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Articles 661081 - 661110 of 5159898
Full-Text Articles in Entire DC Network
The Application Of International Standards In Kosovo: Challenges And Opportunities For Export Promotion, Rita Thaci
The Application Of International Standards In Kosovo: Challenges And Opportunities For Export Promotion, Rita Thaci
Theses
The core aim of this study is to identify and analyze the extent to which international standards are applied in Kosovo, the challenges firms in Kosovo face with regards to the application of international standards, and the opportunities and benefits that the application of international standards brings to firms and the economy of Kosovo, with a special consideration to exports. The analysis uses primary and secondary data. Secondary data were attained through the literature review and the Kosovo Exporters Directory available in KIESA’s website, whereas primary data were attained through semi-structured interviews with representatives of exporting firms operating in Kosovo. …
Repercussions Of A Disruption: The Impact Of Global Ict Supply Chain Trends In Kosovo, Dior Ramosaj
Repercussions Of A Disruption: The Impact Of Global Ict Supply Chain Trends In Kosovo, Dior Ramosaj
Theses
This study seeks to analyze what type of impact the global ICT supply chain trends, apparent in the last two and a half years, have had in Kosovo. Specifically, the study will focus on two areas, the global shortage of electronic chips, affecting the hardware sector, and a rise in demand for software, due to the transition of working from home following the recent COVID- 19 pandemic. A parallel will be drawn between the global trends and Kosovo. The research methodology is comprised of a combination of primary and secondary data. Primary data has been collected through interviews with representatives …
Implications Of Unregistered Employment In Kosovo’S Pension System, Drin Cela
Implications Of Unregistered Employment In Kosovo’S Pension System, Drin Cela
Theses
Governments give substantial importance towards retirement. Pension spending accounts for one of the largest spending items of public expenditure. The importance of pensions is going to increase in the future, as demographic trends reflect the greying of the population, in which a decreasing number of working people will need to support an increasing amount of retired people. At the same time, informal employment is a pressing economic issue as is apparent when comparing its size to the general economy. Kosovo is a country that faces both problems, ageing and high informal employment. This study explores the relationship between these two …
Skills Gap In The Information Technology Sector In Kosovo, Erze Ahmeti
Skills Gap In The Information Technology Sector In Kosovo, Erze Ahmeti
Theses
The main focus of this research project is to identify the extent to which companies in the IT sector in Kosovo are being affected by the skill gaps and the ways through which they are trying to bridge these skill gaps. While the IT industry in Kosovo shows great growth potential, the skill gap appears to be a prevailing problem that hinders this sector’s development. The study analyzes the implications of the skill gap for the growth of private companies and the sector in general; as well as the ways used by the sector to narrow the skill gap. To …
How Many Mutex Bugs Can A Simple Analysis Find In Go Programs?, Fumi Takeuchi, Hidehiko Masuhara, Raffi Khatchadourian, Youyou Cong, Keisuke Ishibashi
How Many Mutex Bugs Can A Simple Analysis Find In Go Programs?, Fumi Takeuchi, Hidehiko Masuhara, Raffi Khatchadourian, Youyou Cong, Keisuke Ishibashi
Publications and Research
In open-source software, it is known that there are many concurrency bugs. A previous study in Go revealed that a considerable number of such bugs are simple (for example, 9% of the bugs are the ones that forget to unlock a mutex,) through a manual program investigation. This paper tries to detect such bugs by applying a simple analysis to see how far such a tool can match the manual analysis. We built a simple intraprocedural control flow analysis in Go, and evaluated its performance concerning the open source programs with concurrency bugs reported in the previous study. Consequently, as …
