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Back Matter Vol.58 No.3 September 2022, Folia Medica Indonesiana

Folia Medica Indonesiana

Back Matter Vol.58 No.3 September 2022

Fabrication Of Nanostructured Lipid Carriers Ocugel For Enhancing Loratadine Used In Treatment Of Covid-19 Related Symptoms: Statistical Optimization, In-Vitro, Ex-Vivo, And In-Vivo Studies Evaluation, Rehab Abdelmonem, Inas Essam Ibrahim Al-Samadi, Rasha M. El Nashar, Bhaskara R. Jasti, Mohamed A. El-Nabarawi

Pacific Faculty Work

Loratadine (LORA), is a topical antihistamine utilized in the treatment of ocular symptoms of COVID-19. The study aimed to develop a Loratadine Nanostructured Lipid Carriers Ocugel (LORA-NLCs Ocugel), enhance its solubility, trans-corneal penetrability, and bioavailability. full-factorial design was established with 2⁴ trials to investigate the impact of several variables upon NLCs properties. LORA-NLCs were fabricated by using hot melt emulsification combined with high-speed stirring and ultrasonication methods. All obtained formulae were assessed in terms of percent of entrapment efficiency (EE%), size of the particle (PS), zeta potential (ZP), as well as in-vitro release. Via using Design Expert® software the …

Bacterial And Antibiogram Profile Of Urinary Tract Infection Patients In A Tertiary Hospital, Surabaya, Indonesia, Mahrumi Dewi Tri Utami, Manik Retno Wahyunitisari, Nunuk Mardiana, Rebekah Juniati Setiabudi

Folia Medica Indonesiana

Highlights: • Most urinary tract infections are caused by Gram-negative bacteria with E. coli being the most common bacteria. • Antibiotics with the highest susceptibility for Gram-negative bacteria were ertapenem, meropenem, amikacin, and imipenem. • Antibiotics with the highest susceptibility for Gram-positive bacteria mainly were susceptible to chloramphenicol,streptomycin, vancomycin, rifampin, tigecycline, teicoplanin, and ampicillin. Abstract: Urinary tract infection (UTI) is one of the most common bacterial infections. Inappropriate antibiotic use for UTI treatment may lead to antibiotic resistance. This study aimed to provide an updated bacterial and antibiogram profile from urine specimens of patients diagnosed with UTI. This study was …

Vascular Dementia Patients Characteristics With A History Of Stroke In A National Brain Center Hospital Jakarta, Indonesia, Afifah Kusuma Hanifah, Riezky Valentina Astari, Hikmah Muktamiroh, Arman Yurisaldi Saleh

Folia Medica Indonesiana

Highlights: • Characteristics of vascular dementia patients with a history of stroke was aimed. • The most characteristics of vascular dementia patients with stroke history are men, post-ischemic stroke, hypertension grade 1, and lesions in the basal ganglia. Abstract: Stroke patients increase each year. Stroke is a cerebrovascular disorder caused by disruption of cerebral blood flow, which could reason vascular lesions within the mind parenchyma to be a threat to significant disorders. One of them is vascular dementia. Each affected person is prone to growing dementia after a stroke in three to five instances. Thisstudy aimed to decide the traits …

Discovering Patterns Of Cardiovascular Disease And Diabetes In Myocardial Infarction Patients Using Association Rule Mining, Anju Singh, Divakar Singh, Shikha Sharma, Kamal Upreti, Manish Maheshwari, Vimal Mehta, Jitender Sharma, Pratishtha Mehra, Pradeep Kumar Dabla

Folia Medica Indonesiana

Highlights: • Association Rule Mining tools predict the association of early-onset Myocardial Infarction with Hypertension and Diabetes Mellitus. • Association Rule Mining tools using clinical and biochemical attributes can predict the development of Hypertension and Diabetes Mellitus in Myocardial Infarction patients. Abstract: Cardiovascular diseases (CVDs) are a major cause of mortality in diabetic patients. Hypertensive patients are more likely to develop diabetes and hypertension contributes to the high prevalence of CVDs, in addition to dyslipidemia and smoking. This study was to find the different patterns and overall rules among CVD patients, including rules broken down by age, sex, cholesterol and …

