Digital Commons Network^™

Inconceivable Families, Malinda L. Seymore

Faculty Scholarship

Basic biology tells us that each child has no more than two biological parents, one who supplies the egg and one who supplies the sperm. Adoption law in this country has generally followed biology, insisting only two parents be legally recognized for each child. Thus, every adoption begins with loss. Before a child can be adopted, that child must first be cut off from their family of birth, rendering the equation of adoption one of subtraction, not addition. This Article examines the biological model of adoption that insists on mimicking the nuclear family—erasing one set of parents and replacing them …

Fashion In The Times Of War: The Recent Exodus Of Luxury Brands From Russia And What It Means For Trademark Law, Irene Calboli, Vera Sevastianova

Faculty Scholarship

In February 2022, Russia infamously invaded Ukraine, starting an unprovoked war. As a result, many foreign companies left their Russia-based operations, including most luxury fashion houses. In these remarks, we elaborate on the possible issues that these companies may face regarding the enforcement of their IP rights in Russia, particularly trademark rights, following their departure resulting from the sanctions imposed by Western countries.

At the time of writing, perhaps the most pressing issue is whether luxury fashion houses risk losing their trademark rights in Russia due to their decision to suspend their operations, even though temporarily. An additional issue facing …

Optimal Standards Of Proof In Antitrust, Murat C. Mungan, Joshua Wright

Faculty Scholarship

Economic analyses of antitrust institutions have thus far focused predominantly on optimal penalties and the design of substantive legal rules, and have largely ignored the standard of proof used in trials as a policy tool in shaping behavior. This neglected tool can play a unique role in the antitrust context, where a given firm may have the choice to engage in exceptional anticompetitive or procompetitive behavior, or simply follow more conventional business practices. The standard of proof used in determining the legality of a firm’s conduct affects not only whether the firm chooses to engage in pro- versus anticompetitive behavior, …

Choice-Based Crowdshipping: A Dynamic Task Display Problem, Alp Arslan, Firat Kilci, Shih-Fen Cheng, Archan Misra

Research Collection School Of Computing and Information Systems

This paper studies the integration of the crowd workforce into a generic last-mile delivery setting in which a set of known delivery requests should be fulfilled at a minimum cost. In this setting, the crowd drivers are able to choose to perform a parcel delivery among the available and displayed requests. We specifically investigate the question: what tasks should be displayed to an individual driver, so as to minimize the overall delivery expenses? In contrast to past approaches, where drivers are either (a) given the choice of a single task chosen so as to optimize the platform’s profit, or (b) …

An Attribute-Aware Attentive Gcn Model For Attribute Missing In Recommendation, Fan Liu, Zhiyong Cheng, Lei Zhu, Chenghao Liu, Liqiang Nie

Research Collection School Of Computing and Information Systems

As important side information, attributes have been widely exploited in the existing recommender system for better performance. However, in the real-world scenarios, it is common that some attributes of items/users are missing (e.g., some movies miss the genre data). Prior studies usually use a default value (i.e., "other") to represent the missing attribute, resulting in sub-optimal performance. To address this problem, in this paper, we present an attribute-aware attentive graph convolution network (A(2)-GCN). In particular, we first construct a graph, where users, items, and attributes are three types of nodes and their associations are edges. Thereafter, we leverage the graph …

A Heuristic Approach To Predict The Tensile Strength Of A Non-Persistent Jointed Brazilian Disc Under Diametral Loading, Mostafa Asadizadeh, Nima Babanouri, Taghi Sherizadeh

Mining Engineering Faculty Research & Creative Works

The mechanical response of rock bridges plays a key role in the stability of concrete and rock structures. In particular, the tensile failure of non-persistent discontinuities can result in their coalescence and the failure of rock or concrete engineering structures. The effect of non-persistent joint parameters on rock structures' failure under tensile mode has not been investigated by many researchers yet. Many non-persistent jointed Brazilian concrete discs are tested under diametral loading in this work, to study the influence of joint spacing, joint continuity factor, loading direction with regard to joint angle, and bridge angle on their tensile behavior. Heuristic …

Metallization Of Polymers And Composites: State-Of-The-Art Approaches, Ruslan Melentiev, Arief Yudhanto, Ran Tao, Todor Vuchkov, Gilles Lubineau

