Digital Commons Network^™

Pim1 Promotes Hepatic Conversion By Suppressing Reprogramming-Induced Ferroptosis And Cell Cycle Arrest, Yangyang Yuan, Chenwei Wang, Xuran Zhuang, Shaofeng Lin, Miaomiao Luo, Wankun Deng, Jiaqi Zhou, Lihui Liu, Lina Mao, Wenbo Peng, Jian Chen, Qiangsong Wang, Yilai Shu, Yu Xue, Pengyu Huang

Faculty, Staff and Student Publications

Protein kinase-mediated phosphorylation plays a critical role in many biological processes. However, the identification of key regulatory kinases is still a great challenge. Here, we develop a trans-omics-based method, central kinase inference, to predict potentially key kinases by integrating quantitative transcriptomic and phosphoproteomic data. Using known kinases associated with anti-cancer drug resistance, the accuracy of our method denoted by the area under the curve is 5.2% to 29.5% higher than Kinase-Substrate Enrichment Analysis. We further use this method to analyze trans-omic data in hepatocyte maturation and hepatic reprogramming of human dermal fibroblasts, uncovering 5 kinases as regulators in the two …

Rosebud Sioux Tribe Gaming Commission V. Todd Hay, Frank Pommersheim

Tribal Court Opinions Authored by Emeritus Professor of Law Frank Pommersheim

No abstract provided.

Independent - Sep. 6, 2022, Monty Stites

The Independent (1988-present)

No abstract provided.

“Flipped” Clinical Rotations: A Novel Approach, Wei Xiong, Simran Singh, Amy Wilson-Delfosse, Robert Jones, Craig Nielsen, Carol Chalkley, Lia Logio

Faculty Scholarship

Background: Near the beginning of the COVID-19 pandemic in the United States, medical students were pulled out of all in-person patient care activities. This resulted in massive disruption to the required clinical rotations (clerkships), necessitating creative curricular solutions to ensure continued education for medical students. Approach: In response to the lockout, our school adopted a “flipped” clinical rotations model that assigned students to remote learning activities prior to in-person patient care activities. This approach allowed students to continue their clinical education virtually with a focus on knowledge for practice while awaiting return to the shortened in-person portions of their rotation. …

Zhao V. Zhang

All Decisions

No abstract provided.

A&L 1664 Llc V. Jaspar Hospitality Llc

All Decisions

No abstract provided.

Jsb Props. Llc V. Yershov

All Decisions

ERAP Case.

County-Level View Of Irrigation Trends In Utah And The West, Matt Yost, Britta L. Schumacher, Luree Johnson, Emily Burchfield, Burdette Barker

All Current Publications

We explored water use management and trends in irrigated agriculture in the U.S. West using operator-level USDA-NASS Farm and Ranch Irrigation Survey (FRIS)/Irrigation and Water Management Survey (IWMS) data aggregated for the first time to the county instead of state scale. Our hope is that this study will guide water managers in developing regional conservation programs, inform extension and research initiatives related to irrigation, promote grower-informed water conservation education, and provide researchers with key information regarding if, how, and why growers consider water conservation in irrigation decision-making.

Independent 435 Cpw Tenants' Assn. V. Park Front Apts., Llc

All Decisions

No abstract provided.

Protein-Protein Interaction-Based High Throughput Screening For Adenylyl Cyclase 1 Inhibitors: Design, Implementation, And Discovery Of A Novel Chemotype, Tiffany S. Dwyer, Joseph B. O'Brien, Christopher P. Ptak, Justin E. Lavigne, Daniel P. Flaherty, Val J. Watts, David L. Roman

Purdue University Libraries Open Access Publishing Fund

Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction in responses to inflammatory pain. Previous drug discovery efforts have centered around the inhibition of AC1 activity in cell-based assays. In the present study, we used an in vitro approach focused on inhibition of the protein-protein interaction (PPI) between Ca2+/calmodulin (CaM) and AC1, an interaction that is required for activation of AC1. We developed a novel fluorescence polarization (FP) assay focused on the …

Randy Grawbowski, Trumpet, With Sean Botkin, Piano, September 6, 2022 [Program], University Of Northern Iowa. School Of Music.

Music Recital Programs

Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.

Intrinsic Disorder In Proteins Associated With Neurodegenerative Diseases, Akshatha Ganne

Theses and Dissertations

A protein’s structure is determined by its amino acid sequence and post-translational modifications, and provides the basis for its physiological functions. Roughly a third of the proteome in mammalian species comprises proteins that contain highly unstructured or intrinsically disordered regions. Proteins with extensive unstructured regions are referred to as intrinsically disordered proteins (IDPs). Recent advances in experimental and computational analyses predicted multiple interacting partners for the disordered regions of proteins, implying critical roles in signal transduction and regulation of biological processes. This dissertation has studied the connection between the misfolding of a protein and an insoluble protein using the ability …

Vyas To Lead Beauregard Center, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

The Changing Lamprey River, Nicholas Gosling

UNH Today Archive

No abstract provided.

