Digital Commons Network^™

Systemic Chemotherapies Retain Antitumor Activity In Desmoid Tumors Independent Of Specific Mutations In Ctnnb1 Or Apc: A Multi-Institutional Retrospective Study, Michael J Nathenson, Katharina Feister, Et Al

2020-Current year OA Pubs

PURPOSE: Determine whether specific CTNNB1 or APC mutations in patients with desmoid tumor were associated with differences in clinical responses to systemic treatments.

EXPERIMENTAL DESIGN: We established a multi-institutional dataset of previously treated patients with desmoid tumor across four U.S. sarcoma centers, including demographic and clinicopathologic characteristics, treatment regimens, and clinical and radiographic responses. CTNNB1 or APC mutation status was determined from prior pathology records, or archival tissue was requested and analyzed by Sanger sequencing and/or next-generation sequencing. Evaluable patients with mutation results were analyzed to determine clinical progression-free survival (cPFS), RECIST 1.1 PFS (rPFS), time to next treatment (TTNT), …

Ehrlich Tumor Induces Trpv1-Dependent Evoked And Non-Evoked Pain-Like Behavior In Mice, Mariana M Bertozzi, Telma Saraiva-Santos, Tiago H Zaninelli, Felipe A Pinho-Ribeiro, Victor Fattori, Larissa Staurengo-Ferrari, Camila R Ferraz, Talita P Domiciano, Cassia Calixto-Campos, Sergio M Borghi, Ana C Zarpelon, Thiago M Cunha, Rubia Casagrande, Waldiceu A Verri

2020-Current year OA Pubs

We standardized a model by injecting Ehrlich tumor cells into the paw to evaluate cancer pain mechanisms and pharmacological treatments. Opioid treatment, but not cyclooxygenase inhibitor or tricyclic antidepressant treatments reduces Ehrlich tumor pain. To best use this model for drug screening it is essential to understand its pathophysiological mechanisms. Herein, we investigated the contribution of the transient receptor potential cation channel subfamily V member 1 (TRPV1) in the Ehrlich tumor-induced pain model. Dorsal root ganglia (DRG) neurons from the Ehrlich tumor mice presented higher activity (calcium levels using fluo-4 fluorescent probe) and an increased response to capsaicin (TRPV1 agonist) …

A Novel Self-Assembled Cobalt-Free Perovskite Composite Cathode With Triple-Conduction For Intermediate Proton-Conducting Solid Oxide Fuel Cells, Hua Tong, Min Fu, Yang Yang, Fanglin Chen, Zetian Tao

Faculty Publications

A traditional composite cathode for proton-conducting solid oxide fuel cells (H-SOFCs) is typically obtained by mixing cathode materials and proton conducting electrolyte of BaCe_0.7Y_0.2Z_r0.1O_3–δ (BZCY), providing chemical and thermal compatibility with the electrolyte. Here, a series of triple-conducing and cobalt-free iron-based perovskites as cathodes for H-SOFCs is reported. Specifically, BaCe_xFe_1–xO_3–δ (x = 0.36, 0.43, and 0.50) shows various contents of two single phase perovskites with an in situ heterojunction structure as well as triple conductivity by tailoring the Ce/Fe ratios. The cell performance with the optimized BaCe_{0.36 …}

Piloting A Systems Level Intervention To Improve Cervical Cancer Screening, Treatment And Follow Up In Kenya., Natabhona M. Mabachi, Catherine Wexler, Harshdeep Acharya, May Maloba, Kevin Oyowe, Kathy Goggin, Sarah Finocchario-Kessler

Manuscripts, Articles, Book Chapters and Other Papers

Although preventable, Cervical Cancer (CC) is the leading cause of cancer deaths among women in Sub-Saharan Africa with the highest incidence in East Africa. Kenyan guidelines recommend an immediate screen and treat approach using either Pap smear or visual screening methods. However, system (e.g., inadequate infrastructure, weak treatment, referral and tracking systems) and patient (e.g., stigma, limited accessibility, finance) barriers to comprehensive country wide screening continue to exist creating gaps in the pathways of care. These gaps result in low rates of eligible women being screened for CC and a high loss to follow up rate for treatment. The long-term …

