Digital Commons Network^™

Imm-Bcp-01, A Patient-Derived Anti-Sars-Cov-2 Antibody Cocktail, Is Active Across Variants Of Concern Including Omicron Ba.1 And Ba.2, Pavel A Nikitin, Suzanne M Scheaffer, Michael S Diamond, Et Al

2020-Current year OA Pubs

Monoclonal antibodies are an efficacious therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, rapid viral mutagenesis led to escape from most of these therapies, outlining the need for an antibody cocktail with a broad neutralizing potency. Using an unbiased interrogation of the memory B cell repertoire of patients with convalescent COVID-19, we identified human antibodies with broad antiviral activity in vitro and efficacy in vivo against all tested SARS-CoV-2 variants of concern, including Delta and Omicron BA.1 and BA.2. Here, we describe an antibody cocktail, IMM-BCP-01, that consists of three patient-derived broadly neutralizing antibodies directed at nonoverlapping surfaces …

Mutations In Bcor, A Co-Repressor Of Crx/Otx2, Are Associated With Early-Onset Retinal Degeneration, Maéva Langouët, Christine Jolicoeur, Awais Javed, Pierre Mattar, Micah D Gearhart, Stephen P Daiger, Mette Bertelsen, Lisbeth Tranebjærg, Nanna D Rendtorff, Karen Grønskov, Catherine Jespersgaard, Rui Chen, Zixi Sun, Hui Li, Najmeh Alirezaie, Jacek Majewski, Vivian J Bardwell, Ruifang Sui, Robert K Koenekoop, Michel Cayouette

Faculty, Staff and Student Publications

Many transcription factors regulating the production, survival, and function of photoreceptor cells have been identified, but little is known about transcriptional co-regulators in retinal health and disease. Here, we show that BCL6 co-repressor (BCOR), a Polycomb repressive complex 1 factor mutated in various cancers, is involved in photoreceptor degenerative diseases. Using proteomics and transcription assays, we report that BCOR interacts with the transcription factors CRX and OTX2 and reduces their ability to activate the promoters of photoreceptor-specific genes. CUT&RUN sequencing further shows that BCOR shares genome-wide binding profiles with CRX/OTX2, consistent with a general co-repression activity. We also identify missense …

Can Body Mass Index Influence The Skin Temperature Of Adolescents? A Preliminary Study With The Use Of Infrared Thermography, Hamilton Henrique Teixeira Reis, Ciro José Brito, Alisson Gomes Da Silva, Manuel Sillero-Quintana, Victória Esther Teixeria Reis, Francisco Zacaron Werneck, Ismael Fernández-Cuevas, Matheus Santos Cerqueira, João Carlos Bouzas Marins

Department of Nutrition and Health Sciences: Faculty Publications

– Infrared thermography (IRT) has been used to assess skin temperature (Tsk), especially during the COVID-19 pandemic, as an important tool in medical screening not only of the general population, but also of young athletes. However, the subcutaneous adipose tissue can act as an insulator when the Tsk is assessed by IRT, modifying the normal Tsk data and leading to their misinterpretation. Considering that the body mass index (BMI) is an important predictor of obesity, the objective of this study was to verify if the Tsk measured by IRT is affected by the BMI in adolescents. A preliminary study was …

Pitfalls And Guidelines For Using Time-Based Git Data, Samuel W. Flint, Jigyasa Chauhan, Robert Dyer

School of Computing: Faculty Publications

Many software engineering research papers rely on time-based data (e.g., commit timestamps, issue report creation/update/close dates, release dates). Like most real-world data however, time-based data is often dirty. To date, there are no studies that quantify how frequently such data is used by the software engineering research community, or investigate sources of and quantify how often such data is dirty. Depending on the research task and method used, including such dirty data could aect the research results. This paper presents an extended survey of papers that utilize time-based data, published in the Mining Software Repositories (MSR) conference series. Out of …

Weight-Loss Supplement Induced Nstemi In The Setting Of Friedrich's Ataxia Cardiomyopathy, Jesse Galuk, Nicholas Beaudrie, Daniel R Harland

Aurora GME

No abstract provided.