University Of New Hampshire Library Faculty Survey, University Of New Hampshire Library, Ithaka S+R

Data Catalog

Survey of UNH faculty conducted fall of 2021.

University Of New Hampshire Library Graduate & Professional Student Survey, University Of New Hampshire Library, Ithaka S+R

Data Catalog

Survey of UNH graduate and professional students conducted fall of 2021

Ndls Communicator: Week Of 09.06.22, Notre Dame Law School

NDLS Communicator

The Latest News

• Professors Matt Barrett and Judy Fox retire from ND Law
• Death penalty abolitionist Sister Helen Prejean to speak at Notre Dame
• Law School’s Office of Admissions eliminates early decision application program
• Marcus Cole was the keynote speaker at the Brigham Young University Founder's Day Keynote dinner.
• Lloyd Maher was on NPR's Morning Edition talking about whether a non-profit charity is violating tax law.
• Phillip Muñoz has published a new book, "Religious Liberty and the American Founding."
• Rick Garnett discusses substantive due process and parental rights in the Pierce v. Society of Sisters case.

Alumni News

• Ballfield to …

Participatory And Spatial Analyses Of Environmental Justice Communities' Concerns About A Proposed Storm Surge And Flood Protection Seawall, Judith Taylor, Norman S. Levine, Ernest Muhammad, Dwayne E. Porter, Annette M. Watson, Paul A. Sandifer

Faculty Publications

In response to increasing threats from sea-level rise and storm surge, the City of Charleston, South Carolina, and the US Army Corps of Engineers (USACE) propose constructing a seawall around the Charleston peninsula. The proposed seawall will terminate close to lower wealth, predominantly minority communities. These communities are identified as environmental justice (EJ) communities due to their history of inequitable burdens of industrial and urban pollution and proximity to highways and US Environmental Protection Agency (EPA) designated Superfund sites. The present study documents community concerns and opinions related to the proposed seawall, existing flooding problems, and other issues. The project …

Polarization Topology At The Nominally Charged Domain Walls In Uniaxial Ferroelectrics, Yurii Tikhonov, Jesi R. Maguire, Conor J. Mccluskey, James P. V. Mcconville, Amit Kumar, Haidong Lu, Dennis Meier, Anna Razumnaya, John Martin Gregg, Alexei Gruverman, Valerii M. Vinokur, Igor Luk’Yanchuk

Department of Physics and Astronomy: Faculty Publications

Ferroelectric domain walls provide a fertile environment for novel materials physics. If a polarization discontinuity arises, it can drive a redistribution of electronic carriers and changes in band structure, which often result in emergent 2D conductivity. If such a discontinuity is not tolerated, then its amelioration usually involves the formation of complex topological patterns, such as flux-closure domains, dipolar vortices, skyrmions, merons, or Hopfions. The degrees of freedom required for the development of such patterns, in which dipolar rotation is a hallmark, are readily found in multiaxial ferroelectrics. In uniaxial ferroelectrics, where only two opposite polar orientations are possible, it …

Moorhead Appointed President Of Cgs Regional Affiliate, Jeremy Gasowski

UNH Today Archive

No abstract provided.

Xpert Mtb/Rif Ultra Assay For Tuberculosis Disease And Rifampicin Resistance In Children, Alexander W Kay, Tara Ness, Sabine E Verkuijl, Kerri Viney, Annemieke Brands, Tiziana Masini, Lucia González Fernández, Michael Eisenhut, Anne K Detjen, Anna M Mandalakas, Karen R Steingart, Yemisi Takwoingi

Faculty, Staff and Students Publications

BACKGROUND: Every year, an estimated one million children and young adolescents become ill with tuberculosis, and around 226,000 of those children die. Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that simultaneously detects Mycobacterium tuberculosis complex and rifampicin resistance. We previously published a Cochrane Review 'Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for tuberculosis disease and rifampicin resistance in children'. The current review updates evidence on the diagnostic accuracy of Xpert Ultra in children presumed to have tuberculosis disease. Parts of this review update informed the 2022 WHO updated guidance on management of …

The Prospector, September 6, 2022, Utep Student Publications

The Prospector

Headline: UTEP Miners Are Extended Family for Lineman

Critical Review Of The Enactment Of The Minimum Wage On Poverty Alleviation In Hong Kong Since 2011, Man Yu Ngan

Lingnan Theses (Doctoral degree)

The academic discussion on the minimum wage law's effect is controversial and continuous. Given that Hong Kong is one of the free economies worldwide with the most competitive labour market, it is one of the best natural laboratories for testing how minimum wage law influences the labour market.

