection and higher cell viability. This paper discusses the creation and use of a simple and cost-effective device using porous membrane for performing localized electroporation.

Biological Flora Of Coastal Wetlands: Sporobolus Cynosuroides (L.) P.M. Peterson & Saarela, Richard Stalter, Robert I. Lonard

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Sporobolus cynosuroides (L.) P.M. Peterson & Saarela¼Spartina cynosuroides (L.) Roth is a temperate zone rhizomatous grass that often is a dominant species in coastal brackish marshes on the Gulf coast and Atlantic coasts of the United States where salinity ranges from 0 to 10 psu. Sporobolus cynosuroides (L.) P.M. Peterson & Saarela ¼ Spartina cynosuroides (L.) Roth is usually absent where salinity values are .12 psu. Sporobolus cynosuroides occurs in coastal habitats characterized by infrequent tidal flooding and moderate nutrient levels. Also known as big cordgrass, it may account for net productivity in high marshes that rivals productivity of Sporobolus …

Analysis Of Sequential Adsorption-Oxidation Of Vocs On Atomic Layer-Deposited Ptni/Zro2-Sio2dual-Function Materials, Busuyi O. Adebayo, Han Yu, Ali A. Rownaghi, Xinhua Liang, Fateme Rezaei

Chemical and Biochemical Engineering Faculty Research & Creative Works

To develop efficient dual-function materials (DFMs) for capture and destruction of volatile organic compounds (VOCs), we prepared a series of composite materials comprising PtNi nanoparticles supported on ZrO₂-promoted SiO₂(PtNi/ZrO₂-SiO₂) via atomic layer deposition (ALD) method and investigated them for sequential adsorption and desorption/catalytic oxidation of benzene, as a model VOC compound. ZrO₂was first deposited on a unimodal SiO₂support, followed by deposition of Pt and Ni nanoparticles with varried amount. Dynamic adsorption experiments were conducted using a 500 ppmv-laden feed at 25 °C and 1 atm, followed by in …

Research Progress Of 3d Printing Of Cereal-Based Materials, Geng Han, Wang Li, Chen Zheng-Xing, Zuo Zhong-Yu

Food and Machinery

In this review, the main processes, principles and equipment suitable for cereal-based 3D printing were introduced, and the printing characteristics and application of cereal-based raw materials in 3D printing were summarized, including the main factors affecting the printing quality. Moreover, the prospects and challenges of cereal-based 3D printing was also discussed.

Study On Pyrolysis Transfer Rules Of Seven Aglycones In Flue Gas Under Two Kinds Of Flavoring Methods, Han Lu, Chu Wen-Juan, Hu Shao-Dong, Zhao Zhi-Wei, Yang Jing, Tian Hai-Ying

Food and Machinery

bjective:The pyrolysis transfer rate of aglycones from 7 kinds of glucosides added to cigarette paper in mainstream and sidestream smoke was studied.Methods:5methylfurfuryl alcohol glucoside, menthol glucoside, anisyl alcohol glucoside, leaf alcohol glucoside, phenylethanol glucoside, ethyl vanillin glucoside and vanillin glucoside were applied to the surface of cigarette paper and inject into cigarette according to the 0.01% of the weight of cut tobacco respectively. The transfer rates of aglycones in mainstream smoke and side stream smoke were determined under two kinds of flavoring Methods. On this basis, the transfer rules of seven aglycones in mainstream smoke and sidestream …

Effects Of Breathing Tumbling On Volatile Substances Of Chinese Soy-Sauced Beef, Liu Dan-Dan, Zhao Pei, Chen Jin-Yu, Zhao Wen-Ying, Liu Zhong-Min, Wu Zi-Jian

Food and Machinery

Objective:This study aimed to improve the production technology and flavor of Chinese beef sauce.Methods:Compared with traditional static curing, the effects of breathing rolling curing on volatile components of beef were analyzed by SPME/GC-MS.Results:The main aroma components of the beef in breathing rolling and curing process were the same as those in traditional static state, which were mainly aldehydes, hydrocarbons, alcohols, esters and ketones, among which the representative substances were benzaldehyde, anisene, cineol, eugenol acetate and 2-butanone. There were some differences in the types and relative contents of volatile substances, among which the number of hydrocarbons …

Comparative Analysis Of Nutrients In Fruiting Bodies Between Wild And Cultivated Morchella In Different Cultivation Models, Zhao Rui-Hua, He Xiao-Long, Gao Xiao-Peng, Wang Fei