High-Entropy Boride–Carbide Ceramics By Sequential Boro/Carbothermal Synthesis, Steven M. Smith, Lun Feng, William Fahrenholtz, Greg Hilmas, Tieshu Huang
High-Entropy Boride–Carbide Ceramics By Sequential Boro/Carbothermal Synthesis, Steven M. Smith, Lun Feng, William Fahrenholtz, Greg Hilmas, Tieshu Huang
Materials Science and Engineering Faculty Research & Creative Works
A dual-phase high-entropy boride (HEB)/carbide (HEC) ceramic with a fine grain size was synthesized by a sequential boro/carbothermal process. In the first step, an Hf–Nb–Ta–Ti–Zr-containing carbide was synthesized by a carbothermal reduction of oxides followed by the reaction of the carbide with B4C and ZrH2 to convert part of the carbide to boride. The resulting composition was ∼29 vol% HEB with an average grain size of ∼1.1 μm. Solid solution formation occurred at the densification temperature of 1900°C resulting in a relative density higher than 99%. The Vickers hardness was 26.5 ± 1.4 GPa. This is the first report of …
Effect Of Rolling Process On Magnetic Properties Of Fe-3.3 Wt% Si Non-Oriented Electrical Steel, Yizhou Du, Ronald J. O'Malley, Mario F. Buchely, Paul Kelly
Effect Of Rolling Process On Magnetic Properties Of Fe-3.3 Wt% Si Non-Oriented Electrical Steel, Yizhou Du, Ronald J. O'Malley, Mario F. Buchely, Paul Kelly
Materials Science and Engineering Faculty Research & Creative Works
In this study, the influence of the rolling process on magnetic properties of Fe-3.3 wt% Si non-oriented electrical steel was investigated. The strip samples were cast using a high solidification cooling rate vacuum sampling method to simulate the solidification conditions of the industrial twin roll thin strip casting (TRSC) process. As-cast samples were subjected to various thermo-mechanical processing routes with different levels of hot-rolling (HR) and cold-rolling (CR). The influence of carbon and sulfur (C&S) contents in the steel were also investigated. Core loss (P1.5/50, P1.5/60, P1.0/50, P1.0/60) and magnetic induction (B25, B50) of the final annealed strip samples were …
Processing And Mechanical Properties Of Hot-Pressed Zirconium Diboride – Zirconium Carbide Ceramics, Eric W. Neuman, William Fahrenholtz, Gregory E. Hilmas
Processing And Mechanical Properties Of Hot-Pressed Zirconium Diboride – Zirconium Carbide Ceramics, Eric W. Neuman, William Fahrenholtz, Gregory E. Hilmas
Materials Science and Engineering Faculty Research & Creative Works
ZrB2 was mixed with 0.5 wt% carbon and up to 10 vol% ZrC and densified by hot-pressing at 2000 °C. All compositions were > 99.8% dense following hot-pressing. The dense ceramics contained 1–1.5 vol% less ZrC than the nominal ZrC addition and had between 0.5 and 1 vol% residual carbon. Grain sizes for the ZrB2 phase decreased from 10.1 µm for 2.5 vol% ZrC to 4.2 µm for 10 vol% ZrC, while the ZrC cluster size increased from 1.3 µm to 2.2 µm over the same composition range. Elastic modulus was ~505 GPa and toughness was ~2.6 MPa·m½ for all compositions. …
Global Tellurium Supply Potential From Electrolytic Copper Refining, Nedal T. Nassar, Haeyeon Kim, Max Frenzel, Michael S. Moats, Sarah M. Hayes
Global Tellurium Supply Potential From Electrolytic Copper Refining, Nedal T. Nassar, Haeyeon Kim, Max Frenzel, Michael S. Moats, Sarah M. Hayes
Materials Science and Engineering Faculty Research & Creative Works
The transition towards renewable energy requires increasing quantities of nonfuel mineral commodities, including tellurium used in certain photovoltaics. While demand for tellurium may increase markedly, the potential to increase tellurium supply is not well-understood. In this analysis, we estimate the quantity of tellurium contained in anode slimes generated by electrolytic copper refining by country between 1986 and 2018, including uncertainties. For 2018, the results indicate that 1930 (1500-2700, 95% confidence interval) metric tons of tellurium were contained in anode slimes globally. This is nearly quadruple the reported tellurium production for that year. China has the greatest potential to increase tellurium …