Risk And Incidence Of Head And Neck Cancers In Veterans Living With Hiv And Matched Hiv-Negative Veterans, Jennifer R Kramer, Donna L White, Kathryn E Royse, Suchismita Raychaudhury, Vlad C Sandulache, Sarah T Ahmed, Jose P Zevallos, Peter A Richardson, Andrew G Sikora, Elizabeth Y Chiao

Faculty, Staff and Students Publications

BACKGROUND: Persons living with HIV/AIDS have a higher incidence of virus-related and tobacco/alcohol-related cancers. This study is the first to estimate the effect of HIV versus HIV-negative veterans on the risk of head and neck squamous cell carcinoma incidence in a large retrospective cohort study.

METHODS: The authors constructed a retrospective cohort study using patient data from 1999 to 2016 from the National Veterans Administration Corporate Data Warehouse and the VA Central Cancer Registry. This cohort study included 45,052 veterans living with HIV/AIDS and 162,486 HIV-negative patients matched by age, sex, and index visit (i.e., HIV diagnosis date or clinic …

The Changing Landscape Of Intermediary Liability For E-Commerce Platforms: Emergence Of A New Regime, Vasundhara Majithia

Indian Journal of Law and Technology

As India becomes the fastest growing market for e-commerce in the world, it is also grappling with the issue of proliferation of counterfeits on e-commerce portals. India’s judicial system has awakened to this predicament and in a spate of judgements, has sought to evolve a mechanism balancing the rights of e-commerce platforms as intermediaries via-a-vis the rights of brand owners and public interest at large. This article explores the evolution of intermediary liability in India by examining its legal framework, as well as the jurisprudence developed by Indian courts in this regard. It traces the shift in this jurisprudence from …

The Conundrum Of ‘Relevant Market’: Market Definition In India’S Complex Tv Distribution Business, Vibodh Parthasarathi

Indian Journal of Law and Technology

The universal problematic of market definition poses peculiar challenges in multi-lingual and fragmented media markets, like in India. This article engages with this problematic by taking up the case of the TV distribution market in India. Here, the rapidly expanding TV distribution business consists of two segments. The larger, wired Cable distribution segment, driven by over 1,000 large cable companies and over 50,000 last mile operators, accounts for 70 percent market share, or around 100 million TV homes. The rest 30 percent is occupied by the wireless segment, comprising 6 Direct to Home TV distributors. Amidst the heightened expansion of …

Trust Me: Combining Online Dispute Resolution, Law And Blockchain Technology, Tina Van Der Linden

Indian Journal of Law and Technology

This piece focuses on the unsettled relationship between online dispute resolution, law and smart contracts (and the ‘trust’ provided by them). It first introduces the ways in which smart contract applications on a blockchain provide the trust required to deal with unknown business partners – trust in the network rather than in an old-fashioned trusted third party. A distinction is also drawn between calculated trust and institutional trust. The piece then attempts to reconcile the trust provided by smart contracts with the demands of business and concludes that some gaps remain. Finally, it examines what online dispute resolution and the …

Competition Law Limits On Ride Sharing Enterprises – Taking Into Account The Experience In India, Max Huffman

Indian Journal of Law and Technology

New economy competition policy is on the forefront of enforcers’ minds across the globe, with numerous competition agencies engaged in competition advocacy efforts regarding the sharing economy generally or ride sharing specifically. In a sharing economy firm, extra-firm contracting may be as efficient as that occurring intra-firm. By reducing search and transaction costs, the sharing economy enables transactions that could not occur in a pre-internet economy. The sharing economy grew strongly in developed economies, all of which were burdened with legacy permitting systems such as taxicab medallions or zoning regulations and other oversight limiting public lodging. The promise in economies …

It’S Raining Crypto: The Need For Regulatory Clarification When It Comes To Airdrops, Carol R. Goforth

