Digital Commons Network^™

Early Versus Late Discontinuation Of Maintenance Therapy In Multiple Myeloma., Jordan Nunnelee, Francesca Cottini, Qiuhong Zhao, Muhammad Salman Faisal, Patrick Elder, Ashley Rosko, Naresh Bumma, Abdullah Khan, Elvira Umyarova, Srinivas Devarakonda, Don M Benson, Yvonne A Efebera, Nidhi Sharma

Oncology Articles

Maintenance therapy after autologous stem cell transplant (ASCT) in multiple myeloma (MM) is the standard treatment and recommended to be continued until disease progression. However, in the real world, patients discontinue treatment due to various reasons. We sought to determine the effect of early versus late discontinuation on survival outcomes in MM patients who underwent ASCT at The Ohio State University. We retrospectively reviewed 340 patients who underwent ASCT from 2005 to 2016 and received maintenance therapy for at least six months without progression. We compared the outcomes of patients who received maintenance for three years or less (early group) …

Montana Kaimin, September 29, 2022, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

D121 Located Within The Dry Motif Of P2y12 Is Essential For P2y12-Mediated Platelet Function., Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P Kunapuli, John C Kostyak

Department of Medicine Faculty Papers

Platelets are anucleate cells that mediate hemostasis. This occurs via a primary signal that is reinforced by secreted products such as ADP that bind purinergic receptors (P2Y1 and P2Y12) on the platelet surface. We recently identified a human subject, whom we termed platelet defect subject 25 (PDS25) with a platelet functional disorder associated with the P2Y12 receptor. PDS25 has normal blood cell counts and no history of bleeding diathesis. However, platelets from PDS25 have virtually no response to 2-MeSADP (a stable analogue of ADP). Genetic analysis of P2Y12 from PDS25 revealed a heterozygous mutation of D121N within the DRY motif. …

Video-Urodynamics Efficacy Of Sacral Neuromodulation For Neurogenic Bladder Guided By Three-Dimensional Imaging Ct And C-Arm Fluoroscopy: A Single-Center Prospective Study, Yingyu Che, Jianguo Wen, Qingwei Wang

Faculty, Staff and Student Publications

To assess the efficacy of sacral neuromodulation (SNM) for neurogenic bladder (NB), guided by intraoperative three-dimensional imaging of sacral computed tomography (CT) and mobile C-arm fluoroscopy through video-urodynamics examination. We enrolled 52 patients with NB who underwent conservative treatment with poor results between September 2019 and June 2021 and prospectively underwent SNM guided by intraoperative three-dimensional imaging of sacral CT and mobile C-arm fluoroscopy. Video-urodynamics examination, voiding diary, quality of life questionnaire, overactive bladder symptom scale (OABSS) scoring, and bowel dysfunction exam were completed and recorded at baseline, at SNM testing, and at 6-month follow-up phases. Finally, we calculated the …

Jazz Ensemble I & Jazz Ensemble Ii

Bailey School of Music Concert Programs

Performance by the KSU Jazz Ensembles

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Ccr2+ Monocyte Subsets Increase In Obese Boys But Not Girls With Abnormally High Carotid Intima-Media Thickness: A Pilot Study, María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan C. Lopez-Alvarenga

School of Medicine Publications

The differential contribution of monocyte subsets expressing the C-C chemokine receptor 2 (CCR2) to subclinical atherosclerosis in girls and boys is unclear. In this pilot study, we compared classical, intermediate, and nonclassical monocyte subsets expressing CCR2 in 33 obese children of both sexes aged 8 to 16 divided by carotid intima-media thickness (IMT), considering values above the 75th percentile (p75) as abnormally high IMT. Obesity was defined as body mass index above the 95th percentile according to age and sex. Flow cytometry analyses revealed that boys but not girls with IMT ≥ p75 displayed increased CCR2⁺ cell percentage and …

Smokejumper Obituary: Borst, Ronald L. “Ron” (North Cascades 1964), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Measurement Of The Mass Dependence Of The Transverse Momentum Of Lepton Pairs In Drell–Yan Production In Proton–Proton Collisions At √S = 13tev, A. Tumasyan

