Digital Commons Network^™

Health Literacy And New Mexico's Covid-19 Initiatives, Deborah J. Rhue

Posters and Presentations

No abstract provided.

Our Book Club Kit Experience - What Happened? What Went Wrong?, Amy E. Weig-Pickering

Posters and Presentations

This poster was presented at SCC/MLA. To see more about this project please look at our full description and video at: https://digitalrepository.unm.edu/hslic-posters-presentations/100/

20220922_Nih Requires A New Data-Sharing Plan Starting January 2023. Here Is What You Need To Know, Lori D. Sloane

HSLIC Blog Post

No abstract provided.

Kenyon Collegian - September 22, 2022

The Kenyon Collegian

No abstract provided.

An Assessment Model Of The Healthcare Entrepreneurship Ecosystem To Foster Solutions For Underserved Communities, Abdalilah Saleh Owaishiz

Dissertations and Theses

There are significant disparities in access to healthcare treatment and this study investigates the healthcare entrepreneurship ecosystem and the challenges and considerations associated within. There is a lack of research on how to evaluate and assess the healthcare entrepreneurship ecosystem especially when applying multi-criteria decision-making (MCDM) methods. The Hierarchical Decision Model (HDM) has been utilized to identify several perspectives and factors grouped under them by the expert’s quantification. This research concentrates on underserved communities because that is where the biggest needs and impact can be made to support achieving health equity and universal health coverage. The findings of this research …

September 22, 2022, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Bmi And Physical Activity, Military-Aged U.S. Population 2015–2020, Bryant J. Webber, Daniel B. Bornstein, Patricia A. Deuster, Francis G. O'Connor, Sohyun Park, Kenneth M. Rose, Geoffrey P. Whitfield

Faculty Publications

Excerpt: Obesity and physical inactivity are considered possible U.S. national security threats because of their impact on military recruitment. The objectives of this study were to estimate the prevalence of (1) BMI eligibility for military entrance, (2) adequate physical activity participation among the BMI-eligible population, and (3) combined BMI eligibility and adequate physical activity.

This cross-sectional study of nonpregnant, military-aged civilians (aged 17–42 years) used objectively measured weight and height data and self-reported aerobic physical activity data from the 2015–2020 National Health and Nutrition Examination Survey. BMI eligibility was defined as 19.0–27.5 kg/m2, per Department of Defense regulation. Adequate physical …

Using Whole-Brain Diffusion Tensor Analysis To Evaluate White Matter Structural Correlates Of Delayed Visuospatial Memory And One-Week Motor Skill Retention In Nondemented Older Adults: A Preliminary Study, Jennapher Lingo Vangilder, Maurizio Bergamino, Andrew Hooyman, Megan C. Fitzhugh, Corianne Rogalsky, Jill C. Stewart, Scott C. Beeman, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated that delayed visuospatial memory performance may predict motor skill retention in older and neuropathological populations. White matter integrity between parietal and frontal cortices may explain variance in upper-extremity motor learning tasks and visuospatial processes. We performed a whole-brain analysis to determine the white matter correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults. We hypothesized that better frontoparietal tract integrity would be positively related to better behavioral performance. Nineteen participants (age>58) completed diffusion-weighted imaging, then a clinical test of delayed visuospatial memory …

Chronic Neuropsychiatric Sequelae Of Sars-Cov-2: Protocol And Methods From The Alzheimer's Association Global Consortium, Gabriel A. De Erausquin, Heather Snyder, Traolach S. Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, John Blangero, Gladys E. Maestre, Sarah Williams Blangero

School of Medicine Publications

Introduction

Coronavirus disease 2019 (COVID‐19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID‐19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID‐19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity …

Superatom Molecular Orbitals Of Li@C60: Effects Of The Li Position And The Substrate, Artem V. Kuklin, Rahul Suresh, Konoha Shimizu, Yoichi Yamada, Hans Ågren

Research Outputs: 2025-Present

No abstract provided.

