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Dietary Risk Factors And Eating Behaviors In Peripheral Arterial Disease (Pad), Andrea Leonardo Cecchini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Giovanni Pecorini, Luis H. Eraso, Paul J. Dimuzio, Antonio Gasbarrini, Massimo Massetti, Andrea Flex

Department of Surgery Faculty Papers

Dietary risk factors play a fundamental role in the prevention and progression of atherosclerosis and PAD (Peripheral Arterial Disease). The impact of nutrition, however, defined as the process of taking in food and using it for growth, metabolism and repair, remains undefined with regard to PAD. This article describes the interplay between nutrition and the development/progression of PAD. We reviewed 688 articles, including key articles, narrative and systematic reviews, meta-analyses and clinical studies. We analyzed the interaction between nutrition and PAD predictors, and subsequently created four descriptive tables to summarize the relationship between PAD, dietary risk factors and outcomes. We …

Causes Of Death Among Patients With Initially Inoperable Pancreas Cancer After Induction Chemotherapy And Ablative 5-Fraction Stereotactic Magnetic Resonance Image Guided Adaptive Radiation Therapy, Michael Chuong, Roberto Herrera, Antonio Ucar, Santiago Aparo, Fernando De Zarraga, Domenech Asbun, Javier Jimenez, Horacio Asbun, Govindarajan Narayanan, Sarah Joseph, Rupesh Kotecha, Matthew Hall, Kathryn Mittauer, Diane Alvarez, James Mcculloch, Tino Romaguera, Alonso Gutierrez, Adeel Kaiser

All Publications

Purpose: Nearly all patients with pancreatic ductal adenocarcinoma (PDAC) eventually die of progressive cancer after exhausting treatment options. Although distant metastases (DMs) are a common cause of death, autopsy studies have shown that locoregional progression may be directly responsible for up to one-third of PDAC-related deaths. Ablative stereotactic magnetic resonance-guided adaptive radiation therapy (A-SMART) is a novel treatment strategy that appears to improve locoregional control compared with nonablative radiation therapy, potentially leading to improved overall survival.

Methods and materials: A single-institution retrospective analysis was performed of patients with nonmetastatic inoperable PDAC treated between 2018 to 2020 using the MRIdian Linac …

A Global Examination Of Clinical Ladder Programs –A Synthesis Of Commonalities And Opportunities For Standardization, Nada Wakim

All Publications

Background: Clinical ladder programs (CLPs) have been part of the nursing profession for nearly 4 decades. However, the structure and implementation of CLPs vary widely throughout healthcare systems. CLPs are a valuable factor in nurse retention and employee satisfaction initiatives, but globally replicating and measuring their impact is difficult due to lack of standardization. Aim: To identify opportunities for global standardization of CLPs through a systematic review of published evidence and facility-sourced CLPs applications and program documents. Method: This study used a systematic literature search and scan of existing programs from facilities within the United States (US), Lebanon, and Ghana …

2022-09-16 Research And Creative Productions Committee Meeting Minutes, Morehead State University. Faculty Senate., Research And Creative Productions Committee.

Faculty Senate Records

Research and Creative Productions Committee meeting minutes for September 16, 2022.

Overcoming The Cardiac Toxicities Of Cancer Therapy Immune Checkpoint Inhibitors, Omoruyi Credit Irabor, Nicolas Nelson, Yash Shah, Muneeb Khan Niazi, Spencer Poiset, Eugene Storozynsky, Dinender K Singla, D. Craig Hooper, Bo Lu

Division of Cardiology Faculty Papers

Immune checkpoint inhibitors (ICIs) have led recent advances in the field of cancer immunotherapy improving overall survival in multiple malignancies with abysmal prognoses prior to their introduction. The remarkable efficacy of ICIs is however limited by their potential for systemic and organ specific immune-related adverse events (irAEs), most of which present with mild to moderate symptoms that can resolve spontaneously, with discontinuation of therapy or glucocorticoid therapy. Cardiac irAEs however are potentially fatal. The understanding of autoimmune cardiotoxicity remains limited due to its rareness. In this paper, we provide an updated review of the literature on the pathologic mechanisms, diagnosis, …

