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The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

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Message From The President, Georgia Southern University

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Comment Letter For Draft Final Bpsou Subdrain Pump Station Remedial Design (Rd) Work Plan (Dated June 14, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Predictors Of Enhancing Human Physical Attractiveness: Data From 93 Countries, Marta Kowal, Piotr Sorokowski, Katarzyna Pisanski, Jaroslava V. Valentova, Marco A.C. Varella, David A. Frederick, Laith Al-Shawaf, Felipe E. García, Isabella Giammusso, Biljana Gjoneska, Luca Kozma, Tobias Otterbring, Marietta Papadatou-Pastou, Gerit Pfuhl, Sabrina Stöckli, Anna Studzinska, Ezgi Toplu-Demirtaş, Anna K. Touloumakos, Bence E. Bakos, Carlota Batres, Solenne Bonneterre, Johanna Czamanski-Cohen, Jovi C. Dacanay, Eliane Deschrijver, Maryanne L. Fisher, Caterina Grano, Dmitry Grigoryev, Pavol Kačmár, Mikhail V. Kozlov, Efisio Manunta, Karlijn Massar, Joseph P. Mcfall, Moises Mebarak, Maria Rosa Miccoli, Taciano L. Milfont, Pavol Prokop, Toivo Aavik, Patrícia Arriaga, Roberto Baiocco, Jiří Čeněk, Hakan Çetinkaya, Izzet Duyar, Farida Guemaz, Tatsunori Ishii, Julia A. Kamburidis, Hareesol Khun-Inkeeree, Linda H. Lidborg, Hagar Manor, Ravit Nussinson, Mohd Sofian B. Omar-Fauzee, Farid Pazhoohi, Koen Ponnet, Anabela Caetano Santos, Oksana Senyk, Ognen Spasovski, Mona Vintila, Austin H. Wang, Gyesook Yoo, Oulmann Zerhouni, Rizwana Amin, Sibele Aquino, Merve Boğa, Mahmoud Boussena, Ali R. Can, Seda Can, Rita Castro, Antonio Chirumbolo, Ogeday Çoker, Clément Cornec, Seda Dural, Stephanie J. Eder, Nasim Ghahraman Moharrampour, Simone Grassini, Evgeniya Hristova, Gözde Ikizer, Nicolas Kervyn, Mehmet Koyuncu, Yoshihiko Kunisato, Samuel Lins, Tetyana Mandzyk, Silvia Mari, Alan D.A. Mattiassi, Aybegum Memisoglu-Sanli, Mara Morelli, Felipe C. Novaes, Miriam Parise, Irena Pavela Banai, Mariia Perun, Nejc Plohl, Fatima Zahra Sahli, Dušana Šakan, Sanja Smojver-Azic, Çağlar Solak, Sinem Söylemez, Asako Toyama, Anna Wlodarczyk, Yuki Yamada, Beatriz Abad-Villaverde, Reza Afhami, Grace Akello, Nael H. Alami, Leyla Alma, Marios Argyrides, Derya Atamtürk, Nana Burduli, Sayra Cardona, João Carneiro, Andrea Castañeda, Izabela Chałatkiewicz, Wiliam J. Chopik, Dimitri Chubinidze, Daniel Conroy-Beam, Jorge Contreras-Garduño, Diana Ribeiro Da Silva, Yahya B. Don, Silvia Donato, Dmitrii Dubrov, Michaela Duračková, Sanjana Dutt, Samuel O. Ebimgbo, Ignacio Estevan, Edgardo Etchezahar, Peter Fedor, Feten Fekih-Romdhane, Tomasz Frackowiak, Katarzyna Galasinska, Łukasz Gargula, Benjamin Gelbart, Talia Gomez Yepes, Brahim Hamdaoui, Ivana Hromatko, Salome N. Itibi, Luna Jaforte, Steve M.J. Janssen, Marija Jovic, Kevin S. Kertechian, Farah Khan, Aleksander Kobylarek, Maida Koso-Drljevic, Anna Krasnodębska, Valerija Križanić, Miguel Landa-Blanco, Alvaro Mailhos, Tiago Marot, Tamara Martinac Dorcic, Martha Martinez-Banfi, Mat Rahimi Yusof, Marlon Mayorga-Lascano, Vita Mikuličiūtė, Katarina Mišetić

Psychology Faculty Articles and Research

People across the world and throughout history have gone to great lengths to enhance their physical appearance. Evolutionary psychologists and ethologists have largely attempted to explain this phenomenon via mating preferences and strategies. Here, we test one of the most popular evolutionary hypotheses for beauty-enhancing behaviors, drawn from mating market and parasite stress perspectives, in a large cross-cultural sample. We also test hypotheses drawn from other influential and non-mutually exclusive theoretical frameworks, from biosocial role theory to a cultural media perspective. Survey data from 93,158 human participants across 93 countries provide evidence that behaviors such as applying makeup or using …