Spike-Receptor Binding Domain (Srbd) Antibodies Secretion In Covid-19 Survivors And Non-Survivors Post-Pre-Endemic Vaccination, Museyaroh, Evy Dyah Woelansari, Dwi Kriharyani

Folia Medica Indonesiana

Highlights • The research this for determine the presence of immune response post-vaccine • The results of this study indicate that there are differences in immune responses, in survivors patients have higher SRBD antibody levels than non-survivors Abstract : The development of a vaccine for SARS-COV-2 began in mid-2020 with the aim of stimulating an individual's immune response against SARS-CoV-2 infection. The purpose of this study was to determine the levels of post-vaccine SRBD antibody secreted in COVID-19 survivors and non-survivors. Antibodies are considered to play a more important role in evaluating immunity because antibody tests may provide information about …

Unusual Choanal Atresia In Children, Yunis Sucipta Ibnu, Irwan Kristyono

Folia Medica Indonesiana

Highlights: • Unusual CA in a 5-year-old boy with paranasal sinuses malformation in the ORL-HNS. • Transnasal endoscopy posterior septectomy was successfully done. Abstract: Choanal atresia is a developmental failure of the nasal cavity to connect with the nasopharynx. The cause is either unilateral or bilateral nasal obstruction. Bilateral choanal atresia is a very rare condition and diagnosed soon after birth because neonates are obligate nasal breathers. Delayed diagnosis can cause death due to respiratory distress. The objective of this study was to report bilateral choanal atresia in 5-year-old boy who survived by breathing through his mouth using a simple …

Diagnosis And Management Of Adrenal Crisis In 46xx Congenital Adrenal Hyperplasia Infant, Nur Rochmah, Muhammad Faizi, Neurinda Permata Kusumastuti, Leonardo Ferryanto Mak Samadhi, Wika Yuli Deakandi

Folia Medica Indonesiana

Highlight: • The diagnosis and therapy of Congenital Adrenal Hyperplasia (CAH) children with Adrenal crisis (AC) case report. • Adrenal crisis (AC) is a life-threatening emergency that contributes to the high death rate of children with adrenal insufficiency. • The early detection and prompt treatment can improve the outcomes of patients with CAH and AC. Abstract: Adrenal crisis is the acute complication of the patient with congenital adrenal hyperplasia. Congenital adrenal hyperplasia (CAH) is a rare condition. Children with CAH commonly come to the emergency room due to acute complications. The condition has high mortality and thus needs early recognition. …

Hookworm In Stray Cats (Felis Silvestris Catus) As Cutaneous Larva Migrant Agent (Clm) In Humans, Fadhil Ihsan Mahendra, Soebaktiningsih Soebaktiningsih, Risma Karlina Prabawati

Folia Medica Indonesiana

Highlights : • Risk factors that can increase the incidence of CLM in humans include male sex, children aged <15 years, low-income people, and daily behaviour of walking outdoors without using footwear, especially on the sand. • Risk factors that play the most role in increasing the incidence of CLM in humans are walking outdoors without using footwear, especially on the sand. Abstract : Cats arethe host of a wide variety of microorganisms including ectoparasites and endoparasites.One of theendoparasites that infect cats is hookworm. The hookworms consists of two groups, the animal hookworms, and the human hookworms. The manifestation that can be caused by animal hookworms to humans is Cutaneous Larva Migrant (CLM). This study aimed to discover whether hookworm in stray cats (Felis silvestris catus) can cause CLM in humans. We performed a systematic search in Pubmed/Medline and Cochrane published between 2016 and 2021 with no restrictions by language, research country, or type of research design . The results of the analysis showed that the high level of hookworms infection in stray cats could increase the risk of CLM in humans. Based on the study, we could conclude that the high prevalence of hookworm infection in cats plays an important role in the increased risk of zoonoses in humans which in turn could also increase the prevalence of CLM in humans.