Betty Foy Sanders Department Of Art Newsletter, Georgia Southern University

Art: News & Publications (2008-2023)

• Hines Featured on All About Photo on Photo.Com

Epigenetic Dysregulations In Arsenic-Induced Carcinogenesis, Ranakul Islam, Lei Zhao, Yifang Wang, Grace Lu-Yao, Ling-Zhi Liu

Department of Medical Oncology Faculty Papers

Arsenic is a crucial environmental metalloid whose high toxicity levels negatively impact human health. It poses significant health concerns to millions of people in developed and developing countries such as the USA, Canada, Bangladesh, India, China, and Mexico by enhancing sensitivity to various types of diseases, including cancers. However, how arsenic causes changes in gene expression that results in heinous conditions remains elusive. One of the proposed essential mechanisms that still has seen limited research with regard to causing disease upon arsenic exposure is the dysregulation of epigenetic components. In this review, we have extensively summarized current discoveries in arsenic-induced …

Robert Kingston Vickery, Jr.—In Memoriam, E. Durant Mcarthur

Western North American Naturalist

No abstract provided.

Notre Dame Law School Religious Liberty Initiative, Marcus Cole, Stephanie Barclay, Mona Polacca, Aly Cox, Paolo Carozza, John Meiser, Zahraa Nasser, Olivia Rogers, Rick Garnett

2019–Present: G. Marcus Cole

"I want Notre Dame to be a light for the people who are suffering darkness. I want this to be a place that people all around the world can see as a source of hope, where they can find people who are willing to fight for them, for their religious freedom and for their human flourishing." — Dean G. Marcus Cole, Notre Dame Law School

Learn more about Notre Dame Law School's Religious Liberty Initiative at https://law.nd.edu/RLI.

Mild And Severe Traumatic Brain Injury Longitudinally Profiled Using High-Resolution Metabolomics, Ali Yilmaz, Sigal Liraz Zaltsman, Esther Shohami, Juozas Gordevicius, Jack E. Sherman, Ray Bahado-Singh, Stewart F. Graham

Conference Presentation Abstracts

No abstract provided.

An Epi-Metabolomics Approach For Studying Epigenetic And Metabolic Changes In Alzheimer’S Disease Brain, Nadia Ashrafi, Sangeetha Vishweswaraiah, Ali Yilmaz, Sumeyya Akyol, Juozas Gordevicius, Stewart Graham

Conference Presentation Abstracts

No abstract provided.

Support The Blazer Kitchen By Donating School Supplies Sept. 20, Staff

Browse All News

No abstract provided.

O'Neal Comprehensive Cancer Center Receives Patient Navigation Grant From American Cancer Society, Staff

Browse All News

No abstract provided.

Melanoma Treatment: Potential Target Bypasses Therapeutic Resistance To Immune Checkpoint Blockers, Public Relations

Browse All News

No abstract provided.

Er, Urgent Care Or Your Doctor? What Experts Really Want You To Know, Alicia Rohan

Browse All News

No abstract provided.

Clinical Profile, Diagnostic Yield, And Procedural Outcomes Of Single Balloon Enteroscopy: A Tertiary Care Hospital Experience, Maha Inam, Masood Muhammad Karim, Umar Tariq, Faisal Wasim Ismail

Medical College Documents

Background: Single balloon enteroscopy (SBE) allows ease of access for small bowel visualization and has multiple diagnostic and therapeutic indications. It provides the advantage of performing various therapeutic interventions alongside the diagnostic procedure. SBE has also been considered a relatively safe procedure with no major complications.
Aim: To investigate the indications, safety, and clinical yield of SBE, and determine its effect on disease outcome.
Methods: A retrospective, descriptive study was conducted at a tertiary care hospital in Karachi, Pakistan. Medical records of 56 adult patients (≥ 18 years) who underwent SBE between July 2013 and December 2021 were reviewed and …