Department of Physics and Astronomy: Faculty Publications

The double differential cross sections of the Drell–Yan lepton pair (ℓ ⁺ ℓ ⁻, dielectron or dimuon) production are measured as functions of the invariant mass m_ℓℓ, transverse momentum p_T(ℓℓ), and ϕ^∗_η. The ϕ^∗_η observable, derived from angular measurements of the leptons and highly correlated with p_T(ℓℓ), is used to probe the low-p_T(ℓℓ) region in a complementary way. Dilepton masses up to 1 TeV are investigated. Additionally, a measurement is performed requiring at least one jet in the final state. To benefit from partial cancellation …

Using A Literature Based Discovery Approach To Study Moderating Effects And Preventive Mechanisms Of Online Game Addiction Problems Among Gamers, Ananya Sinha Choudhury

Lingnan Theses (MPhil & PhD)

This research makes use of a hypothesis generation technique known as Literature-Based Discovery (LBD) to study certain under-researched topics related to online game addiction problems in our society. This research work tries to primarily address two problems related to game addiction which have been under-studied according to the literature available on this topic. In the first problem, we try to identify certain moderating factors of massively multiplayer games which weakens the relationship between the psychological flow state and game addiction. In this data-driven approach, we studied 2829 abstracts to generate a list of keywords that suggest potential moderating factors for …

Symmetry-Resolved Co Desorption And Oxidation Dynamics On O/Ru(0001) Probed At The C K-Edge By Ultrafast X-Ray Spectroscopy, Jerry Larue, Boyang Liu, Gabriel L. S. Rodrigues, Chang Liu, Jose Antonio Garrido Torres, Simon Schreck, Elias Diesen, Matthew Weston, Hirohito Ogasawara, Fivos Perakis, Martina Dell'angela, Flavio Capotondi, Devon Ball, Conner Carnahan, Gary Zeri, Luca Giannessi, Emanuele Pedersoli, Denys Naumenko, Peter Amann, Ivaylo Nikolov, Lorenzo Raimondi, Carlo Spezzani, Martin Beye, Johannes Voss, Hsin-Yi Wang, Filippo Cavalca, Jörgen Gladh, Sergey Koroidov, Frank Abild-Pedersen, Manuel Kolb, Piter S. Miedema, Roberto Costantini, Tony F. Heinz, Alan C. Luntz, Lars G. M. Pettersson, Anders Nilsson

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We report on carbon monoxide desorption and oxidation induced by 400 nm femtosecond laser excitation on the O/Ru(0001) surface probed by time-resolved x-ray absorption spectroscopy (TR-XAS) at the carbon K-edge. The experiments were performed under constant background pressures of CO (6 × 10⁻⁸ Torr) and O2 (3 × 10⁻⁸ Torr). Under these conditions, we detect two transient CO species with narrow 2π* peaks, suggesting little 2π* interaction with the surface. Based on polarization measurements, we find that these two species have opposing orientations: (1) CO favoring a more perpendicular orientation and (2) CO favoring a more parallel orientation …

A Question Of Fundamental Methodology: Reply To Mikhail Katz And His Coauthors, Tom Archibald, Richard T. W. Arthur, Giovanni Ferraro, Jeremy Gray, Douglas Jesseph, Jesper Lützen, Marco Panza, David Rabouin, Gert Schubring

Philosophy Faculty Articles and Research

This paper is a response by several historians of mathematics to a series of papers published from 2012 onwards by Mikhail Katz and various co-authors, the latest of which was recently published in the Mathematical Intelligencer, “Two-Track Depictions of Leibniz’s Fictions” (Katz, Kuhlemann, Sherry, Ugaglia, and van Atten, 2021). At issue is a question of fundamental methodology. These authors take for granted that non-standard analysis provides the correct framework for historical interpretation of the calculus, and castigate rival interpretations as having had a deleterious effect on the philosophy, practice, and applications of mathematics. Rather than make this case by reasoned …

3 Traditional Health Plan Options Available For 2023, Linda Gunter

Browse All News

No abstract provided.