Indian Journal of Law and Technology

Worldwide regulatory restrictions have pushed crypto entrepreneurs to take creative and novel approaches in their struggle to create viable user networks for new tokens. One of the most interesting vehicles for dispersing tokens is the ‘airdrop’, a process by which a developer essentially ‘gives away’ tokens. The developers’ motives in these airdrops are typically not completely altruistic. Instead, the goal is to increase the ‘buzz’ about new forms of crypto, and to encourage recipients to voluntarily promote the token that they now also own. The regulatory reaction to this technique has been mixed. A few nations, most notably China, have …

The Case For Regulating Crypto-Assets, Jaideep Reddy

Indian Journal of Law and Technology

In July 2019, the Ministry of Finance, Government of India announced that an Inter-Ministerial Committee (the ‘Committee’) had submitted its report (the ‘Committee Report’) recommending that possessing or dealing with cryptocurrency be banned and made a criminal offence. This article examines whether such a ban is justified under our constitutional scheme. The article finds that the right to carry on various kinds of crypto-asset activities can be traced to various enumerated fundamental rights under the Constitution of India. Analyzing the Committee Report, the article finds that its recommendation of an outright ban is unlikely to be a reasonable restriction on …

Regulators Nurturing Fintech Innovation: Global Evolution Of The Regulatory Sandbox As Opportunity-Based Regulation, Deirdre Ahern

Indian Journal of Law and Technology

The regulatory sandbox is a real-world alternative to regulatory lag. Its emergence as a novel regulatory development responds to challenges faced by FinTech innovators in navigating an unwieldy regulatory landscape not designed with FinTech in mind. Regulatory sandboxes are in operation in developed countries including Australia, Canada, Denmark, Hong Kong, Singapore, Switzerland, the Netherlands, the United Arab Emirates, the United Kingdom, and the United States. Within the European Union they are seen in Denmark, Hungary, Lithuania, Poland and the Netherlands. The concept has also gained traction with regulators in developing countries such as India, Indonesia, Malaysia, Mauritius and Thailand. Not …

Legal And Taxation Issues Concerning E-Commerce, Gopal Saxena

Indian Journal of Law and Technology

The Internet has evolved from a network of computers to a global social phenomenon. Once a medium that offered access only to a few, the smartphone and mobile network revolution has thrown it open to a much wider and more varied audience. In the process it is transforming itself from a place where people exchange information to a place where people conduct business as well. The convenience provided by online business transactions – e-commerce – is the reason why more and more users are turning to the Internet for their buying and selling. This is not only changing the face …

Patenting Human Genes: Wherein Lies The Balance Between Private Rights And Public Access In India And The United States?, Elizabeth Siew-Kuan Ng

Indian Journal of Law and Technology

This article examines the patentability of human genes by evaluating where the balance should lie between the protection of private rights and public access for the promotion of further innovation and public health. The author investigates this issue by providing a comparative study on the approaches adopted in India and the United States – two highly divergent nations that offer unique contrasts in a comparative analysis of their patent regimes. The outcome of the appraisal discerns a potential convergence in the Indian and US approaches on certain aspects of human gene patent-eligibility. This interesting result reveals that contrary to intuition, …

Surveying The Damage: A Study Of Damages Payouts By The Delhi High Court In Trademark Infringement Cases (2005-2014), Eashan Gosh

Indian Journal of Law and Technology

A comprehensive ten year study of damages awarded by the Delhi High Court in trademark infringement cases reveals the remarkable extent to which the quantum of damages can be correlated to the presence of certain factual criteria. It brings into sharp focus exactly how far the reasoning behind awarding and quantifying damages – often the biggest takeaway and most powerful deterrent in trademark infringement cases – has been rendered an afterthought. Commencing with a critical commentary on the headline damages payouts by the Delhi High Court in 1, I break down the significant statistical outcomes of damages awarded based on …

Surface Mount Technology Rj45 Stretchable Pin Against Pull Force, Jeff Yao, Kexian Huang, Jason Zhang

Defensive Publications Series

Techniques are provided herein for a stretchable, spring-like structure that is added into the copper pin of Surface Mount Technology (SMT) RJ45. The structure can stretch when the RJ45 is pulled to mitigate the force on the RJ45 pin.

