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Articles 673951 - 673980 of 5209520
Full-Text Articles in Entire DC Network
Public Health Liberation – An Emerging Transdiscipline To Elucidate And Transform The Public Health Economy, Christopher Williams Mph, Joy Birungi Msc, Melody Brown Mph, Mhsa, James Deutsch Md, Phd, Felecia Williams Phd, Mpa, P.S. Perkins Ma, Patricia Bishop, Dena Walker, Ebony Moody, Rhonda Hamilton Ma, Jehan El-Bayoumi Md
Public Health Liberation – An Emerging Transdiscipline To Elucidate And Transform The Public Health Economy, Christopher Williams Mph, Joy Birungi Msc, Melody Brown Mph, Mhsa, James Deutsch Md, Phd, Felecia Williams Phd, Mpa, P.S. Perkins Ma, Patricia Bishop, Dena Walker, Ebony Moody, Rhonda Hamilton Ma, Jehan El-Bayoumi Md
Advances in Clinical Medical Research and Healthcare Delivery
Public Health Liberation (PHL) is an innovative general theory of public health aimed at accelerating health equity. This paper provides a rich synthesis of philosophical traditions, novel theories, and approaches to establish the basis for a new public health transdiscipline. The authors argue that the "public health economy" as a single analytic lens elucidates the contradictions and tensions that reproduce vast health inequity. Authored by a majority of Black women, community experiences and perspectives are a major strength of this paper because they draw upon leadership experiences with contemporary issues.
The authors begin by describing their background in public health …
An Unexpected Case Of Herpes Simplex Virus Esophagitis Presenting Amidst Corticosteroid Therapy For An Acute Copd Exacerbation: A Case Report, Aqeel Khanani, Kayvan Mirhadi
An Unexpected Case Of Herpes Simplex Virus Esophagitis Presenting Amidst Corticosteroid Therapy For An Acute Copd Exacerbation: A Case Report, Aqeel Khanani, Kayvan Mirhadi
Advances in Clinical Medical Research and Healthcare Delivery
Herpes simplex virus (HSV) is prevalent worldwide, with a recent report by the World Health Organization estimating that 3.7 billion individuals under the age of 50 have been infected by the virus. After the initial infection, HSV-1 enters a latent phase with the potential for intermittent reactivation, often secondary to episodes of infection, stress, or immunosuppression. Per current literature review, esophageal involvement in the form of herpes simplex virus esophagitis (HSVE) is more commonly associated with immunocompromised patients, such as transplant recipients and HIV-positive individuals. The patient discussed in this report is a 79-year-old female with a past medical history …
The Management Of Newly Diagnosed Probable Creutzfeldt-Jakob Disease In Acute Rehabilitation Setting: A Case Report, Royce Copeland, Shefali Amin, Anthony Donato
The Management Of Newly Diagnosed Probable Creutzfeldt-Jakob Disease In Acute Rehabilitation Setting: A Case Report, Royce Copeland, Shefali Amin, Anthony Donato
Advances in Clinical Medical Research and Healthcare Delivery
Abstract
Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disease. The purpose of this report is to demonstrate the role of inpatient rehabilitation for a patient recently diagnosed with probable Creutzfeldt-Jakob disease. A 62-year-old male was readmitted to an acute care hospital after a recent mechanical fall. For several weeks, he had a constellation of symptoms, including cognitive impairment and progressive memory loss, gait and postural instability, 20 pounds of unintentional weight loss, visual hallucinations, myoclonus, and hypophonia. After an extensive workup, a diagnosis of probable Creutzfeldt-Jakob disease was made, and he was transferred to an acute inpatient rehabilitation hospital. …
Stones, Bones, And Groans With Cancerous Overtones - A Rare Case Of Diffuse Large B Cell Lymphoma Presenting As Hypercalcemia, Evan Becker, Caitlyn Moss, Steve Chung
Stones, Bones, And Groans With Cancerous Overtones - A Rare Case Of Diffuse Large B Cell Lymphoma Presenting As Hypercalcemia, Evan Becker, Caitlyn Moss, Steve Chung
Advances in Clinical Medical Research and Healthcare Delivery
