Digital Commons Network^™

Mechanisms Of Carbapenemase-Mediated Resistance Among High-Risk Pseudomonas Aeruginosa Lineages In Peru, Isabella A. Tickler, Juan Carlos Gomez De La Torre, Luis Alvarado, Anne E. Obradovich, Fred C. Tenover

Biology Faculty Publications

Objectives: Pseudomonas aeruginosa is one of the leading causes of healthcare-associated infections globally. High-risk carbapenemase-encoding P. aeruginosa clones are disseminating in many regions. The aim of this study was to learn more about the lineages and mechanisms of resistance of P. aeruginosa circulating in Peru.

Methods: A total of 141 carbapenemase-producing isolates recovered from hospitalized and ambulatory patients in Lima were sequenced and analyzed to infer their lineages through whole-genome sequence typing (wgST) and to identify their antimicrobial resistance genes.

Results: wgST identified nine sequence types (STs); ST111 and ST357 were the most frequently encountered (44.0% and 38.3%, respectively), followed …

2022-August-19-Welcome Week 2022, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (Aug. 19, 2022) – Students are making their way to campus for the fall semester, and East Tennessee State University is gearing up to revel in their arrival with the traditional Welcome Week celebration. The week-long event will take place from Sunday-Saturday, Aug. 21-27, and will provide new and returning students with the opportunity to enjoy entertainment; learn about campus life, organizations and services; engage with fellow students; and win prizes including tablets, headphones and more. 

Highlights of the week include a block party, a variety of tabling events, giveaways from local businesses and a free concert.

Students …

Gendering Cabinet Reshuffles In France And Spain, Karen Beckwith

Faculty Scholarship

Presidents and prime ministers who form gender-parity cabinets receive positive news coverage and public praise. Cabinet reshuffles, with less attention, may offer scope to decrease the numbers of female ministers. Although research on the gendered impact of reshuffles is sparse, some studies suggest that women’s presence declines during reshuffles. This article explores the gendered dynamics of reshuffles that follow initial gender-parity cabinets, asking whether the reshuffle context affects the proportions of men and women in reorganized cabinet teams. Employing a comparative case study approach, the article analyses initial gender-parity cabinets and subsequent reshuffled cabinets in France and Spain across three …

Teaching Fisheries Bycatch: Exploring Economic And Behavioral Drivers Of Bycatch Through A Classroom Game, Mitch B. Priestley, J. Forrest Williams, Sahan Dissanayake

Economics Faculty Publications and Presentations

This paper presents a pedagogical exercise to explore the economics of price-based fisheries bycatch. In the exercise students experience the economic incentives that lead to bycatch due to highgrading; the discarding of low-value fish. We first discuss existing fisheries economics pedagogical activities and how our exercise is distinct. We then identify over forty economics, environmental studies, geography, management, and philosophy courses where the exercise could be played. Next, we describe the game and share results and student feedback. Finally, we provide discussion prompts and extensions to illustrate how incentives and policies can change fishing behavior to lead to sustainable fisheries.

Fort Hays State University Tiger Weekly, August 19, 2022, University Relations

Tiger Weekly Newsletters

No abstract provided.

Intermediates In Sars-Cov-2 Spike–Mediated Cell Entry, Tara C. Marcink, Thomas Kicmal, Emily Armbruster, Zhening Zhang, Gillian Zipursky, Kate L. Golub, Mohab Idris, Jonathan Khao, Jennifer Drew-Bear, Gael Mcgill, Tom Gallagher, Matteo Porotto, Amédée Des Georges, Anne Moscona

Advanced Science Research Center

SARS-CoV-2 cell entry is completed after viral spike (S) protein–mediated membrane fusion between viral and host cell membranes. Stable prefusion and postfusion S structures have been resolved by cryo–electron microscopy and cryo–electron tomography, but the refolding intermediates on the fusion pathway are transient and have not been examined. We used an antiviral lipopeptide entry inhibitor to arrest S protein refolding and thereby capture intermediates as S proteins interact with hACE2 and fusion-activating proteases on cell-derived target membranes. Cryo–electron tomography imaged both extended and partially folded intermediate states of S2, as well as a novel late-stage conformation on the pathway to …