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Polymers and their composites are widely used for designing structures in aerospace, automotive, electronic, sport industries due to their lightweight, cost, and processing advantages. However, the surface of polymeric materials typically exhibits intrinsic deficiencies, limiting their durability and functionalities, e.g., low wear resistance, low thermal and electrical conductivity, low adhesion, low bioactivity, low reflectiveness, and weak photochemical resistance. Polymer metallization is an emerging concept that addresses these deficiencies by forming a metallic skin on polymeric surfaces. Herein, the working principles, recent advances, challenges, functional capabilities, and applications of the state-of-the-art polymer metallization methods in the fields of additive manufacturing, coating …

Faq On The U.S. Archivist And The Future Of The Equal Rights Amendment, Center For Gender And Sexuality Law

Center for Gender & Sexuality Law

On Wednesday, September 21, 2022, the Senate will hold hearings on the nomination of Colleen Shogan as the new Archivist of the United States. This FAQ offers a short primer on what the Archivist does, her official role in the finalization of proposed amendments to the U.S. Constitution, including the Equal Rights Amendment (ERA), and the impact of Archivist action on the validity of the ERA.

Parading The Horribles: The Risks Of Expanding Religious Exemptions, Law, Rights, And Religion Project

Center for Gender & Sexuality Law

People of faith now have a constitutional right to practice their religion—even when doing so conflicts with a government law or policy — that is more rigorously protected than nearly any other right. Some states have passed bills that provide an even broader right to such “religious exemptions” from the law than provided under the U.S. Constitution. Other religious exemption bills have been introduced and await consideration.

International Investment Law And The Extractive Industries, Ella Merrill, Jesse Coleman, Lisa E. Sachs, Lise Johnson

Columbia Center on Sustainable Investment

As of April 2022, the United Nations Conference on Trade and Development (UNCTAD) tallied 3,218 international investment treaties, of which 2,558 are in force. Investors in extractive industries (the oil, gas, and mining sectors) have used investor-state dispute settlement (ISDS) mechanisms embedded in these treaties to challenge a wide range of host state actions and inactions that have allegedly negatively affected their investments. Those claims, and the threats thereof, restrict states’ ability to maximize the benefits, and their ability to limit environmental and social harms, resulting from the exploitation of natural resources. This briefing note provides an introduction to international …

Newsletter Catholic Deaf Of Detroit, September 2022

Newsletter Catholic Deaf of Detroit

A newsletter published for Deaf Catholics in Detroit, MI

Newsletter Catholic Deaf of Detroit Finding Aid

Vision, Fall 2022

Vision

A newsletter published for Deaf Catholics in USA

VisionFinding Aid

Develop New Art, Incorporating Augmented Reality And Animation Skills (Summer 2022), Frank Estrada

Staff Residencies

Frank Estrada is the Visual Resources Specialist and Gallery Coordinator in the Department of Art and Art History. He has been on staff at the University of Mississippi since August 6, 2018.

Photo of Frank Estrada by Bruce Newman.

Developed A Novel (Summer 2022), Sara Camp Milam

Staff Residencies

Sara Camp Milam is the managing editor of the Southern Foodways Alliance. She has been on staff at the University of Mississippi since May 15, 2012.

Photo of Sara Camp Milam by Danny Klimetz.

Advancing Quilting Skills With A Mentor, Coulter Fussell (Summer 2022), Sydney Dupriest

Staff Residencies

Sydney DuPriest is the Associate Director of Campus Communication and Engagement in University Marketing and Communications. She has been on staff at the University of Mississippi since June 1, 2016.

Writing A Book About Mississippi Poet Hubert Creekmore (Summer 2022), Mary Knight

Staff Residencies

Mary Knight is a Communications Specialist in University Development. She has been on staff at the University of Mississippi since April 8, 2005. She is writing a book that will be part biography on Water Valley native and Cold War poet Hubert Creekmore; part autobiography, as it will include aspects of her search to find out more about the closeted Mississippi writer; and part pictorial essay on the places of importance to both Creekmore and Knight.

Regulation Weakness And Lack Of Public Awareness Has Impeded The Implementation Of Environmental Policies In Saudi Arabia, Nada Gurmalla Algamdy

Dissertations & Theses

This research aimed to substantially illustrate that the weakness of environmental regulations and lack of public participation in urban planning alongside poor public awareness in Saudi Arabia has inhibited the implementation of environmental policies across this region. To study these issues, this research compared the Kingdom of Saudi Arabia (“KSA”) to the United States (“US”) building on numerous studies to illustrate how the identified weaknesses correlate with weak or ineffective environmental policies. It is well known that it would be better to use a European country “because it's known that the EU has tough environmental measures" as a model for …