The Culture Of Reading: The Benefits, The Role Of Libraries, And The Challenges In The 21st Century, Usman Abdulsalam

Library Philosophy and Practice (e-journal)

In Nigerian society, the serious drawback of reading culture is becoming more and more common. This paper discusses the culture of reading: the benefits, the role of libraries, and the challenges in the twenty-first century. World Book Day is a day to celebrate reading around the world. One searches for solutions to problems. The role of the library when it comes to this cannot be overemphasized. Promote the culture of reading as it provides various services to information users. Libraries' roles in promoting a reading culture have included offering a favorable setting and resources that deliver information that is more …

Legacy Pinning Ceremony Oct. 14 Connects Uab Alumni Past To The Present, Staff

Browse All News

No abstract provided.

Heersink School Of Medicine Identifies Four New Research Focus Areas, Mary Ashley Canevaro

Browse All News

No abstract provided.

September 29, 2022, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

September 29, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

De Novo Variants In Emc1 Lead To Neurodevelopmental Delay And Cerebellar Degeneration And Affect Glial Function In Drosophila, Hyung-Lok Chung, Patrick Rump, Di Lu, Megan R Glassford, Jung-Wan Mok, Jawid Fatih, Adily Basal, Paul C Marcogliese, Oguz Kanca, Michele Rapp, Johanna M Fock, Erik-Jan Kamsteeg, James R Lupski, Austin Larson, Mark C Haninbal, Hugo Bellen, Tamar Harel

Duncan NRI Faculty and Staff Publications

Background: The endoplasmic reticulum (ER)-membrane protein complex (EMC) is a multi-protein transmembrane complex composed of 10 subunits that functions as a membrane-protein chaperone. Variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration. Multiple families with biallelic variants have been published, yet to date, only a single report of a monoallelic variant has been described, and functional evidence is sparse.

Methods: Exome sequencing was used to investigate the genetic cause underlying severe developmental delay in three unrelated children. EMC1 variants were modeled in Drosophila, using loss-of-function (LoF) and overexpression studies. Glial-specific and neuronal-specific assays were used to determine whether the …

Multicenter, Randomized Trial Of A Bionic Pancreas In Type 1 Diabetes, Steven J Russell, Janet B Mcgill, Maamoun Salam, Julie M Silverstein, Samantha Adamson, Andrea Cedeno, Et Al.

2020-Current year OA Pubs

BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting.

METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery …

Reconstructing Sedimentary Processes In A Permian Channel–Lobe Transition Zone: An Outcrop Study In The Karoo Basin, South Africa, F Pohl, Jt Eggenhuisen, J De Leeuw, Et Al

School of Biological and Marine Sciences

Turbidity currents commonly bypass sediment in submarine channels on the continental slope, and deposit sediment lobes farther down-dip on the flat and unconfined abyssal plain. Seafloor and outcrop data have shown that the transition from bypass to deposition usually occurs over complex zones referred to as channel–lobe transition zones (CLTZs). Recognition of these zones in cores and outcrop remains challenging due to a lack of characteristic sedimentary facies and structures. This paper focuses on Unit E of the Permian Fort Brown Formation in the Karoo Basin, South Africa, in the Slagtersfontein outcrop complex, which has previously been interpreted as a …

Mucus-Degrading Bacteroides Link Carbapenems To Aggravated Graft-Versus-Host Disease, Eiko Hayase, Tomo Hayase, Mohamed A Jamal, Takahiko Miyama, Chia-Chi Chang, Saira S Ahmed, Christopher A Sanchez, Alexandria N Brown, Rawan K El-Himri, Ivonne I Flores, Lauren K Mcdaniel, Dung Pham, Taylor Halsey, Annette C Frenk, Valerie A Chapa, Brooke E Heckel, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Lin Tan, Lucas Veillon, Nadim J Ajami, Jennifer A Wargo, Jessica Galloway-Peña, Samuel Shelburne, Roy F Chemaly, Lauren Davey, Robert W P Glowacki, Chen Liu, Gabriela Rondon, Amin M Alousi, Jeffrey J Molldrem, Richard E Champlin, Elizabeth J Shpall, Raphael H Valdivia, Eric C Martens, Philip L Lorenzi, Robert R Jenq

