Digital Commons Network^™

Genome-Wide Interaction Analysis Identified Low-Frequency Variants With Sex Disparity In Lung Cancer Risk, Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James Mckay, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Maria T Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John K Field, Michael P A Davies, Sanjay S Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Hongbing Shen, Ryan Sun, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn M Teare, Yun-Chul Hong, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Ann G Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Yanhong Liu, Younghun Han, Joan E Bailey-Wilson, Susan M Pinney, Diptasri Mandal, James C Willey, Colette Gaba, Paul Brennan, Christopher I Amos, Integral-Ilcco Lung Cancer Consortium

Faculty, Staff and Students Publications

Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.

Iwu Ranked Among Best Colleges By Princeton Review, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

2021 3q Btl Daily Pts Field Dump, Environmental Protection Agency, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Midterm Oral Exams Add Value As A Predictor Of Final Written Exam Performance In Engineering Classes: A Multiple Regression Analysis, Minju Kim, Celeste Pilegard, Huihui Qi, Curt Schurgers, Marko Lubarda, Saharnaz Baghdadchi, Alex Phan

Psychology Faculty Articles and Research

What is gained when midterm oral exams are implemented in the undergraduate engineering classroom? This research paper examines whether midterm oral exam scores add value above and beyond midterm written exam scores in predicting students’ final written exam scores. The purpose of this study is to evaluate the potential utility of oral exams as formative assessments: if oral exam scores provide additional information beyond written exam scores, they may add meaningful value for students and instructors. The current study investigates this question using data from 10 undergraduate engineering classes (N = 925), representing 6 different courses and 5 different instructors. …

Advancing Student Futures In Stem, Urmi Ghosh-Dastidar, Sandie Han, Nadia Kennedy, Diana Samaroo Phd, Armando Solis

Publications and Research

This work reports a programmatic effort devoted to increasing diversity, equity, and inclusion in STEM education at a Hispanic-serving undergraduate higher-education institution. Between Fall 2015 and Spring 2020, the STEM program offered comprehensive academic and financial support to ninety-four students from five STEM majors: Bachelor of Science degrees in Biomedical Informatics, Applied Chemistry, and Applied Mathematics; and Associate of Science degrees in Chemical Technology and Computer Science. The goals of the program were to: (1) support, retain and graduate academically talented low-income and underrepresented minority students in the five targeted STEM majors; (2) establish a model for a comprehensive support …

Michael Robert Tilleman, Appellant V. Michal Christine Tilleman, Appellee : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

appeal from an order of the Honorable James Brady in the Fourth Judicial District Court, Case No. 164402522

Julie J. Nelson, Attorney for Michael Robert Tilleman

Douglas B. Thayer, Attorneys for Michal Christine Tilleman

Do Undergraduate Data Science Program Competencies Vary By College Rankings?, Elizabeth Milonas, Qiping Zhang, Duo Li

Publications and Research

No abstract provided.

Building Capacity: Enhancing Undergraduate Stem Education By Improving Transfer Success, Pamela Brown

Publications and Research

Several evidence-based practices were combined to reduce barriers to transfer from associate to baccalaureate programs, and baccalaureate degree completion. The first strategy was creation of the STEM Transfer Collaborative (STC), an adaption of the CUNY Pathways general education articulation initiative (1). The STC focuses on collaboration by both the sending and receiving college faculty to begin transfer preparation and support before transfer occurs, through articulation agreements, shared professional development to align pedagogy and curriculum, and outreach to potential transfer students. There was also regular feedback to community college faculty on the success of their transfer students. A second strategy employed …

Retaining Diverse Groups In Stem, Melanie L. Villatoro

Publications and Research

Colleges across the United States must produce more engineering graduates in order to keep up with demands in the engineering workforce. Population trends indicate that women and minorities are highly underrepresented in the STEM fields therefore recruitment and retention of these populations is critical to closing the predicted gap in the workforce. Perkins Peer Advisement is a grant funded program at New York City College of Technology (City Tech) committed to increasing enrollment and retention of nontraditional students in engineering technology programs. Program activities include professional development, mentoring, and community outreach. Participants of the program have higher retention rates than …

