Digital Commons Network^™

Resilience: Key Factors Associated With Resilience Of Older People In Botswana, Magen Mhaka-Mutepfa, Sheila Shaibu

School of Nursing & Midwifery, East Africa

This study aims to determine key factors that predict resilience in older people. A cross-sectional design and quantitative methods were used for this study. Four districts were selected in Botswana using cluster random sampling. Data on resilience from 378 older adults aged 60 years+ [Mean Age (SD) = 71.1(9.0)] was collected using snowballing technique. Data on socio-demographics, protective and risk factors were also collected from urban and rural areas. CHAID (Chi-squared Automatic Interaction Detection) analysis was used to predict the strengths of the relationships among resilience and all predictor variables because the data were skewed. Five major predictor …

Preadmission Testing For Covid-19 As A Screening Strategy: A Retrospective Chart Review From A Tertiary Hospital In Kenya, David Odada, James Ndai, Jemimah Kimeu, Jasmit Shah, Reena Shah

School of Nursing & Midwifery, East Africa

Background: Since COVID-19 was declared a pandemic in March 2020, hospitals and patient care facilities have faced challenges in protecting healthcare workers and patients from being exposed to the infection. The main challenge has been how exposure to COVID-19 can be controlled when asymptomatic patientscan transmit the infection. This study aims to evaluate pre-admission testing of COVID-19 in patients at the Aga Khan University Hospital, Nairobi as a screening strategy for understanding, preventing and controlling exposure to COVID-19.

Methods: This was a descriptive retrospective chart review study that analysed the incidence of COVID-19, incidental detection of laboratory-confirmed COVID-19 …

Inclusive And Anti-Racist Collecting At Unlv: Draft Report And Recommendations, Annette Day, Sarah R. Jones, Amy Tureen, Susan B. Wainscott, Amanda Melilli, Thomas Padilla, Aidy Weeks

Library Faculty Research

The UNLV University Libraries recognizes that as both a direct and indirect result of colonialism and white supremacy the historical and contemporary scholarly publishing market atypically centers and prioritizes voices that are white, male, Christian, able-bodied, and heterosexual (Muka, 2018; Ray, 2018; Baffoe, Asimeng-Boahene, & Buster, 2014; and Buggs, Sims, & Kramer, 2020). In an attempt to redress this imbalance, the UNLV University Libraries is committed to collecting content by and about people and communities that have historically been excluded. This effort includes but is not limited to the intentional collection of materials about and by groups historically excluded by …

Diverse Stem Cells For Periodontal Tissue Formation And Regeneration, Mizuki Nagata, Jeryl D English, Noriaki Ono, Wanida Ono

Faculty, Staff and Student Publications

The periodontium is comprised of multiple units of mineralized and nonmineralized tissues including the cementum on the root surface, the alveolar bone, periodontal ligament (PDL), and the gingiva. PDL contains a variety of cell populations including mesenchymal stem/progenitor cells (MSCs) termed PDLSCs, which contribute to periodontal regeneration. Recent studies utilizing mouse genetic models shed light on the identities of these mesenchymal progenitors in their native environment, particularly regarding how they contribute to homeostasis and repair of the periodontium. The current concept is that mesenchymal progenitors in the PDL are localized to the perivascular niche. Single-cell RNA sequencing (scRNA-seq) analyses reveal …

Bmkt 325.00: Principles Of Marketing, Samuel D. Spector

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Edu 497.01: Methods: 5-8 Mathematics (Undergraduate), Georgia A. Cobbs

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Artz 311.01: Drawing Ii, Sarah A. Jones

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Pubh 475e: Public Health Ethics, Jeffrey C. Peterson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Thtr 499.01: Senior Project - Bfa Acting, Performance / Practice, Bernadette Sweeney

University of Montana Course Syllabi, 2021-2025

No abstract provided.

An Inexpensive Maximum Power Point Tracking System For An Insulated Solar Electric Cooker Using An Off-The-Shelf Buck Converter, Andrew A. Perez

Physics

A specialized control circuit using an off-the-shelf buck converter is built for an Insulated Solar Electric Cooker (ISEC). Cost and efficient power delivery are the focus. An ISEC is synonymous to a direct load heat resistor, allowing a specific maximum power point tracking (MPPT) algorithm and fewer components. Only a microcontroller, voltage sensor, and digital-to-analog converter are used with the buck converter to maximize the power delivered by a 100W solar panel for the 3.3Ω load.