Examining Synchronous Technology And Corrective Feedback In High School Mathematics Courses: A Collective Case Study, Sharon Owens

Doctoral Dissertations and Projects

The purpose of this collective case study was to present an in-depth understanding of teachers' (N = 9) implementing and using online synchronous technology that provides real-time corrective feedback for students in a high school mathematics course at a Christian school in Taiwan. This qualitative research design examined the implementation of platforms that provided correctives within international high schools in Taiwan. The research-based data analysis methodologies involved within-case and across-case analysis. The theories that guided this study were Bloom's (1968) mastery learning theory and Piaget's (1972) cognitive learning theory. One central research question and two sub-questions guided the study. The …

A Quantitative Research Study On Probability Risk Assessments In Critical Infrastructure And Homeland Security, Alfred B. Lee

Doctoral Dissertations and Projects

This dissertation encompassed quantitative research on probabilistic risk assessment (PRA) elements in homeland security and the impact on critical infrastructure and key resources. There are 16 crucial infrastructure sectors in homeland security that represent assets, system networks, virtual and physical environments, roads and bridges, transportation, and air travel. The design included the Bayes theorem, a process used in PRAs when determining potential or probable events, causes, outcomes, and risks. The goal is to mitigate the effects of domestic terrorism and natural and man-made disasters, respond to events related to critical infrastructure that can impact the United States, and help protect …

Infographic: Digital Copyright Laws And Online Teaching, Zoe Kaskamanidis

Teacher infographics

A new report has assessed whether copyright limitations for educational purposes are unfit for remote education through a legal analysis of copyright laws in 40 countries. This infographic shows the number of countries in the report for which the following online teaching scenarios are not legal.

Sleep, Sirtuin 1 And Alzheimer’S Disease: A Review, Mehrane Mehramiz, Tenielle Porter, Simon Laws, Stephanie R. Rainey-Smith

Research outputs 2022 to 2026

Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer’s disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded by the SIRT1 gene, impacts sleep via its relationship to wake-sleep neurotransmitters and somnogens. Evidence from animal and human studies supports a significant and complex relationship between sleep, Sirt 1/ SIRT1 and AD. Numerous hypotheses attempt to explain the critical impact of Sirt 1/ SIRT1 on wake- and sleep- promoting neurons, their related mechanisms and neurotransmitters. However, there is a paucity of studies …

Ionic Liquid Pilocarpine Analog As An Antiglaucoma Drug Candidate, Juan Wang, Boxuan Li, Jing Tang, Li Qiu, Xin Qiao, Na Xu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Ionic liquid pilocarpine analog [Pilo-OEG]Cl, the first-of-its-kind ionic liquid antiglaucoma drug candidate, is synthesized and reported. To synthesize [Pilo-OEG]Cl, pilocarpine was reacted with the oligo-polyethylene glycol chloride, 2-[2-(2-chloroethoxy)ethoxy] ethanol, to form an ionic liquid molecule with an imidazole cation and a chloride anion. The chemical structure of [Pilo-OEG]Cl was confirmed with 1H NMR spectroscopy. Compared with pilocarpine (Pilo) and pilocarpine hydrochloride (PiloHCl), [Pilo-OEG]Cl has improved structural stability according to pH measurements and LC-MS analysis. The corneal permeability coefficient of [Pilo-OEG]Cl is 2-fold higher than that of Pilo and 8-fold higher than that of PiloHCl. [Pilo-OEG]Cl does not show apparent toxicity …

Effect Of Ethephon Ripening And Peeling On Quality Of Fresh Walnut During Freezing Storage, Wu Xiao-Hua, Chen Bai, Li Ming-Ze, Zhang Rui, Feng Ji-Hu

Food and Machinery

Objective:To evaluate the feasibility of the production of ethephon in the freezing thawing and fresh keeping of fresh walnut, and to provide theoretical basis and technical support for fresh walnut freezing thawing and fresh keeping technology system. Methods:The late fruiting walnut variety 'Qingxiang' from Longnan county of Gansu province was used as the experimental material, and then the green walnut was picked by hand and then peeled by Ethephon. Meanwhile, the artificial peeling was used as the control (CK). The fresh walnut was peeled and stored in a constant temperature freezer with temperature of -7~-5 ℃ and humidity …

Health Workers’ Documentation Process As A Prerequisite To The Integration Of Patient Care At A Regional Referral Hospital In Uganda, Grace Nakate, Mary Moleki, Ahmed Sarki, Valerie Fleming

School of Nursing & Midwifery, East Africa

Background: Integrated patient care is necessary for better care outcomes. Documentation enhances the integration of care; however, in the Ugandan setting, documentation of care is poor (e.g., omissions and incomplete records) and integration of patient care is not visible. This study presents a review of patient health records that was undertaken to understand documentation of care at a regional referral hospital in Eastern Uganda. This information will help in developing a documentation model to facilitate the integration of patient care in Uganda.