Differing Moisture Content In Concrete And Mitigation Methods: Research Of Sacramento, Taylor S. Tonda
Differing Moisture Content In Concrete And Mitigation Methods: Research Of Sacramento, Taylor S. Tonda
Construction Management
The city of Sacramento and its concrete foundations face one of the most challenging conditions in the flooring industry, high RH Moisture. RH Moisture or Relative Humidity Moisture is one of the main causes for flooring systems to fail. The source of High RH Moisture consists of surrounding geographic features like rivers, flood plains, and elevation, as well as improper or nonexistent use of a vapor barrier beneath the concrete foundation. Mapping and other data is used to support these claims. If a flooring system is not properly prepared for high RH Moisture levels, issues such as bubbling, delamination, and …
Ultrafast Stiffening Of Concentrated Thermoresponsive Mineral Suspensions, Sharu Bhagavathi Kandy, Iman Mehdipour, Narayanan Neithalath, Aditya Kumar, Mathieu Bauchy, Edward Garboczi, Samanvaya Srivastava, Torben Gaedt, Gaurav Sant
Ultrafast Stiffening Of Concentrated Thermoresponsive Mineral Suspensions, Sharu Bhagavathi Kandy, Iman Mehdipour, Narayanan Neithalath, Aditya Kumar, Mathieu Bauchy, Edward Garboczi, Samanvaya Srivastava, Torben Gaedt, Gaurav Sant
Materials Science and Engineering Faculty Research & Creative Works
Extrusion-based 3D printing with rapidly hardening polymeric materials is capable of building almost any conceivable structure. However, concrete, one of the most widely used materials for large-scale structural components, is generally based on inorganic binder materials like Portland cement. Unlike polymeric materials, a lack of precise control of the extent and rate of solidification of cement-based suspensions is a major issue that affects the ability to 3D-print geometrically complex structures. Here, we demonstrate a novel method for controllable-rapid solidification of concentrated mineral suspensions that contain a polymer binder system based on epoxy and thiol precursors as well as one or …
Mechanical Activation And Cation Site Disorder In Mgal2o4, Cole A. Corlett, Matthias D. Frontzek, Nina Obradovic, Jeremy Lee Watts, William Fahrenholtz
Mechanical Activation And Cation Site Disorder In Mgal2o4, Cole A. Corlett, Matthias D. Frontzek, Nina Obradovic, Jeremy Lee Watts, William Fahrenholtz
Materials Science and Engineering Faculty Research & Creative Works
The synthesis and crystallographic site occupancy were investigated for MgAl2O4 with and without mechanical activation of the precursor powders. Heating to 1200 °C or higher resulted in the formation of a single spinel phase regardless of whether the powders were mechanically activated or not. Neutron diffraction analysis was used to determine cation site occupancy and revealed that mechanical activation resulted in a lower degree of cation site inversion compared to the nonactivated materials, which indicated that the powders were closer to thermodynamic equilibrium. This is the first study to characterize the effects of mechanical activation on crystallographic site occupancy in …
Best Practices For Reducing Construction Accidents Involving Hispanic Construction Workers, Michael E. Asuquo, Khalid Siddiqi
Best Practices For Reducing Construction Accidents Involving Hispanic Construction Workers, Michael E. Asuquo, Khalid Siddiqi
The Professional Constructor
The objective of this study was to determine best practices for reducing accidents among Hispanic construction workers. It was hypothesized that language barrier between the Hispanics and American workers contributed immensely to high rate of construction accidents on industrial projects. Accident case studies and questionnaire survey were both used. Data was collected through semi-structured interviews with Hispanic workers involved in industrial construction projects in Metro Atlanta. Findings from the study concluded that most accidents involving Hispanic workers were caused due to lack of communication from supervisors, ignorance of workers on work procedures, lack of equipment training, and worker negligence. Language …