Human Csf Movement Influenced By Vascular Low Frequency Oscillations And Respiration, Vidhya Vijayakrishnan Nair, Brianna R. Kish, Benita Inglis, Ho-Ching Shawn Yang, Adam M. Wright, Yu-Chen Wu, Xiaopeng Zhou, Amy J. Schwichtenberg, Yunjie Tong

Purdue University Libraries Open Access Publishing Fund

Cerebrospinal fluid (CSF) movement through the pathways within the central nervous system is of high significance for maintaining normal brain health and function. Low frequency hemodynamics and respiration have been shown to drive CSF in humans independently. Here, we hypothesize that CSF movement may be driven simultaneously (and in synchrony) by both mechanisms and study their independent and coupled effects on CSF movement using novel neck fMRI scans. Caudad CSF movement at the fourth ventricle and hemodynamics of the major neck blood vessels (internal carotid arteries and internal jugular veins) was measured from 11 young, healthy volunteers using novel neck …

Maternal Early-Life Risk Factors And Later Gestational Diabetes Mellitus: A Cross-Sectional Analysis Of The Uae Healthy Future Study (Uaehfs), Nirmin F. Juber, Abdishakur Abdulle, Abdulla Aljunaibi, Abdulla Alnaeemi, Amar Ahmad, Andrea Leinberger-Jabari, Ayesha S. Al Dhaheri, Eiman Alzaabi, Fatima Mezhal, Fatma Al-Maskari, Fatme Alanouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Michael Weitzman, Mohammad Al-Houqani, Mohammed Hag Ali, Naima Oumeziane, Omar El-Shahawy, Scott Sherman, Sharifa Alblooshi, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Raghib Ali

All Works

Limited studies have focused on maternal early-life risk factors and the later development of gestational diabetes mellitus (GDM). We aimed to estimate the GDM prevalence and examine the associations of maternal early-life risk factors, namely: maternal birthweight, parental smoking at birth, childhood urbanicity, ever-breastfed, parental education attainment, parental history of diabetes, childhood overall health, childhood body size, and childhood height, with later GDM. This was a retrospective cross-sectional study using the UAE Healthy Future Study (UAEHFS) baseline data (February 2016 to April 2022) on 702 ever-married women aged 18 to 67 years. We fitted a Poisson regression to estimate the …

Effect Of Surgical Experience And Spine Subspecialty On The Reliability Of The Ao Spine Upper Cervical Injury Classification System, Mark J. Lambrechts, Gregory D. Schroeder, Brian A Karamian, Jose A Canseco, F Cumhur Oner, Lorin M Benneker, Richard J Bransford, Frank Kandziora, Shanmuganathan Rajasekaran, Mohammad El-Sharkawi, Rishi Kanna, Andrei Fernandes Joaquim, Klaus Schnake, Christopher K Kepler, Alex R. Vaccaro, Ao Spine Upper Cervical Injury Classification International Members

Rothman Institute Papers

Objective: The objective of this paper was to determine the interobserver reliability and intraobserver reproducibility of the AO Spine Upper Cervical Injury Classification System based on surgeon experience (< 5 years, 5-10 years, 10-20 years, and > 20 years) and surgical subspecialty (orthopedic spine surgery, neurosurgery, and "other" surgery).