Methodology: This retrospective review involved 513 patient health records from the medical-surgical, pediatric, and obstetric/gynecological departments of Jinja …

Uab Voice Professor Releases New Album, Will Present Free Performance Sept. 19, Shannon Thomason

Browse All News

No abstract provided.

Professional Development Of Cataloguers In Electronic Era In Academic Libraries In Selected Private Universities, Osun State, Franca Ngeme, Grace Morenike Ajewole, Oluwole Banji Ajayi

Library Philosophy and Practice (e-journal)

Abstract

This paper examines professional development of cataloguers in electronic era in academic library in selected private universities, Osun state. The research was necessitated by the postulation that cataloguers competency depend on their professional development. Two research questions were drawn and the population of the study was made up of 8 cataloguers. Data was collected through questionnaire. The descriptive survey research method was adopted in the study. Findings revealed that cataloguers are faced with lack of organizational sponsorship to conference, seminar and workshop; it was shown that, they have challenges on the job training. The study further revealed that cataloguers …

Timely Intervention, Monitoring And Education Matters In Ms (Time Matters In Ms): Development Of A Globally Applicable Quality Improvement Tool, Jeremy Hobart, Helmut Butzkueven, Jodi Haartsen, Tjalf Ziemssen, Thirusha Lane, Gavin Giovannoni

Peninsula Medical School

Background Previously, consensus MS care standards were defined by MS specialist neurologists from 19 countries. We developed, piloted and refined an Excel-based quality improvement tool to enable MS services to benchmark against these standards. Here, we examine the refined tool. Objective To determine the applicability of the quality improvement tool in different healthcare settings. Methods MS centres across the globe were invited to pilot the quality improvement tool by coding the medical records of 36 adults with MS. We invited feedback on user friendliness, quality improvement tool usefulness and relevance of data collected. Results Seventeen centres from 14 countries participated; …

Visual Attention For Linguistic And Non-Linguistic Body Actions In Non-Signing And Native Signing Children, Rain G. Bosworth, So One Hwang, David P. Corina

Articles

Evidence from adult studies of deaf signers supports the dissociation between neural systems involved in processing visual linguistic and non-linguistic body actions. The question of how and when this specialization arises is poorly understood. Visual attention to these forms is likely to change with age and be affected by prior language experience. The present study used eye-tracking methodology with infants and children as they freely viewed alternating video sequences of lexical American sign language (ASL) signs and non-linguistic body actions (self-directed grooming action and objectdirected pantomime). In Experiment 1, we quantified fixation patterns using an area of interest (AOI) approach …

Weeding Ebooks At An Academic Library (Presentation), Marc Jaffy

All Faculty and Staff Scholarship

Libraries can improve their ebook collections by weeding them to remove outdated and irrelevant content. This presentation discusses an ebook weeding project at Franklin University in Columbus, Ohio. It discusses the reasons the library attempted an eweeding project, the obstacles it encountered, the decisions it made and the results of the project.

Decolonisation Of Curricula In Undergraduate Dental Education: An Exploratory Study, Kamran Ali, Jennie Winter, Oliver Webb, Daniel Zahra

Peninsula Dental School

AbstractAims To explore experiences and perceptions of students and staff regarding decolonisation of the curriculum in a dental undergraduate programme.Methods Participants were invited to respond to an online survey on decolonisation of the dental curriculum. The target population included current students on the Bachelor of Dental Surgery and Bachelor of Dental Therapy and Hygiene programmes, as well as dental staff at a university in the South West region of England. The common items for student and staff versions of the survey were focused on six themes: representation; content; peer engagement; assessment; language and communication; and culture. All responses were anonymous. …

Outcome Evaluation Of Active Herts: A Community-Based Physical Activity Programme For Inactive Adults At Risk Of Cardiovascular Disease And/Or Low Mental Wellbeing, Angel M. Chater, Joerg Schulz, Andy Jones, Amanda Burke, Shelby Carr, Dora Kukucska, Nick Troop, Daksha Trivedi, Neil Howlett