Faculty, Staff and Student Publications

The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT). Broad-spectrum antibiotics such as carbapenems increase the risk for intestinal GVHD, but mechanisms are not well understood. In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT). BT has a broad ability to degrade dietary polysaccharides and host mucin glycans. BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans. These mice also had thinning of the colonic …

Prognostic Molecular Biomarkers In Chordomas: A Systematic Review And Identification Of Clinically Usable Biomarker Panels, Franco Rubino, Christopher Alvarez-Breckenridge, Kadir Akdemir, Anthony P Conley, Andrew J Bishop, Alexander J Lazar, Franco Demonte, Shaan M Raza

Faculty, Staff and Student Publications

INTRODUCTION AND OBJECTIVE: Despite the improvements in management and treatment of chordomas over time, the risk of disease recurrence remains high. Consequently, there is a push to develop effective systemic therapeutics for newly diagnosed and recurrent disease. In order to tailor treatment for individual chordoma patients and develop effective surveillance strategies, suitable clinical biomarkers need to be identified. The objective of this study was to systematically review all prognostic biomarkers for chordomas reported to date in order to classify them according to localization, study design and statistical analysis.

METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) …

Testing A Behavioral Activation Gaming App For Depression During Pregnancy: Multimethod Pilot Study, Stephanie T Juenger, Ramin A Morshed, Alexander F Haddad, Yalan Zhang, Sophia Stoecklein, Michael A Vogelbaum, Juergen Beck, Nitin Tandon, Shawn Hervey-Jumper, Annette M Molinaro, Roberta Rudà, Lorenzo Bello, Oliver Schnell, Yoshua Esquenazi, Maximilian I Ruge, Stefan J Grau, Martin Van Den Bent, Michael Weller, Mitchel S Berger, Susan M Chang, Joerg-Christian Tonn

Faculty, Staff and Student Publications

In IDH-wildtype glioblastomas which meet the histopathological or molecular diagnosis criteria, it remains unclear whether the presence of TERT promotor mutations provides additional prognostic information. Based on a multicenter cohort of 466 IDH-wildtype glioblastomas (including 396 with and 70 patients without TERT promotor mutations), we found that TERT promotor mutations were neither associated with progression-free survival nor overall survival. This held true in various treatment-based or molecular subgroups. This argues against standardized analysis for TERT promotor mutation status for the purpose of prognostic or therapeutic relevance in newly diagnosed IDH-wildtype glioblastoma that otherwise meets the histopathological and …

Identifying Candidate Genes And Drug Targets For Alzheimer’S Disease By An Integrative Network Approach Using Genetic And Brain Region-Specific Proteomic Data, Nitesh Enduru, Peilin Jia, Zhongming Zhao

Faculty, Staff and Student Publications

Genome-wide association studies (GWAS) have identified more than 75 genetic variants associated with Alzheimer's disease (ad). However, how these variants function and impact protein expression in brain regions remain elusive. Large-scale proteomic datasets of ad postmortem brain tissues have become available recently. In this study, we used these datasets to investigate brain region-specific molecular pathways underlying ad pathogenesis and explore their potential drug targets. We applied our new network-based tool, Edge-Weighted Dense Module Search of GWAS (EW_dmGWAS), to integrate ad GWAS statistics of 472 868 individuals with proteomic profiles from two brain regions from two large-scale ad cohorts [parahippocampal gyrus …

A Process Evaluation, With Mediation Analysis, Of A Web-Based Intervention To Augment Primary Care Exercise Referral Schemes: The E-Coacher Randomised Controlled Trial, Jeffrey Lambert, A Taylor, Adam Streeter, Colin Greaves, Wendy M. Ingram, Sarah Dean, Kate Jolly, Nanette Mutrie, Rs Taylor, Lucy Yardley, Lisa Price, John Campbell

