Digital Commons Network^™

Clinical Trial Data Of Anti-Pd-1/Pd-L1 Therapy For Recurrent Or Metastatic Nasopharyngeal Carcinoma: A Review, Douglas R Adkins, Robert I. Haddad

2020-Current year OA Pubs

IMPORTANCE: Anti-programmed cell death receptor-1 (PD-1) therapy is standard of care for incurable recurrent or metastatic non-nasopharyngeal head and neck cancer. In contrast, there are no regulatory agency-approved anti-PD-1 agents indicated for the treatment of recurrent or metastatic nasopharyngeal carcinomas (RM-NPC) in the Western hemisphere, and no standard treatment option exists beyond first-line chemotherapy for RM-NPC. The pace of development of novel systemic therapy regimens for RM-NPC has been slow compared to many other advanced tumor types, leaving an unmet clinical need for these patients with a poor prognosis.

OBSERVATIONS: Recent clinical trials have documented the clinical activity of anti-PD-1 …

Pharmacophore Modeling For Biological Targets With High Flexibility: Lxrβ Case Study, Sophia Kchouk, Lamees Hegazy

2020-Current year OA Pubs

No abstract provided.

Updated Diagnostic Criteria And Nomenclature For Neurofibromatosis Type 2 And Schwannomatosis: An International Consensus Recommendation, Scott R Plotkin, David H Gutmann, Et Al.

2020-Current year OA Pubs

PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in genetics, ophthalmology, neuropathology, and neuroimaging.

METHODS: We used a multistep process, beginning with a Delphi method involving global disease experts and subsequently involving non-neurofibromatosis clinical experts, patients, and foundations/patient advocacy groups.

RESULTS: We reached consensus on the minimal clinical and genetic criteria for diagnosing NF2 and SWN. These criteria incorporate mosaic forms of these conditions. In addition, we recommend updated nomenclature for these disorders to emphasize their …

Perspectives Of Participation In Daily Life From Cancer Survivors: A Qualitative Analysis, Allison J L'Hotta, Nirmala Shivakumar, Kathleen D Lyons, Audrey Trebelhorn, Annamayil Manohar, Allison A King

2020-Current year OA Pubs

OBJECTIVE: To characterize how survivors of cancer define participation.

DESIGN: Cross-sectional qualitative study.

SETTING: Participants were enrolled from a large academic medical center in the Midwestern United States. Interviews were conducted over Zoom or phone.

PARTICIPANTS: Survivors of cancer (N=40) with brain, breast, colorectal, or lung cancer (n=10 per group). Participants were purposively sampled to maximize variation in the study sample. Participant ages ranged from 26-83 years, with a mean age of 55 years. Seventy percent of participants were receiving active cancer treatment at the time of the interview.

INTERVENTIONS: Not applicable.

MAIN OUTCOME MEASURES: Participant perspectives gathered from 1-on-1 …

Recommendations For Whole Genome Sequencing In Diagnostics For Rare Diseases, Erika Souche, Sergi Beltran, Erwin Brosens, John W Belmont, Magdalena Fossum, Olaf Riess, Christian Gilissen, Amin Ardeshirdavani, Gunnar Houge, Marielle Van Gijn, Jill Clayton-Smith, Matthis Synofzik, Nicole De Leeuw, Zandra C Deans, Yasemin Dincer, Sebastian H Eck, Saskia Van Der Crabben, Meena Balasubramanian, Holm Graessner, Marc Sturm, Helen Firth, Alessandra Ferlini, Rima Nabbout, Elfride De Baere, Thomas Liehr, Milan Macek, Gert Matthijs, Hans Scheffer, Peter Bauer, Helger G Yntema, Marjan M Weiss

Center for Medical Ethics and Health Policy Staff Publications

In 2016, guidelines for diagnostic Next Generation Sequencing (NGS) have been published by EuroGentest in order to assist laboratories in the implementation and accreditation of NGS in a diagnostic setting. These guidelines mainly focused on Whole Exome Sequencing (WES) and targeted (gene panels) sequencing detecting small germline variants (Single Nucleotide Variants (SNVs) and insertions/deletions (indels)). Since then, Whole Genome Sequencing (WGS) has been increasingly introduced in the diagnosis of rare diseases as WGS allows the simultaneous detection of SNVs, Structural Variants (SVs) and other types of variants such as repeat expansions. The use of WGS in diagnostics warrants the re-evaluation …