Kat-Arc Accelerated 4d Flow Cmr: Clinical Validation For Transvalvular Flow And Peak Velocity Assessment, Tha H Nyi, Jean-Paul Aben, Kurian Thampi, David Hewson, Chris Sawh, Richard Greenwood, Marina Hughes, Bahman Kasmai, Liang Zhong, Marcus Flather, Vassilios S Vassiliou, Pankaj Garg

Faculty, Staff and Student Publications

BACKGROUND: To validate the k-adaptive-t autocalibrating reconstruction for Cartesian sampling (kat-ARC), an exclusive sparse reconstruction technique for four-dimensional (4D) flow cardiac magnetic resonance (CMR) using conservation of mass principle applied to transvalvular flow.

METHODS: This observational retrospective study (2020/21-075) was approved by the local ethics committee at the University of East Anglia. Consent was waived. Thirty-five patients who had a clinical CMR scan were included. CMR protocol included cine and 4D flow using Kat-ARC acceleration factor 6. No respiratory navigation was applied. For validation, the agreement between mitral net flow (MNF) and the aortic net flow (ANF) was investigated. Additionally, …

Therapeutic Management Of Chronic Lymphocytic Leukemia Presenting With Recurrent Massive Ascites

Faculty, Staff and Student Publications

Chronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy that is categorized by the production and accumulation of CD5+ monoclonal B cell lymphocytes, commonly in the spleen, bone marrow, and peripheral blood; these are morphologically mature lymphocytes with abnormal immune function. Ascites, although common in solid organ malignancies such as ovarian, breast, and gastrointestinal, is a rare clinical manifestation in hematological malignancies. The case presented herein describes an elderly male patient with CLL who presented with transudative ascites 7 years after the completion of chemotherapy. Microscopic analysis and flow cytometry of the patient's ascitic fluid were consistent with CLL, and he …

The Colonization Of Saline Waters Is Associated With Lowered Immune Responses In Aquatic Beetles, María Botella-Cruz, S Pallares, Josefa Velasco, A. John Moody, Richard Billington, A Millan, David T. Bilton

School of Biological and Marine Sciences

No abstract provided.

Engineering Sars-Cov-2 Specific Cocktail Antibodies Into A Bispecific Format Improves Neutralizing Potency And Breadth, Bin Wu, Xiaohua Ye, Eddie Yongjun Tan, Xin Li, Xuejun Fan, Boon Chong Goh, Wei Xiong, Hannah Boyd, Antonio E Muruato, Hui Deng, Hongjie Xia, Jing Zou, Birte K Kalveram, Vineet D Menachery, Ningyan Zhang, Julien Lescar, Pei-Yong Shi, Zhiqiang An

Faculty, Staff and Student Publications

One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement of costly cocktails to reduce emergence of antibody resistance. Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared them with parental antibodies and their cocktail. Single molecules of both bsAbs block the two epitopes targeted by parental antibodies on the receptor-binding domain (RBD). However, bsAb with the IgG-(scFv)2 design (14-H-06) but not the CrossMAb design (14-crs-06) shows increased antigen-binding and virus-neutralizing activities against multiple SARS-CoV-2 variants as well as increased breadth of neutralizing activity compared to the cocktail. X-ray crystallography and cryo-EM reveal distinct binding models …

A Resources Ecosystem For Digital And Heritage-Led Holistic Knowledge In Rural Regeneration, Rosa Tamborrino, Edoardo Patti, Alessandro Aliberti, Mesut Dinler, Matteo Orlando, Claudia De Luca, Simona Tondelli, Francisco Barrientos, John Martin, Luís F.M. Cunha, Andries Stam, Aad Nales, Aitziber Egusquiza, Zahra Amirzada, Irina Pavlova

Professional Services

This paper presents a digital resources ecosystem prototype of integrated tools and resources to support heritage-led regeneration of rural regions, thanks to a deeper understanding of the complexity of cultural natural landscapes throughout their historical and current development. The ecosystem is conceived as a distributed software platform establishing data ecosystem and open standards for the management of information, aimed at providing different services and applications to address the needs of the various end-users identified. The platform has been conceived and realised in the framework of a Horizon 2020 research project, with a view to building a set of holistic knowledge …

Glycemia Reduction In Type 2 Diabetes - Glycemic Outcomes, Henry B Burch, John B Buse, Nicole M Butera, Robert M Cohen, Jill P Crandall, Steven E Kahn, Heidi Krause-Steinrauf, Mary E Larkin, Neda Rasouli, Margaret Tiktin, Deborah J Wexler, Naji Younes

Faculty, Staff and Students Publications

BACKGROUND: The comparative effectiveness of glucose-lowering medications for use with metformin to maintain target glycated hemoglobin levels in persons with type 2 diabetes is uncertain.