Assessing Companion Animal Attachment Among Future Latino Human Services Professionals, Yuleinys A. Castillo, Roy K. Chen

Journal of Social, Behavioral, and Health Sciences

As the population of individuals from minoritized ethnic background continues to grow in the United States, the relationship between humans and their companion animals can provide valuable information for human services professionals. Attachment to companion animals can play a significant part in clients’ emotional well-being, family dynamics, and quality of life. This study aimed to examine the associations between human attachment with companion animals and their educational training and attitudes about animals. Analysis revealed that relational attachment was significant among Latino students in the study, and particpants’ positive attitudes and beliefs about animals significantly predicted their level of attachment to …

Florida Governor Desantis’ Transport Of Migrants To Massachusetts Is A “Crude Political Tactic…Playing With People’S Lives,” Law Expert Says, Rich Barlow, Sarah R. Sherman-Stokes

Shorter Faculty Works

Massachusetts officials say Florida may have broken the law by transporting 50 Venezuelan immigrants to Martha’s Vineyard on September 14.

Rachel Rollins, US Attorney for the District of Massachusetts, says she’s reviewing whether the unannounced transport violated laws against human trafficking, coercion, or other crimes. Lawyers and aid workers on the Vineyard report that the immigrants were lied to about jobs and housing awaiting them in Massachusetts, about landing in Boston, and about having to register their new addresses with federal citizenship and immigration officials.

Epa – Partners Of Protection Of Tribal Environments, Americans For Indian Opportunity (Aio), Epa

LaDonna Harris Native American Collection

This is a set of two copies of reports on the EPA/Tribal Leaders Environmental Forums entitled: ‘Partners for the Protection of Tribal Environments’ and the ‘EPA-Tribal Leaders Workshop’. The first copy of a final report covers activities undertaken by Americans for Indian Opportunity (AIO) under a contract from the Environmental Protection Agency to identify barriers to the protection of the environment on and around Tribal lands and to facilitate the development of options for overcoming those barriers. The second report aims to enhance tribes’ ability to be proactive rather than reactive, to identify strategic options, and find a way to …

Association Between Abnormal Lipid Profile And Inflammation And Progression Of Myelodysplastic Syndrome To Acute Leukemia, Wei Qiao, Elliana Young, Chun Feng, Suyu Liu, Jeff Jin, Cristhiam M Rojas Hernandez, Olga Gorlova, Vahid Afshar-Kharghan

Faculty, Staff and Student Publications

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with a small risk of developing hematologic malignancies and a higher risk of cardiovascular diseases (CVD). We asked whether the reverse correlation exists and cardiometabolic risk factors have an impact on the progression of myelodysplastic syndrome (MDS) to acute myeloid leukemia (AML). We investigated the association between abnormal lipid profiles and inflammation in MDS, which shares many genetic mutations with CHIP, and the risk of developing acute leukemia. We examined the medical records of 11071 MDS patients. Among them, 5422 had at least one lipid profile or C-reactive protein (CRP) measurement. In …

Association Between Abnormal Lipid Profile And Inflammation And Progression Of Myelodysplastic Syndrome To Acute Leukemia, Wei Qiao, Elliana Young, Chun Feng, Suyu Liu, Jeff Jin, Cristhiam M Rojas Hernandez, Olga Gorlova, Vahid Afshar-Kharghan

Faculty, Staff and Student Publications

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with a small risk of developing hematologic malignancies and a higher risk of cardiovascular diseases (CVD). We asked whether the reverse correlation exists and cardiometabolic risk factors have an impact on the progression of myelodysplastic syndrome (MDS) to acute myeloid leukemia (AML). We investigated the association between abnormal lipid profiles and inflammation in MDS, which shares many genetic mutations with CHIP, and the risk of developing acute leukemia. We examined the medical records of 11071 MDS patients. Among them, 5422 had at least one lipid profile or C-reactive protein (CRP) measurement. In …