Gray Dragons: Assessing China’S Senior Military Leadership, Joel Wuthnow

China Strategic Perspectives

This report analyzes more than 300 biographies of senior Chinese military officers from 2015 and 2021 to assess the composition, demographics, and career patterns of the People’s Liberation Army (PLA) leadership.

Can Affordable Homes Be Healthy? Legal Strategy, Socio-Legal Studies And Activism In Indonesia, Santy Kouwagam

The Indonesian Journal of Socio-Legal Studies

This article uses two Constitutional Court decisions in Indonesia to exemplify the importance of analysing legal strategies. These decisions declared a rule barring developers from building and selling tiny houses to be unconstitutional and invalid. The article shows that ‘justice’ in legal procedures still needs further definition, and that judges’ elaboration of decisions and their legal reasoning still needs improvement. The article will first discuss the cases, using Legal Strategy analysis. It will then highlight problems with the commoditisation of houses. Finally, it will argue that the problem of unhealthy and unaffordable housing in Indonesia can be resolved, by bringing …

Undergraduate Engineering And Education Students Reflect On Their Interdisciplinary Teamwork Experiences Following Transition To Virtual Instruction Caused By Covid-19, Kristie S. Gutierrez, Jennifer J. Kidd, Min Jung Lee, Pilar Pazos, Krishnanand Kaipa, Stacie I. Ringleb, Orlando Ayala

Teaching & Learning Faculty Publications

This study explores undergraduate engineering and education students’ perspectives on their interdisciplinary teams throughout the rapid transition to online learning and instruction from a face-to-face to a virtual format. In this qualitative study, students’ reflections and focus groups from three interdisciplinary collaborations were analyzed using the lens of Social Cognitive Theory. COVID-19 created a dramatic change in the environment such that the most immediate and direct impact on students’ experiences was on the environmental aspects of Bandura’s triadic reciprocal determinism model, which then triggered behavioral and personal responses to adapt to the new environment. Subsequent evidence of reciprocal effects between …

Sununu Holds Commanding Lead Over Rivals In Gop Primary For Nh Governor 9/1/2022, Unh Survey Center

All UNH Survey Center Polls

Incumbent Governor Chris Sununu holds a wide lead in the 2022 Republican gubernatorial primary over his Republican rivals. Sununu remains popular among likely Republican primary voters while a majority don't know enough to have an opinion of each of his challengers. A majority of Granite Staters, and 85% of Republicans, approve of Sununu's performance as Governor.

Understanding The Role Of Transportation In Combating Human Trafficking In California, Kezban Yagci Sokat

Faculty Research, Scholarly, and Creative Activity

Human trafficking, a form of modern slavery, is the recruitment, transport, transfer of persons using force, fraud or coercion to exploit them for act of labor or sex. According to the International Labor Organization, human trafficking is the fastest growing organized crime with approximately $150 billion in annual profits and 40.3 million individuals trapped in slave-like conditions. While it is not compulsory to involve transportation for human trafficking, the transportation industry plays a critical role in combating human trafficking as traffickers often rely the transportation system to recruit, move or transfer victims of human trafficking for either sex or forced …

Multichannel Blind Deconvolution Of Circularly Polarized Imagery, Patrick B. Cunningham

Theses and Dissertations

Current methods can be used to recreate an expected Stokes polarization vector from measured light for characterization purposes. However, this only applies to three of the Stokes parameters, that is, the linear polarization components. Circular polarization is not currently being utilized for object characterization because the mathematical complexity is greater than for that of linear polarization. This research will analyze a way to expand existing algorithms to include circular polarization and enable the complete reconstruction of the Stokes vector from the measured light into a blind deconvolution algorithm for Stokes estimation and image reconstruction.