In-Person Instruction Or Remote Learning?: Understanding Students' Learning Experiences During Covid-19, Eleazar Marquez, Samuel Garcia

Mechanical Engineering Faculty Publications

Research attests that student success in engineering education is cultivated largely due to classroom environments, academic inclusion, and engagement in undergraduate research. It is further revealed that the social and academic fabric of the institution such as academic advising, peer tutoring, disability services, and outdoor recreational programs is essential towards fostering well-being, recruitment, retention, and student success. However, these studies were conducted in a period in which students experienced traditional face-to-face instruction. In the wake of COVID-19, most institutions responded by terminating in-person instruction, mandating to seek off-campus housing, and shifting to a fully remote context. As such, educators were …

Narratives Close The Gap: The Limited Role Of Temporal Distance In Binding Events Into Coherent Memories, Angelique Delarazan

Arts & Sciences Graduate Student Theses and Dissertations

Temporal information has been identified as a powerful influence on memory retrieval. Much of this arise from studies that tend to focus on associations between items. In contrast, real-life experiences consist of discrete events that encompass more than mere associations. While events can be remembered based on temporal proximity, events that are farther apart in time can also be linked together by forming a coherent narrative. Given that daily experiences are multifaceted, it is unclear to what extent prior work generalizes to real-world memories. Here, we sought to determine the influence of temporal features and narrative coherence on memory for …

Morphodynamics Of Wave-Dominated Beaches, B Castelle, G Masselink

School of Biological and Marine Sciences

Abstract Wave-dominated sandy beaches are highly valued by societies and are amongst the world’s most energetic and dynamic environments. On wave-dominated beaches with unlimited sand supply and limited influence of tide and geology, beach change has long been conceptualised in the morphodynamic framework of Wright and Short (1984). Such framework describes the occurrence of beach types based on wave conditions and sediment characteristics across the complete reflective–dissipative spectrum. Building on theoretical work, field/laboratory measurements and monitoring programmes, the physical mechanisms underpinning this morphodynamic framework have been progressively unravelled. Cross-shore morphological changes are primarily controlled by equilibrium and beach memory principles …

2021 Btl O&M Events Log / 2021 Daily Log, Pioneer Technical Services, Inc., Environmental Protection Agency

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2021 3q Laboratory Edds, Pioneer Technical Services, Inc., Environmental Protection Agency

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2021 3q Btl Chemdump, Pioneer Technical Services, Inc., Environmental Protection Agency

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Novel Dominant And Recessive Variants In Human Robo1 Cause Distinct Neurodevelopmental Defects Through Different Mechanisms, Yan Huang, Mengqi Ma, Xiao Mao, Davut Pehlivan, Oguz Kanca, Feride Un-Candan, Li Shu, Gulsen Akay, Tadahiro Mitani, Shenzhao Lu, Sukru Candan, Hua Wang, Bo Xiao, James R Lupski, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The Roundabout (Robo) receptors, located on growth cones of neurons, induce axon repulsion in response to the extracellular ligand Slit. The Robo family of proteins controls midline crossing of commissural neurons during development in flies. Mono- and bi-allelic variants in human ROBO1 (HGNC: 10249) have been associated with incomplete penetrance and variable expressivity for a breath of phenotypes, including neurodevelopmental defects such as strabismus, pituitary defects, intellectual impairment, as well as defects in heart and kidney. Here, we report two novel ROBO1 variants associated with very distinct phenotypes. A homozygous missense p.S1522L variant in three affected siblings with nystagmus; and …

Sketchtivity, An Intelligent Tutoring Software: Broadening Applications And Impact, Morgan Weaver, Hillary Merzdorf, Donna Jaison, Vimal Kumar Viswanathan, Kerrie A. Douglas, Tracy Anne Hammond, Julie S. Linsey

Faculty Research, Scholarly, and Creative Activity

Freehand sketching is an essential skill for engineers. Sketching enables designers to represent ideas rapidly and offload working memory. Sketches in the design process also correlate with positive design outcomes. Teaching sketching to engineers, however, presents many challenges in engineering curriculums. Sketching is most often taught in large entry-level courses where individualized feedback, which is vital to learning sketching, is not possible. Sketchtivity is an intelligent tutoring software designed to aid in the practice and feedback on freehand sketching skills. Sketchtivity teaches the basics of two-point perspective sketching providing lessons, feedback, and tips on how to improve. The goal of …