Watching The Clocks: Interpreting The Page-Wootters Formalism And The Internal Quantum Reference Frame Programme, Emily Adlam

Mathematics, Physics, and Computer Science Faculty Articles and Research

We discuss some difficulties that arise in attempting to interpret the Page–Wootters and Internal Quantum Reference Frames formalisms, then use a ‘final measurement’ approach to demonstrate that there is a workable single-world realist interpretation for these formalisms. We note that it is necessary to adopt some interpretation before we can determine if the ‘reference frames’ invoked in these approaches are operationally meaningful, and we argue that without a clear operational interpretation, such reference frames might not be suitable to define an equivalence principle. We argue that the notion of superposition should take into account the way in which an instantaneous …

Translational Development Of Abcb5+ Dermal Mesenchymal Stem Cells For Therapeutic Induction Of Angiogenesis In Non-Healing Diabetic Foot Ulcers, Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Jünger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schröder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth

Research outputs 2022 to 2026

Background

While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5⁺ mesenchymal stem cells (MSCs) might provide a new adjunctive DFU treatment, based on their remarkable skin wound homing and engraftment potential, their ability to adaptively respond to inflammatory signals, and their wound healing-promoting efficacy in mouse wound models and human chronic venous ulcers.

Methods

The angiogenic potential of ABCB5⁺ MSCs was characterized with respect to angiogenic factor expression at the mRNA and protein level, in vitro endothelial trans-differentiation and …

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Orange County Parks Trail Use Designation Pilot Project, Christopher Monz, Noah Creany

Environment and Society Faculty Publications

This report provides an analysis and summary of the survey research findings from the Orange County (OC) Parks Trail Use Designation Pilot Project conducted during the summer of 2021. Repeat ecological monitoring flights were completed in May 2022 and the analysis and findings of the ecological effects of the Trail Use Designation Pilot Project will be delivered in a forthcoming addendum to this report.

Clinical Status, Nutritional Behavior, And Lifestyle, And Determinants Of Community Well-Being Of Patients From The Perspective Of Physicians: A Cross-Sectional Study Of Young Older Adults, Nonagenarians, And Centenarians In Salerno And Province, Italy, Silvana Mirella Aliberti, Richard H W Funk, Luigi Schiavo, Aldo Giudice, Elena Ciaglia, Annibale Alessandro Puca, Joseph S. Gonnella, Mario Capunzo

Department of Medicine Faculty Papers

Longevity is rightly considered one of the greatest achievements of modern society. Biomedical research has shown that aging is the major risk factor for many diseases, so to find the right answers to aging it is necessary to identify factors that can positively influence longevity. This study investigated the clinical status, nutritional behavior, lifestyle, and social and community determinants of the well-being of young older adults and nonagenarians/centenarians in Salerno and province through the judgment of their physicians. Data were collected through an online survey. Multivariate Poisson and logistic regression models were used to calculate significant predictors of the outcomes …

Two Mental Models Of Integrated Care For Advanced Liver Disease: Qualitative Study Of Multidisciplinary Health Professionals, Donna Smith, Fasiha Kanwal, Aanand D Naik

Faculty, Staff and Student Publications

OBJECTIVES: The purpose of this paper is to present two divergent mental models of integrated advanced liver disease (AdvLD) care among 26 providers who treat patients with AdvLD.

SETTING: 3 geographically dispersed United States Veterans Health Administration health systems.

PARTICIPANTS: 26 professionals (20 women and 6 men) participated, including 9 (34.6%) gastroenterology, hepatology, and transplant physicians, 2 (7.7%) physician assistants, 7 (27%) nurses and nurse practitioners, 3 (11.5%) social workers and psychologists, 4 (15.4%) palliative care providers and 1 (3.8%) pharmacist.