Additive Manufacturing Of Molybdenum For High Temperature Structural Applications, Megan L. Bustin

Theses and Dissertations

This research considered additive manufactured (AM) molybdenum (Mo) and the effect of three variables on microstructure, mechanical properties, and the relationship between the two. Test temperature, laser speed, and shield gas or build atmosphere were varied, and samples tested and analyzed using a three-point bending test, chemical composition, and optical and scanning electron microscopy. The relationship among variables and results using a Design of Experiments was limited compared to the inclusion of every tested sample. Most effects were expected: samples tested at room temperature were brittle without statistical significance; increasing laser speed resulted in decreased ductility and strain, smaller grain …

Evaluating Performance Competencies In The Royal Saudi Air Force Engineering Directorate And Squadrons, Faisal A. Al Dawood

Theses and Dissertations

The effectiveness of tasks performed by the directorate of aeronautical engineering and squadrons in RSAF directly impacts flight safety, which in turn influences the organization either positively or negatively. Therefore, improving engineers' competencies will improve the overall performance of the organization. The study refined and reconstructed a model, namely a T-shape competency model, to assess the engineers' competencies which revealed some management and competency-related deficiencies and concluded with managerial recommendations.

Development Of A Security-Focused Multi-Channel Communication Protocol And Associated Quality Of Secure Service (Qoss) Metrics, Paul M. Simon

Theses and Dissertations

The threat of eavesdropping, and the challenge of recognizing and correcting for corrupted or suppressed information in communication systems is a consistent challenge. Effectively managing protection mechanisms requires an ability to accurately gauge the likelihood or severity of a threat, and adapt the security features available in a system to mitigate the threat. This research focuses on the design and development of a security-focused communication protocol at the session-layer based on a re-prioritized communication architecture model and associated metrics. From a probabilistic model that considers data leakage and data corruption as surrogates for breaches of confidentiality and integrity, a set …

A Case Study Of The Efficacy Of Model-Based Requests For Information, Kyle J. Arruda

Theses and Dissertations

The Department of Defense (DoD) has encouraged the transition to digital engineering, yet there are limited guides for how to transition and there is limited data to show where an organization like a program office can reap the most benefit from the transition. To identify areas where potential benefits may be realized, this thesis compares two Requests for Information (RFIs), one document-based and one model-based, from generation to response. A survey was developed and administered to 7 members of a single program office to grade the RFI responses. The survey was based on the 43 benefit categories identified in the …

Generative Methods, Meta-Learning, And Meta-Heuristics For Robust Cyber Defense, Marc W. Chalé

Theses and Dissertations

Cyberspace is the digital communications network that supports the internet of battlefield things (IoBT), the model by which defense-centric sensors, computers, actuators and humans are digitally connected. A secure IoBT infrastructure facilitates real time implementation of the observe, orient, decide, act (OODA) loop across distributed subsystems. Successful hacking efforts by cyber criminals and strategic adversaries suggest that cyber systems such as the IoBT are not secure. Three lines of effort demonstrate a path towards a more robust IoBT. First, a baseline data set of enterprise cyber network traffic was collected and modelled with generative methods allowing the generation of realistic, …

A Practical Tool To Enhance Faculty And Student Interactions Surrounding E-Learning Platforms, Kimberly N. Williams, Alexandria K. Gombas, Claudia Cornejo Happel, Tracy C. Parodi, Elizabeth H. Lazzara, Barbara Chaparro

Publications

Learning management systems (LMS) are prevalent in modern day education, but their implementation is often highly diverse based on individual faculty and course needs. This can result in students falling behind in their schoolwork if they do not understand how faculty use the e-learning platform in specific courses, which may be further exacerbated when students are exposed to many different faculty using learning management systems in different ways at a single institution. The current research sought to create a practical tool to reduce the impact of diverse LMS implementation through the generation of a homepage template that could be customized …

Local Norms And Gifted/Talented Identification In Arkansas, Sarah C. Mckenzie, Josh B. Mcgee, Bich Tran, Kathryn Barnes, Charlene A. Reid

Policy Briefs

In this brief, we summarize recent research from OEP examining if using school- or district-level norms from state assessments would increase the racial and programmatic diversity of Arkansas students identified as Gifted and Talented (G/T). Using ten years of administrative data to analyze the outcomes of a local norms approach compared to the current G/T identification strategies, we find no consistent evidence that using a local norms approach for G/T identification would improve racial or programmatic diversity.