METHODS: In this trial involving participants with type 2 diabetes of less than 10 years' duration who were receiving metformin and had glycated hemoglobin levels of 6.8 to 8.5%, we compared the effectiveness of four commonly used glucose-lowering medications. We randomly assigned participants to receive insulin glargine U-100 (hereafter, glargine), the sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist liraglutide, or sitagliptin, a dipeptidyl peptidase 4 inhibitor. The primary metabolic outcome was a glycated hemoglobin level, …

Dietary Inflammatory Index And Mortality From All Causes, Cardiovascular Disease, And Cancer: A Prospective Study, Zhen Lin, Yanfei Feng, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Xin Xu

Faculty Publications

The Energy-adjusted Dietary Inflammatory Index (E-DIITM) is a comprehensive, literature-derived index for assessing the effect of dietary constituents on inflammatory biomarkers and inflammation-related chronic diseases. Several studies have examined the association between E-DII scores and mortality, with results that vary across populations. Therefore, in the present study, we aimed to investigate the potential association between E-DII scores and all-cause, cardiovascular disease (CVD), and cancer mortality using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial. E-DII scores, calculated based on a food-frequency questionnaire, were analyzed both as a continuous variable and after categorization into quintiles. A multivariate Cox …

Long-Term Neurologic Outcomes Of Covid-19, Evan Xu, Yan Xie, Ziyad Al-Aly

2020-Current year OA Pubs

The neurologic manifestations of acute COVID-19 are well characterized, but a comprehensive evaluation of postacute neurologic sequelae at 1 year has not been undertaken. Here we use the national healthcare databases of the US Department of Veterans Affairs to build a cohort of 154,068 individuals with COVID-19, 5,638,795 contemporary controls and 5,859,621 historical controls; we use inverse probability weighting to balance the cohorts, and estimate risks and burdens of incident neurologic disorders at 12 months following acute SARS-CoV-2 infection. Our results show that in the postacute phase of COVID-19, there was increased risk of an array of incident neurologic sequelae …

Tbx21 Methylation As A Potential Regulator Of Immune Suppression In Cms1 Subtype Colorectal Cancer, Yuanyuan Shen, Yulia I Nussbaum, Yariswamy Manjunath, Justin J Hummel, Matthew A Ciorba, Wesley C Warren, Jussuf T Kaifi, Christos Papageorgiou, Rene Cortese, Chi-Ren Shyu, Jonathan B Mitchem

2020-Current year OA Pubs

Cytotoxic T lymphocyte (CTL) infiltration is associated with survival, recurrence, and therapeutic response in colorectal cancer (CRC). Immune checkpoint inhibitor (ICI) therapy, which requires CTLs for response, does not work for most CRC patients. Therefore, it is critical to improve our understanding of immune resistance in this disease. We utilized 2391 CRC patients and 7 omics datasets, integrating clinical and genomic data to determine how DNA methylation may impact survival and CTL function in CRC. Using comprehensive molecular subtype (CMS) 1 patients as reference, we found TBX21 to be the only gene with altered expression and methylation that was associated …

Efficacy Of A Smartphone-Based Care Support Programme In Improving Post-Traumatic Stress In Families With Childhood Cancer: Protocol Of A Randomised Controlled Trial, Jun Ma, Han-Zhu Qian, Yueyang Peng, Yali Xiang, Minghua Yang, Jessica Hahne, Can Gu

2020-Current year OA Pubs

INTRODUCTION: Diagnosis and treatment represent distressing experiences for the families of children with cancer. Psychosocial challenges are faced by these families in China because of limited health services and resources for psychosocial oncology care. Effective interventions tailored to the knowledge level and cultural values of this population are needed. The goal of this study is to evaluate a smartphone-based care support (SBCS) programme for the families of children with cancer in China.

