Digital Commons Network^™

The Impact Of Obesity And Adipokines On Breast And Gynecologic Malignancies, Surabhi Tewari, Roberto Vargas, Ofer Reizes

Faculty Scholarship

The link between obesity and multiple disease comorbidities is well established. In 2003, Calle and colleagues presented the relationship between obesity and several cancer types, including breast, ovarian, and endometrial malignancies. Nearly, 20% of cancer-related deaths in females can be accounted for by obesity. Identifying obesity as a risk factor for cancer led to a focus on the role of fat-secreted cytokines, known as adipokines, on carcinogenesis and tumor progression. Early studies indicated that the adipokine leptin increases cell proliferation, invasion, and inhibition of apoptosis in multiple cancer types. As a greater appreciation of the obesity–cancer link has amassed, we …

Grafton County 4-H Jingle Bell Parade - Flyer, Extension

UNH Cooperative Extension

No abstract provided.

Challenges And Opportunities Associated With The Md Anderson Impact2 Randomized Study In Precision Oncology, Henry Hiep Vo, Siqing Fu, David S Hong, Daniel D Karp, Sarina Piha-Paul, Vivek Subbiah, Filip Janku, Aung Naing, Timothy A Yap, Jordi Rodon, Jaffer A Ajani, Carrie Cartwright, Amber Johnson, I-Wen Song, Jennifer Beck, Michael Kahle, Graciela M Nogueras-Gonzalez, Vincent Miller, Calvin Chao, David J Vining, Donald A Berry, Funda Meric-Bernstam, Apostolia-Maria Tsimberidou

Faculty, Staff and Student Publications

We investigated the challenges of conducting IMPACT2, an ongoing randomized study that evaluates molecular testing and targeted therapy (ClinicalTrials.gov: NCT02152254). Patients with metastatic cancer underwent tumor profiling and were randomized between the two arms when eligibility criteria were met (Part A). In Part B, patients who declined randomization could choose the study arm. In Part A, 69 (21.8%) of 317 patients were randomized; 78.2% were not randomized because of non-targetable alterations (39.8%), unavailability of clinical trial (21.8%), other reasons (12.6%), or availability of US Food and Drug Administration (FDA)-approved drugs for the indication (4.1%). In Part B, 32 (20.4%) of …

Loneliness And Alcohol-Related Problems Among College Students Who Report Binge Drinking Behavior: The Moderating Role Of Food And Alcohol Disturbance, Luke Herchenroeder, Stacy M Post, Michelle L Stock, Ellen W Yeung

Faculty, Staff and Student Publications

Loneliness and alcohol misuse are common among college students and pose a threat to public health. To better understand the longitudinal association between these public health concerns we examined food and alcohol disturbance (FAD; i.e., restricting one's caloric intake prior to drinking) as a moderator in the association between loneliness and alcohol-related problems. Participants were 456 college students from a mid-sized university who engaged in past 30-day binge drinking. The majority of participants identified as being White (67.1%), female (78.1%), and reported a mean age of 19.61 (SD = 1.54) years. Participants completed two surveys (3 weeks apart) over the …

Uber Tech., Inc. V. Royz, 138 Nev. Adv. Op. 66 (Sept. 29, 2022), Mark Mulhall

Nevada Supreme Court Summaries

The Nevada Supreme Court is bound to the United States’ Supreme Court decision in Schein regarding contacts governed by the Federal Arbitration Act (FAA). Therefore, when parties enter into an arbitration agreement that clearly and unmistakably delegates the arbitrability threshold question to the arbitrator, the district court must refer the case to arbitration even if the district court concludes the dispute is not subject to the arbitration agreement

Eby V. Johnston Law Office, P.C., 138 Nev. Adv. Op. 56 (Sep. 08, 2022), Davit Sargsian

