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The Association Of Baseline Plasma Sars-Cov-2 Nucleocapsid Antigen Level And Outcomes In Patients Hospitalized With Covid-19, Angela J Rogers, Deborah Wentworth, Andrew Phillips, Katy Shaw-Saliba, Robin L Dewar, Neil R Aggarwal, Abdel G Babiker, Weizhong Chang, Nila J Dharan, Victoria J Davey, Elizabeth S Higgs, Norman Gerry, Adit A Ginde, J W Awori Hayanga, Helene Highbarger, Jeroen L Highbarger, Mamta K Jain, Virginia Kan, Kami Kim, Perrine Lallemand, Bradley G Leshnower, Joseph K Lutaakome, Gail Matthews, Ahmad Mourad, Eleftherios Mylonakis, Ven Natarajan, Maria L Padilla, Lavannya M Pandit, Roger Paredes, Sarah Pett, Srikanth Ramachandruni, M Tauseef Rehman, Brad T Sherman, D Clark Files, Samuel M Brown, Michael A Matthay, B Taylor Thompson, James D Neaton, H Clifford Lane, Jens D Lundgren

Faculty, Staff and Students Publications

BACKGROUND: Levels of plasma SARS-CoV-2 nucleocapsid (N) antigen may be an important biomarker in patients with COVID-19 and enhance our understanding of the pathogenesis of COVID-19.

OBJECTIVE: To evaluate whether levels of plasma antigen can predict short-term clinical outcomes and identify clinical and viral factors associated with plasma antigen levels in hospitalized patients with SARS-CoV-2.

DESIGN: Cross-sectional study of baseline plasma antigen level from 2540 participants enrolled in the TICO (Therapeutics for Inpatients With COVID-19) platform trial from August 2020 to November 2021, with additional data on day 5 outcome and time to discharge.

SETTING: 114 centers in 10 countries. …

Imbalanced Il-37/Tnf-Α/Ctss Signaling Disrupts Corneal Epithelial Barrier In A Dry Eye Model In Vitro, Yun Zhang, Jin-Miao Li, Rong Lu, Zhao Liu, Xin Chen, Cintia S De Paiva, Stephen C Pflugfelder, De-Quan Li

Faculty, Staff and Students Publications

PURPOSE: To explore novel role and molecular mechanism of a natural anti-inflammatory cytokine interleukin (IL) 37 in preventing corneal epithelial barrier disruption from hyperosmolar stress as can occur in dry eye disease.

METHODS: Primary human corneal epithelial cells (HCECs) were cultured from fresh donor limbal explants. An in vitro dry eye model with hyperosmolar stress was established by switching HCECs from isosmolar (312mOsM) to hyperosmolar medium (350-500 mOsM), and some cells were treated with rhIL-37 or rhTNF-α, for different periods (2-48 h). The expression of cytokines and cathepsin S, and barrier protein integrity were evaluated by RT-qPCR, ELISA, and immunofluorescent …

Age Differential Response To Bevacizumab Therapy In Choroidal Neovascularization In Rabbits, Van Phuc Nguyen, Jessica Henry, Josh Zhe, Quynh Kieu, Wei Qian, Yingbin Fu, Xueding Wang, Yannis M Paulus

Faculty, Staff and Students Publications

Choroidal neovascularization (CNV) in young rabbits has been shown to have a rapid, robust response after treatment with bevacizumab, an anti-vascular endothelial growth factor (VEGF) medication. This investigation evaluates an age differential response to bevacizumab in older populations of rabbits using multimodal high resolution molecular imaging. Young (4 months old) and life span (14 months old) rabbits were given subretinal injections of Matrigel and VEGF to produce CNV. All CNV rabbit models were then treated with a bevacizumab intravitreal injection. Rabbits were then monitored longitudinally using photoacoustic microscopy (PAM), optical coherence tomography (OCT), color photography, and fluorescence imaging. Chain-like gold …

Usd Magazine Fall 2022, University Of San Diego

University of San Diego Magazine (1992- )

Torero News; Torero Athletics; Relentless Incrementalism; Hard Work Works; Forward Motion; Class Notes

Section 377a Repeal: How To Handle Disagreements, David Chan

Research Collection School of Social Sciences

In a commentary, Professor David Chan (SMU Behavioural Sciences Initiative Director and Lee Kong Chian Professor of Psychology) discussed the repeal of Section 377A of the Penal Code and proposed adopting five practical approaches for a more constructive discussion on the emotive issue.