Diffuse large B cell lymphoma (DLBCL) is a type of non-Hodgkin lymphoma that can present in a variety of ways including fever, weight loss, weakness, and drenching night sweats. Uncommonly, hypercalcemia of malignancy can be associated with DLBCL through multiple mechanisms that include synthesis of parathyroid hormone related peptide (PTHrP) or elevated calcitriol levels. It is estimated that hypercalcemia in the setting of DLBCL is present in 18% of newly diagnosed cases. This report details a case of an 80-year-old man with history of chronic anemia and CKD stage 3b that presented with weakness, decreased oral intake, and self-reported weight …
A Case Of Intractable Hyperhidrosis In Spinal Cord Injury: Role Of Stellate Ganglion Block, Soun Sheen, Hemant Kalia, Victoria Kung
A Case Of Intractable Hyperhidrosis In Spinal Cord Injury: Role Of Stellate Ganglion Block, Soun Sheen, Hemant Kalia, Victoria Kung
Advances in Clinical Medical Research and Healthcare Delivery
Objective:
Autonomic dysreflexia (AD) in spinal cord injury (SCI) can present as hyperhidrosis due to sudomotor dysfunction. Hyperhidrosis can also occur without an identifiable etiology. There are no standard treatment guidelines for refractory hyperhidrosis in the setting of persistent noxious stimulation. Stellate ganglion blockade may prevent hyperhidrosis by inhibiting profound sympathetic surge and vasoconstriction.
Case:
58-year-old female with C7 ASIA-A quadriplegia was admitted to the hospital for episodes of profuse sweating in the setting of autonomic dysreflexia secondary to underlying T7-8 discitis. Despite conservative treatment of discitis, patient continued experience 50-60 episodes of profuse sweating daily. Stellate ganglion block was …
Decreasing Unnecessary Laboratory Testing In Medical Critical Care, Nirajan Adhikari, Kriti Suwal, Sushmita Khadka, Binita Dahal, Litty Thomas, Chandrakala Dadeboyina, Sri Senapathi, James Walsh
Decreasing Unnecessary Laboratory Testing In Medical Critical Care, Nirajan Adhikari, Kriti Suwal, Sushmita Khadka, Binita Dahal, Litty Thomas, Chandrakala Dadeboyina, Sri Senapathi, James Walsh
Advances in Clinical Medical Research and Healthcare Delivery
The overuse of laboratory testing is common in the intensive care unit (ICU) which leads to an increased cost of care and an increased potential for harm to the patient. There is no evidence that obtaining daily laboratory tests helps to reduce mortality or morbidity in critical care patients. We conduced a retrospective study where chart review was performed to assess the frequency of unnecessary laboratory testing followed by a quality improvement initiative. With our study we were successful at reducing the inappropriate laboratory testing and improving the appropriate laboratory testing through our study.
Cancer Patient Beliefs And Attitudes Regarding Immune Checkpoint Inhibitor Therapy, Nedal Darwish, Delaney C. Stuhr, Haily M. Datz, Halima Bakillah, Tenzin Tseky, Mohamed Manaa, Serge Dauphin
Cancer Patient Beliefs And Attitudes Regarding Immune Checkpoint Inhibitor Therapy, Nedal Darwish, Delaney C. Stuhr, Haily M. Datz, Halima Bakillah, Tenzin Tseky, Mohamed Manaa, Serge Dauphin
Advances in Clinical Medical Research and Healthcare Delivery
The development and widespread use of immune checkpoint inhibitors (ICIs) have advanced the field of oncology in a short period of time. Despite this, patient perception regarding this new medication class has not been adequately assessed, which may affect treatment decisions and adherence. The Belief about Medicines Questionnaire (BMQ) is a validated survey composed of 18 questions which analyzes patient’s beliefs about the necessity of prescribed medication and concern about the potential adverse events caused by the medication. General medication overuse and harm are also determined. This is the first study to utilize the BMQ for patients on ICI therapy.
Obesity And Covid-19 Outcomes In A Primarily Black Population, Raj Dangol, Olga Lurye, Sadaf Mustafa, Lyn Camire, Krupa Patel, Eshetu Tefera, David S. Weisman
Obesity And Covid-19 Outcomes In A Primarily Black Population, Raj Dangol, Olga Lurye, Sadaf Mustafa, Lyn Camire, Krupa Patel, Eshetu Tefera, David S. Weisman
Advances in Clinical Medical Research and Healthcare Delivery
ABSTRACT
Background:
Studies have noted higher COVID-19 mortality with more severe obesity in populations that included a small percentage of Black patients.
