Digital Commons Network^™

A Differential Diagnosis Of Unusual Gastric Ulcer

Faculty, Staff and Student Publications

The endoscopic findings of diffuse large B cell lymphoma have various presentations. In our case, the patient had developed multiple elevated central ulceration lesions, and the peripheral elevated portion had a heaped-up margin. The margin had a sharp, smooth edge that was not infiltrative and could be confused with a simple gastric ulcer. Endoscopists should be aware of the possibility of multiple lymphoma ulcers with heaped-up margins. We present some unusual endoscopic features of lymphoma, which are easily misdiagnosed as gastric ulcers.

Increased Expression Of Interferon-Induced Transmembrane 3 (Ifitm3) In Stroke And Other Inflammatory Conditions In The Brain, Sean P Marrelli

Faculty, Staff and Student Publications

Microglia, the resident innate immune cells of the brain, become more highly reactive with aging and diseased conditions. In collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. Recently, IFITM3 (a member of the "interferon-inducible transmembrane" family) has been revealed as a molecular mediator between amyloid pathology and neuroinflammation. Expression of IFITM3 in glial cells, especially microglia following stroke, is not well described. Here, we present evidence that ischemic stroke causes an increase in IFITM3 expression along …

The Immune Response To Airway Mycosis, Jochen Daniel Muehlschlegel, Holger K Eltzschig

Faculty, Staff and Student Publications

Despite increasing availability and more successful interventional approaches to restore coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of morbidity and mortality worldwide. During myocardial ischemia, the myocardium becomes profoundly hypoxic, thus causing stabilization of hypoxia-inducible transcription factors (HIF). Stabilization of HIF leads to a transcriptional program that promotes adaptation to hypoxia and cellular survival. Transcriptional consequences of HIF stabilization include increases in extracellular production and signaling effects of adenosine. Extracellular adenosine functions as a signaling molecule via the activation of adenosine receptors. Several studies implicated adenosine signaling in cardioprotection, particularly through the activation of the Adora2a and Adora2b …

Random Field Modeling Of Multi-Trait Multi-Locus Association For Detecting Methylation Quantitative Trait Loci, Chen Lyu, Manyan Huang, Nianjun Liu, Zhongxue Chen, Philip J Lupo, Benjamin Tycko, John S Witte, Charlotte A Hobbs, Ming Li

Center for Medical Ethics and Health Policy Staff Publications

Motivation: CpG sites within the same genomic region often share similar methylation patterns and tend to be co-regulated by multiple genetic variants that may interact with one another.

Results: We propose a multi-trait methylation random field (multi-MRF) method to evaluate the joint association between a set of CpG sites and a set of genetic variants. The proposed method has several advantages. First, it is a multi-trait method that allows flexible correlation structures between neighboring CpG sites (e.g. distance-based correlation). Second, it is also a multi-locus method that integrates the effect of multiple common and rare genetic variants. Third, it models …

A Novel Prognostic 7-Methylguanosine Signature Reflects Immune Microenvironment And Alternative Splicing In Glioma Based On Multi-Omics Analysis, Zihan Wang, Zhiwei Zhong, Zehua Jiang, Zepeng Chen, Yuequn Chen, Yimin Xu

Research outputs 2022 to 2026

Glioma is the most common type of central nervous system tumor with increasing incidence. 7-methylguanosine (m7G) is one of the diverse RNA modifications that is known to regulate RNA metabolism and its dysregulation was associated with various cancers. However, the expression pattern of m7G regulators and their roles in regulating tumor immune microenvironments (TIMEs) as well as alternative splicing events (ASEs) in glioma has not been reported. In this study, we showed that m7G regulators displayed a close correlation with each other and most of them were differentially expressed between normal and glioma tissues. Two m7G signatures were then constructed …

Digestibility Of Wheat Alpha-Amylase/Trypsin Inhibitors Using A Caricain Digestive Supplement, Angéla Juhász, Mitchell G. Nye-Wood, Gregory J. Tanner, Michelle L. Colgrave