School of Psychology

BackgroundA high proportion of UK adults are inactive, which can lead to a range of physical and mental health concerns. Active Herts is a community-based physical activity programme for inactive adults at risk of cardiovascular disease and/or low mental wellbeing. This paper provides a pragmatic evaluation of this programme.MethodThis longitudinal study observed 717 adults (68% female, mean age = 56.9 years) from the “Active Herts” programme. Programme users were provided with a 45-min consultation with a “Get Active Specialist,” who talked them through an Active Herts self-help booklet and then signposted them to free or subsidized local exercise sessions. Programme …

Incisional Hernia Following Colorectal Cancer Surgery According To Suture Technique: Hughes Abdominal Repair Randomized Trial (Hart), J Torkington, R. Harries, S. O'Connell, L. Knight, S. Islam, N. Bashir, A. Watkins, G. Fegan, J. Cornish, B. Rees, H. Cole, H. Jarvis, S Jones, I. Russell, D. Bosanquet, A. Cleves, B. Sewell, A. Farr, N. Zbrzyzna, N. Fiera, R. Ellis-Owen, Z Hilton, C. Parry, A. Bradbury, P. Wall, J. Hill, D. Winter, K. Cocks, D. Harris, J Hilton

Peninsula Medical School

Background Incisional hernias cause morbidity and may require further surgery. HART (Hughes Abdominal Repair Trial) assessed the effect of an alternative suture method on the incidence of incisional hernia following colorectal cancer surgery. Methods A pragmatic multicentre single-blind RCT allocated patients undergoing midline incision for colorectal cancer to either Hughes closure (double far–near–near–far sutures of 1 nylon suture at 2-cm intervals along the fascia combined with conventional mass closure) or the surgeon’s standard closure. The primary outcome was the incidence of incisional hernia at 1 year assessed by clinical examination. An intention-to-treat analysis was performed. Results Between August 2014 and …

Wave Interaction And Energy Absorption From Arrays Of Complex-Shaped Point Absorbers, Y Liu, S Zheng, H Liang, P Cong

School of Engineering, Computing and Mathematics

Water wave interactions with arrays of wave energy converters are numerically investigated based on the interaction theory. The converter is a heaving point absorber that can harness the ocean wave energy through up-and-down movements. A semi-analytical hybrid method is developed that combines the boundary element method and the interaction theory. The developed numerical method is verified against theoretical solutions for arrays of truncated vertical circular cylinders. Three different array layouts are studied in detail. It is found that trapped waves exist at critical wave numbers just below the cutoff values, and the peak load on the middle device increases with …

Height Information Aided 3d Real-Time Large-Scale Underground User Positioning, Houbing Song, Chengkai Tang, Cunle Zhang, Lingling Zhang, Yi Zhang

Publications

Due to the cost of inertial navigation and visual navigation equipment and lake of satellite navigation signals, they cannot be used in large‐scale underground mining environment. To solve this problem, this study proposes large‐scale underground 3D real‐time positioning method with seam height assistance. This method uses the ultrawide band positioning base station as the core and is combined with seam height information to build a factor graph confidence transfer model to realise3D positioning. The simulation results show that the proposed real‐time method is superior to the existing algorithms in positioning accuracy and can meet the needs of large‐scale underground users.

Ionospheric Feedback And Ulf Quarter-Waves, Anatoly Streltsov, Evgeny V. Mishin

Publications

This paper presents results from the numerical investigation of nonlinear feedback interactions between ULF field-aligned currents (FACs) and the ionospheric plasma in the global magnetospheric resonator with a non-symmetrical distribution of the plasma density in the conjugate hemispheres. The density asymmetry is enhanced by the introduction of the ionospheric valley in the hemisphere where the plasma density is already lower. The main result from this study is that in the non-symmetrical resonator, the ionospheric feedback mechanism, driven by the electric field with the maximum amplitude of 50 mV/m, develops nonlinear, intense, small-scale upward currents with a characteristic quarter-wavelength structure along …

Using Cross-User Understanding To Develop Better User Embeddings, Nithya Kota, Maneesh Dewan, Ganesh Mallya, Jatin Chhugani

Defensive Publications Series

Digital payment apps, e.g., available via smartphones, can make multiple payment instruments available to a user; however, a user may not link all their cards to a payment app. Some payment apps include analytics features based on data from cards linked to the app. However, such data can give an incomplete financial picture of the user. This disclosure describes techniques to develop a more complete representation of a user that has provided only a partial view of their finances. Two embedding vector spaces are created, one trained over users with incomplete financial profiles and another trained over users with complete …