METHODS AND ANALYSIS: A parallel randomised controlled trial will be conducted to examine the efficacy of an evidence-based and culturally tailored SBCS programme for the families of children …

Analysis Of Sars-Cov-2 Viral Loads In Stool Samples And Nasopharyngeal Swabs From Covid-19 Patients In The United Arab Emirates, Mariane Daou, Hussein Kannout, Mariam Khalili, Mohamed Almarei, Mohamed Alhashami, Zainab Alhalwachi, Fatima Alshamsi, Mohammad Tahseen Al Bataineh, Mohd Azzam Kayasseh, Abdulmajeed Al Khajeh, Shadi W. Hasan, Guan Kwang Tay, Samuel F. Feng, Dymitr Ruta, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership

Research outputs 2022 to 2026

Coronavirus disease 2019 (COVID-19) was first identified in respiratory samples and was found to commonly cause cough and pneumonia. However, non-respiratory symptoms including gastrointestinal disorders are also present and a big proportion of patients test positive for the virus in stools for a prolonged period. In this cross-sectional study, we investigated viral load trends in stools and nasopharyngeal swabs and their correlation with multiple demographic and clinical factors. The study included 211 laboratory-confirmed cases suffering from a mild form of the disease and completing their isolation period at a non-hospital center in the United Arab Emirates. Demographic and clinical information …

Characterising Lower-Body Musculoskeletal Morphology And Whole-Body Composition Of Elite Female And Male Australian Football Players, Callum J. Mccaskie, Marc Sim, Robert U. Newton, Jarryd Heasman, Brent Rogalski, Nicolas H. Hart

Research outputs 2022 to 2026

Background: Physical demands and injury rates differ between elite female and male Australian Football (AF) players. To improve understanding of contributing physical factors to these differences, the purpose of this study was to investigate lower-body morphology and whole-body composition of elite footballers competing in the Australian Football League (AFL) and Australian Football League Women’s (AFLW). Methods: Lower-body morphology and whole-body composition of 23 AFL players and 23 AFLW players were assessed using peripheral Quantitative Computed Tomography and Dual-energy X-ray Absorptiometry at the beginning of pre-season. Differences between cohorts, with sub-analyses of kicking vs. support limbs, and experienced vs. inexperienced player …

Trial Of Antisense Oligonucleotide Tofersen For Sod1 Als, Timothy M Miller, Robert C Bucelli, Et Al.

2020-Current year OA Pubs

BACKGROUND: The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in

METHODS: In this phase 3 trial, we randomly assigned adults with

RESULTS: A total of 72 participants received tofersen (39 predicted to have faster progression), and 36 received placebo (21 predicted to have faster progression). Tofersen led to greater reductions in concentrations of SOD1 in CSF and of neurofilament light chains in plasma than placebo. In the faster-progression subgroup (primary analysis), the change to week 28 in the ALSFRS-R …

Multidimensional Analysis And Therapeutic Development Using Patient Ipsc-Derived Disease Models Of Wolfram Syndrome, Rie Asada Kitamura, Kristina G. Maxwell, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Jeffrey R Millman, Fumihiko Urano, Et Al

2020-Current year OA Pubs

Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram syndrome as a spectrum disorder. Therefore, a genotype-phenotype correlation analysis is needed for diagnosis and therapeutic development. Here, we focus on the WFS1 c.1672C>T, p.R558C variant, which is highly prevalent in the Ashkenazi Jewish population. Clinical investigation indicated that patients carrying the homozygous WFS1 c.1672C>T, p.R558C variant showed mild forms of Wolfram syndrome phenotypes. Expression of WFS1 p.R558C was more stable compared with …

Improving Accuracy Of Capacitance Tests For Supercapacitors, Wayne Ando, Amogh Simha

Defensive Publications Series

Supercapacitors are often controlled by controller chips. Controller chips may also perform tests to determine the ESR and capacitance of the supercapacitors. Some controller chips may not hold the charge/voltage of the supercapacitors at a desired level for a desired amount of time. By changing the settings/parameters of the test, a user may be able to emulate or simulate the behavior of holding the charge/voltage of the supercapacitors at the desired level for the desired amount of time.

Parole Interview Transcript/Decision - Fusl000097 (2019-10-02)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000102 (2012-12-18)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000102 (2018-11-28)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000114 (2019-02-20)

Parole Interview Transcripts and Decisions

No abstract provided.

Compas Risk Assessment - Fusl000115 (2018-08-09)

COMPAS Risk Assessments

No abstract provided.