Digital Commons Network^™

Optimasi Hubungan Kuantitatif Struktur Senyawa Turunan Quercetin Yang Berpotensi Terhadap Aktivitas Antivirus Dengue Dengan Metode Austin Model 1, Ika Diana Evita, Charles Banon, Salprima Yudha, Morina Adfa

Chimica et Natura Acta

Antivirus dengue merupakan suatu senyawa yang memiliki kemampuan dalam menghambat aktivitas dari virus DENV. Salah satu senyawa yang memiliki aktivitas antivirus dengue yaitu quercetin. Telah dilakukan analisis Hubungan Kuantitatif Struktur Aktivitas (HKSA) secara teoritik dengan memprediksi turunan senyawa quercetin yang dioptimasi dengan menggantikan atom H dan gugus –OH dengan substituen NO2 dan/atau F (flour) pada posisi 3, 5, 7, 8, 2’, 3’, 4’ dan 5’, sehingga didapatkan 16 senyawa turunan quercetin. Metode yang digunakan adalah semiempiris AM1 dengan aplikasi Hyperchem 8.0.8 untuk pengoptimasi struktur dan metode backward untuk analisis regresi multilinier dengan aplikasi SPSS v24.0. Analisis regresi multilinier menunjukkan bahwa …

Bioplastik Berbahan Dasar Tepung Tapioka Dengan Modifikasi Gliserin Dan Serat Bambu, Herman Yoseph Sriyana, Berliana Putri Indrasmara

Chimica et Natura Acta

Plastik konvensional yang saat ini sering digunakan berasal dari polimer minyak bumi yang tidak dapat diperbaharui dan sulit terurai oleh mikroorganisme sehingga mencemari lingkungan. Bioplastik adalah plastik yang terbuat dari bahan alam yang mampu terurai oleh mikroorganisme menghasilkan air dan gas karbon dioksida. Bioplastik merupakan solusi untuk mengatasi pencemaran lingkungan yang disebabkan oleh plastik yang tidak mudah terurai. Tepung tapioka dengan kandungan pati yang tinggi sebesar 98% berpotensi sebagai bahan baku pembuatan bioplastik. Penelitian ini bertujuan untuk mengetahui karakteristik bioplastik dari tepung tapioka dengan modifikasi gliserin dan serat bambu. Gliserin dan serat bambu ditambahkan dengan tujuan meningkatkan karakteristik bioplastik. Meliputi …

Karakterisasi Hasil Reaksi Ion Gadolinium (Iii) Dengan Ligan Dibutilditiokarbamat Menggunakan Metode Mekanika Molekular (Mm2), Sani Widyastuti Pratiwi, Anni Anggraeni, Husein H. Bahti

Chimica et Natura Acta

Gadolinium dalam bentuk murni memiliki nilai ekonomis tinggi banyak digunakan untuk keperluan industri, kedokteran, kimia,dan metalurgi. Dibutilditiokarbamat merupakan ligan dengan dua atom sulfur yang berperan sebagai donor atom sehingga dapat membentuk kompleks dengan gadolinium. Dengan simulasi dinamika molekul dapat mempelajari sifat makroskopik suatu sistem melalui simulasi mikroskopik Dalam penelitian ini akan diprediksikan struktur dari senyawa gadolinium(III) dibutilditiokarbamat berdasarkan energi sterik yang dihasilkan dari dinamika molekul dalam berbagai pelarut. Dalam penentuan struktur ini digunakan metoda mekanika molekul (MM2) dengan perangkat lunak CS ChemBio3D Ultra 12.0. Dinamika molekul diatur pada suhu  25°C dengan variasi pelarut. hasil dinamika molekul dari senyawa gadolinium(III) dibutilditiokarbamat …

Sintesis Dan Karakterisasi Nanopartikel Zirkonia Terstabilkan Kalsium (Csz) Berbasis Prekursor Zirkonium Hidroksida Dari Pasir Zirkon Menggunakan Templat Etilen Glikol, Hasna Rofifah Novianti, Eneng Maryani, Diana Rakhmawaty Eddy, Solihudin Solihudin, Ferry Arifiadi, Dewi Idamayanti