Methods: A total of 11,601 assessments of upper cervical spine injuries were evaluated based on the AO Spine Upper Cervical Injury Classification System. Reliability and reproducibility scores were obtained twice, with a 3-week time interval. Descriptive statistics were utilized to examine the percentage of accurately classified injuries, and Pearson's chi-square or Fisher's exact test was used to screen for …

Framing Trust In Artificial Intelligence (Ai) Ethics Communication: Analysis Of Ai Ethics Guiding Principles Through The Lens Of Framing Theory, Namrata Nagar

Theses

With the fast proliferation of Artificial Intelligence (AI) technologies in our society, several corporations, governments, research institutions, and NGOs have produced and published AI ethics guiding documents. These include principles, guidelines, frameworks, assessment lists, training modules, blogs, and principle-to-practice strategies. The priorities, focus, and articulation of these innumerable documents vary to different extents. Though they all aim and claim to ensure AI usage for the common good, the actual AI system outcomes in various social applications have invigorated ethical dilemmas and scholarly debates. This study presents the analysis of AI ethics principles and guidelines text published by three pioneers from …

Architecture Of Video Games: Potential Reference, Wael Mkaouar

Theses

The Architecture perspective / scale in video games has evolved throughout time to an extent that it is no longer a mere spatial visualization to host the game, but it has become an interaction medium between the player and the game. Architecture in recent video games played a fundamental role in bridging the gap between the real and the digital world. The analogy between these two is increasingly established through the representational immersion and the participation of the player in a highly realistic environment transforming the gaming experience into an entertaining and educational journey. The aim of this thesis is …

Eden V. Alvillar

All Decisions

No abstract provided.

Kelly V. Williams

All Decisions

No abstract provided.

Gallagher V. Zaloga

All Decisions

No abstract provided.

Editorial: Mitochondria, Metabolism And Cardiovascular Diseases, Jun-Ichiro Koga, Xinghui Sun, Masuko Ushio-Fukai

Department of Biochemistry: Faculty Publications

No abstract provided.

Artificial Neural Networks And Gradient Boosted Machines Used For Regression To Evaluate Gasification Processes: A Review, Owen Sedej, Eric Mbonimpa, Trevor Sleight, Jeremy M. Slagley

Faculty Publications

Waste-to-Energy technologies have the potential to dramatically improve both the natural and human environment. One type of waste-to-energy technology that has been successful is gasification. There are numerous types of gasification processes and in order to drive understanding and the optimization of these systems, traditional approaches like computational fluid dynamics software have been utilized to model these systems. The modern advent of machine learning models has allowed for accurate and computationally efficient predictions for gasification systems that are informed by numerous experimental and numerical solutions. Two types of machine learning models that have been widely used to solve for quantitative …

The Developmental Significance Of The Social Context As An Additional Self-Continuity Strategy: A Comparison Of Emerging Adults From Brazil And The United States, Jonathan Santo, Josafa M. Da Cunha, Annesha Mitra

Psychology Faculty Publications

Self-continuity refers to the strategies individuals use to justify a stable sense of self despite the various changes they experience. Among young adults, in particular, self-continuity over time has been associated with indicators of mental health. The aim of the current project was to identify whether aspects of the social context are measurably distinct from other established strategies of self-continuity. Data were collected from emerging adults from the US Midwest (n = 309) and southern Brazil (n = 285). Self-continuity and its opposite, self-discontinuity, were measured, in addition to essentialism or narrativism and the social context as strategies. …

Illinois Wesleyan Announces Spring 2022 Dean’S List, University Communications, Illinois Wesleyan University

News and Events (Discontinued Series)

No abstract provided.

Seventy-Five Years Of Pakistan’S Economy, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

A large majority of Pakistan’s population was born after the country got its independence. The median age today is 23 years and the youth have only experienced economic difficulties and hardships in their lifetime. They are hardly aware of the glory days of Pakistan. Despite the many articles that have appeared on this subject, it is essential to make them aware of the historical context in which they are today leading their lives. At the time of independence, the prospects of the economic survival of a ramped Pakistan appeared quite dim as it inherited an extremely weak and fragile economy. …

Waste Plastic Direct Extrusion Hangprinter, Aliaksei Petsiuk, Bharath Lavu, Rachel Dick, Joshua M. Pearce