Gata Now!, Georgia Southern University

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Gata Now!, Georgia Southern University

Athletics: News & Publications

• True Blue vs Big Red
• Men's Soccer Faculty Appreciation
• Single Game Tickets
• Pick 3 Mini Plans
• Season Tickets
• Pledge Per Win
• Away Game Tickets
• 2022 Football Schedule
• Volleyball Schedule
• Women's Soccer
• Men's Soccer
• Headlines

Polarization Topology At The Nominally Charged Domain Walls In Uniaxial Ferroelectrics, Yurii Tikhonov, Jesi R. Maguire, Conor J. Mccluskey, James P. V. Mcconville, Amit Kumar, Haidong Lu, Dennis Meier, Anna Razumnaya, John Martin Gregg, Alexei Gruverman, Valerii M. Vinokur, Igor Luk’Yanchuk

Department of Physics and Astronomy: Faculty Publications

Ferroelectric domain walls provide a fertile environment for novel materials physics. If a polarization discontinuity arises, it can drive a redistribution of electronic carriers and changes in band structure, which often result in emergent 2D conductivity. If such a discontinuity is not tolerated, then its amelioration usually involves the formation of complex topological patterns, such as flux-closure domains, dipolar vortices, skyrmions, merons, or Hopfions. The degrees of freedom required for the development of such patterns, in which dipolar rotation is a hallmark, are readily found in multiaxial ferroelectrics. In uniaxial ferroelectrics, where only two opposite polar orientations are possible, it …

The Decline Of Two Native Fish In The Moapa (Muddy) River, Nevada, 2007–2015, Ronald B. Kegerries, Ronald J. Rogers, Zachary R. Shattuck, Brandon Albrecht, David J. Syzdek

Western North American Naturalist

Aquatic ecosystems in the American Southwest have experienced biotic and abiotic degradation, which have deleteriously impacted the native fish communities that have evolved in these systems. The native fish community in the Moapa (Muddy) River in Nevada faces many of these challenges, including changes in flow regimes, changes in temperature regimes, habitat fragmentation, and nonnative species introductions. By 2007, the only native fishes to occupy the Muddy River downstream of the warm, spring-fed headwaters were Virgin River Chub Gila seminuda and Moapa Speckled Dace Rhinichthys osculus moapae. From 2007 to 2015, biannual standardized hoop-net sampling of portions of a …

Student Life E-Newsletter September 06, 2022, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Nano-Preterm Infants May Not Benefit From Noninvasive Versus Invasive Ventilation At Birth, Public Relations

Browse All News

No abstract provided.

Uab Radiation Oncologists Provide First Sbrt Treatments To Lung Cancer Patients In The Alexander City Area, Staff

Browse All News

No abstract provided.

Quantifying The Relationship Between Sub-Population Wastewater Samples And Community-Wide Sars-Cov-2 Seroprevalence., Ted Smith, Rochelle H. Holm, Rachel J. Keith, Alok R. Amraotkar, Chance R. Alvarado, Krzysztof Banecki, Boseung Choi, Ian Santisteban, Adrienne M. Bushau-Sprinkle, Kathleen T. Kitterman, Joshua Fuqua, Krystal T. Hamorsky, Kenneth E. Palmer, J. Michael Brick, Aruni Bhatnagar, Grzegorz A. Rempala

Faculty and Staff Scholarship

Robust epidemiological models relating wastewater to community disease prevalence are lacking. Assessments of SARS-CoV-2 infection rates have relied primarily on convenience sampling, which does not provide reliable estimates of community disease prevalence due to inherent biases. This study conducted serial stratified randomized samplings to estimate the prevalence of SARS-CoV-2 antibodies in 3717 participants and obtained weekly samples of community wastewater for SARS-CoV-2 concentrations in Jefferson County, KY (USA) from August 2020 to February 2021. Using an expanded Susceptible-Infected-Recovered model, the longitudinal estimates of the disease prevalence were obtained and compared with the wastewater concentrations using regression analysis. The model analysis …