Chimica et Natura Acta

Zirkonia yang distabilkan (stabilized zirconia) sangat menjanjikan karena memiliki sifat fisik, mekanik, termal, serta biokompatibilitas yang baik. Penelitian terkini memperlihatkan zirkonia yang distabilkan dapat digunakan pada bidang lingkungan, elektrolit, dan katalis. Zirkonia memiliki tiga fase yang stabil pada rentang suhu berbeda yaitu fase monoklinik, tetragonal dan kubik. Transformasi yang terjadi dari fase tetragonal ke monoklinik menyebabkan terjadinya retak mikro. Zirkonia perlu ditambahkan doping untuk dapat stabil selama pendinginan setelah tahap kalsinasi. Telah dilakukan sintesis zirkonia yang distabilkan dengan penambahan doping CaCl2 sebesar 1, 5 dan 10% b/b serta variasi suhu 600, 800 dan 1000°C untuk melihat pengaruhnya terhadap pembentukan fase …

Karakterisasi Enzim Amilase Isolat Bakteri R2m Larva Kumbang Sagu Dari Luwu Utara, Maswati Baharuddin, Nur Alfina, Amalyah Febryanti, Fitria Azis, Wulan Wahyuningsih

Chimica et Natura Acta

Karakterisasi ekstrak kasar enzim amilase isolat bakteri R2M dari larva kumbang sagu telah dilakukan. Penelitian ini bertujuan untuk mengetahui aktivitas enzim amilase pada suhu, pH, dan konsentrasi substrat optimum terhadap substrat amilum murni dan amilum dari kulit singkong. Penentuan aktivitas enzim amilase menggunakan metode asam 3,5-dinitrosalisilat (DNS) yang diukur dengan spektrofotometer visible pada panjang gelombang (λ) 540 nm. Hasil penelitian menunjukkan bahwa enzim amilase isolat bakteri R2M larva kumbang sagu yang direaksikan dengan substrat amilum optimum pada suhu 70°C, pH 4, dan konsentrasi substrat 1,25% dengan aktivitas enzim masing-masing sebesar 0,116 U/mL; 0,049 U/mL; dan 0,044 U/mL. Aktivitas enzim amilase …

Peningkatan Efisiensi Dye Sentisized Solar Cell (Dssc) Dari Antosianin Kulit Manggis (Garcinia Mangostana L) Menggunakan Papain, Ika Nirmalasari, Ratri Ariatmi Nugrahani, Budiyanto Budiyanto

Chimica et Natura Acta

Untuk membantu aksesibilitas energi listrik, sumber energi alternatif misalnya, sel berorientasi matahari telah dibuat. Dye Sentisized Solar Cell (DSSC) mengubah energi bertenaga matahari menjadi energi listrik dengan zat warna (dye) sebagai sensitizer dan semikonduktor sebagai elektroda. TiO2 diaplikasikan pada kaca konduktif indium tin oxide (ITO) sebagai elektroda di DSSC. Warna sebagai sensitizer yang digunakan adalah antosianin dari kulit manggis. Tujuan penelitian ini adalah melakukan ekstraksi antosianin kulit manggis dengan metode maserasi,  menghasilkan DSSC yang dapat mengkonversi secara maksimal energi cahaya menjadi energi listrik dengan material komposit grafit-TiO2 menggunakan dye organik ekstrak manggis dan papain; menentukan pengaruh variasi waktu perendaman dye …

The Impacts Of Shariah-Compliant Hotel Attributes On Muslim Travellers Revisit Intention: Religiosity As A Moderator, Zaidatul Akma Sulaiman, Mohammad Iranmanesh, Behzad Foroughi, Othman Rosly

Research outputs 2014 to 2021

Purpose

This paper aims to investigate the impact of Shariah-compliant hotel attributes on Muslim travellers’ revisit intention.