Infinite Storage Of Expendable Goods For Consumer Access, Dmitrii Boiarshinov

Defensive Publications Series

The present disclosure describes computer-implemented systems and methods for maintaining a reliable and sufficient supply of expendable goods in a storage pod designated for consumer access. The storage pod may be configured for the delivery of expendable goods to improve the accessibility of expendable goods to consumers by implementing techniques for managing inventory data, securing access to the storage pod, and using data-driven models to coordinate the resupply of expendable goods.

Optimizing Closed Month Accounting By Utilizing Leases On Data Access And Editing, Shanchi Wang, Xin Chen, L Jagannathan, Yuan Li, Vivi Huang, Chuanqi Shen

Defensive Publications Series

The present disclosure describes computer-implemented systems and methods for improved efficiency of closed month accounting procedures. More particularly, systems and methods can reduce system queries pertaining to a closed month by utilizing time-based locks, hereinafter “leases,” when preparing entries for the closed month. When a month begins to close, it is provided with a lease and an expiration time of the lease. During the lease, a user can commit entries to the closing month without creating data errors.

Improved Ranking Of Web Results For Image Based Search Using Click Data, N/A

Defensive Publications Series

The present disclosure describes computer-implemented systems and methods for improving image-based search results by using result click data and/or similar metadata to rank or order results so as to reduce search time and provide more relevant search results. In one particular embodiment, the count of clicks for a result URL may be used to train an search result ranking model for ranking image search results. For a set of search results, the trained model can be used to determine a probability of a user selecting a particular search result in response to a query. The search results may be ranked …

Automatic Suggestion Of Message Category/Tag, Krzysztof Dziuba

Defensive Publications Series

Techniques are provided herein for automated suggestion of a message category/tag to help users organize their conversations. This may help filter or highlight important messages (e.g., to improve communication between users), particularly in hybrid work scenarios.

Virtual Be-Right-Back Status For Teleconferencing Application, Varun Pandit, Praveen G, Jayesh Menghani, Rishitha Valla

Defensive Publications Series

Techniques are provided herein to notify, in real-time, participants of a teleconference/meeting that one of the participants is absent. The notification may be a virtual Be Right Back (BRB) indicator. In some examples, the participant may be sent a personalized message with the transcript of the meeting for the duration they were absent. This may allow participants to step away without disrupting the flow of the meeting.

Inside The Machine: Constitutionality Of India’S Surveillance Apparatus, Bedavyasa Mohanty

Indian Journal of Law and Technology

(This article was published prior to the Puttaswamy judgement) This paper seeks to analyse the nuances of some of those laws and tools that enable the State to keep a constant watch over its citizens’ activities. It also attempts to test the validity of the State’s surveillance powers against the principles of liberty and justice enshrined in the Indian Constitution. In doing so, the author aims to challenge the archaic foundations of Indian surveillance laws while drawing attention to areas that are in need of re-examination or, in some cases, complete overhaul. Part II of the paper is a brief …

Free And Open Source Software And The Twin Tragedies, Ananth Padmanabhan

Indian Journal of Law and Technology

The past decade has seen the rise and rise of free and open source software (FoSS). Part I of this paper surveys the FoSS movement from its early days to the present, including its fundamental philosophy. This part also looks into the different factors that have contributed to the growth of FoSS, such as the motivations of coders to be part of a “free” creative endeavor, the relatively flexible hierarchical structures that give considerable space for “free play”, and the shared values that integrate coders completely into the movement thus nurturing new creative activity from time to time. Part II …

How To Design An Indian Net Neutrality Law, Chaitanya Ramachandran

Indian Journal of Law and Technology

The past two years have seen net neutrality rise to prominence as a topic of public debate in India. Multiple policy development processes have been instituted within the executive and legislative branches of the government to formulate policies and regulations protecting net neutrality. While proponents demand robust legal protection for net neutrality, opponents have tended to focus on broadening the scope of exceptions to net neutrality. It is conceivable that, as the various policy development processes continue to unfold, a consensus will emerge amongst policymakers in favour of protecting net neutrality through law (regardless of the extent of that protection). …