Fused Deposition Modeling With Induced Vibrations: A Study On The Mechanical Characteristics Of Printed Parts, Joseph Dei Rossi, Ozgur Keles, Vimal Viswanathan

Faculty Research, Scholarly, and Creative Activity

The recent development of RepRap style 3D printers has made additive manufacturing technology available to the public at a low cost. While these 3D printers are being used for a variety of purposes, one of the main applications is prototyping in design projects. The quality of the 3D-printed parts has been a concern in such cases. Many variables within these printers’ operation can be varied to obtain optimum print quality. This study explores a setup that uses externally induced mechanical vibrations to the nozzle tip as a potential method to improve the quality of 3D-printed parts. Induced vibration is expected …

Use Of Machine Learning For Early Detection Of Knee Osteoarthritis And Quantifying Effectiveness Of Treatment Using Force Platform, Ashish John Prabhakar, Srikanth Prabhu, Aayush Agrawal, Siddhisa Banerjee, Abraham M. Joshua, Yogeesh Dattakumar Kamat, Gopal Nath, Saptarshi Sengupta

Faculty Research, Scholarly, and Creative Activity

Knee osteoarthritis is one of the most prevalent chronic diseases. It leads to pain, stiffness, decreased participation in activities of daily living and problems with balance recognition. Force platforms have been one of the tools used to analyse balance in patients. However, identification in early stages and assessing the severity of osteoarthritis using parameters derived from a force plate are yet unexplored to the best of our knowledge. Combining artificial intelligence with medical knowledge can provide a faster and more accurate diagnosis. The aim of our study is to present a novel algorithm to classify the occurrence and severity of …

Crisis In Services: Self-Care, Self-Directed Care, And The Use Of Technology Supporting All, Evidence To Practice, Cep Crisis Reports, Stephen Phillippi, Casey L. Thomas

Policy & Position Papers

No abstract provided.

County-Level Social Vulnerability And Breast, Cervical, And Colorectal Cancer Screening Rates In The Us, 2018, Cici Bauer, Kehe Zhang, Qian Xiao, Jiachen Lu, Young-Rock Hong, Ryan Suk

Faculty, Staff and Student Publications

IMPORTANCE: Area-level factors have been identified as important social determinants of health (SDoH) that impact many health-related outcomes. Less is known about how the social vulnerability index (SVI), as a scalable composite score, can multidimensionally explain the population-based cancer screening program uptake at a county level.

OBJECTIVE: To examine the geographic variation of US Preventive Services Task Force (USPSTF)-recommended breast, cervical, and colorectal cancer screening rates and the association between county-level SVI and the 3 screening rates.

DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study used county-level information from the Centers for Disease Control and Prevention's PLACES and SVI data …