Design/methodology/approach

A total of 361 Muslim travellers who have stayed at Shariah-compliant hotels in the previous 12 months were recruited to take part in this research. The hypothesized research model was assessed using the partial least squares (PLS) approach.

Findings

The analysis revealed that Muslim travellers’ revisit intention is dependent on the halal food and beverages and the provision of Shariah-compliant facilities at the hotel, whereas the Shariah-compliant operation and interior design of hotels are not significantly associated with it. The findings also …

Subcortical-Cortical Dynamical States Of The Human Brain And Their Breakdown In Stroke, Chiara Favaretto, Michele Allegra, Gustavo Deco, Nicholas V Metcalf, Joseph C Griffis, Gordon L Shulman, Andrea Brovelli, Maurizio Corbetta

2020-Current year OA Pubs

The mechanisms controlling dynamical patterns in spontaneous brain activity are poorly understood. Here, we provide evidence that cortical dynamics in the ultra-slow frequency range (<0.01-0.1 Hz) requires intact cortical-subcortical communication. Using functional magnetic resonance imaging (fMRI) at rest, we identify Dynamic Functional States (DFSs), transient but recurrent clusters of cortical and subcortical regions synchronizing at ultra-slow frequencies. We observe that shifts in cortical clusters are temporally coincident with shifts in subcortical clusters, with cortical regions flexibly synchronizing with either limbic regions (hippocampus/amygdala), or subcortical nuclei (thalamus/basal ganglia). Focal lesions induced by stroke, especially those damaging white matter connections between basal ganglia/thalamus and cortex, provoke anomalies in the fraction times, dwell times, and transitions between DFSs, causing a bias toward abnormal network integration. Dynamical anomalies observed 2 weeks after stroke recover in time and contribute to explaining neurological impairment and long-term outcome.

Mutant P53 Depletion By Novel Inhibitors For Hsp40/J-Domain Proteins Derived From The Natural Compound Plumbagin., Mohamed A.A. Alalem, Mrinalini Bhosale, Atul Ranjan, Satomi Yamamoto, Atsushi Kaida, Shigeto Nishikawa, Alejandro Parrales, Sana Farooki, Shrikant Anant, Subhash Padhye, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Accumulation of missense mutant p53 (mutp53) in cancers promotes malignant progression. DNAJA1, a member of HSP40 (also known as J-domain proteins: JDPs), is shown to prevent misfolded or conformational mutp53 from proteasomal degradation. Given frequent addiction of cancers to oncogenic mutp53, depleting mutp53 by DNAJA1 inhibition is a promising approach for cancer therapy. However, there is no clinically available inhibitor for DNAJA1. Our in silico molecular docking study with a natural compound-derived small molecule library identified a plumbagin derivative, PLIHZ (plumbagin-isoniazid analog), as a potential compound binding to the J domain of DNAJA1. PLIHZ efficiently reduced the levels of DNAJA1 …

Friendly But Faulty: A Pilot Study On The Perceived Trust Of Older Adults In A Social Robot, Ioanna Giorgi, Francesca Tirotto, Oksana Hagen, Farida Aider, Mario Gianni, Marco Palomino, Giovanni L. Masala

School of Engineering, Computing and Mathematics

No abstract provided.

Recital: Jury Recognition, August 29, 2022, Illinois State University School Of Music

School of Music Programs

Kemp Recital Hall
August 29, 2022
Monday Evening
7:30 p.m.

A New Technique For Solving Neutral Delay Differential Equations Based On Euler Wavelets, Mutaz Mohammad, Alexander Trounev

All Works

An effective numerical scheme based on Euler wavelets is proposed for numerically solving a class of neutral delay differential equations. The technique explores the numerical solution via Euler wavelet truncated series generated by a set of functions and matrix inversion of some collocation points. Based on the operational matrix, the neutral delay differential equations are reduced to a system of algebraic equations, which is solved through a numerical algorithm. The effectiveness and efficiency of the technique have been illustrated by several examples of neutral delay differential equations. The main advantages and key role of using the Euler wavelets in this …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

The George-Anne Reflector Magazine Newsletter, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