Research outputs 2022 to 2026

Wheat is a major source of nutrition, though in susceptible people it can elicit inappropriate immune responses. Wheat allergy and non-celiac wheat sensitivity are caused by various wheat proteins, including alpha-amylase trypsin inhibitors (ATIs). These proteins, like the gluten proteins which can cause celiac disease, are incompletely digested in the stomach such that immunogenic epitopes reach the lower digestive system where they elicit the undesirable immune response. The only completely effective treatment for these immune reactions is to eliminate the food trigger from the diet, though inadvertent or accidental consumption can still cause debilitating symptoms in susceptible people. One approach …

Potentiation Of Combined P19arf And Interferon-Beta Cancer Gene Therapy Through Its Association With Doxorubicin Chemotherapy, Ruan F V Medrano, Thiago A Salles, Rafael Dariolli, Fernanda Antunes, Valker A Feitosa, Aline Hunger, João P P Catani, Samir A Mendonça, Rodrigo E Tamura, Marlous G Lana, Elaine G Rodrigues, Bryan E Strauss

2020-Current year OA Pubs

Balancing safety and efficacy is a major consideration for cancer treatments, especially when combining cancer immunotherapy with other treatment modalities such as chemotherapy. Approaches that induce immunogenic cell death (ICD) are expected to eliminate cancer cells by direct cell killing as well as activation of an antitumor immune response. We have developed a gene therapy approach based on p19Arf and interferon-β gene transfer that, similar to conventional inducers of ICD, results in the release of DAMPS and immune activation. Here, aiming to potentiate this response, we explore whether association between our approach and treatment with doxorubicin (Dox), a known inducer …

3d Fracture Propagation Simulation And Pressure Decline Analysis Research For I-Shaped Fracture Of Coalbed, Chengwang Wang, Zixi Guo, Lifeng Zhang, Yunwei Kang, Zhenjiang You, Shuguang Li, Yubin Wang, Huaibin Zhen

Research outputs 2022 to 2026

After hydraulic fracturing, some treatments intended for production enhancement fail to yield predetermined effects. The main reason is the insufficient research about the fracture propagation mechanism. There is compelling evidence that I-shaped fracture, two horizontal fractures at the junction of coalbed and cover/bottom layer, and one vertical fracture in the coalbed have formed in part of the coalbed after hydraulic fracturing. Therefore, this paper aims at I-shaped fracture propagation simulation. A novel propagation model is derived on the basis of a three-dimensional (3D) model, and the coupling conditions of vertical fracture and horizontal fractures are established based on the flow …

Longitudinal Expression Profiling Identifies A Poor Risk Subset Of Patients With Abc-Type Diffuse Large B Cell Lymphoma, F Bewicke-Copley, K Korfi, S Araf, Et Al

Peninsula Medical School

Despite the effectiveness of immuno-chemotherapy, 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience relapse or refractory disease. Longitudinal studies have previously focused on the mutational landscape of relapse but fell short of providing a consistent relapse-specific genetic signature. In our study, we have focussed attention on the changes in gene expression profile accompanying DLBCL relapse using archival paired diagnostic/relapse specimens from 38 de novo DLBCL patients. Cell of origin remained stable from diagnosis to relapse in 80% of patients, with only a single patient showing COO switching from ABC to GCB. Analysis of the transcriptomic changes that occur …

An Analysis Of The Strengths And Weaknesses Of The Tulsa Remote Program, As An Effective Economic Development Strategy, Kristen J. Padilla

Dissertations and Theses

Cities do not exist in a vacuum. They are in constant competition for talented, educated individuals and growing, innovative businesses -even if that competition is not explicit or specific. Traditionally cities have been left with two economic development paths to help diversify their economies: attract talent but without jobs, or attract business but without a strong talent pool. However, due to technological advancements, exacerbated by the pandemic, a new and growing workforce that can work from anywhere has emerged, remote workers. This talent pool shifts traditional economic development attraction strategies from city to industry to city to talent.