Strengthening The Procedural Fidelity Research-To-Practice Loop In Animal Behavior, Tiffany Kodak, Samantha Bergmann, Mindy Waite

Psychology Faculty Research and Publications

Procedural fidelity is the extent to which components of an intervention are implemented as designed. Procedural fidelity is measured as a dependent variable and manipulated as an independent variable. In research and practice, procedural-fidelity data should be collected, monitored, and reported. Procedural fidelity as an independent variable has been investigated in humans using parametric analyses, and the current article summarizes some of the research conducted on the effects of procedural-fidelity errors in behavior-reduction and skill-acquisition interventions. Connections were drawn to applied animal researchers and the work of animal behavior practitioners to produce implications for practice with human and animal clients …

Remodeling Of The Cortical Structure Connectome In Posttraumatic Stress Disorder: Results From The Enigma-Pgc Posttraumatic Stress Disorder Consortium, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background

Posttraumatic Stress Disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).

Methods

Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n …

The Future Of Crispr Gene Editing According To Plant Scientists, Job De Lange, Lawton Lanier Nalley, Wei Yang, Aaron Shew, Hans De Steur

Agricultural Economics and Agribusiness Faculty Publications and Presentations

This study surveyed 669 plant scientists globally to elicit how (which outcomes of gene editing), where (which continent) and what (which crops) are most likely to benefit from CRISPR research and if there is a consensus about specific barriers to commercial adoption in agriculture. Further, we disaggregated public and private plant scientists to see if there was heterogeneity in their views of the future of CRISPR research. Our findings suggest that maize and soybeans are anticipated to benefit the most from CRISPR technology with fungus and virus resistance the most common vehicle for its implementation. Across the board, plant scientists …

Critical Care Nurse Burnout, Moral Distress, And Mental Health During The Covid-19 Pandemic: A United States Survey, Jill L. Guttormson, Kelly Calkins, Natalie S. Mcandrew, Jacklynn M. Fitzgerald, Holly Lynn Losurdo, Danielle Loonsfoot

Psychology Faculty Research and Publications

Background

The COVID-19 pandemic has and will continue to have a tremendous influence on intensive care unit (ICU) nurses’ mental health.

Objectives

The purpose of this study was to describe the impact of COVID-19 on nurse moral distress, burnout, and mental health.

Methods

Between October 2020 and January 2021 this descriptive study recruited a national sample of nurses who worked in the ICU during the COVID-19 pandemic through American Association of Critical Care Nurses newsletters and social media.

Results

A total of 488 survey responses were received from critical care nurses working in the U.S. during the COVID pandemic. Over …

Lindenwood Digest, September 1, 2022, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

An Integrated Approach For Controlling Verticillium Wilt Of Strawberry, Jack T. Koster

Master's Theses

Strawberry (Fragaria x ananassa, Duch.) is an important crop in California, with more than 35,000 acres planted in 2018 resulting in a farm gate value of $3.1 billion. In 2020, California strawberry production accounted for more than 85% of national strawberry production and faces serious threats to production due to various soil-borne diseases. One such disease, Verticillium wilt, is caused by the fungal pathogen Verticillium dahliae and is commonly found in temperate zones around the world where strawberries are grown. Due to the phase-out of efficacious fumigants like methyl bromide, alternative disease management methods have become necessary to …

Analysis Of Current And Future Flood Hazard In The Sacramento-San Joaquin Delta, Nicholas L. Mcguire

Master's Theses

The primary motivation of this study is to estimate the current and future flood hazard throughout the Sacramento-San Joaquin Delta in the context of sea-level rise. I also analyzed the effects of storm surge and river flow on extreme events to better understand how these events originate and vary spatially and in time. To address this goal, I combined digital water level records (primarily 1983-present) with archival data collected by the California Department of Water Resources (1929-1983) to reevaluate flood hazard in the Delta and investigate the possible sensitivity of the region different sea-level rise projections. Available archival records from …