Are There Transit Deserts In Europe? A Study Focusing On Four European Cases Through Publicly Available Data, Yefu Chen, Junfeng Jiao

Research Collection College of Integrative Studies

Public transit has been proven as an affordable travel method, while the inequitable distribution is a rising concern among practitioners and researchers. A transit desert, based on the demand and supply concept in measuring the mismatch in allocating the level of public transit service, has proved its ability to be applied in cases across countries. According to this concept, this study investigated transit deserts in four cases in Europe. Results indicate that the public transit system in Grand Paris and Madrid are superior due to a smaller population living in areas where public transit cannot meet the demand. Moreover, we …

Ischemic Dual Papillary Muscle Rupture In A Postpartum Patient With Vascular Ehlers-Danlos Syndrome, J. Mark Erfe, Paul Devlin, Jonathan Rich, Lisa Wilsbacher, Daniel Schimmel, Patrick Mccarthy, Amit Pawale

2020-Current year OA Pubs

No abstract provided.

Stress Radiography Is A Reliable Method To Quantify Posterior Cruciate Ligament Insufficiency: A Systematic Review, J. Jared Guth, Robert H. Brophy, Matthew J. Matava, R. Garrett Steinmetz, Matthew V. Smith

2020-Current year OA Pubs

PURPOSE: To perform a systematic review of posterior tibial stress radiography techniques and radiographic measurement methods to compare their accuracy and efficacy to aid clinicians in quantifying posterior cruciate ligament laxity.

METHODS: Electronic databases, including PubMed, MEDLINE, Embase.com 1947- , Ovid Medline 1946- , Scopus 1823- , Cochrane Central Register of Controlled Trials (CENTRAL), and Clinicaltrials.gov 1997- were queried in December 2020. The abstracts of articles were reviewed by 2 authors for published studies comparing posterior tibial stress radiography techniques, describing, and comparing radiographic measurement methods, and comparing stress radiographs with instrumented knee testing.

RESULTS: The systematic review included 13 …

Margetuximab With Retifanlimab As First-Line Therapy In Her2+/Pd-L1+ Unresectable Or Metastatic Gastroesophageal Adenocarcinoma: Mahogany Cohort A, D. V. T. Catenacci, H. Park, Et Al.

2020-Current year OA Pubs

BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-positive metastatic gastric and gastroesophageal adenocarcinoma (GEA) is globally treated with chemotherapy plus trastuzumab. Novel therapeutic strategies strive to not only optimize efficacy, but also limit toxicities. In MAHOGANY cohort A, margetuximab, an Fc-engineered, anti-HER2 monoclonal antibody (mAb) was combined with retifanlimab, an anti-programmed cell death protein 1 mAb, in the first-line HER2-positive/programmed death-ligand 1 (PD-L1)-positive GEA.

PATIENTS AND METHODS: MAHOGANY cohort A part 1 is a single-arm trial to evaluate margetuximab plus retifanlimab in patients with HER2 immunohistochemistry 3+, PD-L1-positive (combined positive score ≥1%), and non-microsatellite instability-high tumors. Primary objectives for cohort …

Telomere Biology Disorders: Time For Moving Towards The Clinic?, Luis F Z Batista, Inderjeet Dokal, Roy Parker

2020-Current year OA Pubs

Telomere biology disorders (TBDs) are a group of rare diseases caused by mutations that impair telomere maintenance. Mutations that cause reduced levels of TERC/hTR, the telomerase RNA component, are found in most TBD patients and include loss-of-function mutations in hTR itself, in hTR-binding proteins [NOP10, NHP2, NAF1, ZCCHC8, and dyskerin (DKC1)], and in proteins required for hTR processing (PARN). These patients show diverse clinical presentations that most commonly include bone marrow failure (BMF)/aplastic anemia (AA), pulmonary fibrosis, and liver cirrhosis. There are no curative therapies for TBD patients. An understanding of hTR biogenesis, maturation, and degradation has identified pathways and …