32970 Efficacy And Safety Of A Fixed-Dose Clindamycin 1.2%, Benzoyl Peroxide 3.1%, And Adapalene 0.15% Gel For Moderate-To-Severe Acne: Randomized Phase 2 And Phase 3 Studies Of The First Triple-Combination Drug, Linda F. Stein Gold, Leon H. Kircik, Emil A. Tanghetti

Dermatology Meeting Abstracts

A 3-pronged approach to acne treatment—combining an antibiotic, antibacterial, and retinoid—may provide greater efficacy and tolerability than single/double treatments while potentially reducing antibiotic resistance and increasing patient compliance. Clindamycin 1.2%/BPO 3.1%/adapalene 0.15% (IDP-126) gel is the first triple-combination, fixed-dose topical acne product in development that addresses the major pathophysiological abnormalities in acne patients. A phase 2 (N = 741) and two phase 3 (N = 183; N = 180), double-blind, randomized, 12-week studies enrolled participants aged ≥9 years with moderate-to-severe acne. Participants were randomized to receive once-daily IDP-126 or vehicle; the phase 2 study included 3 additional randomization arms containing …

33463 Pooled Efficacy And Safety Results From The Dermis-1 And Dermis-2 Phase 3 Trials Of Once-Daily Roflumilast Cream 0.3% By Baseline Body Surface Area, Linda F. Stein Gold, Jerry Bagel, James Del Rosso, Lawrence J. Green, Mark Lebwohl, Leon H. Kircik, Amy Feng, Scott Snyder, Robert C. Higham, Patrick Burnett, David R. Berk

Dermatology Meeting Abstracts

Roflumilast cream 0.3% is a selective and potent phosphodiesterase-4 inhibitor under investigation as a once-daily treatment for psoriasis. Here we describe pooled efficacy and safety results from 2 identical phase 3 randomized controlled trials of roflumilast cream (DERMIS-1: NCT04211363 and DERMIS-2: NCT04211389) analyzed by baseline body surface area (BSA) affected ( 10%). Patients (≥2 years) with psoriasis involving 2-20% BSA were randomized to roflumilast (n = 576) or vehicle (n = 305) for 8 weeks. Overall, significantly more roflumilast- vs. vehicle-treated patients achieved the primary efficacy endpoint of Investigator Global Assessment (IGA) Success (Clear or Almost Clear IGA status plus …

34039 Maintenance Of Skin Clearance In A Long-Term Open-Label Study Of Fixed-Combination Halobetasol Propionate And Tazarotene Lotion For Psoriasis In Participants With Prior Use Of Topical Treatments, Linda F. Stein Gold, Javier Alonso-Llamazares, Joshua Zeichner

Dermatology Meeting Abstracts

Background: Most patients with psoriasis are dissatisfied with their current treatment, primarily because of limited effectiveness. This post hoc subgroup analysis evaluated long-term efficacy and safety of fixed-combination halobetasol propionate (0.01%) and tazarotene (0.045%) lotion (HP/TAZ) in participants with use of topical corticosteroid (TCS; 137/550 [24.9%]) or other antipsoriatic topical medications (51/550 [9.3%]) before entry in an open-label study of HP/TAZ (NCT02462083).

Methods: Participants in the open-label study received HP/TAZ once daily. At week 8, participants who achieved treatment success (investigator’s global assessment [IGA] score of 0 or 1) stopped treatment and were reevaluated monthly through 52 weeks; those who …

33714 Palisaded Neutrophilic And Granulomatous Dermatitis In The Setting Of Srsf2-Mutated Chronic Myelomonocytic Leukemia: Case Report And Review Of The Literature, Christina D. Enescu, Avni Patel, Ben J. Friedman

Dermatology Meeting Abstracts

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a rare cutaneous histopathologic reaction pattern associated with several underlying disorders. Few cases of PNGD have been associated with hematologic malignancies, in particular with chronic myelomonocytic leukemia (CMML), a malignant hematopoietic disorder with features of myeloproliferative neoplasm and myelodysplastic syndrome. CMML is characterized by peripheral blood monocytosis and bone marrow dysplasia, and can be supported by an acquired clonal cytogenetic abnormality most commonly in TET2, SRSF2, ASXL1, RUNX1, NRAS, and CBL. We present a patient with a papulosquamous rash on the neck, chest, and shoulders with histomorphological features on the spectrum of PNGD. …