Construction Management Internship: A Key Opportunity For Assessment And Continuous Curriculum Improvement, James S. Vaux, Bree Dority, Dana E. Vaux
Construction Management Internship: A Key Opportunity For Assessment And Continuous Curriculum Improvement, James S. Vaux, Bree Dority, Dana E. Vaux
The Professional Constructor
The internship is an integral part of most Construction Management curricula. Studies have noted the importance and reciprocal value of internships for the student, the employer, and the academic program. However, to date, no studies have specifically outlined the value internships provide to the CM program for assessment and evaluation. This paper examines the value of the CM internship as an indirect measure to assess and incorporate change into program curricula. With 10 years of qualitative and quantitative data collected from CM student interns, industry employers, and university internship supervisors, this study supports that CM internships are a valuable tool …
Social Media Mining Under The Covid-19 Context: Progress, Challenges, And Opportunities, Xiao Huang, Siqin Wang, Mengxi Zhang, Tao Hu, Alexander Hohl, Bing She, Jianxin Li, Xiao Liu, Oliver Gruebner, Regina Liu, Xiao Li, Zhewei Liu, Xinyue Ye, Zhenlong Li
Social Media Mining Under The Covid-19 Context: Progress, Challenges, And Opportunities, Xiao Huang, Siqin Wang, Mengxi Zhang, Tao Hu, Alexander Hohl, Bing She, Jianxin Li, Xiao Liu, Oliver Gruebner, Regina Liu, Xiao Li, Zhewei Liu, Xinyue Ye, Zhenlong Li
Geosciences Faculty Publications and Presentations
Social media platforms allow users worldwide to create and share information, forging vast sensing networks that allow information on certain topics to be collected, stored, mined, and analyzed in a rapid manner. During the COVID-19 pandemic, extensive social media mining efforts have been undertaken to tackle COVID-19 challenges from various perspectives. This review summarizes the progress of social media data mining studies in the COVID-19 contexts and categorizes them into six major domains, including early warning and detection, human mobility monitoring, communication and information conveying, public attitudes and emotions, infodemic and misinformation, and hatred and violence. We further document essential …
Evaluation Of Potassium Borate As A Volatility-Reducing Agent For Dicamba, Mason Castner, Jason K. Norsworthy, Trenton Roberts
Evaluation Of Potassium Borate As A Volatility-Reducing Agent For Dicamba, Mason Castner, Jason K. Norsworthy, Trenton Roberts
Crop, Soil and Environmental Sciences Faculty Publications and Presentations
Dicamba was labeled in dicamba-resistant cotton (Gossypium hirsutum L.) and soybean [Glycine max (L.) Merr.] in 2017, resulting in a record number of off-target complaints. To address off-target movement via volatilization, experiments were conducted to evaluate the effectiveness of potassium tetraborate tetrahydrate (KBo) as a volatility-reducing agent (VRA) with dicamba. Low-tunnel experiments examined: (1) whether KBo functions as a dicamba VRA, (2) the relationship between KBo concentration and dicamba volatilization, (3) the effectiveness of KBo compared with potassium acetate as a VRA, and (4) the impact of KBo on dicamba volatilization with and without glufosinate. In a large-scale trial (0.4-ha …
Construction Of Modular Concrete Footings For Use In Cal Poly’S High Bay Laboratory, Tyler W. Giddens
Construction Of Modular Concrete Footings For Use In Cal Poly’S High Bay Laboratory, Tyler W. Giddens
Construction Management