MAIN OUTCOME MEASURES: We conducted qualitative in-depth interviews of providers caring for patients with AdvLD. We used framework analysis …

The Current Status Of Acceptance And Commitment Therapy (Act) In Iran: A Systematic Narrative Review, Mehdi Akbari, Mohammad Seydavi, Carter H. Davis, Michael E. Levin, Michael P. Twohig, Elahe Zamani

Psychology Faculty Publications

Research on acceptance and commitment therapy (ACT) and its application to various clinical issues have proliferated across the world. Despite very active clusters of ACT research occurring worldwide, the science that is disseminated through the literature does not fully reflect this scope and diversity, with Iran serving as a prime example of this issue. To increase awareness of ACT research findings in Iran, we conducted a systematic review of 110 randomized trials and extracted data on key study features. RCTs were identified, suggesting the efficacy of ACT in Iran for a wide range of clinical areas, including anxiety disorders, obsessive-compulsive …

Knowledge On The Risk Of The Ischemic Heart Disease Estimation By Who Charts In Cempaka Baru, Indonesia, Hasna Luthfiah Fitriani, Karina Ajeng Da Ridwan

Folia Medica Indonesiana

Highlights: • The risk estimation of ischemic heart disease. • High blood pressure and cholesterol levels affect Ischemic heart disease. Abstract: In 2018, Indonesia became the country with the second-highest number of deaths and disabilities (DALYs) due to ischemic heart disease. Based on Riskesdas data in 2018, Jakarta is one of the provinces with a high percentage (1.9%) of ischemic heart disease. Risk factors for ischemic heart disease that are not treated quickly will increase the severity of ischemic heart disease in the future. Therefore, this study was to provide education regarding the assessment of risk estimation for ischemic heart …

Urogenital Fistula Patients Profile At A Tertiary Hospital In Surabaya, Indonesia From 2015 To 2021, Muhammad Arif Hakim Jamhari, Mohammad Ayodhia Soebadi, Johan Renaldo

Folia Medica Indonesiana

Highlights: • Vesicovaginal fistula is the most common urogenital fistula. • The transvaginal approach is preferred in treating urogenital fistula. Abstract: A fistula is an extra-anatomical channel between two or more hollow organs, or between an organ and the body surface. WHO estimated there were two million patients with untreated urogenital fistula, with 130,000 new cases every year. The ideal approach for urogenital fistula depends on surgeon preference and individual clinical characteristics. Accordingly, we aimed to determine the profile of patients with a urogenital fistula at a tertiary hospital of Dr. Soetomo General Academic Hospital in Surabaya, Indonesia, from 2015 …

Penetrating Ocular Injury Management In Intraocular Foreign Body (Iofb) And Traumatic Cataract, Nerissa Tamara Putri, Muhammad Firmansjah, Reni Prastyani

Folia Medica Indonesiana

Highlight: • The management of penetrating ocular injury with IOFB and traumatic cataracts needs a thorough examination of the mechanism of injury, location, size, and composition of IOFB. • Endophthalmitis, retinal detachment, and development of PVR are potentially vision-threatment. Abstract: Most IOFB are metallic and found in males of productive age as a consequence of work-related accidents. A 45-year-old man complained of sudden blurred vision in the left eye (3/60 pinhole 5/12) after getting hit by a foreign body when cutting grass with a lawn mower. Anterior segment examination revealed a 10 mm long, one-plane, straight, full thickness, already sutured …

Advances In High-Order Sensitivity Analysis For Uncertainty Quantification And Reduction In Nuclear Energy Systems, Dan Gabriel Cacuci

Faculty Publications

No abstract provided.