Determination Of Fungicide Resistance In Botrytis Cinerea On Wine Grapes In California's Central Coast Region, Evelyn Alvarez-Mendoza

Master's Theses

Botrytis bunch rot, caused by Botrytis cinerea, is a fungal disease that primarily affects the fruit of wine grapes. Infection of fruit consequently results in reduced yields and wine quality. These factors lead to significant economic losses for growers which prompts the implementation of management practices to control the disease. One objective of this study was to evaluate the level of resistance that populations of B. cinerea in the Central Coast region showed to various chemicals. A fungicide assay was conducted to determine resistant phenotypes to six fungicide active ingredients (pyrimethanil, iprodione, fenhexamid, fludioxonil, trifloxystrobin, boscalid). Thirty-five (2020) and …

Design And Analysis Of A Discrete, Pcb-Level Low-Power, Microwave Cross-Coupled Differential Lc Voltage-Controlled Oscillator, Pavin Singh Virdee

Master's Theses

Radio Frequency (RF) and Microwave devices are typically implemented in Integrated Circuit (IC) form to minimize parasitics, increase precision and tolerances, and minimize size. Although IC fabrication for students and independent engineers is cost-prohibitive, an abundance of low-cost, easily accessible printed circuit board (PCB) and electronic component manufacturers allows affordable PCB fabrication.

While nearly all microwave voltage-controlled oscillator (VCO) designs are IC-based, this study presents a discrete PCB-level cross-coupled, differential LC VCO to demonstrate this more affordable and accessible approach. This thesis presents a 65 mW, discrete component VCO PCB with industry-comparable RF performance. A phase noise of -103.7 dBc/Hz …

Cofermentation, Post-Alcoholic, And Post-Malolactic Fermentation Blending Of Malbec, Merlot And Petite Sirah Wines, Armando Arturo Vega-Osorno

Master's Theses

A two-year study was conducted to assess the effects of cofermentation on red wine varietals. During the winemaking process, wines can be made from two or more varieties by picking, crushing and fermenting them together, a practice known as cofermentation. They can also be blended either after the completion of alcoholic fermentation or after malolactic fermentation. In the first year of the study, two grape varieties, Merlot (Mer), and Malbec (Mal) were cofermented. On the second year, a third varietal, Petite Sirah (PS) was also studied. Cofermented wines containing every possible binomial combination of the varietals was made and one …

Hydrologic Response Of Little Creek To The 2020 Czu Lightning Complex Fire At The Swanton Pacific Ranch, Kylie E. Dupuis

Master's Theses

In this study, stage, streamflow, and precipitation data was collected from small watersheds in the Swanton Pacific Ranch for the first two hydrologic years following the 2020 CZU Lightning Complex. The Little Creek watershed was setup for high-resolution data collection with four separate stage gauge sites (Main Stem, North Fork, South Fork, and Upper North Fork) and four rain gauge sites (Al Smith House, Ridgeline, Upper North Fork, and Landing 23). Stage gauge sites were also established at Queseria, Archibald, and Mill creeks. Preliminary post-fire rating curves were developed for the four sites of Little Creek. The Main Stem (MS) …

Optimal Standards Of Proof In Antitrust, Murat C. Mungan, Joshua Wright

Faculty Scholarship

Economic analyses of antitrust institutions have thus far focused predominantly on optimal penalties and the design of substantive legal rules, and have largely ignored the standard of proof used in trials as a policy tool in shaping behavior. This neglected tool can play a unique role in the antitrust context, where a given firm may have the choice to engage in exceptional anticompetitive or procompetitive behavior, or simply follow more conventional business practices. The standard of proof used in determining the legality of a firm’s conduct affects not only whether the firm chooses to engage in pro- versus anticompetitive behavior, …

Fashion In The Times Of War: The Recent Exodus Of Luxury Brands From Russia And What It Means For Trademark Law, Irene Calboli, Vera Sevastianova

Faculty Scholarship

In February 2022, Russia infamously invaded Ukraine, starting an unprovoked war. As a result, many foreign companies left their Russia-based operations, including most luxury fashion houses. In these remarks, we elaborate on the possible issues that these companies may face regarding the enforcement of their IP rights in Russia, particularly trademark rights, following their departure resulting from the sanctions imposed by Western countries.