Peninsula Medical School

Background: The e-coachER trial aimed to determine whether adding web-based behavioural support to exercise referral schemes (ERS) increased long-term device-measured physical activity (PA) for patients with chronic conditions, compared to ERS alone, within a randomised controlled trial. This study explores the mechanisms of action of the e-coachER intervention using measures of the behaviour change processes integral to the intervention’s logic model. Methods: Four hundred ffty adults with obesity, diabetes, hypertension, osteoarthritis or history of depression referred to an ERS were recruited in Plymouth, Birmingham and Glasgow. The e-coachER intervention comprising 7-Steps to Health was aligned with Self-Determination Theory and mapped …

Single-Cell Analysis Of Immune Cell Transcriptome During Hiv-1 Infection And Therapy., Justin Pollara, Santosh Khanal, R Whitney Edwards, Bhavna Hora, Guido Ferrari, Barton F. Haynes, Todd Bradley

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Cellular immune responses are phenotypically and functionally perturbed during HIV-1 infection, with the majority of function restored upon antiretroviral therapy (ART). Despite ART, residual inflammation remains that can lead to HIV-related co-morbidities and mortality, indicating that ART does not fully restore normal immune cell function. Thus, understanding the dynamics of the immune cell landscape during HIV-1 infection and ART is critical to defining cellular dysfunction that occurs during HIV-1 infection and imprints during therapy.

RESULTS: Here, we have applied single-cell transcriptome sequencing of peripheral blood immune cells from chronic untreated HIV-1 individuals, HIV-1-infected individuals receiving ART and HIV-1 negative …

Exercise Counselling And Referral In Cancer Care: An International Scoping Survey Of Health Care Practitioners’ Knowledge, Practices, Barriers, And Facilitators, Imogen Ramsey, Alexandre Chan, Andreas Charalambous, Yin Ting Cheung, H. S. Darling, Lawson Eng, Lisa Grech, Nicolas H. Hart, Deborah Kirk, Sandra A. Mitchell, Dagmara Poprawski, Elke Rammant, Margaret I. Fitch, Raymond J. Chan

Research outputs 2022 to 2026

Purpose:

Evidence supports the role of prescribed exercise for cancer survivors, yet few are advised to exercise by a healthcare practitioner (HCP). We sought to investigate the gap between HCPs’ knowledge and practice from an international perspective.

Methods:

An online questionnaire was administered to HCPs working in cancer care between February 2020 and February 2021. The questionnaire assessed knowledge, beliefs, and practices regarding exercise counselling and referral of cancer survivors to exercise programs.

Results:

The questionnaire was completed by 375 participants classified as medical practitioners (42 %), nurses (28 %), exercise specialists (14 %), and non-exercise allied health practitioners (16 …

Comparative Study, Using Transthoracic Echocardiography Versus Left Ventriculography To Assesses Ventricular Septal Defect Eligibility For Device Closure, Akram Kdiar Abbas Altmimi, Ahmed Farhan Abusuda

Muthanna Medical Journal

Accurate evaluation of ventricular septal defects types (locations) and measurement of the size of ventricular septal defects and distance from ventricular septal defects to aortic valve are essential for successful trans catheter device closure. The aim of study to assess in patient with ventricular septal defects the accuracy of transthoracic echocardiography in determining the size, position (type), and the distance from ventricular septal defects to the aortic valve as compared to trans- catheter approaches. Cross sectional study included patients with a diagnosis of ventricular septal defects with specific criteria suitable for treatment with transcatheter device closure. Eligibility was confirmed during …

Indigenous Community Grounded Research. Perspectives From Atikamekw Youth (Manawan, Nitaskinan, Lanaudière, Québec, Canada)., Laurent Jérôme, Étienne Levac, Anthony Quitich Dubé, Laurie Guimond (Facilitator)

Nulungu Research Week

In this session, we will discuss the history, the structure and the impacts of the Matakan project, a participative research project designed for promoting and passing down atikamekw knowledge to young people of the Atikamekw community of Manawan (Lanaudière, Québec). We will address issues related to the decolonization of research and knowledge, and show how this project is also part of the Atikamekw strategies and priorities related to education and youth.