Genome-Wide Association Analyses Of Physical Activity And Sedentary Behavior Provide Insights Into Underlying Mechanisms And Roles In Disease Prevention, Zhe Wang, Andrew Emmerich, Nicolas J Pillon, Tim Moore, Daiane Hemerich, Marilyn C Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S Ahluwalia, Traci M Bartz, Amy R Bentley, Lawrence F Bielak, Mike Chong, Audrey Y Chu, Diane Berry, Rajkumar Dorajoo, Nicole D Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F Feitosa, Christian Gieger, Mariaelisa Graff, Leanne M Hall, Toomas Haller, Fernando P Hartwig, David A Hillis, Ville Huikari, Nancy Heard-Costa, Christina Holzapfel, Anne U Jackson, Åsa Johansson, Anja Moltke Jørgensen, Marika A Kaakinen, Robert Karlsson, Kathleen F Kerr, Boram Kim, Chantal M Koolhaas, Zoltan Kutalik, Vasiliki Lagou, Penelope A Lind, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Massimo Mangino, Christoph Metzendorf, Kristine R Monroe, Alexander Pacolet, Louis Pérusse, Rene Pool, Rebecca C Richmond, Natalia V Rivera, Sebastien Robiou-Du-Pont, Katharina E Schraut, Christina-Alexandra Schulz, Heather M Stringham, Toshiko Tanaka, Alexander Teumer, Constance Turman, Peter J Van Der Most, Mathias Vanmunster, Frank J A Van Rooij, Jana V Van Vliet-Ostaptchouk, Xiaoshuai Zhang, Jing-Hua Zhao, Wei Zhao, Zhanna Balkhiyarova, Marie N Balslev-Harder, Sebastian E Baumeister, John Beilby, John Blangero, Dorret I Boomsma, Soren Brage, Peter S Braund, Jennifer A Brody, Marcel Bruinenberg, Ulf Ekelund, Ching-Ti Liu, John W Cole, Francis S Collins, L Adrienne Cupples, Tõnu Esko, Stefan Enroth, Jessica D Faul, Lindsay Fernandez-Rhodes, Alison E Fohner, Oscar H Franco, Tessel E Galesloot, Scott D Gordon, Niels Grarup, Catharina A Hartman, Gerardo Heiss, Jennie Hui, Thomas Illig, Russell Jago, Alan James, Peter K Joshi, Taeyeong Jung, Mika Kähönen, Tuomas O Kilpeläinen, Woon-Puay Koh, Ivana Kolcic, Peter P Kraft, Johanna Kuusisto, Lenore J Launer, Aihua Li, Allan Linneberg, Jian'an Luan, Pedro Marques Vidal, Sarah E Medland, Yuri Milaneschi, Arden Moscati, Bill Musk, Christopher P Nelson, Ilja M Nolte, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Christine Power, Olli T Raitakari, Mägi Reedik, Alex P Reiner, Paul M Ridker, Igor Rudan, Kathy Ryan, Mark A Sarzynski, Laura J Scott, Robert A Scott, Stephen Sidney, Kristin Siggeirsdottir, Albert V Smith, Jennifer A Smith, Emily Sonestedt, Marin Strøm, E Shyong Tai, Koon K Teo, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Andre G Uitterlinden, Jagadish Vangipurapu, Natasja Van Schoor, Uwe Völker, Gonneke Willemsen, Kayleen Williams, Quenna Wong, Huichun Xu, Kristin L Young, Jian Min Yuan, M Carola Zillikens, Alan B Zonderman, Adam Ameur, Stefania Bandinelli, Joshua C Bis, Michael Boehnke, Claude Bouchard, Daniel I Chasman, George Davey Smith, Eco J C De Geus, Louise Deldicque, Marcus Dörr, Michele K Evans, Luigi Ferrucci, Myriam Fornage, Caroline Fox, Theodore Garland, Vilmundur Gudnason, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo L Horta, Elina Hyppönen, Marjo-Riitta Jarvelin, W Craig Johnson, Sharon L R Kardia, Lambertus A Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimäki, Loic Le Marchand, Patrik K E Magnusson, Nicholas G Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E North, Claes Ohlsson, Albertine J Oldehinkel, Marju Orho-Melander, Guillaume Pare, Taesung Park, Oluf Pedersen, Brenda W J H Penninx, Tune H Pers, Ozren Polasek, Inga Prokopenko, Charles N Rotimi, Nilesh J Samani, Xueling Sim, Harold Snieder, Thorkild I A Sørensen, Tim D Spector, Nicholas J Timpson, Rob M Van Dam, Nathalie Van Der Velde, Cornelia M Van Duijn, Peter Vollenweider, Henry Völzke, Trudy Voortman, Gérard Waeber, Nicholas J Wareham, David R Weir, Heinz-Erich Wichmann, James F Wilson, Andrea L Hevener, Anna Krook, Juleen R Zierath, Martine A I Thomis, Ruth J F Loos, Marcel Den Hoed

Faculty, Staff and Student Publications

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle …

Alcohol And Cannabis Co-Use And Longitudinal Gray Matter Volumetric Changes In Early And Late Adolescence, Xi Luo, James J Yang, Anne Buu, Elisa M Trucco, Chiang-Shan R Li

Faculty, Staff and Student Publications

Background: Previous studies have characterized the impact of substance use on cerebral structure and function in adolescents. Yet, the great majority of prior studies employed a small sample, presented cross-sectional findings, and omitted potential sex differences.