A Small Molecule Antagonist Of Smn Disrupts The Interaction Between Smn And Rnap Ii, Yanli Liu, Aman Iqbal, Weiguo Li, Zuyao Ni, Yalong Wang, Karan Joshua Abraham, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T Bedford, Jack F Greenblatt, Jinrong Min

Faculty, Staff and Student Publications

Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency of SMN leads to spinal muscular atrophy. Here we report a potent and selective antagonist with a 4-iminopyridine scaffold targeting the Tudor domain of SMN. Our structural and mutagenesis studies indicate that both the aromatic ring and imino groups of compound 1 contribute to its selective binding to SMN. Various on-target engagement assays support that compound 1 specifically recognizes SMN in a cellular context and prevents the interaction of SMN with the R1810me2s of RNA polymerase …

Protocol For Establishing A Protein-Protein Interaction Network Using Tandem Affinity Purification Followed By Mass Spectrometry In Mammalian Cells, Weixiang Bian, Hua Jiang, Shan Feng, Junjie Chen, Wenqi Wang

Faculty, Staff and Student Publications

Identification of protein interactors is fundamental to understanding their functions. Here, we describe a modified protocol for tandem affinity purification coupled with mass spectrometry (TAP/MS), which includes two-step purification. We detail the S-, 2×FLAG-, and Streptavidin-Binding Peptide (SBP)- tandem tags (SFB-tag) system for protein purification. This protocol can be used to identify protein interactors and establish a high-confidence protein-protein interaction network based on computational models. This is particularly useful for identifying

Targeting Ras Mutant Colorectal Cancer With Dual Inhibition Of Mek And Cdk4/6, Alexey V Sorokin, Preeti Kanikarla Marie, Lea Bitner, Muddassir Syed, Melanie Woods, Lawrence N Kwong, Van K Morris, Philip Jones, David G Menter, Michael S Lee, Scott Kopetz

Faculty, Staff and Student Publications

UNLABELLED: KRAS and NRAS mutations occur in 45% of colorectal cancers, with combined MAPK pathway and CDK4/6 inhibition identified as a potential therapeutic strategy. In the current study, this combinatorial treatment approach was evaluated in a co-clinical trial in patient-derived xenografts (PDX), and safety was established in a clinical trial of binimetinib and palbociclib in patients with metastatic colorectal cancer with RAS mutations. Across 18 PDX models undergoing dual inhibition of MEK and CDK4/6, 60% of tumors regressed, meeting the co-clinical trial primary endpoint. Prolonged duration of response occurred predominantly in TP53 wild-type models. Clinical evaluation of binimetinib and palbociclib …

Multicenter Collaborative Study Of The Interaction Of Antifungal Combinations Against Browzine Journal Cover Candida Spp By Loewe Additivity And Bliss Independence-Based Response Surface Analysis, Cindy C Knapp, Thomas J Walsh

Faculty, Staff and Student Publications

Combination antifungal therapy is widely used but not well understood. We analyzed the spectrophotometric readings from a multicenter study conducted by the New York State Department of Health to further characterize the in vitro interactions of the major classes of antifungal agents against Candida spp. Loewe additivity-based fractional inhibitory concentration index (FICi) analysis and Bliss independence-based response surface (BIRS) analysis were used to analyze two-drug inter- and intraclass combinations of triazoles (AZO) (voriconazole, posaconazole), echinocandins (ECH) (caspofungin, micafungin, anidulafungin), and a polyene (amphotericin B) against Candida albicans, C. parapsilosis, and C. glabrata. Although mean FIC indices did not differ statistically …