Methods:
We retrospectively analyzed COVID-19 outcomes associated with obesity in our largely African American patient population. A total of 1101 symptomatic patients with a positive COVID-19 laboratory test March 5 to June 3, 2020, were categorized into weight groups based on body mass index (BMI). Of these patients, 679 (61.7%) were Black. A total of 355 (32.2%) patients had overweight and 516 (46.9%) had obesity.
Results:
BMI was an independent risk factor for intubation and an independent predictor …
Short-Term Pain Outcomes In Robotic Versus Manual Total Hip Arthroplasty, Brienne Paradis Oms3, Andrea M. Bodine Md
Short-Term Pain Outcomes In Robotic Versus Manual Total Hip Arthroplasty, Brienne Paradis Oms3, Andrea M. Bodine Md
Advances in Clinical Medical Research and Healthcare Delivery
Background: Four-hundred-fifty-thousand patients annually undergo total hip arthroplasty (THA) in the United States. THA has been shown to alleviate pain, restore function, and improve quality of life. Manual implant postoperative complications have led to a need for more advanced technology. Robotic assisted THA has the potential for greater accuracy in component positioning compared to manual. Comparing robotic and manual THA, significant differences have been shown in hip-specific functional outcomes, component positioning, complications, and patient-centered outcomes. The effects of these techniques on differences from baseline pain have yet to be investigated.
Methods: A retrospective review of the Berkshire Medical Center electronic …
What's New?, Richard Alweis, Elizabeth Mamo, Christina Goodermote
What's New?, Richard Alweis, Elizabeth Mamo, Christina Goodermote
Advances in Clinical Medical Research and Healthcare Delivery
The editors discuss updates with the journal.
Decadal Validation Of The Lasp Trf Radiometer By Nist And Establishment Of A Replacement Room Temperature Standard, Malcolm White, Nathan Tomlin, Chris Yung, Michelle Stephens, Ping-Shine Shaw, Joe Rice, John Lehman, Karl Heuerman, Joel Rutkowski, Cameron Straatsma, Peter Pilewskie, Erik Richard, Dave Harber
Decadal Validation Of The Lasp Trf Radiometer By Nist And Establishment Of A Replacement Room Temperature Standard, Malcolm White, Nathan Tomlin, Chris Yung, Michelle Stephens, Ping-Shine Shaw, Joe Rice, John Lehman, Karl Heuerman, Joel Rutkowski, Cameron Straatsma, Peter Pilewskie, Erik Richard, Dave Harber
The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)
We present the results of a recent, extensive measurement campaign validating the traceability of the solar irradiance record and earth radiation budget data. The campaign also established future traceability, thus ensuring confidence in the continuing climate-data record. The Total Solar Irradiance Radiometer Facility (TRF) at the Laboratory for Atmospheric and Space Physics (LASP) Boulder, uses a liquid helium cooled cryogenic radiometer as the reference standard for the validation of spaceflight total solar irradiance instrumentation. In 2008 the radiometer was directly compared to the National Institute of Standards and Technology (NIST) Primary Optical Watt Radiometer (POWR) at a wavelength of 532.12 …
Strengthening The Radiometric Link To The Si: Achievements From The Chipscale Project, Marit Ulset Nordsveen, Jarle Gran
Strengthening The Radiometric Link To The Si: Achievements From The Chipscale Project, Marit Ulset Nordsveen, Jarle Gran
The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)
The EURAMET European Metrology Programme for Innovation and Research (EMPIR) project chipS·CALe aims to improve and simplify radiometric traceability with a focus on strengthening the link between radiometric measurements and the international system of units (SI). In this project, several national metrology institutes (NMIs) and research institutions in Europe have collaborated to develop improved low-loss Predictable Quantum Efficient Detector (PQED) photodiodes with an external quantum deficiency in the 10 ppm range or below from 400 nm to 850 nm.