Treatment Of Stage I Lung Cancer Detected By Computed Tomography Screening, David S. Gierada, Yun Zhu Bai, Matthew B. Spraker, Anne Stilinovic, Ruben G. Nava

2020-Current year OA Pubs

INTRODUCTION: Reducing lung cancer deaths through early detection by computed tomography (CT) screening requires delivery of effective treatment. We performed this retrospective study to determine the types of treatment used for screen-detected stage I lung cancer at our academic center and to compare the demographic and clinical characteristics of patients by type of treatment.

METHODS: All persons screened in the lung cancer screening program at our institution through June 16, 2021, were included. Those with screening CT findings needing follow-up were managed through a thoracic surgery clinic. Demographic and clinical characteristics of patients diagnosed with having stage I lung cancer …

Evaluating Brain Damage In Multiple Sclerosis With Simultaneous Multi-Angular-Relaxometry Of Tissue, Biao Xiang, Jie Wen, Robert E Schmidt, Alexander L Sukstanskii, Daniel Mamah, Dmitriy A Yablonskiy, Anne H Cross

2020-Current year OA Pubs

OBJECTIVE: Multiple sclerosis (MS) is a common demyelinating central nervous system disease. MRI methods that can quantify myelin loss are needed for trials of putative remyelinating agents. Quantitative magnetization transfer MRI introduced the macromolecule proton fraction (MPF), which correlates with myelin concentration. We developed an alternative approach, Simultaneous-Multi-Angular-Relaxometry-of-Tissue (SMART) MRI, to generate MPF. Our objective was to test SMART-derived MPF metric as a potential imaging biomarker of demyelination.

METHODS: Twenty healthy control (HC), 11 relapsing-remitting MS (RRMS), 22 progressive MS (PMS), and one subject with a biopsied tumefactive demyelinating lesion were scanned at 3T using SMART MRI. SMART-derived MPF metric …

Calciphylaxis Arising Following Bariatric Surgery: A Case Series, Bethany Cucka, Bianca Biglione, Lauren Ko, Emily D Nguyen, Charbel C Khoury, Sagar U Nigwekar, Malcolm K Robinson, Daniela Kroshinsky

2020-Current year OA Pubs

No abstract provided.

Improving Hypertension Self Management In African American Men, Elizabeth C. Felix

Electronic Theses and Dissertations

Hypertension is a cardiopulmonary condition linked to genetic, environmental, and social factors. Left untreated, it can lead to fatal conditions such as heart disease. In the United States, African Americans experience disproportionately high rates of hypertension, earlier onset of symptoms, greater severity, and higher related mortality rates. African Americans also statistically have more difficulty self-managing their hypertension than other demographics. The aim of this project was (a) to identify, define, and measure perceived barriers to self-management of hypertension among African American men and (b) to target these barriers and increase patient engagement through personalized intervention plans. The researcher recruited 24 …

Functional Characterization Of Enhancer Activity During A Long Terminal Repeat's Evolution, Alan Y Du, Xiaoyu Zhuo, Vasavi Sundaram, Nicholas O Jensen, Hemangi G Chaudhari, Nancy L Saccone, Barak A Cohen, Ting Wang

2020-Current year OA Pubs

Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs are rarely functionally tested for regulatory activity, which in turn limits our understanding of how TE regulatory activity has evolved. We systematically tested the human LTR18A subfamily for regulatory activity using massively parallel reporter assay (MPRA) and found AP-1- and CEBP-related binding motifs as drivers of enhancer activity. Functional analysis of evolutionarily reconstructed ancestral sequences revealed that LTR18A elements have generally lost regulatory activity over time through sequence changes, with the largest effects occurring owing to mutations in the AP-1 and CEBP …

Exploring The Effects Of Meaningful Tactile Display On Perception And Preference In Automated Vehicles, Kimberly D. Martinez, Gaojian Huang