Clonal Hematopoiesis Is Associated With Increased Risk Of Severe Neurotoxicity In Axicabtagene Ciloleucel Therapy Of Large B-Cell Lymphoma, Neeraj Y Saini, David M Swoboda, Uri Greenbaum, Junsheng Ma, Romil D Patel, Kaberi Das, Paolo Strati, Ranjit Nair, Luis Fayad, Sairah Ahmed, Hun Ju Lee, Swaminathan P Iyer, Raphael Steiner, Nitin Jain, Loretta Nastoupil, Sanam Loghavi, Guilin Tang, Roland L Bassett, Preetesh Jain, Michael Wang, Jason R Westin, Michael R Green, David A Sallman, Eric Padron, Marco L Davila, Frederick L Locke, Richard E Champlin, Guillermo Garcia-Manero, Elizabeth J Shpall, Partow Kebriaei, Christopher R Flowers, Michael D Jain, Feng Wang, Andrew P Futreal, Nancy Gillis, Sattva S Neelapu, Koichi Takahashi

Faculty, Staff and Student Publications

To explore the role of clonal hematopoiesis (CH) in chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep sequencing on buffy coats collected during the 21 days before lymphodepleting chemotherapy from 114 large B-cell lymphoma patients treated with anti-CD19 CAR T cells. We detected CH in 42 (36.8%) pretreatment samples, most frequently in PPM1D (19/114) and TP53 (13/114) genes. Grade ≥3 immune effector cell-associated neurotoxicity syndrome (ICANS) incidence was higher in CH-positive patients than CH-negative patients (45.2% vs. 25.0%, P = 0.038). Higher toxicities with CH were primarily associated with DNMT3A, TET2, and ASXL1 genes (DTA mutations). Grade …

Genetic- And Diet-Induced Ω-3 Fatty Acid Enrichment Enhances Trpv4-Mediated Vasodilation In Mice, Rebeca Caires, Tessa A C Garrud, Luis O Romero, Carlos Fernández-Peña, Valeria Vásquez, Julio F Cordero-Morales

Faculty, Staff and Student Publications

TRPV4 channel activation in endothelial cells leads to vasodilation, while impairment of TRPV4 activity is implicated in vascular dysfunction. Strategies that increase TRPV4 activity could enhance vasodilation and ameliorate vascular disorders. Here, we show that supplementation with eicosapentaenoic acid (EPA), an ω-3 polyunsaturated fatty acid known to have beneficial cardiovascular effects, increases TRPV4 activity in human endothelial cells of various vascular beds. Mice carrying the C. elegans FAT-1 enzyme, which converts ω-6 to ω-3 polyunsaturated fatty acids, display higher EPA content and increased TRPV4-mediated vasodilation in mesenteric arteries. Likewise, mice fed an EPA-enriched diet exhibit enhanced and prolonged TRPV4-dependent vasodilation …

Ablating Lgr5-Expressing Prostatic Stromal Cells Activates The Erk-Mediated Mechanosensory Signaling And Disrupts Prostate Tissue Homeostasis, Xing Wei, Li Zhang, Yiqun Zhang, Cody Cooper, Chris Brewer, Yi-Ting Wang, Hunter B Wessells, Jianwen Que, Mark A Titus, Vincenzino Cirulli, Adam Glaser, Tao Liu, Nicholas P Reder, Chad J Creighton, Li Xin

Faculty, Staff and Student Publications

Functional implication of stromal heterogeneity in the prostate remains incompletely understood. Using lineage tracing and light-sheet imaging, we show that some fibroblast cells at the mouse proximal prostatic ducts and prostatic urethra highly express Lgr5. Genetic ablation of these anatomically restricted stromal cells, but not nonselective ablation of prostatic stromal cells, rapidly induces prostate epithelial turnover and dedifferentiation that are reversed following spontaneous restoration of the Lgr5

Follicular Lymphoma Microenvironment Characteristics Associated With Tumor Cell Mutations And Mhc Class Ii Expression, Guangchun Han, Qing Deng, Mario L Marques-Piubelli, Enyu Dai, Minghao Dang, Xubin Li, Jared Henderson, Olga Kudryashova, Mark Meerson, Sergey Isaev, Nikita Kotlov, Krystle J Nomie, Alexander Bagaev, Edwin R Parra, Luisa M Solis Soto, Simrit Parmar, Fredrick B Hagemeister, Sairah Ahmed, Swaminathan P Iyer, Felipe Samaniego, Raphael Steiner, Luis Fayad, Hun Lee, Nathan H Fowler, Christopher R Flowers, Paolo Strati, Jason R Westin, Sattva S Neelapu, Loretta J Nastoupil, Francisco Vega, Linghua Wang, Michael R Green