34794 Long-Term Safety And Disease Control Of Ruxolitinib Cream Among Black Or African American Patients With Atopic Dermatitis: Pooled Results From 2 Phase 3 Studies, Lawrence F. Eichenfield, Linda F. Stein Gold, Zelma C. Chiesa Fuxench, May E. Venturanza, Haobo Ren, Kanwaljit K. Brar

Dermatology Meeting Abstracts

Atopic dermatitis (AD) is an inflammatory skin disease with a prevalence in the United States of approximately 20%/5%–10% in Black or African American children/adults. In 2 phase 3 studies (TRuE-AD1/TRuE-AD2), 1249 patients (≥12 years old, Investigator’s Global Assessment [IGA] score 2/3, 3%–20% affected body surface area [BSA]) were randomized (2:2:1) to twice-daily 0.75% ruxolitinib (Janus kinase [JAK] 1/JAK2 inhibitor) cream, 1.5% ruxolitinib cream, or vehicle for an 8-week, double-blind vehicle-controlled period, followed by a double-blind long-term safety period (LTS; as-needed treatment; assessments every 4 weeks) up to Week 52. Patients initially randomized to ruxolitinib remained on their regimen during the …

32329 Assessing The Utility Of Fontana-Masson And Mart-1 Stains In Evaluating Skin Pigmentary Changes Induced By Ultraviolet Radiation And Visible Light, Marissa Ceresnie, Indermeet Kohli, Ben J. Friedman, Henry W. Lim, Iltefat H. Hamzavi

Dermatology Meeting Abstracts

One of the observed effects of ultraviolet radiation (UVR) and visible light (VL) on melanocompetent skin is increased pigmentation, also known as skin darkening or tanning. Many methods are used to measure skin pigment, including the Fontana-Masson stain (FMS) and MART-1 immunostain, which histologically highlight melanin and melanocyte density, respectively. While these approaches may be adequate in assessing baseline skin pigment among individuals of different races and phototypes, detecting the skin darkening induced by UVR and VL within the same individual is a challenge, especially in darker skin phototypes. We conducted a literature search and analyzed 16 articles comparing skin …

Clinical Outcomes Associated With Melanocytic Lesions Assessed Via Ancillary Gene Expression Profiling (Gep), Wyatt Boothby-Shoemaker, Brittani Jones, Linna L. Guan, Ben J. Friedman

Dermatology Meeting Abstracts

Aims/Objectives: Compare GEP assay prediction of 434 melanocytic lesions with dermatopathologist interpretation.

Methods: Sensitivity and specificity of assay were calculated based on disagreement of assay prediction with dermatopathologist interpretation. Histologic features were recorded in disagreeing cases.

Results: Eighty-five percent of lesions (369/434) had sufficient RNA for scoring. 74.2% 274/369 lesions were classified as “benign”, 11.9% (44/369) “indeterminate”, and 13.8% (51/369) “malignant”. 38/51 of lesions rendered “malignant” by dermatopathologists were classified “malignant” by assay (sensitivity = 74.5%). Lesions rendered by assay as “benign” but “malignant” by dermatopathologists were more likely to have rarer cytologic features. (13/51) lesions rendered “malignant” by dermatopathologists …

34631 Do Patients With Vitiligo And Health Care Professionals Treating Them Recognize The Burden In Living With The Disease In The United States? Findings From The Valiant Study, Kristen Bibeau, John E. Harris, Iltefat H. Hamzavi, Anouk Lindley, Christine Lafiura, Khaled Ezzedine

Dermatology Meeting Abstracts

Vitiligo is a chronic autoimmune disease characterized by the destruction of melanocytes, resulting in pale or white patches of skin. The population-based Vitiligo and Life Impact Among International Communities (VALIANT) study sought to understand the impact and burden of vitiligo on quality of life (QoL) from the patient and physician perspective from around the world. The VALIANT study recruited adult participants (aged ≥18 years who self-reported a vitiligo diagnosis) via an online panel. Participants were asked questions regarding their mental health, psychosocial burden, and behavior in professional and social situations. Separately, health care professionals (HCPs; physicians, nurse practitioners, or physician …

33356 A Multinational Chart Review To Examine Gastrointestinal Symptoms And Their Management In Patients Treated With Apremilast For Plaque Psoriasis, Linda F. Stein Gold, Edward Tuttle, Wendy Y. Cheng, Rose Chang, Catherine Nguyen, Louise H. Yu, Anne Bouloc, Yuri Klyachkin, Tara Nazareth, Denis Jullien

Dermatology Meeting Abstracts

Background: Diarrhea and nausea are the most common adverse events observed in phase 3 clinical trials and real-world studies of apremilast, an oral phosphodiesterase-4 inhibitor indicated for moderate-to-severe plaque psoriasis.