This study aims to answer four important research questions:1.What are the effects of statutory minimum wage legislation and its adjustment level?2.Which groups of employees will mostly benefit or suffer, and to what extent?3.Can Hong Kong’s minimum wage law achieve its policy goal of reducing poverty?4.How could Hong Kong’s minimum wage policy re-enter …

The Cultivation Of Social Consciousness In Chinese Urban Communities From The Perspective Of Community Governance : Taking The Community In Shandong As An Example, Li Jie Wang

Lingnan Theses (Doctoral degree)

The social consciousness of residents has been changing since China's reform and opening up. The grassroots governance of the society has also become more and more difficult. In the last decade, the Chinese government has been improving the level of social community governance, and since COVID-19 pandemic, the government has been strengthening democratic social governance. It has become very possible to cultivate social consciousness and democratic consciousness among the residents in the community. I conducted two rounds of questionnaires and three rounds of interviews in several communities in Shandong province.

I interviewed over 30 residents, visited a dozen communities, and …

An Experimental Study Of Norton And Thule Cooking Pot Performance, Caelie Marshall Butler

Dissertations and Theses

Ceramic technology was adopted by hunter-gatherers of the Paleo-Inuit Norton tradition in the Western Arctic between 2800 and 2500 years B.P., corresponding with an increase in the use of aquatic resources. Pottery production and use continued until approximately 1,500 BP, and resumed during the Neo-Inuit Birnirk and Thule periods, approximately 1,350 years BP. The technical characteristics of Norton and Thule ceramics suggest they performed differently when used for cooking, with Norton ceramics best suited for cooking using direct or suspended heat, and Thule ceramics best suited for indirect heat. Prior experimental archaeological research has focused on Thule ceramics, with limited …

Host A 2023 Sustainability Fellow, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

Technoeconomic Analysis Of Changing Pv Array Convective Cooling Through Changing Array Spacing, Matthew Prilliman, Sarah E. Smith, Brooke Stanislawski, Janine M.F. Keith, Timothy J. Silverman, Marc Calaf, Raul Bayoan Cal

Mechanical and Materials Engineering Faculty Publications and Presentations

Accuracy in photovoltaic (PV) module temperature modeling is crucial to achieving precision in energy performance yield calculations and subsequent economic evaluations of PV projects. While there have been numerous approaches to PV temperature modeling based on both the steady-state and transient thermal assumptions, there have been few attempts to account for changing convective cooling on PV module surfaces resulting from changes in the PV system layout. Changes in system row spacing, in particular, can have a meaningful impact on module electrical efficiency and subsequent economic performance, even when considering additional costs from the changes in row spacing. Using a heat …

State Of Utah, Plaintiff / Appellee V. Justin Jessop, Defendant / Appellant : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from denials of motions to suppress and dismiss, in the Second Judicial District, Weber County, the Honorable Michael DiReda presiding

EMILY ADAMS, FREYJA JOHNSON, Scott D. Goodwin, Counsel for Appellant

NATALIE M. EDMUNDSON, SEAN D. REYES, DEAN L. SAUNDERS, NICHOLAS E. CAINE, Counsel for Appellee

Artificial Gravity Partially Protects Space-Induced Neurological Deficits In Drosophila Melanogaster, Siddhita D. Mhatre, Janani Iyer, Juli Petereit, Roberta M. Dolling-Boreham, Anastasia Tyryshkina, Amber M. Paul, Rachel Gilbert, Matthew Jensen, Rebekah J. Woolsey, Sulekha Anand, Marianne B. Sowa, David R. Quilici, Sylvain V. Costes, Santhosh Girirajan, Sharmila Bhattacharya

Faculty Research, Scholarly, and Creative Activity

Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFμg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFμg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multi-omics analysis shows alterations in metabolic, oxidative stress and synaptic transmission pathways in both SFμg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative …

Ethical Issues And Decision Making Related To Resuscitation Of Severely Injured Patients: Perceptions Of Emergency Department Nurses, Mindy B. Zeitzer

Dissertations

Nurses working in emergency departments (EDs) of trauma centers are integral members of the trauma team during the initial resuscitation of severely injured patients. Decisions regarding these resuscitations are made in high stress environments and are inevitably rife with ethical issues due to the high frequency and severity of injury and its exorbitant costs to society. These decisions are made with little background knowledge about the patients during a complex process of rapid assessment of physiological status overlaid by ethical principles, societal norms and expectations, and legal mandates. The purpose of this study was to assess the specific ethical issues …