Zero-Rating, Net Neutrality And The Progressive Realisation Of Human Rights, Balaji Subramaniam

Indian Journal of Law and Technology

The net neutrality debate today, specifically with respect to zero-rating, is invariably characterised as a clash between the noble aspiration to universalise access on one hand, and a handful of “core values of the internet” on the other. Such framing makes for a lively dialogue – neutrality proponents can extol the virtues of an “open internet”, and can argue that access universalisation is impossible, and therefore any failed attempt toward that goal is not worth the risk of permanently altering the nature of the network. Proponents of net neutrality argue that zero-rating would stifle innovation and distort consumer choice to …

The Politics Of Pirates: Jonas Andersson Schwarz’S “Online File Sharing”, Gautam Bhatia

Indian Journal of Law and Technology

The international debate over file-sharing is defined by polarities. Some view this conflict as a battle for internet openness against the efforts of the film and music industry to bring about a second Enclosure Movement, this time against the worldwide digital commons. Others, however, consider it to be a legitimate law-enforcement operation against wilful facilitators of large-scale copyright infringement. In his book, Online File Sharing, published in early 2014, Jonas Andersson Schwarz argues that this dichotomy is a deeply flawed way of understanding the file-sharing dispute. Using tools from critical theory and political philosophy, Schwarz aims to break down the …

Technology Innovations In Securities Trading: Can Sebi’S Bicycle Catch The High- Frequency Trading Ferrari, Armaan Patkar

Indian Journal of Law and Technology

Algorithmic high-frequency trading is a techinnovation of securities trading. It is enabled by high-tech trading algorithms and communication and computing infrastructure that allows traders to profit based on the speed and volume of their trading, rather than by trading based on conventional trading fundamentals. However, its strategies have become ubiquitous with market manipulation, regulatory arbitrage and clouding the ability of investors to accurately read the market. Understandably, regulators have been making efforts to protect the markets and stay abreast with the rapid evolution of highfrequency trading. In this endeavour, the U.K. Financial Services Authority remarked that regulators are riding bicycles …

The Internet Of Citizens: A Lawyer’S View On Some Technological Developments In The United Kingdom And India*, Guido Noto La Diega

Indian Journal of Law and Technology

This article aspires to constitute a useful tool for both Asian and European readers as regards some of the state-of-the-art technologies revolving around the Internet of Things (‘IoT’) and their intersection with cloud computing (the Clouds of Things, ‘CoT’) in both the continents. The main emerging legal issues will be presented, with a focus on intellectual property, consumer protection, and privacy. The cases chosen are from India and the United Kingdom, two countries that are conspicuously active on this front. I will give an account only of (what I consider to be) the highlights of the IoT in India and …

Picket Patents: Non-Working As An Ip Abuse, Dr. Feroz Ali

Indian Journal of Law and Technology

Patents picket when the patent holder practices the patent in certain jurisdictions but refuses to work the patent in others. The concept of patent picketing developed as a result of a shift from the representation of the working of an invention physically to the merely describing, effectively, the inventions in patent applications. Patent holders picket with their patents and demand a higher price, thereby not only preventing others from using their invention but also ensuring that the product is not made available in all markets. Such behaviour can be regarded as an intellectual property (IP) abuse when the non-working of …

Liver Disease In Aboriginal And Torres Strait Islander People, Yasmina Tashkent, John K. Olynyk, Alan J. Wigg

Journal of the Australian Indigenous HealthInfoNet

Aboriginal and Torres Strait Islander people have a substantially higher prevalence of liver disease than non-Indigenous Australians. Cirrhosis and its complications were the sixth leading cause of mortality for Aboriginal and Torres Strait Islander people in 2020. Liver disease has been estimated to be the third leading cause of the mortality gap between Aboriginal and Torres Strait Islander and non-Indigenous people due to chronic disease, accounting for 11% of this gap. While current trends show reducing mortality rates for Aboriginal and Torres Strait Islander people for conditions including circulatory disease, diabetes and kidney disease, there are no data to suggest …