Nevada Supreme Court Summaries

The Nevada Supreme Court affirmed the district court’s decision to strike the second amended complaint and reversed the decision to dismiss the remaining malpractice claim with prejudice. According to Nevada’s Uniform Power of Attorney Act, the Court held a non-lawyer agent working under a power of attorney regarding claims and litigation could not litigate an action pro se in place of the principal or engage in the practice of law on the principal’s behalf. The trial court correctly held that the appellant’s non-lawyer agent under a power of attorney was engaged in the unauthorized practice of law. The decision to …

The Field Research Grant Colloquium, Latin American And Iberian Institute

LAII Events

Thursday, October 27, 2022 | 02:00 pm

Latin American and Iberian Institute (801 Yale Blvd NE)

801 Yale Blvd NE (campus building #165)

About:

LAII Field Research Grants provide graduate students with the ability to conduct pilot studies and preliminary investigations in Latin America. Join us for presentations from the grant recipients. FOR MORE INFORMATION: http://laii.unm.edu/funding/student-field-research-grants.html

Notes:

This event is free and open to the public.

Washington Townhomes, Llc; Homes By Harmony, Inc.; Cotton Meadows, Llc; Salisburty Development Llc; Southern Utah Home Builders Assn.; Ivory Southern, Llc; Perry Homes Utah; Henry Walker Construction Of Southern Utah, Llc, Plaintiffs /Appellees, V. Washington County Water Conservancy District, Defendant /Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Fifth Judicial Court, Salt Lake County, State of Utah Honorable Jeffrey C. Wilcox, District Court No. 130500465

Benson L. Hathaway, Jr., Adam D. Wahlquist, Thomas K. Checketts, Craig M. Call, Attorneys for Appellees

Robert C. Keller, Scott P. Powers, Attorneys for Appellant

Bruce Protocol Test Affects Postural Stability In Healthy Young Adults, Andreas Germanos, Tessa Heiberg, Annie Jeon, Emi Heisterkamp, Hao Giang, Jessica Cota, Laura Corona, Thomas Loi, Vincent Bovino, Shayce Cordero, Sunny Kim, Michael Shiraishi, Rahul Soangra

Physical Therapy Faculty Articles and Research

Maintaining balance is key in avoiding falls and injury. However, little is known on how increased cardiac activity may affect postural stability. This study investigated if increase in cardiac activity to 85% maximal heart rate (HR) when exercising with standard Bruce Protocol Test (BPT) influence postural sway. Ten young adults were tested for three postural stances, quiet bilateral standing with i) eyes open, ii) eyes closed, and iii) tandem stance, before and after performing the BPT. Resting Heart Rate (HR) and HR variability along with standard postural sway parameters like sway velocity, sway area, turn index, and power frequency in …

Implementation Of Infant Driven Feeding™ In A Level Ii Nicu, Kelly Gardner

Graduate Theses, Dissertations, and Capstones

In the United States, currently, 1 in 10 babies are born premature. Due to the immaturity of their neurological, gastrointestinal, and cardio-respiratory functions, preterm infants can experience the inability to coordinate sucking, swallowing, and breathing that is essential to oral feed. Cue-based oral feeding methods are designed to give the caregiver the ability to recognize signs of readiness and respond appropriately to the infant cues to adjust the manner in which feeding intervention is performed to match the infant’s current state of physiologic tolerance. The Infant Driven Feeding™ program incorporates scales to assess readiness and quality of the oral feeding, …

The Colby Echo (2022-10-27), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

Tennessee State University For The Year Ended June 30, 2021, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Highly Efficient, Perfect, Large Angular And Ultrawideband Solar Energy Absorber For Uv To Mir Range, Shobhit K. Patel, Arun Kumar Udayakumar, G. Mahendran, B. Vasudevan, Jaymit Surve, Juveriya Parmar

Department of Mechanical and Materials Engineering: Faculty Publications

Although different materials and designs have been tried in search of the ideal as well as ultrawideband light absorber, achieving ultra-broadband and robust unpolarized light absorption over a wide angular range has proven to be a major issue. Light-field regulation capabilities provided by optical metamaterials are a potential new technique for perfect absorbers. It is our goal to design and demonstrate an ultra-wideband solar absorber for the ultraviolet to a mid-infrared region that has an absorptivity of TE/TM light of 96.2% on average. In the visible, NIR, and MIR bands of the solar spectrum, the absorbed energy is determined to …

985 Bruckner Blvd. Owners Llc V. Fuentes

All Decisions

No abstract provided.