A Most Christian King: Church And State During The Reign Of Henry Iii Of England, Mason Gerald Smith

History Theses, Dissertations, and Student Creative Activity

The reign of Henry III (1216-1272) was one of many firsts. The first reign under the Magna Carta, a watershed reign for relations with the Papacy, and demonstrated the degree to which Church and State were integrally united during his reign, to the degree that it is anachronistic to speak of them as two separate institutions. The reign of Henry III was marked by religious sensibility from the beginning of his reign in the minority, shepherded by his regents: Papal Legates and his educator Bishop Peter Des Roches. Henry’s life reflected his position in relation to the English Kingdom and …

Comorbidity Of Novel Crhr2 Gene Variants In Type 2 Diabetes And Depression, Mutaz Amin, Jurg Ott, Derek Gordon, Rongling Wu, Teodor T Postolache, Michael Vergare, Claudia Gragnoli

Department of Psychiatry and Human Behavior Faculty Papers

The corticotropin-releasing hormone receptor 2 (CRHR2) gene encodes CRHR2, contributing to the hypothalamic-pituitary-adrenal stress response and to hyperglycemia and insulin resistance. CRHR2-/- mice are hypersensitive to stress, and the CRHR2 locus has been linked to type 2 diabetes and depression. While CRHR2 variants confer risk for mood disorders, MDD, and type 2 diabetes, they have not been investigated in familial T2D and MDD. In 212 Italian families with type 2 diabetes and depression, we tested 17 CRHR2 single nucleotide polymorphisms (SNPs), using two-point parametric-linkage and linkage-disequilibrium (i.e., association) analysis (models: dominant-complete-penetrance-D1, dominant-incomplete-penetrance-D2, recessive-complete-penetrance-R1, recessive-incomplete-penetrance-R2). We detected novel linkage/linkage-disequilibrium/association …

Research On Safe Return To Port Capability Of Large Ships And Its Key Factors, Tian Wu

World Maritime University Dissertations

No abstract provided.

Research On The Development Of Port Digitalization And Swot Analysis For Digital Ports, Ling Dong

World Maritime University Dissertations

No abstract provided.

Environment Protection In The South China Sea : A Study Of The Applicability In The Designation Of A Particularly Sensitive Sea Area (Pssa), Tao Yang

World Maritime University Dissertations

No abstract provided.

The Attack On The Vasily Bekh And Targeting Logistics Ships, James Kraska

International Law Studies

This article originally appeared in Articles of War, the online publication of the Lieber Institute at the U.S. Military Academy, July 11, 2022, https://lieber.westpoint.edu/attack-vasily-bekh-targeting-logistics-ships/.

Maritime Exclusion Zones In Armed Conflicts, Raul (Pete) Pedrozo

International Law Studies

This article originally appeared in Articles of War, the online publication of the Lieber Institute at the U.S. Military Academy, Apr. 12, 2022, https://lieber.westpoint.edu/maritime-exclusion-zones-armed-conflicts/.

Do Educators Value The Promotion Of Students’ Wellbeing? Quantifying Educators’ Attitudes Toward Wellbeing Promotion, David Byrne, Colm Mcguinness Phd, Aiden Carthy Phd

Articles

Educators’ attitudes toward Social and Emotional Learning (SEL) and health and wellbeing promotion can significantly influence the success (or otherwise) of such policies and practices. While numerous studies exist, from which a broad understanding of such attitudes can be garnered, there is currently no attendant measurement which quantifies educators attitudes regarding the promotion of student wellbeing. The aim of this study was to address this gap in knowledge by quantifying the degree to which educators are positively or negatively disposed to the promotion of student wellbeing. The Attitudes Toward Wellbeing Promotion (ATWP) scale was administered …

Are Women With Disabilities Less Likely To Utilize Essential Maternal And Reproductive Health Services?-A Secondary Analysis Of Pakistan Demographic Health Survey, Shafaq Mahmood, Waqas Hameed, Sameen Siddiqi