At the time of writing, perhaps the most pressing issue is whether luxury fashion houses risk losing their trademark rights in Russia due to their decision to suspend their operations, even though temporarily. An additional issue facing …

Involvement Of Glutamine Synthetase 2 (Gs2) Amplification And Overexpression In Amaranthus Palmeri Resistance To Glufosinate, Matheus M. Noguera, Aimone Porri, Isabel S. Werle, James Heiser, Frank Brandle, Jens Lerchl, Brent Murphy, Michael Betz, Fanny Gatzmann, Martin Penkert, Clara Tuerk, Lucie Meyer, Nilda Roma-Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Amaranthus palmeri has recently evolved resistance to glufosinate herbicide. Several A. palmeri populations from Missouri and Mississippi, U.S.A. had survivors when sprayed with glufosinate-ammonium (GFA, 657 g ha⁻¹). One population, MO#2 (fourfold resistant) and its progeny (sixfold resistant), were used to study the resistance mechanism, focusing on the herbicide target glutamine synthetase (GS). We identified four GS genes in A. palmeri; three were transcribed: one coding for the plastidic protein (GS2) and two coding for cytoplasmic isoforms (GS1.1 and GS1.2). These isoforms did not contain mutations associated with resistance. The 17 glufosinate survivors …

A Case Study Of Community Of Inquiry Presences And Cognitive Load In Asynchronous Online Stem Courses, Emily K. Faulconer, Darryl J. Chamberlain Jr.

Publications

The design and facilitation of asynchronous online courses can have notable impacts on students related to persistence, performance, and perspectives. This case study presents current conditions for cognitive load and Community of Inquiry (CoI) presences in an asynchronous online introductory undergraduate STEM course. Researchers present the novel use of Python script to clean and organize data and a simplification of the instructional efficiency calculation for use of anonymous data. Key relationships between cognitive load and CoI presences are found through validated use of NASA-TLX instrument and transcript analysis of discussion posts. The data show that student presences are not consistent …

The Economic Impact Of Buying And Redeveloping Ellis Park By Churchill Downs, Thomas E. Lambert

Faculty and Staff Scholarship

Churchill Downs’ acquisition of Ellis Park Racing and Gaming in Henderson, Kentucky reflects the growing number of mergers across the US among racetracks, racetracks and casinos, and casinos with other casinos. Some years back, Ellis racetrack closed for one year due to declining profitability, yet after new ownership took over and a gaming center was added, it began a rebound in earnings (Courier and Press 2008). The $75 million that Churchill Downs plans to spend to transform Ellis Park (Schulz 2022) will have a much bigger impact than the construction, revamping, and expansion of park facilities. This is in addition …

Educating Sanitation Professionals: Moving From Stem To Specialist Training In Higher Education In Malawi., Brighton A. Chunga, David Mkwambisi, Cassandra L. Workman, Francis L. De Los Reyes Iii, Rochelle H. Holm

Faculty and Staff Scholarship

Achieving the United Nations Sustainable Development Goals (SDGs) requires effective changes in multiple sectors including education, economics, and health. Malawi faces challenges in attaining the SDGs in general, and specifically in the sanitation sector. This paper aims to describe the existing landscape within public universities in Malawi to build a framework for training a cadre of locally trained experts. This is achieved by reviewing science, technology, engineering, and mathematics (STEM) degree programmes and assessing the extent of inclusion of sanitation education. The historical compartmentalization of academic programmes has resulted in few programmes to build on. Deliberate investment is needed to …

Faculty Research Profile: Dr. Shang Jia, Lutishoor Salisbury, Fardy Faustin, Jeremy Smith

University Libraries Faculty Publications and Presentations

This poster was compiled to highlight Dr. Jia’s research as a new research faculty in the Department of the Chemistry and Biochemistry at the University of Arkansas. It provides a summary of his research achievements and his scholarly impact.