These induced-junction photodiodes are simple in their structure, making them suitable for 3D computer simulations. In a 2 minute animation video …
Cooking/Keep Warm Function For Religious Preferences (Sabbath) - Id-06083, Christian Mohr
Cooking/Keep Warm Function For Religious Preferences (Sabbath) - Id-06083, Christian Mohr
Defensive Publications Series
The invention relates to an oven with a Sabbath mode. The oven comprises a control unit with an algorithm enabled to control both a heating arrangement and a user interface in compliance with the Jewish Laws for Sabbath celebration. Furthermore, the heating arrangement is adapted to deliver a low and constant power output without cycling intervals, thereby achieving a relatively low temperature inside an oven cavity. The heating arrangement comprises a two-circuit bottom heater or alternatively a first and a second heating elements in serial connection. Accordingly, a Sabbath mode enables an oven to warm food for a prolonged period …
Diallyl Disulfide Inhibits Proliferation, Epithelial—Mesenchymal Transition, And Invasion Through Rorα-Mediated Downregulation Of Wnt1/Β-Catenin Pathway In Gastric Cancer Cells, Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su
Diallyl Disulfide Inhibits Proliferation, Epithelial—Mesenchymal Transition, And Invasion Through Rorα-Mediated Downregulation Of Wnt1/Β-Catenin Pathway In Gastric Cancer Cells, Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su
Journal of Food and Drug Analysis
Overactivation of Wnt/β-catenin pathway due to dysfunction of retinoid-related orphan receptor α (RORα) is related to cancer development and progression. Diallyl disulfide (DADS), an active component of garlic, has been reported in our previous study for upregulation of RORα expression in gastric cancer (GC) cells. It remains to be elucidated the role and mechanism of RORα in DADS against GC. This study revealed that DADS treatment resulted in reduced expression levels of Wnt1, β-catenin, TCF-4, intranuclear β-catenin and p-β-catenin in GC cells, concomitant with the compromised expression of β-catenin target genes (Axin, c-Jun, and c-Myc). RORα overexpression augmented DADS-induced downregulation …
Melatonin Exerts Anti-Fibrinolytic Effects By Regulating Il-1Β-Induced Changes In Upa, Upar, And Pai-1 Expression/Production In Human Dental Pulp Cells, Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng
Melatonin Exerts Anti-Fibrinolytic Effects By Regulating Il-1Β-Induced Changes In Upa, Upar, And Pai-1 Expression/Production In Human Dental Pulp Cells, Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng
Journal of Food and Drug Analysis
Interleukin-1b (IL-1β) is a pro-inflammatory cytokine and its expression is increased in inflamed dental pulp. IL-1β affects plasminogen activation system molecules, which are crucial for tissue inflammation, fibrinolysis, matrix turnover, and cell adhesion and migration. Melatonin, which provides circadian and seasonal signals, is a physiological endocrine generated by the pineal gland. It has anti-oxidant and anti-inflammatory properties. Studies are warranted to determine whether melatonin prevents IL-1β-induced expression/production of plasminogen system molecules. Human dental pulp cells (HDPCs) were exposed to IL-1β or melatonin alone or to IL-1β with/without pretreatment with melatonin or other inhibitors. The mRNA expression of uPA, uPAR, and …
Stress Amelioration And Anti-Inflammatory Potential Of Shiikuwasha (Citrus Depressa Hayata) Essential Oil, Limonene, And Γ-Terpinene, Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada
Stress Amelioration And Anti-Inflammatory Potential Of Shiikuwasha (Citrus Depressa Hayata) Essential Oil, Limonene, And Γ-Terpinene, Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada
Journal of Food and Drug Analysis
Shiikuwasha (Citrus depressa Hayata) essential oil (SEO) extracted from Shiikuwasha fruit pulp contains two major volatile components, limonene and γ-terpinene (56.56–57.31 and 24.41–24.98%, respectively). In this study, we showed that the aroma streams of SEO, limonene, and γ-terpinene exhibited significant physiological stress amelioration effects in nine healthy female panelists tested in a 30-min visual display task. While SEO administration significantly reduced work errors by 15 min compared to the odorless control condition, the limonene stream reduced work errors only at the first and fourth 5-min intervals, and the γ-terpinene effect lasted only for the initial 5-min. However, γ-terpinene inhalation …
Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference., Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang
Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference., Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang
Journal of Food and Drug Analysis
The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p‐coumaroyl‐CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With …
Phytochemical Characterization, Antioxidant Potential, And Health Risk Assessment Of Radix Oryzae Glutinosae, Hai-Ping Liu, Jian-Feng Tang, Kai Ren, Tong-Jun Chen, Ping-Ping Zhu, Dong-Dong Sun, Wei-Yun Wang
Phytochemical Characterization, Antioxidant Potential, And Health Risk Assessment Of Radix Oryzae Glutinosae, Hai-Ping Liu, Jian-Feng Tang, Kai Ren, Tong-Jun Chen, Ping-Ping Zhu, Dong-Dong Sun, Wei-Yun Wang
Journal of Food and Drug Analysis
Radix Oryzae Glutinosae (ROG) has been used as a traditional anhidrotic agent in China. Ten samples were systematically assessed based on four aspects of their chemical profiles and antioxidant activity. The former was achieved using ultraviolet-visible spectra (UV), infrared absorption spectra (IR), proton nuclear magnetic resonance spectroscopy (1H NMR), and inductively coupled plasma-mass spectrometry (ICP-MS) fingerprints, and antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assay, and the ferric reducing antioxidant power (FRAP) assay. The presence of amino acids, flavonoids, organic acids, and sugars was indicated in all samples. A hierarchical …
Systems Pharmacology Dissection Of The Mechanisms And Therapeutic Potential Of Cassiae Semen For Hepatoprotection And Brightening Eyes, Jing-Xiao Zhang, Zi-Yi Chen, Xue-Zhen Huang, Lin-Yue Qi, Wei Zhou
Systems Pharmacology Dissection Of The Mechanisms And Therapeutic Potential Of Cassiae Semen For Hepatoprotection And Brightening Eyes, Jing-Xiao Zhang, Zi-Yi Chen, Xue-Zhen Huang, Lin-Yue Qi, Wei Zhou
Journal of Food and Drug Analysis
Cassiae semen has been shown to play significant roles in reversing “liver fire” to improve vision. The systems mechanism of Cassiae semen for hepatoprotection and brightening eyes has not been fully explored. The systems pharmacology approach is proposed to dissect the potential pharmacological mechanism of Cassiae semen for hepatoprotection and brightening eyes. The results showed that 26 active components of Cassiae semen that connected with 230 targets were obtained. Gene ontology enrichment, network and pathway analysis explored that Cassiae semen is responsible for hepatoprotection and brightening eyes. The current study will contribute to the research and development of functional foods.
Exploring The Relationship Between Metabolite Composition And The Cold/Hot Properties Ascribed In Traditional Chinese Medicine By Mass Spectral Molecular Networking–A Pilot Study, Chun-Han Su, Yu-Chieh Cheng, Kuei-Hung Lai, Yu-Chia Chang, Chi-Hui Sun, Po-Wen Tu, Ching-Chih Lin, Tsong-Long Hwang, Yu-Liang Yang
Exploring The Relationship Between Metabolite Composition And The Cold/Hot Properties Ascribed In Traditional Chinese Medicine By Mass Spectral Molecular Networking–A Pilot Study, Chun-Han Su, Yu-Chieh Cheng, Kuei-Hung Lai, Yu-Chia Chang, Chi-Hui Sun, Po-Wen Tu, Ching-Chih Lin, Tsong-Long Hwang, Yu-Liang Yang
Journal of Food and Drug Analysis
Traditional Chinese medicine (TCM) has been applied to improve human health for millennia. In the TCM system, “medicinal property” (yao xing; hot and cold properties) is a core concept used to describe the influences of medicinal materials on human physiological conditions, and metabolites are believed to be one of the major ingredients of TCMs that affect their medicinal property. However, due to a lack of comprehensive analyses of TCM metabolomes, information about the relationships between TCM metabolite composition and medicinal property remains limited. In this pilot study, a mass spectral molecular networking-based platform was established and applied to …
Quantification Of Anthocyanosides In Grapes By Quechers And Biphenyl-Uhplc Tandem Mass Spectrometry, Lun-Chi Yang, Sung-Fang Chen
Quantification Of Anthocyanosides In Grapes By Quechers And Biphenyl-Uhplc Tandem Mass Spectrometry, Lun-Chi Yang, Sung-Fang Chen
Journal of Food and Drug Analysis
In this study, the QuEChERS and UHPLC-MS/MS method using a biphenyl stationary phase was developed and applied for the rapid separation of 12 anthocyanosides in grapes. Efficient separation was achieved for a wide range of mono- and un-glycosylated anthocyanosides. The linear ranges of the target anthocyanosides were 0.5 to 500 ng mL−1. The intra- and inter-day precisions were both below 11.8%. Anthocyanosides in grapes from different sources were successfully quantified. Thus, the developed QuEChERS and UHPLC-MS/MS method provide an attractive alternative for the quantification of anthocyanosides in grapes.