Synthesis And Characterization Of Non‑Stoichiometric Li1.1co0.3fe2.1o4 Ferrite Nanoparticles For Humidity Sensors, Mohamed Morsy

Nanotechnology Research Centre

A humidity sensor plays a crucial role in determining the efciency of materials and the precision of apparatuses. To measure and control humidity, a non-stoichiometric Li1.1Co0.3Fe2.1O4 mesopore sensor is synthesized by a modifed citrate auto combustion technique. The XRD study confrms that prepared nanoparticles are cubic spinel structures having an Fd3m space group. The crystallite size is approximately 36 nm. Thermal analysis measurements show that samples become thermally stable at a temperature of 600 °C. Additionally, the kinetic studies of the prepared samples are calculated via a pseudofrst-order kinetic model. The temperature dependence of AC conductivity is found to increase …

Recurrent Giant Cell Myocarditis After Heart Transplant: A Case Report, Eitan S. Frankel, Alexander G. Hajduczok, Indranee N. Rajapreyar, Yevgeniy Brailovsky

Division of Cardiology Faculty Papers

BACKGROUND: Giant cell myocarditis (GCM) is a rare but well-known cause of fulminant myocarditis. Despite optimal medical therapy, many patients progress to orthotopic heart transplant (OHT). We present a case of recurrent GCM following OHT, including complex considerations in patient management and infectious sequelae.

CASE SUMMARY: A 33-year-old previously healthy male presented with 2 months of worsening shortness of breath. Transthoracic echocardiogram (TTE) demonstrated a left ventricular ejection fraction of 30-35%. After ruling out an ischaemic aetiology, he was discharged on guideline-directed medical therapy and later presented with productive cough, worsening dyspnoea on exertion, and diarrhoea. He was found to …

Students’ Self-Efficacy In Self-Regulation Together With Behavioural And Emotional Strengths: Investigating Their Self-Perceptions, Minna Ikävalko, Erkko Sointu, Matthew C. Lambert, Jaana Viljaranta

Department of Special Education and Communication Disorders: Faculty Publications

Students’ self-perceptions are a foundation for educational and psychosocial development. In order to investigate self-perceptions, we need to recognise the preconceptions (e.g. doubts and confidence) students hold about themselves. In this study, we examined 10–16-year-old students’ (N=599) self–perceptions from the viewpoints of the sources of self-efficacy in self-regulation and behavioural and emotional strengths. Specifically, we used descriptive analyses to examine whether students’ ages or received pedagogical support played a role in how they perceived themselves, and whether these viewpoints are related to each other. Our results indicate that, in general, primary school students perceived their sources of self-efficacy in self-regulation …

Investigating The Psychological Mechanisms Underlying The Relationship Between Parenting Stress And Mental Health Among Adolescent Mothers In Zambia, Kalunga Cindy Nakazwe

Lingnan Theses (MPhil & PhD)

Adolescent motherhood has received insufficient research attention especially in low-and middle-income countries (LMICs). It increases physical and mental health burdens and is linked to premature death among young mothers and their children. Past research on adolescent mothers’mental health has mostly been conducted in higher income countries. Moreover, relevant research has predominantly focused on the direct effects of parenting stress on adolescent mothers’ mental health and overlooked possible mediating and moderating processes. The main aim of this research project was to examine the psychological mechanisms in the relationship between parenting stress and mental health among adolescent mothers in Zambia. The project …

‘Aging In Place’ Or ‘Stuck In Place’? The Aging In Place Experiences Of Older Adults In A Gentrifying Neighborhood In Hong Kong, Ho Wing Lau

Lingnan Theses (MPhil & PhD)

Urbanization and population aging are two of the most critical global trends in the 21st century. In particular, the aging experiences of older adults living in gentrified urban areas has raised the attention of scholars from various disciplines. Urban aging concerns how and why some older adults can thrive in urban life while others are struggling to adapt. Hong Kong is experiencing ‘double aging’ —an aging population and a large scale of aging buildings, which make it particularly challenging to strike a balance between urban renewal and preservation of the community for older adults to age in place. The challenges …