This project-based senior project had the end goal of creating two concrete modular foundations that can be used in the High Bay Laboratory for testing procedures. The concrete modular blocks are 6’ long by 3’ wide, and 1.5’ tall. The foundations each held 100 embeds. Each embed serves as an anchor point for various attachments for testing purposes. This was an interdisciplinary project amongst two CM students and one ARCE student. The ARCE student was responsible for the design of the blocks, encompassing the formwork and the rebar. The CM students were responsible for estimating, scheduling, and the construction of …
Genetic Loci And Prioritization Of Genes For Kidney Function Decline Derived From A Meta-Analysis Of 62 Longitudinal Genome-Wide Association Studies, Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix Günther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Ben Brumpton, Robert J Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y Chu, Marina Ciullo, Massimiliano Cocca, James P Cook, Josef Coresh, Daniele Cusi, Martin H De Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Michele K Evans, Mary F Feitosa, Andre Franke, Sandra Freitag-Wolf, Christian Fuchsberger, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Christian Gieger, Daniel F Gudbjartsson, Stein Hallan, Pavel Hamet, Asahi Hishida, Kevin Ho, Edith Hofer, Bernd Holleczek, Hilma Holm, Anselm Hoppmann, Katrin Horn, Nina Hutri-Kähönen, Kristian Hveem, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Irma Karabegović, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Krämer, Brigitte Kühnel, Johanna Kuusisto, Markku Laakso, Leslie A Lange, Terho Lehtimäki, Man Li, Wolfgang Lieb, Lifelines Cohort Study, Lars Lind, Cecilia M Lindgren, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Anubha Mahajan, Pamela R Matias-Garcia, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Andrew P Morris, Josyf C Mychaleckyj, Girish N Nadkarni, Mariko Naito, Masahiro Nakatochi, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Teresa Nutile, Michelle L O'Donoghue, Jeffrey O'Connell, Isleifur Olafsson, Marju Orho-Melander, Afshin Parsa, Sarah A Pendergrass, Brenda W J H Penninx, Mario Pirastu, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Myriam Rheinberger, Kenneth M Rice, Federica Rizzi, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Daniela Ruggiero, Kathleen A Ryan, Charumathi Sabanayagam, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Markus Scholz, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Karsten B Sieber, Xueling Sim, Mario Sims, Harold Snieder, Kira J Stanzick, Unnur Thorsteinsdottir, Hannah Stocker, Konstantin Strauch, Heather M Stringham, Patrick Sulem, Silke Szymczak, Kent D Taylor, Chris H L Thio, Johanne Tremblay, Simona Vaccargiu, Pim Van Der Harst, Peter J Van Der Most, Niek Verweij, Uwe Völker, Kenji Wakai, Melanie Waldenberger, Lars Wallentin, Stefan Wallner, Judy Wang, Dawn M Waterworth, Harvey D White, Cristen J Willer, Tien-Yin Wong, Mark Woodward, Qiong Yang, Laura M Yerges-Armstrong, Martina Zimmermann, Alan B Zonderman, Tobias Bergler, Kari Stefansson, Carsten A Böger, Cristian Pattaro, Anna Köttgen, Florian Kronenberg, Iris M Heid
Genetic Loci And Prioritization Of Genes For Kidney Function Decline Derived From A Meta-Analysis Of 62 Longitudinal Genome-Wide Association Studies, Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix Günther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Ben Brumpton, Robert J Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y Chu, Marina Ciullo, Massimiliano Cocca, James P Cook, Josef Coresh, Daniele Cusi, Martin H De Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Michele K Evans, Mary F Feitosa, Andre Franke, Sandra Freitag-Wolf, Christian Fuchsberger, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Christian Gieger, Daniel F Gudbjartsson, Stein Hallan, Pavel Hamet, Asahi Hishida, Kevin Ho, Edith Hofer, Bernd Holleczek, Hilma Holm, Anselm Hoppmann, Katrin Horn, Nina Hutri-Kähönen, Kristian Hveem, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Irma Karabegović, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Krämer, Brigitte Kühnel, Johanna Kuusisto, Markku Laakso, Leslie A