Two Interaction Surfaces Between Xpa And Rpa Organize The Preincision Complex In Nucleotide Excision Repair, Mihyun Kim, Hyun-Suk Kim, Areetha D'Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka Topolska-Wós, Kateryna Ogorodnik Le Meur, Chi-Lin Tsai, Miaw-Sheue Tsai, Minyong Kee, John A Tainer, Jung-Eun Yeo, Walter J Chazin, Orlando D Schärer

Faculty, Staff and Student Publications

The xeroderma pigmentosum protein A (XPA) and replication protein A (RPA) proteins fulfill essential roles in the assembly of the preincision complex in the nucleotide excision repair (NER) pathway. We have previously characterized the two interaction sites, one between the XPA N-terminal (XPA-N) disordered domain and the RPA32 C-terminal domain (RPA32C), and the other with the XPA DNA binding domain (DBD) and the RPA70AB DBDs. Here, we show that XPA mutations that inhibit the physical interaction in either site reduce NER activity in biochemical and cellular systems. Combining mutations in the two sites leads to an additive inhibition of NER, …

Grk3 Is A Poor Prognosticator And Serves As A Therapeutic Target In Advanced Gastric Adenocarcinoma, Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho, Kevin N Dalby, Namita D Shanbhag, Zhenning Wang, Wenliang Li, Shumei Song, Jaffer A Ajani

Faculty, Staff and Student Publications

Background: G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma (GAC) patients. However, GRK3's functions and clinical utility in GAC progression and metastases are unknown.

Methods: We studied GRK3 expression in normal, primary, and metastatic GAC tissues. We identified a novel GRK3 inhibitor, LD2, through a chemical-library screen. Through genetic and pharmacologic modulations of GRK3, a series of functional and molecular studies were performed in vitro and in vivo. Impact of GRK3 on …

Understanding The Views Of Beef Show Cattle Parents And The Reasons Why Their Children Participate In Beef Cattle Shows, Matt Schiel

LSU Master's Theses

The population for this qualitative study were 10 families who participated in showing a heifer at the 2022 Fort Worth Stock Show and Rodeo during the junior heifer show weekend. The families were all from Texas. This study examined why parents allow their children to participate in showing cattle using a case study design. The study was grounded in human capital theory. Interviews and observations were used for the study’s findings. Results showed that the children who showed beef cattle learned responsibility, interpersonal skills, character development, and hard work.

Future research topics include further case studies using the same methodology …

Whole Genome Association Study Of The Plasma Metabolome Identifies Metabolites Linked To Cardiometabolic Disease In Black Individuals, Usman A. Tahir, Daniel H. Katz, Julian Avila-Pachecho, Alexander G. Bick, Akhil Pampana, John Blangero, Joanne Curran, Juan M. Peralta, Harald H. H. Goring, Michael Mahaney

School of Medicine Publications

Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known metabolites, with the majority of the profiled peaks left unannotated. Here, we perform a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study. We identify 519 locus-metabolite associations for 427 metabolite peaks and validate our findings in two multi-ethnic cohorts. A significant proportion of these …

10577877 Edd, Environmental Protection Agency, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Perioperative Mental Health Intervention Bundle For Older Surgical Patients: Protocol For An Intervention Development And Feasibility Study, Joanna Abraham, Katherine J Holzer, Emily M Lenard, Kenneth E Freedland, Bethany R Tellor Pennington, Rachel C Wolfe, Theresa A Cordner, Ana A Baumann, Mary Politi, Michael Simon Avidan, Eric Lenze

2020-Current year OA Pubs

INTRODUCTION: The perioperative period is high risk for older adults. Depression and anxiety are common perioperative problems, frequently coexisting with cognitive impairment. Older patients with these conditions are more likely than younger patients to experience postoperative delirium, long hospital stays, poor quality of life and rehospitalisation. These experiences can, in turn, exacerbate anxiety and depressive symptoms. Despite these risks, little is known about how to treat perioperative anxiety and depression among older adults.