Methods: A retrospective chart review was conducted between June and November 2020 in the United States (US) and France among patients with moderate psoriasis experiencing gastrointestinal (GI) symptoms within 3 months of initiating apremilast.

Results: Dermatologists in US (200) and in France (52) abstracted patient charts (US: 494, France: 128). The following GI symptoms were reported: ‒diarrhea (US: 67% [331/494]; France: 76% [97/128]) with median time from onset to resolution/improvement …

Updates On The Hidradenitis Suppurativa From The Usa, Iltefat H. Hamzavi

Dermatology Meeting Abstracts

Background: There has been so much progress in hidradenitis suppurativa across the world.

Objectives: The focus of this talk will be the American contributions to this effort but very few of these efforts involve any one nation.

Methods/Results: Updates from American institutions will be provided with a focus on immunology, the microbiome, genetics, outcome measures, antibiotics, biologics, lasers, surgery multidisciplinary clinics, big data and support groups. Updates about the efforts of the American HS foundation will also be discussed.

Conclusion: There is much to celebrate about the advances in HS across the world. North America and the United States are …

34612 Exploring The Natural History Of Vitiligo In The United States: Findings From The Valiant Study, John E. Harris, Kristen Bibeau, Iltefat H. Hamzavi, Pearl Grimes, Anouk Lindley, Christine Lafiura, Khaled Ezzedine

Dermatology Meeting Abstracts

Vitiligo is a chronic autoimmune disease characterized by the destruction of melanocytes, resulting in depigmented skin lesions. Epidemiology studies in vitiligo are often limited to smaller sample sizes and rely on dermatology clinics as the source population. The population-based Vitiligo and Life Impact Among International Communities (VALIANT) study sought to understand the natural history of vitiligo among patients around the world. Here, data from US participants are presented. Participants were recruited via an online panel. Adults (aged ≥18 years) who self-reported a vitiligo diagnosis by a health care professional were eligible to participate. Of 608 US patients, 58% were male; …

31064 The Detroit Keloid Scale: A Validated Tool For Rating Keloids, Alexis B. Lyons, David M. Ozog, Henry W. Lim, Kate V. Viola, Lamont R. Jones, Amy Tang

Dermatology Meeting Abstracts

Background: No keloid-specific outcome measures exist.

Objective: To develop and validate the Detroit Keloid Scale (DKS), a standardized method of keloid assessment to better compare treatments.

Methods: Forty-seven physicians were polled to develop the DKS. The scale was validated in 52 patients with keloids against the Vancouver Scar Scale (VSS), Patient and Observer Scar Assessment Scale (POSAS), and Dermatology Life Quality Index (DLQI) by 3 physicians.

Results: The interrater reliability was “substantial” for observer component of the DKS and only “moderate” for the VSS and observer POSAS (ICC were 0.80, 0.60, and 0.47, respectively). Pearson’s correlation indicated a “moderate” association …

33354 Efficacy Of Apremilast In Patients With Mild To Moderate Psoriasis Assessed By The Physician Global Assessment And Body Surface Area Composite Tool: Post Hoc Analysis From Advance, Linda F. Stein Gold, Kim Papp, David Pariser, Howard Sofen, Mindy Chen, Sue Cheng, Hernan Picard, Yuri Klyachkin, Lawrence Green

Dermatology Meeting Abstracts

Background: In ADVANCE (NCT03721172), apremilast 30 mg BID (APR) demonstrated significantly greater sPGA response vs. PBO at Week 16 (22% vs. 4%; P <.0001) in patients with mild-to-moderate psoriasis. The Physician Global Assessment and Body Surface Area Composite Tool (PGA × BSA) is a simple, sensitive measure of psoriasis severity for patients with BSA<10%. We performed a post hoc analysis of the efficacy results from ADVANCE using the PGA×BSA.

Methods: This current post hoc analysis included all randomized patients. Missing data were imputed by multiple imputation. PGAxBSA-50/75/90 was 50%, 75% and 90% improvement in PGAxBSA from baseline.

Results: Of 595 randomized patients (APR: 297; PBO: 298), baseline characteristics were similar for mean BSA (APR: 6.4; PBO: 6.3), sPGA score 2 (APR 31%; PBO: 31%), sPGA score 3 (APR: 69%; PBO: 70%), and mean PGA×BSA (APR: 17.6; PBO: 17.5). At Week 16, significantly more patients achieved PGAxBSA-50/75/90 …