Lange, Terho Lehtimäki, Man Li, Wolfgang Lieb, Lifelines Cohort Study, Lars Lind, Cecilia M Lindgren, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Anubha Mahajan, Pamela R Matias-Garcia, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Andrew P Morris, Josyf C Mychaleckyj, Girish N Nadkarni, Mariko Naito, Masahiro Nakatochi, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Teresa Nutile, Michelle L O'Donoghue, Jeffrey O'Connell, Isleifur Olafsson, Marju Orho-Melander, Afshin Parsa, Sarah A Pendergrass, Brenda W J H Penninx, Mario Pirastu, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Myriam Rheinberger, Kenneth M Rice, Federica Rizzi, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Daniela Ruggiero, Kathleen A Ryan, Charumathi Sabanayagam, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Markus Scholz, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Karsten B Sieber, Xueling Sim, Mario Sims, Harold Snieder, Kira J Stanzick, Unnur Thorsteinsdottir, Hannah Stocker, Konstantin Strauch, Heather M Stringham, Patrick Sulem, Silke Szymczak, Kent D Taylor, Chris H L Thio, Johanne Tremblay, Simona Vaccargiu, Pim Van Der Harst, Peter J Van Der Most, Niek Verweij, Uwe Völker, Kenji Wakai, Melanie Waldenberger, Lars Wallentin, Stefan Wallner, Judy Wang, Dawn M Waterworth, Harvey D White, Cristen J Willer, Tien-Yin Wong, Mark Woodward, Qiong Yang, Laura M Yerges-Armstrong, Martina Zimmermann, Alan B Zonderman, Tobias Bergler, Kari Stefansson, Carsten A Böger, Cristian Pattaro, Anna Köttgen, Florian Kronenberg, Iris M Heid
Faculty, Staff and Student Publications
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine …
Major Pathologic Response And Prognostic Score Predict Survival In Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy, Apar Pataer, Annikka Weissferdt, Arlene M Correa, Ara A Vaporciyan, Boris Sepesi, John V Heymach, Sabina Berezowska, Tina Cascone, Stephen G Swisher
Major Pathologic Response And Prognostic Score Predict Survival In Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy, Apar Pataer, Annikka Weissferdt, Arlene M Correa, Ara A Vaporciyan, Boris Sepesi, John V Heymach, Sabina Berezowska, Tina Cascone, Stephen G Swisher
Faculty, Staff and Student Publications
INTRODUCTION: Complete pathologic response (CPR) is an acceptable surrogate for survival in clinical trials but it occurs infrequently in patients with NSCLC receiving neoadjuvant chemotherapy (NCT). Therefore, we studied the impact of major pathologic response (MPR) for predicting survival of patients with NSCLC receiving NCT. We also tested a newly reported scoring system-the prognostic score (PRSC)-which combines T category, lymph node status, and MPR status.
METHODS: We analyzed CPR and MPR, defined as 0% and less than or equal to 10% viable tumor cells, respectively, in 339 patients with NSCLC with various histologic types who had been treated with NCT …
Tumor Immune Microenvironment Changes By Multiplex Immunofluorescence Staining In A Pilot Study Of Neoadjuvant Talazoparib For Early-Stage Breast Cancer Patients With A Hereditary Brca Mutation, Tapsi Kumar, Evie Hobbs, Fei Yang, Jeffrey T Chang, Alejandro Contreras, Edwin Roger Parra Cuentas, Haven Garber, Sanghoon Lee, Yiling Lu, Marion E Scoggins, Beatriz E Adrada, Gary J Whitman, Banu K Arun, Elizabeth A Mittendorf, Jennifer K Litton
Tumor Immune Microenvironment Changes By Multiplex Immunofluorescence Staining In A Pilot Study Of Neoadjuvant Talazoparib For Early-Stage Breast Cancer Patients With A Hereditary Brca Mutation, Tapsi Kumar, Evie Hobbs, Fei Yang, Jeffrey T Chang, Alejandro Contreras, Edwin Roger Parra Cuentas, Haven Garber, Sanghoon Lee, Yiling Lu, Marion E Scoggins, Beatriz E Adrada, Gary J Whitman, Banu K Arun, Elizabeth A Mittendorf, Jennifer K Litton
Faculty, Staff and Student Publications
PURPOSE: The immunological profile of early-stage breast cancer treated with neoadjuvant PARP inhibitors has not been described. The aim of this study was to delineate the changes in the tumor immune microenvironment (TiME) induced by talazoparib.