Mineta Transportation Institute

There is an existing issue in human-machine interaction, such that drivers of semi-autonomous vehicles are still required to take over control of the vehicle during system limitations. A possible solution may lie in tactile displays, which can present status, direction, and position information while avoiding sensory (e.g., visual and auditory) channels overload to reliably help drivers make timely decisions and execute actions to successfully take over. However, limited work has investigated the effects of meaningful tactile signals on takeover performance. This study synthesizes literature investigating the effects of tactile displays on takeover performance in automated vehicles and conducts a human-subject …

Large Eddy Simulations Of Wind Shear From Passing Vehicles Under A Freeway Overpass, Hamid Rahai, Assma Begum

Mineta Transportation Institute

California is moving toward a 100% clean energy future, and expanded wind energy will be a major component of the state’s future energy portfolio. Innovations in wind energy resources will move California closer to achieving its goal. To gain a better understanding of transient pressure and the wind shear generated at the bridge poles from passing vehicles, this study performed large-eddy simulations of a vehicle (also called an Ahmed body) moving under a freeway overpass at a distance of 0.75 w (width) from the bridge poles. Results include transient contours of mean velocity, turbulent kinetic energy, vorticity, and pressure around …

Understanding The Safety And Usability Of Personal Vehicles For Non-Driving Individuals With Disabilities And Their Families/Care Providers, Anil R. Kumar, Hannah Bowman

Mineta Transportation Institute

The connections between shared personal vehicles of individuals with disabilities (IWDs) and their household family members play an important role in the mobility, overall health, and well-being of all involved actors, yet this topic remains mostly overlooked within publicly available research. Families that include a non-driving IWD are more likely to be low-income, and often struggle with the costs of operating a family car but, due to insufficient public transportation options, they own vehicles despite their prohibitive cost. This exploratory study utilized the Systems Engineering Initiative for Patient Safety (SEIPS) model, a framework focused on assessing the interplaying sociotechnical factors …

Choline, Dha, And Diarrheal Disease Associated With Growth Faltering In A Case-Control Study, Jenna N Diaz, Sherlie Jean Louis Dulience, Noah Wolthausen, Xuntian Jiang, Emmanuel Gyimah, Francesca J Marhône Pierre, F Matthew Kuhlmann, Lora L Iannotti

2020-Current year OA Pubs

BACKGROUND: Children with recurrent infectious diarrhea are susceptible to growth faltering. DHA and choline may play a role in this relationship due to their involvement in lipid metabolism, gut immunity, and inflammatory pathways.

OBJECTIVES: This study aimed to characterize the contributions made by DHA and choline status and enteric damage in young children in the association between diarrheal illness and child growth.

METHODS: A longitudinal case-control study was conducted among children aged 6-36 mo (

RESULTS: At baseline, mean plasma DHA concentrations (1.03 µg/mL; 95% CI: 0.91, 1.15) were not significantly different between cases and controls, nor was there a …

Neoadjuvant Atezolizumab For Resectable Non-Small Cell Lung Cancer: An Open-Label, Single-Arm Phase Ii Trial, Jamie E Chaft, G Alexander Patterson, Saiama N Waqar, Et Al.

2020-Current year OA Pubs

In an ongoing, open-label, single-arm phase II study ( NCT02927301 ), 181 patients with untreated, resectable, stage IB-IIIB non-small cell lung cancer received two doses of neoadjuvant atezolizumab monotherapy. The primary end point was major pathological response (MPR; ≤10% viable malignant cells) in resected tumors without EGFR or ALK alterations. Of the 143 patients in the primary end point analysis, the MPR was 20% (95% confidence interval, 14-28%). With a minimum duration of follow-up of 3 years, the 3-year survival rate of 80% was encouraging. The most common adverse events during the neoadjuvant phase were fatigue (39%, 71 of 181) …

Paediatrician's Guide To Post-Operative Care For Functionally Univentricular Chd: A Review, Christina Ronai, Sarosh P Batlivala, Quang-Tuyen Nguyen, Markus S Renno, Lindsay Arthur, Julie Glickstein, Jonathan N Johnson, Jacob R Miller, Carolyn A Altman, Elif Seda Selamet Tierney

2020-Current year OA Pubs

IMPORTANCE: Single ventricle CHD affects about 5 out of 100,000 newborns, resulting in complex anatomy often requiring multiple, staged palliative surgeries. Paediatricians are an essential part of the team that cares for children with single ventricle CHD. These patients often encounter their paediatrician first when a complication arises, so it is critical to ensure the paediatrician is knowledgeable of these issues to provide optimal care.