Averting Workplace Tailgating And Cyberstalkers Through Location-Powered Multi-Factor Authentication, Shankar Ramanathan, Jatin Katyal, Robert Barton, Jerome Henry, Akram Sheriff

Defensive Publications Series

With a hybrid workplace environment and an influx of talent, many people in an office barely know or recognize each other in person. Although there are safety and security policies regarding an individual badging into a building, tailgating by individuals standing close to a person remains a common occurrence. Tracking device-powered cyberstalking is also an active threat to safety and security. Techniques are presented herein that re-use existing network components (including wireless capabilities, elements of an advanced digital network architecture, a cloud-based location services platform, and an identity and access control policy/mobile device management (MDM) platform) and leverage existing capabilities …

Extension To Nft Smart Contracts For Fine-Grain Management Of Copy Rights For Digital Media Contents, Hp Inc

Defensive Publications Series

Non-Fungible Tokens (NFTs) enable tracking ownership of digital media contents, such as images, photographs, videos, music, media streams, … in blockchain based distributed ledgers. However, in the current common implementation of NFTs, using de-facto standards such as ERC- 721, there is no way to protect the digital media data associated to the NFT. So, although the intention of the content creator may be protecting the copy rights of the digital media, this cannot be ensured with current common implementations. The proposed solution addresses this issue by allowing the content creator to specify in the NFT contract the rights for using …

Municipalities Could Provide Valuable Second-Life Uses Of Electric Vehicle Li-Ion Batteries While Legislators And Manufacturers Refine Safe Recycling And Disposal Practices, Heather D. Stewart

Environmental and Earth Law Journal (EELJ)

As consumers are embracing emerging electric vehicles (EVs) as an important step to take in combating climate change, the reality is that the EV solution has some serious short-term issues to address, especially when evaluating the lithium-ion batteries (LIBs) that power most EVs. This comment first discusses the potential problems associated with the lack of recycling and disposal technology as well as regulations that are available for EV LIBs. Even though consumers and regulators alike are supportive that fossil fuel-burning internal combustion engines need to be replaced with cleaner transportation options such as EVs, policies, and proclamations are still subject …

Addressing The Disproportionate Adverse Health Effects Among Bipoc Communities As A Result Of Environmental Racism, Lindsay M. Farbent

Environmental and Earth Law Journal (EELJ)

This article examines factors that contribute to the negative health impacts on Black Americans, other minorities, and low-income communities that are living in areas with high levels of air pollution, toxic waste, and environmental hazards. First, this article assesses the role of historical residential redlining on the segregation of BIPOC neighborhoods. Furthermore, the article addresses gaps in both federal and state environmental laws that allow facilities to keep obtaining permits and polluting in BIPOC and primarily low-income neighborhoods. Moreover, the article explains the higher rates of trauma, stress, and stress-related illnesses among BIPOC communities exposed to high levels of environmental …

Is Bitcoin The New Gold? The Two May Be More Similar Than You Think, Including Their Value, Uses, And Deleterious Effects On The Environment, Justin Allen

Environmental and Earth Law Journal (EELJ)

In the 1850s, the Gold Rush started in the United States, and in 2010, an analogous phenomenon, the Cryptoboom, began. Similar to the Gold Rush, Bitcoin’s initial boom was marred by the deleterious effects that mining for valuable coins had on the environment, but there are steps that can be taken to mitigate the negative effect cryptocurrencies have on the environment. Cryptocurrencies, including Bitcoin and the blockchain technology that powers cryptocurrencies, have been widely embraced by many people, corporations, and even entire governments for a multitude of reasons. Some have embraced the fruits of blockchain to use as a decentralized …

Miami Is Setting The Expectation On How Coastal Communities In Florida Should Respond To Protect Homeowners From The Sinking State, Dayana B. Blanco

Environmental and Earth Law Journal (EELJ)

This note begins by explaining what environmental factors are causing the sea level rise to increase at just a rapid pace and how coastal communities are ultimately affected. Because Florida is a slice of paradise within the states, it causes the population to increase vastly. Thus, millions of homeowners could face tragic consequences, such as total inundation of residential homes, flooding within the community, and a drastic decrease in home value. In response to this natural disaster, in 2021, Governor Ron DeSantis passed Senate Bill 1954 into law, which requires the Department of Environmental Protection to complete a statewide flood …