Digital Commons Network^™

Laii K-12 Resources Information Session, Latin American And Iberian Institute

LAII Events

Join the LAII K-12 Educator Outreach team as we provide an overview of our various resources and services we offer to educators. Attendees will be entered into a raffle for an Office Depot gift card.

Interpretable Machine Learning Models For Molecular Design Of Tyrosine Kinase Inhibitors Using Variational Autoencoders And Perturbation-Based Approach Of Chemical Space Exploration, Keerthi Krishnan, Ryan Kassab, Steve Agajanian, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In the current study, we introduce an integrative machine learning strategy for the autonomous molecular design of protein kinase inhibitors using variational autoencoders and a novel cluster-based perturbation approach for exploration of the chemical latent space. The proposed strategy combines autoencoder-based embedding of small molecules with a cluster-based perturbation approach for efficient navigation of the latent space and a feature-based kinase inhibition likelihood classifier that guides optimization of the molecular properties and targeted molecular design. In the proposed generative approach, molecules sharing similar structures tend to cluster in the latent space, and interpolating between two molecules in the latent space …

Temporal Lobe White Matter Asymmetry And Language Laterality In Epilepsy Patients, Panagiotis Lampropoulos

Faculty, Staff and Student Publications

(1) Background: Several studies showed a sustained temperature of 47 °C or 50 °C for one minute resulted in vascular stasis and bone resorption with only limited bone regrowth over a 3–4-week healing period. The purpose of the present study was to evaluate the temperature changes (ΔΤ) that occur during the preparation of dental implant osteotomies using MIS® straight drills versus Densah® burs in a clockwise (cutting) drilling protocol. (2) Methods: Two hundred forty (240) osteotomies of two different systems’ drills were prepared at 6 mm depth at 800, 1000, and 1200 revolutions per minute (RPM), in fresh, unembalmed tibiae, …

Characterization Of Novel Cyp2d6 Alleles Across Sub-Saharan African Populations, Wendy Y. Wang, David Twesigomwe, Charity Nofziger, Amy J. Turner, Lena-Sophie Helmecke, Ulrich Broeckel, Ashley D. Derezinski, Scott Hazelhurst, Andrea Gaedigk

Manuscripts, Articles, Book Chapters and Other Papers

The CYP2D6 gene has been widely studied to characterize variants and/or star alleles, which account for a significant portion of variability in drug responses observed within and between populations. However, African populations remain under-represented in these studies. The increasing availability of high coverage genomes from African populations has provided the opportunity to fill this knowledge gap. In this study, we characterized computationally predicted novel CYP2D6 star alleles in 30 African subjects for whom DNA samples were available from the Coriell Institute. CYP2D6 genotyping and resequencing was performed using a variety of commercially available and laboratory-developed tests in a collaborative effort …

Supporting And Managing Efl Students' Online Learning In Vietnamese Blended Learning Environments, Thi Nguyet Le, Nicola F. Johnson

Research outputs 2022 to 2026

It is well-known that blended learning (BL) makes use of the advantages of both face-to-face learning and online learning and can take many different forms. However, for English as a foreign language (EFL) lecturers in Vietnamese universities, BL is still in its early stages of implementation on which this article is focused. This study examined Vietnamese university lecturers’ perspectives of supporting and managing EFL students’ online learning in BL environments, using semi-structured interviews with 20 EFL lecturers from 10 different Vietnamese universities. The results reveal EFL lecturers implemented five combinations of online and face-to-face learning, of which two were widely …

Single-Cell Rna Transcriptome Analysis Of Cns Immune Cells Reveals Cxcl16/Cxcr6 As Maintenance Factors For Tissue-Resident T Cells That Drive Synapse Elimination, Sarah F Rosen, Allison L Soung, Wei Yang, Shenjian Ai, Marlene Kanmogne, Veronica A Davé, Maxim Artyomov, Jeffrey A Magee, Robyn S Klein

2020-Current year OA Pubs

BACKGROUND: Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits, revealed microglial-mediated synapse elimination within the hippocampus. Moreover, CNS-resident memory T (T

METHODS: Here, we examined immune cells within the murine WNV-recovered forebrain using single-cell RNA sequencing to identify putative ligand-receptor pairs involved in intercellular communication between T cells and microglia. Clustering and differential gene analyses were followed by protein validation and genetic and antibody-based approaches utilizing an established murine model of …

Customary Law Or State Law: The Settlement Of Marine Resource Disputes In The Kei Islands Community, Andreas M.D. Ratuanak, Sulistyowati Irianto, Ratih Lestrarini

The Indonesian Journal of Socio-Legal Studies

The people of the Kei Islands have known cases settlement system since the olden days, namely the Customary judiciary, a forum in the Larvul Ngabal customary law system that holds a high authority, which is obeyed by the community and is often the main choice in resolving disputes. With a field study approach, this study aims to explain how the settlement process of natural resources disputes by a “customary judge” in the Kei Islands is still used as a reference by the community. What are the reasons? This study discovered that customary settlement forums are still used to resolve …

Parole Board Report - Fusl000133 (2021-02-24)

Parole Board Reports

No abstract provided.