OBSERVATIONS: We reviewed the subtypes of single ventricle heart disease and the various palliative surgeries these patients undergo. We then searched the literature to detail the general paediatrician's approach to single ventricle patients at different …

Incisionless Targeted Adeno-Associated Viral Vector Delivery To The Brain By Focused Ultrasound-Mediated Intranasal Administration, Dezhuang Ye, Jinyun Yuan, Yaoheng Yang, Yimei Yue, Zhongtao Hu, Siaka Fadera, Hong Chen

2020-Current year OA Pubs

BACKGROUND: Adeno-associated viral (AAV) vectors are currently the leading platform for gene therapy with the potential to treat a variety of central nervous system (CNS) diseases. There are numerous methods for delivering AAVs to the CNS, such as direct intracranial injection (DI), intranasal delivery (IN), and intravenous injection with focused ultrasound-induced blood-brain barrier disruption (FUS-BBBD). However, non-invasive and efficient delivery of AAVs to the brain with minimal systemic toxicity remain the major challenge. This study aims to investigate the potential of focused ultrasound-mediated intranasal delivery (FUSIN) in AAV delivery to brain.

METHODS: Mice were intranasally administered with AAV5 encoding enhanced …

Dipl 6104 Wba The Art And Science Of Negotiation, Zheng Wang Ph.D.

Diplomacy Syllabi

The ability to negotiate and manage conflicts effectively has become an essential skill in international diplomacy, as well as in our organizational and personal settings. Negotiation is the art and science of securing an agreement between two or more independent parties. This course is an introduction to the wide variety of approaches to the analysis and practice of negotiation and is intended to provide a solid foundation for further inquiry and application. Students will learn the history of thinking about negotiation, frameworks for analyzing negotiation, and the roles of various factors (influences and contexts, tactics and strategies) on the negotiation …

Dipl 6105 Aa/Na International Political Economy, Fredline M’Cormack-Hale Ph.D.

Diplomacy Syllabi

'IPE at its most fundamental, in short, is about the complex interrelationship of economic and political activity at the level of international affairs' (Cohen, 2008, p. 16).

Globalization, or economic, political and cultural integration between countries, was growing at a rapid pace until the 2007-2009 global financial crisis. The crisis has raised questions about the capacity of a market economy to deliver prosperity and to do in an equitable way. Since then, and more so following Brexit and the recent election cycles in Western democracies, there has been a call for more insular policies. What explains this reversal? What forces …

Dipl 6180 Web Comparative Foreign Policy, Ann Marie Murphy Ph.D.

Diplomacy Syllabi

This course examines leading theoretical approaches to the study of foreign policy and their application to a variety of states and issue areas. The goal of this course is to provide students with an understanding of the key concepts necessary to address the fundamental question of foreign policy analysis: how do states define and pursue their national interests in international affairs? During the semester, we will explore some of the key debates in foreign policy analysis. Do differences in the characteristics of states (large versus small, democratic versus authoritarian, industrialized versus developing) lead to differences in their foreign policies? Or …

Sweat Icu-An Observational Study Of Physician Workload And The Association Of Physician Outcomes In Academic Icus, Ankita Agarwal, Patrick G. Lyons, Et Al.

2020-Current year OA Pubs

UNLABELLED: The optimal staffing model for physicians in the ICU is unknown. Patient-to-intensivist ratios may offer a simple measure of workload and be associated with patient mortality and physician burnout. To evaluate the association of physician workload, as measured by the patient-to-intensivist ratio, with physician burnout and patient mortality.

DESIGN: Cross-sectional observational study.