Many remote …

What Explains Smartwatch Adoption? A Comparative Study Of South Korea And Indonesia, Mufida Sekardhani, Sujin Song

Asia Marketing Journal

Identifying factors that influence consumers’ intentions to adopt a smartwatch has become a major research interest in marketing literature, yet little is known about it in dissimilar cultural settings. The current research employs a comparative study of South Korea and Indonesia, which differ in location and cultural heritage, smartwatch penetration rate, geographic size, level of income, and developmental stage as a country. An extended model of TAM is proposed, and PLS-SEM is employed to test the model on data collected from 262 respondents. The findings indicate that complementary goods and healthtology have positive influences on perceived usefulness and visibility has …

Human Mobility, Hospitality, And Tourism Industries: A Perspective On Catastrophes, Asif Hussain

Journal of Sustainability and Resilience

The coronavirus outbreak has resulted in a significant reduction in peoples’ movements, migration and trade at both local and global levels. Lockdowns and travel restrictions all over the world have led to a rapid retrenchment of the world’s hospitality and tourism sector. This is not new. Historically, catastrophes impacted human mobility. Drawing from the historical connections between catastrophes, especially health crises, this paper highlights the impacts of catastrophes on the hospitality and tourism industries. This research shows that the relationship between pandemic and tourism is turbulent, and it explores the implications of the current health crisis for the travel industry …

Ewom Platforms As Productivity Catalyzers In The Travel Industry: A Two-Stage Double Bootstrap Data Envelopment Analysis, Tomas Saralegui

Journal of Sustainability and Resilience

In a fast-paced digitalization context, travel agencies face a challenge to increase productivity. Electronic word of mouth (eWOM) could allow better learning processes, improve communication with customers, and serve as a remarkable diffusion channel. However, this channel is not yet fully embraced by the sector. This research, delimited to Spanish travel agencies in the period 2012-2019, applies a two-stage double bootstrap data envelopment analysis to assess whether eWOM and how firms manage eWOM, contributes to achieving higher levels of efficiency. Results show that firms with higher valence and volume of online reviews tend to be closer to the efficiency frontier. …

Caring As A Fundamental Of Sustainability And Resilience In An Aboriginal Community, Denise Lawungkurr Goodfellow

Journal of Sustainability and Resilience

Caring is a fundamental of cultural/community sustainability and resilience among Aboriginal people. However, caring is not confined to community but, as this paper demonstrates can also be extended to both visitors and the wider society. The kindness engendered has application particularly in this time of COVID-19 for both tourism and mainstream society in general.

Marketing Transformation In Tourism Through Visual Ethnography, Isabel Coll-Barneto, Francesc Fusté-Forné

Journal of Sustainability and Resilience

This paper analyses the role of transformative tourism from the perspective of local establishments. The method is based on a visual ethnography study where 12 ecological accommodations located in Catalonia, north-eastern Spain, were asked to identify a photography that illustrates the philosophy of the establishments. Results discuss the meanings of the pictures focused on previous research in relation to the transformative facilitators. The physical, knowledge, social and psychological dimensions are analysed. The nature, the wood, and the relaxing areas are the most relevant elements provided by the hotels as part of their marketing strategy. Theoretical and practical implications are described.

On-Board Images To Characterize A Cubesat's Adcs, Boris Segret, Sam Bammens, Sergio Bras, Dominik Marszk, Vasundhara Shiradhonkar, Vladimir Zelenevskiy, David Evans

Small Satellite Conference

ADCS for nanosatellites in the New Space sector are frequently offered as Commercial-Off-The-Shelves (COTS) systems. However, when the COTS datasheet and the actual performance in flight differ dramatically, there are few means to assess the discrepancies. Here, we update on the current operations with a flying nanosatellite to assess the attitude stability during inertial pointing mode, based on the analysis of on-board images of the sky. The satellite is OPS-SAT, a 3-unit CubeSat owned and operated by ESA. The imager is directed to the -Z longitudinal axis and the star tracker and a Sun sensor are oriented in the transversal …