A Macrocyclic Molecule With Multiple Antioxidative Activities Protects The Lens From Oxidative Damage, Jinmin Zhang, Yu Yu, Magy A. Mekhail, Hongli Wu, Kayla N. Green

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Growing evidence links oxidative stress to the development of a cataract and other diseases of the eye. Treatments for lens-derived diseases are still elusive outside of the standard surgical interventions, which still carry risks today. Therefore, a potential drug molecule ^OHPy₂N₂ was explored for the ability to target multiple components of oxidative stress in the lens to prevent cataract formation. Several pathways were identified. Here we show that the ^OHPy₂N₂ molecule activates innate catalytic mechanisms in primary lens epithelial cells to prevent damage induced by oxidative stress. This protection was linked to …

Identification And Characterization Of Epicuticular Proteins Of Nematodes Sharing Motifs With Cuticular Proteins Of Arthropods, Bruno Betschart, Marco Bisoffi, Ferial Alaeddine

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Specific collagens and insoluble proteins called cuticlins are major constituents of the nematode cuticles. The epicuticle, which forms the outermost electron-dense layer of the cuticle, is composed of another category of insoluble proteins called epicuticlins. It is distinct from the insoluble cuticlins localized in the cortical layer and the fibrous ribbon underneath lateral alae. Our objective was to identify and characterize genes and their encoded proteins forming the epicuticle. The combination between previously obtained laboratory results and recently made available data through the whole-genome shotgun contigs (WGS) and the transcriptome Shotgun Assembly (TSA) sequencing projects of Ascaris suum allowed us …

Agrostring: Visibility And Provenance Through A Private Blockchain Platform For Agricultural Dispense Towards Consumers, Sukrutha L. T. Vangipuram, Saraju P. Mohanty, Elias Kougianos, Chittaranjan Ray

Department of Civil and Environmental Engineering: Faculty Publications

It is a known fact that large quantities of farm and meat products rot and are wasted if correct actions are not taken, which may lead to serious health issues if consumed. There is no proper system for tracking and communicating the status of the goods to their respective stakeholders in a secure way. Consumers have every right to know the quality of the products they consume. Using monitoring tools, such as the Internet of Agricultural Things (IoAT), and modern data protection techniques for storing and sharing, will help mitigate data integrity issues during the transmission of sensor records, increasing …

Elements For Successful Implementation Of A Clinic-Based Health Literacy Intervention, Mark M. Macauda, Michelle Angelique Arent, Mayank Sakhuja, Brooks Yelton Ma, Lmsw, Samuel Noblet, Delores Fedrick, Diana Zona, Cyndi New, William D. Isenhower, Abraham Wandersman, Daniela B. Friedman Ph.D.

Faculty Publications

Improving health literacy is a national public health priority. Given the context of the COVID-19 pandemic, it is even more critical for health and medical information to be clear and understandable for patients and their families. Clinic-based programs to improve health literacy need to be pragmatic, feasible, and helpful for the implementing clinic and patients. This paper describes the development, implementation, and evaluation of a pragmatic, clinic-based health literacy intervention in a safety-net clinic that serves uninsured and indigent patients. Study methods are guided by a previous pilot study and components recommended for pragmatic interventions. An electronic readiness assessment was …