Fluorescence Detection Of Malachite Green In Fish Based On Aptamer And Sybr Green I, Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang
Fluorescence Detection Of Malachite Green In Fish Based On Aptamer And Sybr Green I, Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang
Journal of Food and Drug Analysis
A simple fluorescence method to quantitatively monitor malachite green (MG) was introduced based on the conformation switch effect of MG-aptamer (Apt) and the fluorochrome of SYBR Green I (SGI). SGI can embed in the stem–loop structure of Apt to produce fluorescence. However, the fluorescence will be quenched when MG is introduced because of the specific binding of Apt to MG. Under the optimal conditions, the fluorescence method displayed excellent linear relationship between the fluorescence quenching efficiencies and the MG concentrations ranging from 0.02 μmol L−1 to 1.0 μmol L−1. The detection limit of the method was 0.67 …
Bromelain Activates The Amp-Activated Protein Kinase-Autophagy Pathway To Alleviate Hepatic Lipid Accumulation, Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee
Bromelain Activates The Amp-Activated Protein Kinase-Autophagy Pathway To Alleviate Hepatic Lipid Accumulation, Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee
Journal of Food and Drug Analysis
Bromelain, a cysteine protease found in pineapple, is known to exert protective effects against non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. In this study, we aimed to investigate the molecular mechanisms underlying the beneficial effects of bromelain using in vivo and in vitro models. C57BL/6 mice were fed a high-fat diet (HFD) with or without bromelain (20 mg/kg/day) for 12 weeks. We found that treatment with bromelain alleviated hepatic lipid accumulation accompanied by the activation of AMP-activated protein kinase (AMPK) and autophagy flux, as evidenced by the elevated levels of phosphorylated AMPK, ATG5, ATG7, LC3-II, and …
Metabolism-Involved Drug Interactions With Traditional Chinese Medicines In Cardiovascular Diseases, Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng
Metabolism-Involved Drug Interactions With Traditional Chinese Medicines In Cardiovascular Diseases, Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng
Journal of Food and Drug Analysis
Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb-drug interactions (HDIs) in this modern era. One of the main causes of HDIs is modulation of drug metabolism, in which cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and transporters play primary roles. In this review, we focus on in vivo studies of HDIs, particularly in the treatment of …
Real-World Evidence Of The Herb-Drug Interactions, Hsueh-Yi Pan, Li-Wei Wu, Pin-Chun Wang, Ping-Hung Chiu, Meng-Ting Wang
Real-World Evidence Of The Herb-Drug Interactions, Hsueh-Yi Pan, Li-Wei Wu, Pin-Chun Wang, Ping-Hung Chiu, Meng-Ting Wang
Journal of Food and Drug Analysis
Herbal medicine (HM) is a type of medicine that uses active ingredients made from plants to treat diseases and maintain health and wellbeing. Due to its increasing worldwide usage, the possibility of HMs and conventional drugs being concurrently used is high, potentially leading to adverse events resulting from herb-drug interactions. Despite the safety concerns regarding such interactions, few studies have been conducted for assessing clinical consequences of using HMs with conventional drugs in real-world settings. As clinical trials are not forthcoming rapidly enough to provide the evidence for herb-drug interactions, observational studies are considered as an alternative approach. The present …
Providing A Meeting Reminder To An Invitee Not In Attendance At A Meeting, John Costello, Ollie Fagan, Robert Headon, Owen Friel
Providing A Meeting Reminder To An Invitee Not In Attendance At A Meeting, John Costello, Ollie Fagan, Robert Headon, Owen Friel
Defensive Publications Series
How often, in this busy world in which we work, has a meeting invitee forgotten to join a meeting (in time or at all)? Let's be honest—it happens all the time and sometimes it's important that a particular invitee is present, particularly for meetings in which other attendees are relying on the invitee's input during a meeting. Techniques presented herein provide for the ability for an absent invitee for a meeting to receive a reminder to join the potentially forgotten and, more importantly, potentially vital meeting when the absent invitee's name is mentioned during the meeting.