Development And Deployment Of Remotely Operable Optical Communication Terminals, Rudd C. Johnson, Josef M. Wicker, Andrew Lin, Erik C. Dillingham, Paul Le, Jairo Esquivel, John C. Mergo, Darren Rowen

Small Satellite Conference

Since the launch of the Optical Communication and Sensor Demonstration (OCSD) Mission in November 2017, The Aerospace Corporation has relied upon a manually operated optical terminal in El Segundo, CA to support optical communications downlinks. Scaling our constellation of laser communication capable small satellites and resulting increase in data volume has necessitated multiple geographically dispersed optical ground stations. In 2021, The Aerospace Corporation developed and deployed two remotely operable optical terminals in Maui, Hawaii and Albuquerque, New Mexico, demonstrating up to 200 Mbps downlink communication rates with Forward Error Correction. The station is comprised primarily of commercial off-the-shelf (COTS) components …

An Updated Overview Of The Satellite Networked Open Ground Stations (Satnogs) Project, Kevin Croissant, Dan White, Xabier Crespo Álvarez, Vasileios Adamopoulos, Cees Bassa, Redouane Boumghar, Hugh Brown, Fredy Damkalis, Ilias Daradimos, Patrick Dohmen, Julien Flawinne, Jan Van Gils, Mark Jessop, Nikos Karamolegos, Eleftherios Kosmas, Julien Nicolas, Aris Nikas, Dimitrios Papadeas, Pierros Papadeas, Manthos Papamatthaiou, Thanos Patsas, Mixalis Raptakis, Fabian Schmidt, Nestoras Sdoukos, Corey Shields, Manolis Surligas, Kostantinos Triantafyllakis, Nikoletta Triantafyllopoulou, George Tsagkarelis, Vasilis Tsiligiannis, Alexandros Tsourapas, Giorgos Vardakis, Agisilaos Zisimatos

Small Satellite Conference

An overview of the SatNOGS project, a network of satellite ground stations around the world, optimized for modularity, built from readily available and affordable tools and resources. The rate of Low Earth Orbit (LEO) satellite launches increases with the participation of old and new entities. In this growing environment, SatNOGS provides a scalable and modular solution to track, identify, receive telemetry from, monitor, and assist operators in command/control of satellites. The SatNOGS global community, dedicated to its free and open-source values, develops hardware ground station designs (antennas, rotators, electronics), software for SDR-based communications, satellite scheduling and mission monitoring platforms. SatNOGS …

An Automated Approach To Maneuver Campaign Management For Skysats, Vishnuu Mallik, Joel Mueting, Adam Reuter, Alex Paul, Lisa Mcgill, Bhavi Jagatia, Vishwa Shah

Small Satellite Conference

Planet Labs PBC currently operates a fleet of 21 high-resolution imaging, Low Earth Orbit (LEO) satellites called SkySats comprised of both a sun-synchronous constellation and a lower inclination constellation. Due to their low altitude, operational constraints, and mission-driven requirements on image resolution and coverage, there is a need to perform routine stationkeeping and occasional constellation reconfiguration maneuver campaigns for these satellites. The Mission Systems team at Planet is currently implementing an automated and robust maneuver management system that autonomously plans and executes all SkySat maneuvers in order to reduce operator workload and improve overall constellation management efficiency. This paper describes …

Cobalt: The Next Step In Low Swap-C Optical Terminal Design, Scott E. Palo, Ryan Kingsbury, Jon C. Twichell

Small Satellite Conference

Blue Cubed has developed Cobalt, a full duplex optical terminal which can support both symmetric crosslinks and downlinks. The system has been engineered to be modular, easily mass produced and available at a competitive price. Cobalt is intended for low earth orbit small satellite applications that require 100 Mbps to 10 Gbps per communication links at ranges of up to 4000 km. The Cobalt core transceiver (excluding the telescope) is roughly 0.5U (9 x 9 x 5 cm), one kilogram, and consumes 10 W of electrical power for the 3 Gbps system variant. An increased data rate can be achieved …