Antibody Prevalence And Risk Factors Associated With Rickettsia Spp. In A Pediatric Cohort: Sfgr Remains Underdiagnosed And Underreported In El Salvador, Kyndall C. Dye-Braumuller, Marvin Stanley Rodríguez Aquino, Kia Zellars, Hanna Waltz, Madeleine Meyer, Lídua Gual-Gonzalez, Stella C.W. Self, Mufaro Kanyangarara, Melissa Nolan Ph.D., Mph

Faculty Publications

Spotted fever group rickettsioses (SFGR) are caused by a group of tick-borne pathogens that are increasing in incidence globally. These diseases are typically underreported and undiagnosed in low- and middle-income countries, and thus, have been classified as neglected bacterial pathogens. Countries with high poverty, low human development index score, and limited health infrastructure—like El Salvador in Central America—lack necessary surveillance for SFGR and other tick-borne pathogens. This paucity of baseline SFGR infection prevalence leaves vulnerable populations at risk of misdiagnosis. Further, tick-borne disease burdens in El Salvador are severely limited. To lay the foundation for tick-borne disease epidemiology in El …

Incidence And Factors Related To Nonmotorized Scooter Injuries In New York State And New York City, 2005–2020, Peter Tuckel

Publications and Research

Background: This study provides an analysis of contemporary trends and demographics of patients treated for injuries from nonmotorized scooters in emergency departments in New York state excluding New York City (NYS) and New York City (NYC).

Methods: The study tracks the incidence of nonmotorized scooter injuries in NYS and NYC from 2005 to 2020 and furnishes a detailed profile of the injured patients using patient-level records from the Statewide Planning and Research Cooperative System (SPARCS). A negative binomial regression analysis is performed on the SPARCS data to measure the simultaneous effects of demographic variables on scooter injuries for NYS and …

Accounting For The Clustering And Nesting Effects Verifies Most Conclusions Corrected Analysis Of: “Randomized Nutrient Bar Supplementation Improves Exercise-Associated Changes In Plasma Metabolome In Adolescents And Adult Family Members At Cardiometabolic Risk”, Yasaman Jamshidi-Naeini, Lilian Golzarri-Arroyo, Colby J Vorland, Andrew W Brown, Stephanie Dickinson, David B Allison

Children’s Nutrition Research Center Staff Publications

In a published randomized controlled trial, household units were randomized to a nutrient bar supplementation group or a control condition, but the non-independence of observations within the same household (i.e., the clustering effect) was not accounted for in the statistical analyses. Therefore, we reanalyzed the data appropriately by adjusting degrees of freedom using the between-within method, and accounting for household units using linear mixed effect models with random intercepts for family units and subjects nested within family units for each reported outcome. Results from this reanalysis showed that ignoring the clustering and nesting effects in the original analyses had resulted …

The Covid-19 Pandemic And Changes In Children’S Physical Activity In A Rural Us Community: A Mixed Methods Study, Debra K. Kellstedt, Ann M. Essay, Michaela A. Schenkelberg, Marisa S. Rosen, Mary J Von Seggern, Regina Idoate, Gregory J. Welk, Richard R. Rosenkranz, David A. Dzewaltowski

Kinesiology and Nutrition Sciences Faculty Research

Objectives To examine differences in rural community children’s moderate-to-vigorous physical activity (MVPA) and participation in out-of-school activities from fall 2019 to fall 2020 and explore enacted PA opportunity modifications post initial COVID-19 disruption.

Design Mixed methods study using the validated Youth Activity Profile (YAP), administrator reports and stakeholder surveys and semistructured interviews.

Setting Children and community stakeholders from one rural US Great Plains community in the state of Nebraska were recruited.