PATIENTS AND METHODS: Patients with operable germline BRCA1/2 pathogenic variant (gBRCA1/2+) breast cancer were enrolled in a feasibility study of neoadjuvant talazoparib. Thirteen patients who received 8 weeks of neoadjuvant talazoparib were available for analysis, including 11 paired pre- and post-talazoparib core biopsies. Treatment-related changes in tumor-infiltrating lymphocytes were examined and immune cell phenotypes and their spatial distribution in the TiME were identified and …
Confirming Subarachnoid Hemorrhage Induction In The Endovascular Puncture Mouse Model, Ari Dienel, Sung-Ha Hong, Jose Guzman, Kumar T Peeyush, Spiros L Blackburn, Devin W Mcbride
Confirming Subarachnoid Hemorrhage Induction In The Endovascular Puncture Mouse Model, Ari Dienel, Sung-Ha Hong, Jose Guzman, Kumar T Peeyush, Spiros L Blackburn, Devin W Mcbride
Faculty, Staff and Student Publications
Background and purpose: Experimental studies of subarachnoid hemorrhage (SAH) using the endovascular perforation model routinely use either cerebral blood flow (CBF) or intracranial pressure (ICP) monitoring to confirm SAH induction. We designed this study to test the hypothesis that contralateral CBF is a better marker of SAH induction than ipsilateral CBF.
Methods: Sixty-eight adult C57BL/6J mice were subjected to endovascular perforation. Mice were monitored using laser Doppler (for relative CBF) or ICP probes.
Results: The ipsilateral CBF significantly decreased prior to ICP rising. However, reduction of the CBF in the contralateral hemisphere occurred at the same time as the rise …
Idh1 Prr32h Ctdna And D-2-Hydroxyglutarate As Csf Biomarkers In Patients With Idh-Mutant Gliomas, Yoko Fujita, Luis Nunez-Rubiano, Antonio Dono, Allison Bellman, Mauli Shah, Juan C Rodriguez, Vasanta Putluri, Abu Hena Mostafa Kamal, Nagireddy Putluri, Roy F Riascos, Jay-Jiguang Zhu, Yoshua Esquenazi, Leomar Y Ballester
Idh1 Prr32h Ctdna And D-2-Hydroxyglutarate As Csf Biomarkers In Patients With Idh-Mutant Gliomas, Yoko Fujita, Luis Nunez-Rubiano, Antonio Dono, Allison Bellman, Mauli Shah, Juan C Rodriguez, Vasanta Putluri, Abu Hena Mostafa Kamal, Nagireddy Putluri, Roy F Riascos, Jay-Jiguang Zhu, Yoshua Esquenazi, Leomar Y Ballester
Faculty, Staff and Student Publications
INTRODUCTION: We aimed to evaluate IDH1 p.R132H mutation and 2-hydroxyglutarate (2HG) in cerebrospinal fluid (CSF) as biomarkers for patients with IDH-mutant gliomas.
METHODS: CSF was collected from patients with infiltrating glioma, and 2HG levels were measured by liquid chromatography-mass spectrometry. IDH1 p.R132H mutant allele frequency (MAF) in CSF-ctDNA was measured by digital droplet PCR (ddPCR). Tumor volume was measured from standard-of-care magnetic resonance images.