Active Thermal Control For The Multispectral Earth Sensors (Acmes) Mission, Lucas Anderson, Michael Kirk, Bruno Mattos, Charles Swenson, Chad Fish, Miguel Nunes, Robin Wright

Small Satellite Conference

The Active Thermal Architecture (ATA) is a sub 1U active thermal control system providing payload thermal support and setpoint thermal control for the Active Cooling for Multispectral Earth Sensors (ACMES) mission. Based on a single-phase fluid loop heat exchanger, the ATA features a micro centrifugal pump, an innovative working fluid, and a two-axis flexible rotary fluid joint coupled to a deployable tracking radiator. The ATA system leverages advanced Ultrasonic Additive Manufacturing (UAM) techniques to directly integrate the ATA system within the payload and CubeSat structure. NASA's Science Mission Directorate has selected the ATA system to fly on the ACMES mission. …

Habeas Response - Fusl000141 (2021-08-03)

Habeas Responses

No abstract provided.

Cubesat Reusable Interface Software Platform (Crisp): A Lightweight Message-Bus-Based Flight Software Architecture For Rapid Payload Integration, Rory H. Scobie, Kevin D. Kaufeld, Bradley J. Hoose, Keith S. Morgan, Kimberly K. Katko, Markus P. Hehlen, John M. Michel

Small Satellite Conference

The Agile Space portfolio of projects at Los Alamos National Laboratory (LANL) develops low-cost, rapidly-deployable space payloads and systems. To increase the agility of future missions, we are developing CRISP: the CubeSat Reusable Interface Software Platform. CRISP provides a lightweight and reusable flight software framework for rapid integration of custom payloads with commercial microsatellite platforms. CRISP cuts development time and costs by reducing non-recurring engineering (NRE); thereby accelerating mission agility. To achieve these goals, CRISP provides a core set of payload/data management functions and abstracts the interface between the bus avionics and the payload(s). CRISP currently consists of the following …

Iterative Design Of Rcs Thruster For Debris Chaser Small Satellite Based On Δv Budget, Roshan Sah, Raunak Srivastava, Kaushik Das

Small Satellite Conference

The active debris removal (ADR) missions have been advanced continuously for debris management in low earth orbit (LEO). One of the emerging ADR methods is space robotics, where robotic manipulators are installed in small satellite setup whose main function is to chase, capture and de-orbit the space debris to a very lower altitude. This poster presents the preliminary iterative design of the RCS thruster which will execute the chase and de-orbit operation by using the value of ΔV requirements for overall operation. The RCS thrusters are a combination of a cold/hot gas thruster with a 3-axis CD nozzle in it …

Nepal's Danfe Space Mission: Technology Demonstration Mission On A 3u Cubesat To Mitigate Glacial Lake Outburst Floods, Sirash Sayanju, Janardhan Silwal, Devraj Pant, Sagar Koirala, Bikalpa Dhungana, Abhas Maskey

Small Satellite Conference

The United Nations Development Program ranks Nepal as the fourth-most country susceptible to climate change. The Global warming has caused more than 40 glacial lakes to potentially burst at any moment. A few Early Warning Systems are in place but are connected by ground cellular networks. A ground-to-space monitoring system instead, can help deter Glacial Lake Outburst Flood reliably. This paper outlines such a system through Nepal's Danfe Space Mission placed on a 3U CubeSat. Danfe demonstrates the first use case of ported PX4 drone Operating System alongside a LoRa integrated STM32 Satellite System-on-Chip. A Ground Sensor Terminal with ultrasonic …

Novel Constellation Design Tool: A Framework For Asymmetric Constellation Design, Kyle Casey, William Hunter