Parole Board Report - Fusl000143 (2020-11-17)

Parole Board Reports

No abstract provided.

Parole Interview Transcript/Decision - Fusl000136 (2021-05-11)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000137 ( 2018-09-19)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000137 (2021-06-15)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000143 (2021-05-04)

Parole Interview Transcripts and Decisions

No abstract provided.

Everything Is Not What It Seems, And What It Is, Is Broken: Re-Defining Production In The Oil And Gas Lease Habendum Clause, Fisher Lynn Fulton

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Millionaires And The Ability To Receive Overtime Compensation, Matt Peace

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Tort Theory, Litigation & Avenues For Relief: Hydraulic Fracturing In Oklahoma, Madeleine Lange

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Sovereign Immunity, Entrenched Power, And Isolationism: How To Hold Ercot Accountable To Texas Residents In The Aftermath Of The February 2021 Winter Storm, Meghan A. Brobst

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Climate Torts Belong In A Number Of Hands: Loosening The Federal Grip Of Preemption, Administrative Control, And Dilatory Procedure, Hank Herren

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Companies Can Condemn Whose Property? A Discussion Of Penneast Pipeline Co., Llc V. New Jersey, Emma Farha

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

To Kill A Mockingbird: A Look Into The Migratory Bird Treaty Act And Its Application To Unintentional Takings, Ben Davis

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Burdened, But Not Burdened Enough: A Long-Term Solution To The Difficulties Posed By Religious Objections To Resource Development, Nathan Downey

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Recent Developments In Oil And Gas Habendum Clause And Savings Clause Interpretation, Emily Richard

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Pigford V. Glickman And The Remnants Of Racism, Alyssa Sloan

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Refining Terms For Small Refineries: The Extension Of Hardship Through Statutory Interpretation, Kylen Chase Huffman

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Editor's Introduction & Front Pages, Hank Herren

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Lessons Learned: Christopher Spoth, Sandra Ward

Journal of Financial Crises

As senior deputy director of the Division of Supervision and Consumer Protection at the Federal Deposit Insurance Corporation (FDIC), Spoth led examinations, enforcement actions, problem bank remediations, and failure resolutions, among a range of responsibilities. During the Global Financial Crisis, he was on the front lines of fast-moving policy discussions and actions to help stabilize the financial system, and he oversaw the closure and restructuring of some of the nation’s largest banks. This abstract is based on an interview with Spoth on February 4, 2021.

Lessons Learned: Kevin Warsh, Matthew A. Lieber

Journal of Financial Crises

As senior deputy director of the Division of Supervision and Consumer Protection at the Federal Deposit Insurance Corporation (FDIC), Spoth led examinations, enforcement actions, problem bank remediations, and failure resolutions, among a range of responsibilities. During the Global Financial Crisis, he was on the front lines of fast-moving policy discussions and actions to help stabilize the financial system, and he oversaw the closure and restructuring of some of the nation’s largest banks. This abstract is based on an interview with Spoth on February 4, 2021.

Lessons Learned: Brian Sack, Sandra Ward

Journal of Financial Crises

Charged with overseeing the implementation of the asset-purchase programs and liquidity facilities in his roles as executive vice president of the Markets Group and manager of the System Open Market Account at the Federal Reserve Bank of New York (FRBNY), Brian Sack played a critical role in keeping markets functioning during the years 2009–2012. He served as an adviser to top policymakers, and, in addition to implementing the various programs designed to stabilize financial conditions, he monitored their impact and measured their performance. This Lessons Learned summary is based on an interview with Sack on November 13, 2020.

Lessons Learned: Nathan Sheets, Yasemin Sim Esmen, Rosalind Z. Wiggins

Journal of Financial Crises

Between 2007 and 2011, Nathan Sheets was director of the Division of International Finance at the Board of Governors of the Federal Reserve System. He oversaw the operations of the division and advised the Federal Open Market Committee (FOMC) on economic and financial developments in foreign countries. Sheets also regularly represented the Federal Reserve Board at international meetings and in its contacts with foreign central banks. Under his helm, the division was involved in helping establish and manage the US dollar liquidity swap lines with foreign central banks. This Lessons Learned abstract is based on an interview with Sheets on …

Lessons Learned: Susan Mclaughlin, Matthew A. Lieber

Journal of Financial Crises

A veteran staff member of the Federal Reserve Bank of New York (FRBNY), Susan McLaughlin served as head of the discount window and chief operating officer of the FRBNY’s Markets Trading Desk during the Global Financial Crisis. She was centrally involved in the Fed’s policy response to the disruptions to secured and unsecured funding markets during 2007–2008. Following the crisis, McLaughlin coordinated an effective Fed initiative to reform the triparty repurchase agreement (repo) market’s settlement infrastructure. The Fed’s reform efforts, engaging the financial industry under FRBNY president Bill Dudley, were instrumental in im-proving the stability of the funding market. This …