Pemberdayaan Perempuan Melalui Lembaga Keuangan Mikro, Ali Aljihad, Arif Wibowo
Pemberdayaan Perempuan Melalui Lembaga Keuangan Mikro, Ali Aljihad, Arif Wibowo
Jurnal Pembangunan Manusia
The existence of disparities between the human development index of women and men and the mandate of the RPJMN regarding gender equality needs to be considered. Empowerment of women through microfinance has long been implemented and is indeed the main target for microfinance institutions that run it. With so many studies on women's empowerment, there needs to be an analysis of how the forms of empowerment are carried out by microfinance institutions. This writing uses a literature review method which discusses five microfinance institutions from existing research, then analyzes how the forms of women's empowerment are carried out by these …
Pendayagunaan Kelembagaan Lokal Dalam Meningkatkan Ketahanan Pangan Masyarakat Pada Masa Pandemi Covid-19, Novita Sari, Isbandi Rukminto Adi
Pendayagunaan Kelembagaan Lokal Dalam Meningkatkan Ketahanan Pangan Masyarakat Pada Masa Pandemi Covid-19, Novita Sari, Isbandi Rukminto Adi
Jurnal Pembangunan Manusia
The Covid-19 pandemic is a disease outbreak that has hit Indonesia since 2020. The impact of this epidemic changed the order and habits of society in general. This pandemic not only destroyed the health and economic structure, but also triggered a world food crisis, including Indonesia. Regions in Indonesia are experiencing various problems and crises, one of which is Kampar Regency. The fulfillment of food needs in Kampar Regency is mostly imported from West Sumatra via the West Sumatra-Riau national road. The dependence of Kampar Regency on West Sumatra can be seen when landslides occur, so there is a spike …
Proses Pembentukan Kampung Tematik Di Kampung Budaya Tehyan, Kelurahan Mekarsari, Kecamatan Neglasari, Kota Tangerang, Rossiana Jasmine, Indra Lestari Fawzi
Proses Pembentukan Kampung Tematik Di Kampung Budaya Tehyan, Kelurahan Mekarsari, Kecamatan Neglasari, Kota Tangerang, Rossiana Jasmine, Indra Lestari Fawzi
Jurnal Pembangunan Manusia
Poverty is a problem that continues to exist in urban and rural areas. With the ‘1 RW 1 Kampung Tematik’ movement, Tangerang city government makes the thematic village an effort to improve environmental conditions while at the same time elevating the socio-economic potential of the community and ultimately alleviating poverty. Kampung Budaya Tehyan is one of the thematic villages located in RW 04, Mekarsari Village, Neglasari District, Tangerang City and it focuses on the cultural theme and potential of the minority Benteng Chinese ethnic community. This article discusses the establishment process of Kampung Budaya Tehyan together with its supporting and …
Program Kartu Prakerja Sebagai Program Pemberdayaan Di Bidang Ketenagakerjaan Di Tengah Pandemi, Mochamad Rangga Septiyadi, Ety Rahayu
Program Kartu Prakerja Sebagai Program Pemberdayaan Di Bidang Ketenagakerjaan Di Tengah Pandemi, Mochamad Rangga Septiyadi, Ety Rahayu
Jurnal Pembangunan Manusia
As predicted, Indonesia will experience a demographic bonus, starting in 2020 as indicated by the population of productive citizens group (15-64 years) which is larger than other population groups. In response to the situation, fundamental efforts need to be made to ensure that the demographic surplus can be an economic driver. In early 2020, the government launched the Pre-employment Card program. This program was launched in the midst of the Covid-19 pandemic which disrupted many aspects of society, especially the economy and health. This research examines the Pre-employment Card program from the point of view of the empowerment concept. Research …