Michigan Tech Publications, Part 1

As the additive manufacturing industry grows, it is compounding the global plastic waste problem. Distributed recycling and additive manufacturing (DRAM) offers an economic solution to this challenge, but it has been relegated to either small-volume 3D printers (limiting waste recycling throughput) or expensive industrial machines (limiting accessibility and lateral scaling). To overcome these challenges, this paper provides proof-of-concept for a novel, open-source hybrid 3D printer that combines a low-cost hanging printer design with a compression-screw-based end-effector that allows for the direct extrusion of recycled plastic waste in large expandable printing volumes. Mechanical testing of the resultant prints from 100% waste …

Real-World Evidence For Covid-19 Delta Variant's Effects On The Digestive System And Protection Of Inactivated Vaccines From A Medical Center In Yangzhou, China: A Retrospective Observational Study, Wenjing Zhao, Yong Li, Ruijin Xie, Yuying Dong, Yan Wei, Ce Cheng, Scott Lowe, Chenyu Sun, Cunjin Wang, Ju Gao

Student Publications

Background: Coronavirus disease 2019 (COVID-19) is rapidly disseminated worldwide, and it continues to threaten global public health. Recently, the Delta variant has emerged as the most dreaded variant worldwide. COVID-19 predominantly affects the respiratory tract, and studies have reported the transient effects of COVID-19 on digestive system function. However, the relationship between the severity of the Delta variant and digestive system function remains to be investigated. Additionally, data on the ability of the inactive Chinese vaccines (Sinovac or Sinopharm) to protect against the Delta variant or COVID-19-induced gastrointestinal symptoms in the real world are insufficient. Thus, the present retrospective observational …

Proteomic Profiling Platforms Head To Head: Leveraging Genetics And Clinical Traits To Compare Aptamer- And Antibody-Based Methods, Daniel H. Katz, Jeremy M. Robbins, Shuliang Deng, Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Zhi Yu, Debby Ngo, Mark D. Benson, Zsu-Zsu Chen, Daniel E. Cruz, Dongxiao Shen, Yan Gao, Claude Bouchard, Mark A. Sarzynski Facsm, Adolfo Correa, Pradeep Natarajan, James G. Wilson, Robert E. Gerszten

Faculty Publications

High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used increasingly in human studies. However, direct analyses to address the relative strengths and weaknesses of these platforms are lacking. We assessed findings from the SomaScan1.3K (N = 1301 reagents), the SomaScan5K platform (N = 4979 reagents), and the Olink Explore (N = 1472 reagents) profiling techniques in 568 adults from the Jackson Heart Study and 219 participants in the HERITAGE Family Study across four performance domains: precision, accuracy, analytic breadth, and phenotypic associations leveraging detailed clinical phenotyping and genetic data. Across these studies, we show evidence …

Food Insecurity Among Low-Income Households With Children Participating In A School-Based Fruit And Vegetable Co-Op, Jayna M Dave, Shreela V Sharma

Faculty, Staff and Student Publications

The purpose of this study was to evaluate the impact of a nutrition intervention on food insecurity among low-income households with children. Data were collected from 371 parent−child dyads in a quasi-experimental evaluation study of a 1-year intervention (n = 6 intervention schools receiving Brighter Bites, n = 6 wait-list control schools), and longitudinal follow-up of the intervention group 2 years post-intervention in Houston, Texas. Data were collected at three timepoints: at baseline and 1 year for all participants, and at 2 year follow-up for the intervention group (the wait-list control group received the intervention during that time). At baseline, …

A Study Of Red Snapper (Lutjanus Campechanus) Ecology In The Northern Gulf Of Mexico And The Effect Of Variable River Outflow Using Stable Isotope Analysis Of The Food Web And Eye Lenses, Caitlin C. Slife