Community Health Sciences

Background: People with disabilities deal with widespread exclusion from healthcare services, including sexual and reproductive health (SRH) rights. Studies analyzing the relationship between disability and key SRH utilization outcomes have often reported mixed findings. In Pakistan, very little to no literature is available on this topic, therefore we aim to determine inequalities in the utilization of essential maternal and reproductive health services between women with and without disabilities in Pakistan.
Methods: This was a secondary analysis of Pakistan Demographic Health Survey 2017-18 performed on a weighted sample of 6,711 women aged 15-49 years with a live birth in the 5 …

Modeling Radiation Belt Electrons With Information Theory Informed Neural Networks, Simon Wing, Drew L. Turner, Aleksandr Y. Ukhorskiy, Jay R. Johnson, Thomas Sotirelis, Romina Nikoukar, Giuseppe Romeo

Faculty Publications

An empirical model of radiation belt relativistic electrons (μ = 560–875 MeV G−1 and I = 0.088–0.14 RE G0.5) with average energy ∼1.3 MeV is developed. The model inputs solar wind parameters (velocity, density, interplanetary magnetic field (IMF) |B|, Bz, and By), magnetospheric state parameters (SYM-H and AL), and L*. The model outputs the radiation belt electron phase space density (PSD). The model is operational from L* = 3 to 6.5. The model is constructed with neural networks assisted by information theory. Information theory is used to select the most effective and relevant solar …

Epithelial Immunomodulation By Aerosolized Toll-Like Receptor Agonists Prevents Allergic Inflammation In Airway Mucosa In Mice, David L. Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V. Kulkarni, Michael K. Longmire, Ana M. Jaramillo, Rosha P. Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T. Lei

School of Medicine Publications

Allergic asthma is a chronic inflammatory respiratory disease associated with eosinophilic infiltration, increased mucus production, airway hyperresponsiveness, and airway remodeling. Epidemiologic data reveal that the prevalence of allergic sensitization and associated diseases has increased in the twentieth century. This has been hypothesized to be partly due to reduced contact with microbial organisms (the hygiene hypothesis) in industrialized society. Airway epithelial cells, once considered a static physical barrier between the body and the external world, are now widely recognized as immunologically active cells that can initiate, maintain, and restrain inflammatory responses, such as those that mediate allergic disease. Airway epithelial cells …

Wise V. 1614 Madison Partners, Llc

All Decisions

No abstract provided.

Zarate V. A&E Tiebout Realty Llc

All Decisions

No abstract provided.

Dbl Study Reflectivity Journal, Gloria Mora

ScholarsArchive Data

This is a reflectivity journal to document all the steps taken to complete the Thesis "Decision-Based Learning as a Tool for Teaching Statistics in a Peruvian University." This journal documents all the conversations that the researchers have about their understanding of DBL and all the major decisions made it
to complete this study.

20220829: Digital Media Services, 1994-2011, Information Technology

Guides to University Archives

These items include materials from Informational Services at Marshall University from 1994-2011. Items were received in 2022 and include notable materials about various "filmed" events across campus during the period year. Items are on disc and are labeled numerically and by title of event. For the discs with just numbers but no titles, we have not examined these discs digitally to see what is on them. This is not an exhaustive list, but the attached inventory will give a broad overview of what is contained in each of the boxes...when possible.

Effects Of Various Solvents On Adsorption Of Organics For Porous And Nonporous Quartz Co2 Brine Systems: Implications For Co2 Geo-Storage, Muhammad Ali, Nurudeen Yekeen, Mujahid Ali, Mirhasan Hosseini, Nilanjan Pal, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit

Research outputs 2022 to 2026

The underground geo-storage of carbon dioxide (CO₂) is an essential component of the carbon capture and sequestration value chain. The success of CO₂ containment depends on the wetting state of the rock, which controls the mechanism of fluid flow and distribution. The presence of organic acids in the storage formation introduces a considerable effect on the wettability of the rock / CO₂ / brine system under various temperature and pressure conditions. Despite the previous studies on this topic, the impact of the substrate pores, the rock surface roughness, and the solvents used to prepare the organic …