SETTING: Fourteen academic centers in the United States from August 2020 to July 2021.

SUBJECTS: We enrolled ICU physicians and collected data on adult ICU patients under the physician's care on the single physician-selected study day for each physician.

MEASUREMENTS AND MAIN RESULTS: The primary exposure was …

Response To Brentuximab Vedotin By Cd30 Expression In Non-Hodgkin Lymphoma, Deepa Jagadeesh, Steve Horwitz, Nancy L Bartlett, Youn Kim, Eric Jacobsen, Madeleine Duvic, Meredith Little, William Trepicchio, Keenan Fenton, Matthew Onsum, Julie Lisano, Ranjana Advani

2020-Current year OA Pubs

BACKGROUND: The safety and efficacy of brentuximab vedotin (BV), an antibody-drug conjugate directed to the CD30 antigen, has been assessed in several trials in patients with peripheral T-cell lymphoma (PTCL), cutaneous T-cell lymphoma (CTCL), or B-cell non-Hodgkin lymphoma (NHL). The objective of this research was to examine the relationship between CD30 expression level and clinical response to BV.

PATIENTS AND METHODS: We analyzed response in patients treated with BV monotherapy in 5 prospective clinical studies in relapsed or refractory PTCL, CTCL, or B-cell NHL. CD30 expression was assessed by immunohistochemistry (IHC) using the Ber H2 antibody for 275 patients.

RESULTS: …

Clinical Use Of Mean Nocturnal Baseline Impedance And Post-Reflux Swallow-Induced Peristaltic Wave Index For The Diagnosis Of Gastro-Esophageal Reflux Disease, Pierfrancesco Visaggi, Lucia Mariani, Federica Baiano Svizzero, Luca Tarducci, Andrea Sostilio, Marzio Frazzoni, Salvatore Tolone, Roberto Penagini, Leonardo Frazzoni, Linda Ceccarelli, Vincenzo Savarino, Massimo Bellini, Prakash C Gyawali, Edoardo V Savarino, Nicola De Bortoli

2020-Current year OA Pubs

The clinical diagnosis of gastro-esophageal reflux disease (GERD) is based on the presence of typical esophageal troublesome symptoms. In clinical practice, heartburn relief following a proton pump inhibitor (PPI) trial or endoscopy can confirm a diagnosis of GERD. In cases of diagnostic uncertainty or before anti-reflux interventions, combined impedance-pH monitoring (MII-pH) provides a comprehensive assessment of both physical and chemical properties of the refluxate, allowing to achieve a conclusive diagnosis of GERD. Recently, the Lyon Consensus proposed the use of mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave index (PSPW-I) as novel MII-pH metrics to support the diagnosis …

Event Scale Analysis Of Streamflow Response To Wildfire In Oregon, 2020, Will B. Long, Heejun Chang

Geography Faculty Publications and Presentations

Wildfire increases the magnitude of runoff in catchments, leading to the degradation of ecosystems, risk to infrastructure, and loss of life. The Labor Day Fires of 2020 provided an opportunity to compare multiple large and severe wildfires with the objective of determining potential changes to hydrologic processes in Oregon Cascades watersheds. Geographic information systems (GIS) were implemented to determine the total percentage burned and percentage of high burn severity class of six watersheds on the west slope of the Oregon Cascade Range. In addition, two control watersheds were included to contrast the influence of climatic effects. Spatial arrangements of burned …

Reliable Mode Tracking For Gradient-Based Optimization With Dynamic Stability Constraints, Taylor Mcdonnell, Andrew Ning

Faculty Publications

In order to construct mode-specific flutter constraints for use in gradient-based multidisciplinary design optimization frameworks, mode tracking must be used to associate the current iteration's modes with the modes corresponding to each constraint function. Existing mode tracking methods, however, do not provide a method by which to ensure the accuracy of mode associations, making them unsuitable for use in situations where obtaining correct mode associations is critical. To remedy this issue, a new mode tracking method is presented which incorporates backtracking logic in order to maintain an arbitrarily high degree of confidence in mode correlations during gradient-based optimization and/or during …