Dissertations

In the Mississippi Bight and surrounding waters, river outflow impacts the basal resources of the Red Snapper food web, altering carbon sources and impacting prey and predator isotopes. In this study, the impact of riverine outflow on nutrients, particulate organic matter (POM), and physical water parameters on Red Snapper and their food web was analyzed using stable isotope and stomach content analysis over 5 years. The Mississippi, Pearl, Pascagoula, and Mobile rivers were included in the analysis of river impact. The Mississippi and Mobile rivers were found to significantly impact nutrients and POM in the region. River outflow was also …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Book Review: Christophe Jaffrelot, 2021. Modi’S India: Hindu Nationalism And The Rise Of Ethnic Democracy. Translated By Cynthia Schoch, Aniket Nandan

Articles

Book review: Christophe Jaffrelot, 2021. Modi’s India: Hindu Nationalism and the Rise of Ethnic Democracy. Translated by Cynthia Schoch

Natural Locus Coeruleus Dynamics During Feeding, Natale R Sciolino, Alexxai V Kravitz, Et Al

2020-Current year OA Pubs

Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found that LC-NE activity was suppressed during food consumption, and the magnitude of this neural response was attenuated as mice consumed more pellets throughout the session, suggesting that LC responses to food are modulated by satiety state. Visual-evoked LC-NE activity was also attenuated in sated mice, suggesting that satiety state modulates LC-NE encoding of multiple behavioral states. We also found that food intake could be attenuated by …

The Application, Character, And Effectiveness Of Person-Centred Care With Service-Users, And The Community Within The Discipline Of Podiatry: A Scoping Review, Sally Abey, Krithika Anil, Philip Hendy, Sara Demain

School of Health Professions

Background The concept of person-centred care is embedded within healthcare policy, focusing on long-term conditions and multimorbidity. The evidence that person-centred care is being operationalised effectively across all areas of healthcare is limited. The aim of this scoping review was to explore the application, features, and effectiveness of person-centred care with service-users, carers, and the community within podiatry. Methods The scoping review was based upon Arksey and Malley’s five stage framework. The following databases were searched between January 2010 and March 2021: AMED, CINAHL, Embase, Cochrane library, SocINDEX, British Education Index, Business Source Complete, MEDLINE (EBSCO), and the EThOS 'Global …

Human Induced Pluripotent Stem Cell Engineering Establishes A Humanized Mouse Platform For Pediatric Low-Grade Glioma Modeling, Corina Anastasaki, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne M Scheaffer, Amanda De Andrade Costa, Anna F Wilson, Chloe M Kernan, Ameera H Zafar, Xia Ge, Joel R Garbow, Fausto J Rodriguez, David H Gutmann

2020-Current year OA Pubs

A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC) engineering to generate low-grade gliomas (LGGs) harboring the two most common pediatric pilocytic astrocytoma-associated molecular alterations, NF1 loss and KIAA1549:BRAF fusion. Herein, we identified that hiPSC-derived neuroglial progenitor populations (neural progenitors, glial restricted progenitors and oligodendrocyte progenitors), but not terminally differentiated astrocytes, give rise to tumors retaining LGG histologic features for at least 6 months in vivo. Additionally, we demonstrated that hiPSC-LGG xenograft formation requires the absence …

Cmv And Ebv Co-Infection In Hiv-Infected Children: Infection Rates And Analysis Of Differential Expression Of Cytokines In Hiv Mono- And Hiv-Cmv-Ebv Co-Infected Groups, Fizza Nazim, Hammad Afzal Kayani, Aspara Ali Nathwani, Fatima Mir, Syed Hani Abidi

Department of Biological & Biomedical Sciences

Background: CMV and EBV co-infections can affect the HIV disease progression by modulating the immune system. The disease dynamics can differ in HIV-positive adults and children. In Pakistan, HIV is rapidly expanding, especially in children; however, the prevalence of CMV and EBV co-infection and the effect on immune modulation in HIV-positive children are not known. This study aimed to bridge this gap by estimating the rate of active CMV and EBV co-infection in HIV-positive children, followed by the analysis of differential expression of cytokines in HIV mono- and HIV/CMV/EBV co-infected children.
Methods: DNA samples from 319 HIV-positive children, previously recruited …