Participants Third through fifth graders in fall 2019 (n=144) and fall 2020 (n=174) reported MVPA and participation in out-of-school activities using the YAP. School administrators reported weekly physical education …

Prodrugs Of A 1-Hydroxy-2-Oxopiperidin-3-Yl Phosphonate Enolase Inhibitor For The Treatment Of Eno1-Deleted Cancers, Victoria C Yan, Cong-Dat Pham, Elliot S Ballato, Kristine L Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J Ackroyd, Dimitra K Georgiou, Steven W Millward, Florian L Muller

Faculty, Staff and Student Publications

Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2). A previous work described the sustained tumor regression activities of a substrate-competitive phosphonate inhibitor of ENO2, 1-hydroxy-2-oxopiperidin-3-yl phosphonate (HEX) (5), and its bis-pivaloyoxymethyl prodrug, POMHEX (6), in an ENO1-deleted intracranial orthotopic xenograft model of glioblastoma [Nature Metabolism 2020, 2, 1423-1426]. Due to poor pharmacokinetics of bis-ester prodrugs, this study was undertaken to identify potential non-esterase prodrugs for further development. Whereas phosphonoamidate esters were efficiently bioactivated in ENO1-deleted glioma …

Fatigue, Self-Efficacy For Physical Activity, Physical Activity, And Quality Of Life In Women With Breast Cancer, Barbara K. Haas

Dissertations

This descriptive correlational study was conducted to examine the direct and indirect influences of fatigue, self-efficacy for physical activity, and physical activity on quality of life (QOL) in women with breast cancer. Relationships among these variables were compared between women with breast cancer and a comparison group of women. A theoretical model, philosophically congruent with a health within illness perspective and generated by integrating selected concepts from Pender's Health Promotion Model and Bandura's Social Cognitive Theory, was used to guide the study. Instruments used to measure study concepts included the Piper Fatigue Scale to evaluate fatigue; a researcher developed Physical …

Faculty Recital Series: Jillian Kouzel, Oboe; Lu Witzig, Piano; October 27, 2022, Jillian Kouzel, Lu Witzig

School of Music Programs

Kemp Recital Hall
October 27, 2022
Thursday Evening
7:00 p.m.

Book Talk | Racial Innocence: Unmasking Latino Anti-Black Bias And The Struggle For Equality, Racial Justice Project

Racial Justice Project

October 27, 2022

2022 October 27 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Johnston V. Eighth Jud. Dist. Ct., 138 Nev. Adv. Op. 67 (Oct. 6, 2022), Joe Morgan

Nevada Supreme Court Summaries

A defendant is constitutionally entitled to a prompt hearing after being taken into custody from pretrial release, and at that hearing, the State bears the burden of demonstrating probable cause. A violation of a condition of a pretrial release may lead to statutory sanctions, and the court does not recognize a distinction between so-called “technical” and “substantive” violations. NRS 178.4851 and Valdez-Jimenez require the district court to make findings of fact on the record that each condition of pretrial release is the least restrictive means of ensuring public safety and the defendant’s return to court.

Airbnb, Inc. V. Rice, 138 Nev. Adv. Op. 65 (Sept. 29, 2022), Roberto Nolasco-Cruz

Nevada Supreme Court Summaries

When parties clearly and unmistakably delegate the issue of arbitrability to an arbitrator, the United States Supreme Court held in Henry Schein, Inc. v. Archer & White Sales, Inc., that, under the Federal Arbitration Act (FAA), a court has no power to determine the arbitrability of a dispute where the contract delegates the arbitrability question to an arbitrator, even if the argument that the arbitration agreement applies to the dispute is “wholly groundless.” Courts err when deciding on an arbitrability question itself if the required standard established in Henry Schein has been met.

State Of Nevada V. Charles Wade Mccall, 138 Nev. Adv. Op. 64 (Sep. 22, 2022), Kiana Parkes

Nevada Supreme Court Summaries

In an opinion written by Justice Stiglich, the Court clarifies whether a protective sweep is lawful when a prior arrest did not occur. The Court looked to other courts to determine if a prior arrest should be a requirement of a protective sweep. The majority approach adopted by courts was that an arrest does not have to occur prior to a protective sweep. This Court agreed with the majority approach and analyzed the lawfulness of the protective sweep in this case. Although the protective sweep in this case occurred before an arrest was made, the Court still found the protective …