Faculty, Staff and Student Publications

Follicular lymphoma (FL) is a B-cell malignancy with a complex tumor microenvironment that is rich in nonmalignant immune cells. We applied single-cell RNA sequencing to characterize the diverse tumor and immune cell populations of FL and identified major phenotypic subsets of FL T cells, including a cytotoxic CD4 T-cell population. We characterized four major FL subtypes with differential representation or relative depletion of distinct T-cell subsets. By integrating exome sequencing, we observed that somatic mutations are associated with, but not definitive for, reduced MHC expression on FL cells. In turn, expression of MHCII genes by FL cells was associated with …

Longitudinal Effects Of Combination Antiretroviral Therapy On Cognition And Neuroimaging Biomarkers In Treatment-Naive People With Hiv, Roberto C Arduino, Xing Qiu, Giovanni Schifitto

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: While combination antiretroviral therapy (cART) has dramatically increased the life expectancy of people with HIV (PWH), nearly 50% develop HIV-associated neurocognitive disorders. This may be due to previously uncontrolled HIV viral replication, immune activation maintained by residual viral replication or activation from other sources, or cART-associated neurotoxicity. The aim of this study was to determine the effect of cART on cognition and neuroimaging biomarkers in PWH before and after initiation of cART compared with that in HIV-negative controls (HCs) and HIV elite controllers (ECs) who remain untreated.

METHODS: We recruited 3 groups of participants from the University …

Hypertension Management In Patients With Chronic Kidney Disease

Faculty, Staff and Student Publications

Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely related to reduced nephron mass, sympathetic nervous system overactivation, involvement of the renin-angiotensin-aldosterone system, and generalized endothelial dysfunction. Consensus guidelines for blood pressure targets have adopted a blood pressure <120/80 mm Hg in native chronic kidney disease and <130/80 mm Hg in kidney transplant recipients. Guidelines also strongly advocate for renin-angiotensin-aldosterone system blockade as the first-line therapy.

An Enzymatically Cleavable Tripeptide Linker For Maximizing The Therapeutic Index Of Antibody-Drug Conjugates, Candice M Haase, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama

Faculty, Staff and Student Publications

Valine-citrulline is a protease-cleavable linker commonly used in many drug delivery systems, including antibody-drug conjugates (ADC) for cancer therapy. However, its suboptimal in vivo stability can cause various adverse effects such as neutropenia and hepatotoxicity, leading to dose delays or treatment discontinuation. Here, we report that glutamic acid-glycine-citrulline (EGCit) linkers have the potential to solve this clinical issue without compromising the ability of traceless drug release and ADC therapeutic efficacy. We demonstrate that our EGCit ADC resists neutrophil protease-mediated degradation and spares differentiating human neutrophils. Notably, our anti-HER2 ADC shows almost no sign of blood and liver toxicity in healthy …

A Novel Qkd Approach To Enhance Iiot Privacy And Computational Knacks, Salman A Alqahtani

Faculty, Staff and Student Publications

The industry-based internet of things (IIoT) describes how IIoT devices enhance and extend their capabilities for production amenities, security, and efficacy. IIoT establishes an enterprise-to-enterprise setup that means industries have several factories and manufacturing units that are dependent on other sectors for their services and products. In this context, individual industries need to share their information with other external sectors in a shared environment which may not be secure. The capability to examine and inspect such large-scale information and perform analytical protection over the large volumes of personal and organizational information demands authentication and confidentiality so that the total data …

Microrna Expression Levels Change In Neonatal Patients During And After Exposure To Cardiopulmonary Bypass, Lance Hsieh, Lan N. Tu, Alison Paquette, Quanhu Sheng, Shilin Zhao, Douglas Bittel, James O'Brien, Kasey Vickers, Peter Pastuszko, Vishal Nigam

Faculty and Staff Publications

Background:

The systemic inflammation that occurs after exposure to cardiopulmonary bypass (CPB), which is especially severe in neonatal patients, is associated with poorer outcomes and is not well understood. In order to gain deeper insight into how exposure to bypass activates inflammatory responses in circulating leukocytes, we studied changes in microRNA (miRNA) expression during and after exposure to bypass. miRNAs are small noncoding RNAs that have important roles in modulating protein levels and function of cells.