Hispanics And Latinos In The Military: The Path From Service To Veteran Entrepreneurship, Rosalinda V. Maury, Mirza Tihic, Adam Pritchard

Institute for Veterans and Military Families

This brief provides highlights from the 2021 National Survey of Military-Affiliated Entrepreneurs (NSMAE) focusing on Hispanic, Latino/a/x, or Spanish origin (for example Mexican or Mexican American, Salvadoran, Puerto Rican, Dominican, Cuban, Colombian, etc.) veteran entrepreneurs. NSMAE monitors trends in the activity, needs, and economic, social, and policy barriers of military-affiliated entrepreneurs in the United States.

The Employment Situation Of Veterans: August 2022, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

Veteran employment trends and statistics among various demographics during August 2022

Faculty Research Profile: Dr. Dylan Girodat, Lutishoor Salisbury, Fardy Faustin, Jeremy Smith

University Libraries Faculty Publications and Presentations

This poster was compiled to highlight Dr. Girodat’s research as a new faculty in the Department of the Chemistry and Biochemistry at the University of Arkansas. It provides a summary of his research achievements and his scholarly impact.

Context For Reproducibility And Replicability In Geospatial Unmanned Aircraft Systems, Cassandra Howe, Jason A. Tullis

Geosciences Faculty Publications and Presentations

Multiple scientific disciplines face a so-called crisis of reproducibility and replicability (R&R) in which the validity of methodologies is questioned due to an inability to confirm experimental results. Trust in information technology (IT)-intensive workflows within geographic information science (GIScience), remote sensing, and photogrammetry depends on solutions to R&R challenges affecting multiple computationally driven disciplines. To date, there have only been very limited efforts to overcome R&R-related issues in remote sensing workflows in general, let alone those tied to unmanned aircraft systems (UAS) as a disruptive technology. This review identifies key barriers to, and suggests best practices for, R&R in geospatial …

Cutaneous Manifestations Of Nutritional Deficiencies In The Context Of Food Deserts Of United States., Justin P Canakis, Shane M. Swink Do, Nicholas P Valle, Diana A. Rivers Do, Kristina M. Lim Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do, Cynthia L. Bartus Md

Department of Medicine

Food deserts exist due to a multitude of factors ranging from socioeconomic status, racial disparities, geography, cost, and healthful food access. Given the vast biological function of vitamins and minerals, the clinical presentation for nutritional deficiencies ranges from benign to life-threatening. Often, the first indicators of underlying nutritional deficiencies are cutaneous manifestations. The first patient case is a 36-year-old female at 25 weeks gestation with a pruritic and painful rash that began in the genital region and spread centrifugally to her legs. The second patient case is a 42-year-old male with a pruritic rash that began at his abdomen and …

Love In The Time Of Covid, Jeanne L. Schroeder

Articles

A striking aspect of the current American cultural divide is divergent attitudes towards expertise, generally, and masking and vaccination to mitigate the Covid-19 pandemic, specifically. Liberal pundits profess shock that Red State America won’t just ‘trust the science’. On the right, politicians and television personalities reject mandates in the name of ‘freedom’.

Lacanian discourse theory gives insight into this. The rejection of expertise is an example of an ‘hysteric discourse’ challenging a ‘university discourse’: the regime of experts. An hysteric discourse is a critique of rules imposed by experts by the subjects-subjected-to them. Hysteria can lead, in turn, to a …

High-Coverage Whole-Genome Sequencing Of The Expanded 1000 Genomes Project Cohort Including 602 Trios, Marta Byrska-Bishop, Haley J Abel, Allison A Regier, Ira M Hall, Et Al.

2020-Current year OA Pubs

The 1000 Genomes Project (1kGP) is the largest fully open resource of whole-genome sequencing (WGS) data consented for public distribution without access or use restrictions. The final, phase 3 release of the 1kGP included 2,504 unrelated samples from 26 populations and was based primarily on low-coverage WGS. Here, we present a high-coverage 3,202-sample WGS 1kGP resource, which now includes 602 complete trios, sequenced to a depth of 30X using Illumina. We performed single-nucleotide variant (SNV) and short insertion and deletion (INDEL) discovery and generated a comprehensive set of structural variants (SVs) by integrating multiple analytic methods through a machine learning …