Electrocatalysis By Design: Low Dissolution Counter Electrode And Highly Efficient Nanostructured Electrocatalysts, Menna Hasan

Theses and Dissertations

Water Electrolysis is one of the most promising techniques to generate H2 gas, which is an alternative clean source of energy. Hydrogen provides almost three times the energy provided by gasoline, helping to solve the global warming problem caused by the currently used fossil fuels. As any electrochemical reaction is composed of two half reactions, a setup of working and counter electrodes is used to study the catalytic activity towards the targeted reaction, where each electrode carries one of the two-half reactions. In this dissertation, the stability of a number of the commonly used counter electrodes was examined to identify …

The Plight Of Managing Audio-Visual Archives In Developing Economies: The Case Of Zimbabwe, Samson Mutsagondo, Sabina Tholanah

Library Philosophy and Practice (e-journal)

This study used the case study of the Audio-Visual Unit of the National Archives of Zimbabwe to interrogate challenges faced in managing audio-visual archives in developing economies despite their centrality as documentary heritage. The study firstly addresses the importance of audio-visual archives such as enhancing collective societal memory, preservation of culture and provision of entertainment. Thereafter, the study addresses challenges faced such as lack of collection development policy, lack of skilled manpower and technological obsolescence. It is against this background that the study proposes a framework that can be used to improve the way audio-visual archives are managed, the Tripartite …

Developing High-Affinity Decoy Receptors To Treat Multiple Myeloma And Diffuse Large B Cell Lymphoma, Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Caiyun Grace Li, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-Sze Leung, Albert C Koong, Amato J Giaccia

Faculty, Staff and Student Publications

Disease relapse and treatment-induced immunotoxicity pose significant clinical challenges for patients with hematological cancers. Here, we reveal distinctive requirements for neutralizing TNF receptor ligands APRIL and BAFF and their receptor activity in MM and DLBCL, impacting protein translation and production in MM cells and modulating the translation efficiency of the ATM interactor (ATMIN/ACSIZ). Therapeutically, we investigated the use of BCMA decoy receptor (sBCMA-Fc) as an inhibitor of APRIL and BAFF. While wild-type sBCMA-Fc effectively blocked APRIL signaling in MM, it lacked activity in DLBCL due to its weak BAFF binding. To expand the therapeutic utility of sBCMA-Fc, we engineered an …

Erdheim-Chester Disease With Isolated Cns Involvement: A Systematic Review Of The Literature

Faculty, Staff and Student Publications

Erdheim-Chester disease (ECD) is a rare, sporadic, non-Langerhans cell histiocytosis that can have various presentations and higher mortality in patients presenting with neurological symptoms. We performed a systematic review to investigate and chronicle the frequency of neurological manifestations, imaging findings, treatments, and outcomes in published ECD patients presenting with neurological symptoms. A PubMed literature search was conducted for articles (published between January 1980 and June 2021) on ECD cases presenting with neurological manifestations. We analyzed the data of 40 patients, including our patient. Cranial neuropathies and ataxia were the most frequent clinical manifestations. A total of 50% of the symptomatic …

Herbivory And Functional Traits Suggest That Enemy Release Is Not An Important Mechanism Driving Invasion Success Of Brown Seaweeds, Al Mabey, Ja Catford, M Rius, A Foggo, Da Smale

School of Biological and Marine Sciences

AbstractInvasive species are a global threat to biodiversity and there is a pressing need to better understand why some species become invasive outside of their native range, and others do not. One explanation for invasive species success is their release from concurrent natural enemies upon introduction to the non-native range. The so-called enemy release hypothesis (ERH) has conflicting support, depending upon the ecosystem and species investigated. To date, most studies testing the generality of the ERH have focused on terrestrial ecosystems. Here, we tested whether enemy release might contribute to the success of the invasive non-native brown seaweeds Undaria pinnatifida …