Methods: Using data based on 724 adolescents (370 females) curated from the NCANDA study, we investigated how gray matter volumes (GMVs) decline longitudinally as a result of alcohol and cannabis use. The impacts of alcohol and cannabis co-use and how these vary across assigned sex at birth and age were examined. Brain imaging data comprised the GMVs of 34 regions of interest and the …

Genetic Analyses Of The Electrocardiographic Qt Interval And Its Components Identify Additional Loci And Pathways, William J Young, Najim Lahrouchi, Aaron Isaacs, Thuyvy Duong, Luisa Foco, Farah Ahmed, Jennifer A Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Linda Repetto, Maria Pina Concas, Marten E Van Den Berg, Stefan Weiss, Antoine R Baldassari, Traci M Bartz, James P Cook, Daniel S Evans, Rebecca Freudling, Oliver Hines, Jonas L Isaksen, Honghuang Lin, Hao Mei, Arden Moscati, Martina Müller-Nurasyid, Casia Nursyifa, Yong Qian, Anne Richmond, Carolina Roselli, Kathleen A Ryan, Eduardo Tarazona-Santos, Sébastien Thériault, Stefan Van Duijvenboden, Helen R Warren, Jie Yao, Dania Raza, Stefanie Aeschbacher, Gustav Ahlberg, Alvaro Alonso, Laura Andreasen, Joshua C Bis, Eric Boerwinkle, Archie Campbell, Eulalia Catamo, Massimiliano Cocca, Michael J Cutler, Dawood Darbar, Alessandro De Grandi, Antonio De Luca, Jun Ding, Christina Ellervik, Patrick T Ellinor, Stephan B Felix, Philippe Froguel, Christian Fuchsberger, Martin Gögele, Claus Graff, Mariaelisa Graff, Xiuqing Guo, Torben Hansen, Susan R Heckbert, Paul L Huang, Heikki V Huikuri, Nina Hutri-Kähönen, M Arfan Ikram, Rebecca D Jackson, Juhani Junttila, Maryam Kavousi, Jan A Kors, Thiago P Leal, Rozenn N Lemaitre, Henry J Lin, Lars Lind, Allan Linneberg, Simin Liu, Peter W Macfarlane, Massimo Mangino, Thomas Meitinger, Massimo Mezzavilla, Pashupati P Mishra, Rebecca N Mitchell, Nina Mononen, May E Montasser, Alanna C Morrison, Matthias Nauck, Victor Nauffal, Pau Navarro, Kjell Nikus, Guillaume Pare, Kristen K Patton, Giulia Pelliccione, Alan Pittman, David J Porteous, Peter P Pramstaller, Michael H Preuss, Olli T Raitakari, Alexander P Reiner, Antonio Luiz P Ribeiro, Kenneth M Rice, Lorenz Risch, David Schlessinger, Ulrich Schotten, Claudia Schurmann, Xia Shen, M Benjamin Shoemaker, Gianfranco Sinagra, Moritz F Sinner, Elsayed Z Soliman, Monika Stoll, Konstantin Strauch, Kirill Tarasov, Kent D Taylor, Andrew Tinker, Stella Trompet, André Uitterlinden, Uwe Völker, Henry Völzke, Melanie Waldenberger, Lu-Chen Weng, Eric A Whitsel, James G Wilson, Christy L Avery, David Conen, Adolfo Correa, Francesco Cucca, Marcus Dörr, Sina A Gharib, Giorgia Girotto, Niels Grarup, Caroline Hayward, Yalda Jamshidi, Marjo-Riitta Järvelin, J Wouter Jukema, Stefan Kääb, Mika Kähönen, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Maria Fernanda Lima-Costa, Yongmei Liu, Ruth J F Loos, Steven A Lubitz, Dennis O Mook-Kanamori, Andrew P Morris, Jeffrey R O'Connell, Morten Salling Olesen, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Bruce M Psaty, Jerome I Rotter, Bruno Stricker, Pim Van Der Harst, Cornelia M Van Duijn, Niek Verweij, James F Wilson, Dan E Arking, Julia Ramirez, Pier D Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B Munroe

Faculty, Staff and Student Publications

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and …