Small Satellite Conference

This paper addresses the problem of optimization of earth orbit space vehicle constellations balancing access over specified earth regions subject to constraints on the constituent members’ orbital elements. Whereas symmetric constellations such as Walker Delta Parameter Constellations are often a convenient starting point for system trade studies, the desire to balance access over multiple earth latitude bands requires exploration of asymmetric constellations. This paper proposes a simple, yet effective method to rapidly test asymmetric constellation designs incorporating arbitrary constraints on the space vehicles’ orbital elements. A user of this novel Constellation Design Tool (CDT) provides inputs to the code, including …

Cold Atom Space Payload Atmospheric Drag Mission (Caspa-Adm), Jorge Ferreras, Joe Spencer, Mike Salter, Tristan Valenzuela, Isabelle Riou, Marton Kiss-Toth, Ryan Renshaw, Michael Trigatzis, Lucy Moore, Steven Maddox, Michael Holynski, Sanaz Roshanmanesh, Johnathan Winch, Andrew Lamb, Farzad Hayati, Kai Bongs

Small Satellite Conference

To gain better understanding of the upper atmospheric dynamics requires more accurate determination of the mass density distribution in the thermosphere. Improved measurements of drag, by means of satellite accelerometery, can be used to more precisely determine this distribution. In addition, atmospheric drag in Low Earth Orbit (LEO) is particularly of interest for climate modelling, weather forecasting and satellite orbit prediction. RAL Space, Teledyne-e2v and the University of Birmingham are developing a Cold Atom Space Payload Atmospheric Drag Mission (CASPA-ADM). The aim of the project, supported by the UK Centre for Earth Observation Instrumentation (CEOI), is to develop a technology …

Avionics System And Attitude Algorithms For A Deorbit Device Based On An Electrodynamic Tether, Sergio Garcia-Gonzalez, Lorenzo Tarabini Castellani, Sofia Orte, Asier Ortega, Gonzalo Sanchez-Arriaga, Enrico C. Lorenzini, Martin Tajmar, Katja Wätzig

Small Satellite Conference

The main goal of the Electrodynamic Tether technology for PAssive Consumable-less deorbit Kit (E.T.PACK) project is to develop a deorbit device based on an electrodynamic tether with TRL 4 by 2022. In September 2022, its continuation, i.e. the E.T.PACK-F project, will carry on with the activities of E.T.PACK to prepare a flight model with TRL 8 that will be tested in an in-orbit demonstration mission in 2025. This work (i) describes the attitude determination and control strategy of the mission, which is used as a means of explaining its different phases and the dynamics of each one of them, (ii) …

Promoting Satellite Communications: Training Students In The Design Of Nano-Satellite Communications, Boston Viorel, Ilco Valentin, Melnic Vladimir, Martiniuc Alexei, Varzaru Vladimir, Secrieru Nicolae

Small Satellite Conference

The National Center for Space Technologies (NCST) of Technical University of Moldova (TUM) has been oriented towards a series of nanosatellites, according to the international standard CubeSat. In 2019, NCST participated in the fourth round of the KiboCUBE Program with the nanosatellite “TUMnanoSAT”.

KiboCUBE Program is a collaboration between UNOOSA and JAXA that aims to provide to the United Nations Organization members opportunity to launch CubeSat satellites developed for educational and research purposes.

The NCST team was selected by the Japan Aerospace Agency (JAXA) and the United Nations Office for Outer Space Affairs (UNOOSA) for the fourth round of the …

Space-Operating Linux: An Operating System For High Performance Ai Computation On Commercial-Grade Equipment In Low Earth Orbit, Eric Miller

Small Satellite Conference

With recent exponential advances in AI—particularly with respect to the tremendous power and efficiency accessible for data processing—there is now a countless array of applications for aerospace missions and space exploration, even in experimental CubeSats. However, with the large volume of data acquisition required for satellite missions, downlinking presents an increasingly expensive bottleneck that drastically reduces mission efficiency. At the University of Georgia Small Satellite Research Laboratory, the Multi-view Onboard Computational Imager (MOCI) employs an NVIDIA Jetson TX2i GPU module to process data in situ and downlink only final products. As is the case for many commercial off-the-shelf (COTS) devices …