Food and Machinery

Objective:This study aimed to estimate the nutritive value of wild and cultivated Morchella in Northern Shaanxi.Methods:Morchella fruiting bodies wildly growing in Northern Shaanxi and cultivated in three models (greenhouse, plastic shed and understory) were used to analyze the difference in the main nutrition components.Results:In terms of crude protein, crude fat, crude fiber and water content, all cultivated Morchella were slightly higher than those in the wild. Moreover, the amino acid content of cultivated Morchella was also higher and the amino acid ratio of understory was the most reasonable. Both the wild and the cultivated were …

Determination And Correlation Analysis Of Tobacco Non-Volatile Organic Acids And Ph, Piao Yong-Ge, Zhang Jia-Bao, Cui Cheng-Zhe, Liu You-Jie, Li He-Lin, Li Rui-Li, Zhang Jun-Song

Food and Machinery

Objective:To explore the effects of organic acids on tobacco pH and flue gas pH.Methods:34 kinds of single-grade tobacco and 11 kinds of finished cigarettes were taken as the research objects, and their non-volatile organic acids, tobacco pH, and the pH of mainstream smoke total particulate matter were measured respectively. Grey correlation analysis and principal component analysis were used to analyze the correlation between organic acids and pH.Results:The results of grey correlation analysis show that oxalic acid, palmitic acid, malic acid and oleic acid have a relatively large influence on the pH of single-grade tobacco; Palmitic …

Rapid Determination Of Drug Residues Of Four Kinds Of Tetracyclines Using Des-Uplc-Ms/Ms In Aquatic Products, Liu Zi-Xiong, Xie Guo-Dan, Tan Gui-Liang, Zheng Hong-Tao, Dong Hai, Huang Jing-Hui

Food and Machinery

Objective:This study aimed to develop a method of rapid detection of tetracyclines including tetracycline, oxytetracycline, aureomycin and doxycyclin in aquatic products with deep eutectic solvents (DES) extraction and ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).Methods:Different parameters of DES, such as the types of solvents, molar ratio of solvents, water content, and pH value were optimized.Results:The optimum deep eutectic solvent conditions for the medicament analysis of four tetracyclines in aquatic products were choline chloride-glycerol combination(molar ratio 1∶4) with 90% moisture content and 0.1% formic acid. Under the control of these condition, the four types of tetracyclines …

Rapid Determination Of 4 Anti-Diabetic Medicines In Health Foods By High Performance Liquid Chromatography-Tandem Mass Spectrometry, Hai-Tao, Zhang Yu-Meng, Yong Yan-Hua, Li Peng, Wang Li-Na, Su Chun-Min

Food and Machinery

Objective:A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established for rapid determination of empagliflozin, linagliptin, saxagliptin and alogliptin in health foods.Methods:Target compounds in samples were ultrasonically extracted by methanol, separated by reverse liquid chromatography and detected by electrospray ionization (ESI) using multiple reaction monitoring (MRM) mode. The quantitation was carried out by external standard method of matrix calibration curve.Results:Good linear relationship displayed in the concentration range of 2~100 μg/L for saxagliptin and alogliptin, with the limits of quantitation (LOQs) of saxagliptin and alogliptin of 0.10 mg/kg. At three spiked concentration levels of …

Research On Rapid Prediction Model Of Rice Moisture Content Based On Near Infrared Spectroscopy, Lu Du, Tang Jian-Bo, Jiang Tai-Ling, Chen Zhong-Ai, Pan Mu

Food and Machinery

Objective:In order to established a non-destructive, rapid and efficient method for detecting the moisture content of rice. Methods:This study, 161 rice samples were collected from 5 different regions were studied by near infrared spectroscopy combined with stoichiometry. By eliminating abnormal spectra and preprocessing the spectra, the prediction model of rice moisture content was established by partial least squares regression. Results:15 abnormal spectrum samples were eliminated using the method of principal component analysis combined with mahalanobis distance. The best spectral pretreatment was to eliminate the constant offset. The prediction model R2CAL established in the training set was 0.994 …

Secondary Extrusion Walnut Shell Breaker, Cheng Guo-Liang, Zheng Jia-Hong, Wang Chao

Food and Machinery

Objective:To solve the problem of low breaking rate and low kernel rate of walnut.Methods:According to the principle of walnut breaking shell, the material mechanism, breaking mechanism and transmission mechanism of walnut breaking shell were designed.Results:the breaking rate of walnut was 100% and the whole kernel rate was 77.58%.Conclusion:Walnut shell breaker designed by experiment is simple in structure, convenient in operation, economical and safe.