Mri-Based Digital Models Forecast Patient-Specific Treatment Responses To Neoadjuvant Chemotherapy In Triple-Negative Breast Cancer, Chengyue Wu, Angela M Jarrett, Zijian Zhou, Nabil Elshafeey, Beatriz E Adrada, Rania M M Mohamed, Lei Huo, Jason B White, Debu Tripathy, Vicente Valero, Jennifer K Litton, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is persistently refractory to therapy, and methods to improve targeting and evaluation of responses to therapy in this disease are needed. Here, we integrate quantitative MRI data with biologically based mathematical modeling to accurately predict the response of TNBC to neoadjuvant systemic therapy (NAST) on an individual basis. Specifically, 56 patients with TNBC enrolled in the ARTEMIS trial (NCT02276443) underwent standard-of-care doxorubicin/cyclophosphamide (A/C) and then paclitaxel for NAST, where dynamic contrast-enhanced MRI and diffusion-weighted MRI were acquired before treatment and after two and four cycles of A/C. A biologically based model was established to …

Serologic Versus Molecular Testing For Screening For Hepatitis C Virus Infection In Patients With Hematologic Malignancies, Harrys A Torres, Georgios Angelidakis, Ying Jiang, Minas Economides, Khalis Mustafayev, Robert Orlowski, Srdan Verstovsek, Issam Raad

Faculty, Staff and Student Publications

Testing for antibody against hepatitis C virus (anti-HCV) is a low-cost diagnostic method worldwide; however, an optimal screening test for HCV in patients with cancer has not been established. We sought to identify an appropriate screening test for HCV infection in patients with hematologic malignancies and/or hematopoietic cell transplants (HCT). Patients in our center were simultaneously screened using serological (anti-HCV) and molecular (HCV RNA) assays (February 2019-November 2019). In total, 214 patients were enrolled in this study. Three patients (1.4%) were positive for anti-HCV, and 2 (0.9%) were positive for HCV RNA. The overall percentage agreement was 99.5% (95% CI: …

Boys Don’T Cry: Trauma, Trauma Narrative And Masculine Practice Among Young Male Who Engaged In Harmful Sexual Behaviour, B Zaniewski, R Dallos, J Stedmon, P Welbourne

School of Health Professions

Compelling evidence suggests that majority of young men who engaged in harmful sexual behaviour (HSB) were subjected to various forms of trauma and adverse childhood experiences. This research explores lived experience of a group of young men who engaged in HSB, what sense they made of it and how their positioned themselves towards these events including HSB, so they are able to maintain their self-integrity. It also explores impact of lived experience with consideration for broader family and cultural discourses. Transition to Adulthood Attachment Interview and Semi-structured interview were employed and Dynamic- Maturation Model of attachment were utilised for this …

Contrast-Enhanced Microct Evaluation Of Degeneration Following Partial And Full Width Injuries To The Mouse Lumbar Intervertebral Disc, Remy E Walk, Hong Joo Moon, Simon Y Tang, Munish C Gupta

2020-Current year OA Pubs

A targeted injury to the mouse intervertebral disc (IVD) is often used to recapitulate the degenerative cascade of the human pathology. Since injuries can vary in magnitude and localization, it is critical to examine the effects of different injuries on IVD degeneration. We thus evaluated the degenerative progression resulting from either a partial- or full-width injury to the mouse lumbar IVD using contrast-enhanced micro-computed tomography and histological analyses. A lateral-retroperitoneal surgical approach was used to access the lumbar IVD, and the injuries to the IVD were produced by either incising one side of the annulus fibrosus or puncturing both sides …

Assessment Of The Effectiveness Of Ventilation Controls In Managing Airborne And Surface Lead Levels At A Newly Commissioned Indoor Shooting Range, Robert Alcock, Magdalena Wajrak, Jacques Oosthuizen

Research outputs 2022 to 2026

Lead levels at a new indoor target shooting range were assessed using both personal and environmental air monitoring methods. Surface swabs were collected from representative locations throughout the range prior to, and at the conclusion of, shooting. Personal samples were compared against the current Australian Workplace Exposure Standards with all results exceeding statutory limits. Static environmental samples exceeded the Air National Environmental Protection Measures (NEPM) air quality standard. Surface swabs showed significant increases from pre- to post-shooting with levels exceeding recommended limits. The performance of the mechanical ventilation system was also assessed and airflow levels were below the required rate …