METHODS AND ANALYSIS: We designed a feasibility study of a perioperative mental health intervention bundle to improve perioperative mental health, specifically depression and anxiety. The overarching goals …

Layer-Specific Developmentally Precise Axon Targeting Of Transient Suppressed-By-Contrast Retinal Ganglion Cells (Tsbc Rgcs), Nai-Wen Tien, Carmela Vitale, Tudor C Badea, Daniel Kerschensteiner

2020-Current year OA Pubs

The mouse retina encodes diverse visual features in the spike trains of >40 retinal ganglion cell (RGC) types. Each RGC type innervates a specific subset of the >50 retinorecipient brain areas. Our catalog of RGC types and feature representations is nearing completion. Yet, we know little about where specific RGC types send their information. Furthermore, the developmental strategies by which RGC axons choose their targets and pattern their terminal arbors remain obscure. Here, we identify a genetic intersection (

C10pred: A First Machine Learning Based Tool To Predict C10 Family Cysteine Peptidases Using Sequence-Derived Features, Adeel Malik, Nitin Mahajan, Tanveer Ali Dar, Chang-Bae Kim

2020-Current year OA Pubs

No abstract provided.

Strategic Management Of A Finnish Bus Company: Challenges And Opportunities, Billy Mushi, Sajal Kabiraj, Juha Mustonen

Management Dynamics

Undoubtedly, strategic management's role has enabled businesses to attain growth, adapt to new trends, and face competition. While examining the bus transportation industry in Finland, which faces competition, we demand to know whether it will lead to a case company's success and competitive advantage by assessing its strategic management methods. Moreover, results show that the case company has gone through many challenging threats throughout its existence. However, by conducting a strategic assessment, strategic choice, and implementing other strategic management methods specified in this case study, the company can grow and compete against other bus transport services companies in Finland.

Predicted Binders For Mnk2 But Not Mnk1 Protein Targets From Machine Learning, Pratik Worah, Wen Torng, Jw Feng

Defensive Publications Series

We used datasets from affinity screening to train machine learning models. The models were then used to rank compounds from commercially available compound collections to generate the following lists of predicted binders for MNK2 but non-binders for MNK1.

Reimagining Classroom Assessment And Feedback To Meet Learner Needs, Fabienne Van Der Kleij

2021-2030 ACER Research Conferences

The power of classroom assessment and feedback to improve student learning outcomes has long been recognised. Yet, decades of research have yielded disappointing and often conflicting outcomes. This presentation challenges traditional conceptions of classroom assessment and feedback as teacher-driven practices. To meet learner needs better, it proposes a student-centred perspective in which students are active and have agency. By drawing on an extensive study of feedback reviews, this presentation illustrates how conceptualisations of feedback have changed over recent decades. This paper provides key insights into how classroom assessment and feedback practices can be changed in ways that are sustainable, afford …

Acer Models Of Writing: Changing The Assessment Mindset, Juliette Mendelovits, Judy Nixon

2021-2030 ACER Research Conferences

This presentation outlines different models of writing assessment that have a proven track record in various programs delivered by ACER. These models include holistic scoring, and partial analytical scoring on a number of criteria. The writing prompts for these models assume extended pieces of writing. The presentation will also introduce a new and alternative model of writing assessment that ACER has implemented in several large-scale assessments. This model is built on shorter pieces of writing from each student, designed to give more accurate and diverse insights into students’ proficiency in writing in a range of text types, within the constraints …

Reimagining The Purpose Of Assessment, Geoff N. Masters

2021-2030 ACER Research Conferences

Assessment is commonly understood as the process of judging how well students have learnt what they have been taught. It comes at the end of a sequence that begins with a curriculum or course syllabus. Teachers are expected to deliver this body of specified content, students are expected to learn it, and assessment is the process of judging and grading students on how well they have learnt what teachers have taught. This is a common view of assessment among students, parents and many teachers. I will argue in this presentation that this traditional understanding of what it means to learn …