RESULTS: The study included 48 patients, 6 with IDH-mutant and 42 with IDH-wildtype gliomas, and 57 samples, 9 from the patients with IDH-mutant and 48 from the patients with IDH-wildtype gliomas. ctDNA was detected in 7 …
Plasmonic Gadolinium Oxide Nanomatryoshkas: Bifunctional Magnetic Resonance Imaging Enhancers For Photothermal Cancer Therapy, Luke Henderson, Oara Neumann, Yara Kadria-Vili, Burak Gerislioglu, James Bankson, Peter Nordlander, Naomi J Halas
Plasmonic Gadolinium Oxide Nanomatryoshkas: Bifunctional Magnetic Resonance Imaging Enhancers For Photothermal Cancer Therapy, Luke Henderson, Oara Neumann, Yara Kadria-Vili, Burak Gerislioglu, James Bankson, Peter Nordlander, Naomi J Halas
Faculty, Staff and Student Publications
Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (Gd2O3-NM), a multilayered (Au core/Gd2O3 shell/Au shell) sub-100 nm nanoparticle capable of combining T1 MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r1 of 1.28 × 108 mM-1 s-1, an MRI contrast enhancement per nanoparticle sufficient for T1 imaging in addition to tumor ablation. Gd2O3-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of …
Automation Of Radiation Treatment Planning For Rectal Cancer, Kai Huang, Prajnan Das, Adenike M Olanrewaju, Carlos Cardenas, David Fuentes, Lifei Zhang, Donald Hancock, Hannah Simonds, Dong Joo Rhee, Sam Beddar, Tina M Briere, Laurence Court
Automation Of Radiation Treatment Planning For Rectal Cancer, Kai Huang, Prajnan Das, Adenike M Olanrewaju, Carlos Cardenas, David Fuentes, Lifei Zhang, Donald Hancock, Hannah Simonds, Dong Joo Rhee, Sam Beddar, Tina M Briere, Laurence Court
Faculty, Staff and Student Publications
PURPOSE: To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy (3DCRT) treatment planning that combines deep learning (DL) aperture predictions and forward-planning algorithms.
METHODS: We designed an algorithm to automate the clinical workflow for 3DCRT planning with field aperture creations and field-in-field (FIF) planning. DL models (DeepLabV3+ architecture) were trained, validated, and tested on 555 patients to automatically generate aperture shapes for primary (posterior-anterior [PA] and opposed laterals) and boost fields. Network inputs were digitally reconstructed radiographs, gross tumor volume (GTV), and nodal GTV. A physician scored each aperture for 20 patients on a 5-point scale (>3 …
In-Situ Measurements Of Temperature And Emissivity During Msw Combustion Using Spectral Analysis And Multispectral Imaging Processing, Shu Zheng, Weiguang Cai, Ran Sui, Zixue Luo, Qiang Lu
In-Situ Measurements Of Temperature And Emissivity During Msw Combustion Using Spectral Analysis And Multispectral Imaging Processing, Shu Zheng, Weiguang Cai, Ran Sui, Zixue Luo, Qiang Lu
Mechanical and Aerospace Engineering Faculty Research & Creative Works
By using a novel multispectral imaging technology, the 2-D distributions of flame temperature and emissivity were measured in a 16 MW incinerator to co-fire municipal solid waste (MSW) and municipal sludge. A way to establish the relationship between the multispectral flame images and the temperature was proposed by combing the Newton iteration method and Hottel emissivity model. The results showed that the measured temperatures at different locations varied by 31.25% with a fixed steam evaporation rate, and 11.76% with different steam evaporation rates at a given port. The temperatures and emissivities decreased at upper locations due to the lower local …
Juvenile Report, September 2022, Tennessee. Department Of Correction.
Juvenile Report, September 2022, Tennessee. Department Of Correction.
Juvenile Reports
No abstract provided.
Tennessee Felon Population Update, September 2022, Tennessee. Department Of Correction.
Tennessee Felon Population Update, September 2022, Tennessee. Department Of Correction.
Felon Population Reports
No abstract provided.
Together With Tosha Newsletter, September 2022, Tennessee. Department Of Labor & Workforce Development.
Together With Tosha Newsletter, September 2022, Tennessee. Department Of Labor & Workforce Development.
TOSHA Newsletter
No abstract provided.
Tennessee Labor Market Report, September 2022, Facts About U.S. Veterans, Tennessee. Department Of Labor & Workforce Development.
Tennessee Labor Market Report, September 2022, Facts About U.S. Veterans, Tennessee. Department Of Labor & Workforce Development.
Labor Market Reports
No abstract provided.
Natural Language Processing For Novel Writing, Leqing Qu, Okan Ersoy
Natural Language Processing For Novel Writing, Leqing Qu, Okan Ersoy
Department of Electrical and Computer Engineering Technical Reports
No abstract provided.