Methods and Results:

We performed miRNA‐sequencing on leukocytes isolated from neonatal patients with CPB (n=5) at 7 time points during the process of CPB, …

The Lawnmower And The Pediatric Lower Extremity: A Catastrophic Combination

Faculty, Staff and Student Publications

Heart failure can lead to renal impairment, an interaction now termed "cardiorenal syndrome." The prevalent physiological explanation for the renal impairment that accompanies heart failure centers around the forward failure hypothesis, which emphasizes the role of left ventricular dysfunction in causing edema, and the backward failure hypothesis, which singles out venous congestion as the dominant mechanism of edema and reduced glomerular filtration rate. In this review, we provide an appraisal on venous congestion, an extremely important contributor that has received little attention. We also summarize the pharmacology of loop diuretics, explain current understanding of diuretic resistance, and address controversies regarding …

Smart Cities, Metaverses, And The Relevance Of Place, Alessandro Aurigi

School of Art, Design and Architecture

A TALE OF TWO (SMART?) CITIES In Yemen sits the 16th Century walled city of Shibam, now listed by UNESCO as a World Heritage site. Beyond its historical and cultural significance, something about the place is striking from a design viewpoint. Shibam, like many other ancient settlements, embeds much local wisdom in its own design. Its unusually tall buildings were constructed with locally sourced mud. Its fabric is dense and creates much needed shade in the city's narrow streets. Studies demonstrate its rather sophisticated—and certainly low‐carbon—approach to passive environmental design at both urban and building level, ensuring degrees of thermal …

Review Of Nuno P. Monteiro And Fritz Bartel, Eds., Before And After The Fall: World Politics And The End Of The Cold War, Cambridge: Cambridge University Press, 2021, Isbn 978-1-108-84334-8, L Cladi

School of Law, Humanities and Social Sciences

Book review

Understanding The Relationship Between Age-Related Hearing Loss And Alzheimer's Disease: A Narrative Review, Hadeel Y. Tarawneh, Dona M. P. Jayakody, Hamid R. Sohrabi, Ralph N. Martins, Wilhelmina H.A.M. Mulders

Research outputs 2022 to 2026

Evidence suggests that hearing loss (HL), even at mild levels, increases the long-term risk of cognitive decline and incident dementia. Hearing loss is one of the modifiable risk factors for dementia, with approximately 4 million of the 50 million cases of dementia worldwide possibly attributed to untreated HL. This paper describes four possible mechanisms that have been suggested for the relationship between age-related hearing loss (ARHL) and Alzheimer's disease (AD), which is the most common form of dementia. The first mechanism suggests mitochondrial dysfunction and altered signal pathways due to aging as a possible link between ARHL and AD. The …

Local Structure And Its Implications For The Relaxor Ferroelectric Cd2nb2 O7, Daniel Hickox-Young, Geneva Laurita, Quintin N. Meier, Daniel Olds, Nicola A. Spaldin, Michael R. Norman, James M. Rondinelli

All Faculty Scholarship

The relaxor ferroelectric transition in Cd2Nb2O7 is thought to be described by the unusual condensation of two Γ-centered phonon modes, Γ4- and Γ5-. However, their respective roles have proven to be ambiguous, with disagreement between ab initio studies, which favor Γ4- as the primary mode, and global crystal refinements, which point to Γ5- instead. Here, we resolve this issue by demonstrating from x-ray pair distribution function measurements that locally, Γ4- dominates, but globally, Γ5- dominates. This behavior is consistent with the near degeneracy of the energy surfaces associated with these two distortion modes found in our own ab initio simulations. …

Issues With Variability In Electronic Health Record Data About Race And Ethnicity: Descriptive Analysis Of The National Covid Cohort Collaborative Data Enclave, Lily Cook, Juan Espinoza, Nicole G Weiskopf, Nisha Mathews, David A Dorr, Kelly L Gonzales, Adam Wilcox, Charisse Madlock-Brown, N3c Consoritium

2020-Current year OA Pubs

BACKGROUND: The adverse impact of COVID-19 on marginalized and under-resourced communities of color has highlighted the need for accurate, comprehensive race and ethnicity data. However, a significant technical challenge related to integrating race and ethnicity data in large, consolidated databases is the lack of consistency in how data about race and ethnicity are collected and structured by health care organizations.

OBJECTIVE: This study aims to evaluate and describe variations in how health care systems collect and report information about the race and ethnicity of their patients and to assess how well these data are integrated when aggregated into a large …

Novel Antiinflammatory Biologics Shaped By Parasite-Host Coevolution, Stephanie M Ryan, Makedonka Mitreva, Et Al

2020-Current year OA Pubs

Parasitic helminth infections, while a major cause of neglected tropical disease burden, negatively correlate with the incidence of immune-mediated inflammatory diseases such as inflammatory bowel diseases (IBD). To evade expulsion, helminths have developed sophisticated mechanisms to regulate their host's immune responses. Controlled experimental human helminth infections have been assessed clinically for treating inflammatory conditions; however, such a radical therapeutic modality has challenges. An alternative approach is to harness the immunomodulatory properties within the worm's excretory-secretory (ES) complement, its secretome. Here, we report a biologics discovery and validation pipeline to generate and screen in vivo a recombinant cell-free secretome library of …