Digital Commons Network^™

Towards Automated Safety Vetting Of Smart Contracts In Decentralized Applications, Yue Duan, Xin Zhao, Yu Pan, Shucheng Li, Minghao Li, Fengyuan Xu, Mu Zhang

Research Collection School Of Computing and Information Systems

We propose VetSC, a novel UI-driven, program analysis guided model checking technique that can automatically extract contract semantics in DApps so as to enable targeted safety vetting. To facilitate model checking, we extract business model graphs from contract code that capture its intrinsic business and safety logic. To automatically determine what safety specifications to check, we retrieve textual semantics from DApp user interfaces. To exclude untrusted UI text, we also validate the UI-logic consistency and detect any discrepancies. We have implemented VetSC and applied it to 34 real-world DApps. Experiments have demonstrated that VetSC can accurately interpret smart contract code, …

Towards Automated Safety Vetting Of Smart Contracts In Decentralized Applications, Yue Duan, Xin Zhao, Yu Pan, Shucheng Li, Minghao Li, Fengyuan Xu, Mu Zhang

Research Collection School Of Computing and Information Systems

We propose VetSC, a novel UI-driven, program analysis guided model checking technique that can automatically extract contract semantics in DApps so as to enable targeted safety vetting. To facilitate model checking, we extract business model graphs from contract code that capture its intrinsic business and safety logic. To automatically determine what safety specifications to check, we retrieve textual semantics from DApp user interfaces. To exclude untrusted UI text, we also validate the UI-logic consistency and detect any discrepancies. We have implemented VetSC and applied it to 34 real-world DApps. Experiments have demonstrated that VetSC can accurately interpret smart contract code, …

The Past, Present, And Future Of China-Related Accounting Research, Qiang Cheng, Luzi Hail, Gwen Yu

Research Collection School Of Accountancy

This discussion makes several observations regarding the past 25 years of China-related accounting research reviewed in Lennox and Wu (2022). First, we discuss factors of supply and demand that led to the rise of China-related studies and how this growth has contributed to the internationalization of accounting research. We note that the taxonomy of the literature by geographic region rather than topic or methodology is unusual and makes it difficult to formulate a common framework that would help organize the many contributions. Next, we distill distinct patterns in authorship, choice of topics, and asserted contributions of China-related studies. Studies are …

Introducing A Model For How Knowledge-Driven Agile Innovation Can Drive Digital Transformation In Firms, Lipika Bhattacharya, Clarence Goh, Gary Pan

Research Collection School Of Accountancy

Digital transformation often arises from the distribution of tasks among interdisciplinary teams of experts. One important factor that determines the success of digital transformation relates to an organization’s ability to innovate in an agile manner. In this article, we identify key drivers of digital transformation, which include organizational agility, knowledge management and innovation. Another crucial aspect of knowledge management relates to the coordination of knowledge. It is important for organizations to focus on knowledge coordination because the lack of coordination can dissuade them from meeting the demands for flexibility and speed during digital transformation, thereby negating the potential benefits from …

Family Still Matters: Human Social Motivation Across 42 Countries During A Global Pandemic, Cari M. Pick, Et. Al.

Research Collection School of Social Sciences

The COVID-19 pandemic caused drastic social changes for many, including separation from friends and coworkers, enforced close contact with family, reductions in mobility, and a number of other health-related precautions. Here we assess the extent to which people’s evolutionarilyrelevant basic motivations and goals—their fundamental social motives—might have been affected. To address this question, we gathered data on these motives in 42 countries (N=15,915) in two waves, including 19 countries (N=10,907) for which data were gathered both before and during the pandemic (Pre-pandemic wave: 32 countries, N=8998; 3302 male, 5585 female; Mage=24.43, SD=7.91; Mid-pandemic wave: 29 countries, N=6917; 2249 male, 4218 …

Intensive Family Observations: A Methodological Guide, Annette Lareau, Aliya Hamid Rao

Research Collection School of Social Sciences

There is a dearth of methodological guidance on how to conduct participant observation in private spaces such as family homes. Yet, participant observations can provide deep and valuable data about family processes. This article draws on two ethnographic studies of family life in which researchers conduct in-depth interviews, recruit families, and ultimately enter the family as a quasi-stranger for daily observations lasting a fixed period (e.g., three weeks). We term this approach "intensive family observations." Here, we provide concrete methodological advice for this method, beginning with guidelines for recruitment and gaining consent. We also discuss logistics of conducting family observation …

The Privacy Of Hak-Shing William Tam: Imagining Asian Families In California’S Proposition 8, Justin Kh Tse

Research Collection School of Social Sciences

In terms of Asian Americans whose reputations have been popularly derided, the concerned parent activist Hak-Shing William Tam perhaps ranks among the top. Tam was a citizen proponent of California’s Proposition 8 in 2008 to amend the state constitution to ban same-sex marriage and became a hostile witness for the plaintiffs in the subsequent 2010 lawsuit to overturn the amendment, Perry v. Schwarzenegger. In this paper, I explore Tam’s claim to privacy in his understanding of these events, both in terms of his sexualized imagination of liberal civil society and his suffering from what he understood as violations of his …

Infrastructure's (Supra)Sacralizing Effects: Contesting Littoral Spaces Of Fishing, Faith, And Futurity Along Sri Lanka's Western Coastline, Orlando Woods

Research Collection School of Social Sciences

This paper explores the ways in which infrastructural development can cause the sacred to become a source of political legitimacy, and sacred authority to become a politically charged construct. For resource-dependent communities, the ecological damage caused by infrastructural development can cause ostensibly profane issues to be imbued with sacred meaning and value. With sacralization comes the expectation that figures of sacred authority will campaign for justice on behalf of the communities that they represent. However, when the authority evoked comes from outside the boundaries of institutionalized religion, processes of suprasacralization come into play. By exploring infrastructure’s (supra)sacralizing effects, I demonstrate …

Does Trait Self-Esteem Serve As A Resilience Factor In Maintaining Affective Well-Being? Findings From Daily Diary Studies In Singapore And The United States, Matthew H. S. Ng, Verity Yu Qing Lua, Nadyanna M. Majeed, Andree Hartanto

Research Collection School of Social Sciences

Research suggests that self-esteem could be a protective factor in stressful or unfavorable situations. However, little research has been done on the buffering role of self-esteem in the context of daily stressors on affective reactivity. Three daily diary studies (of which two were conducted in Singapore and one in the United States) were carried out to examine this relationship. In all three studies, trait self-esteem was measured at baseline. Subsequently, daily assessment was conducted on exposure to daily stressors, and positive and negative affect for seven to eight days. Multilevel modeling showed that trait self-esteem did not moderate the relationship …

Young Singaporeans Abroad And Their Misguided Sense Of Superiority Towards S-E Asia, Lily Kong

Research Collection School of Social Sciences

In a commentary, SMU President and Lee Kong Chian Chair Professor of Social Sciences Lily Kong –whose research has focused over the decades on social and cultural change in Asian cities – discussed why young Singaporeans can have a misguided sense of superiority towards South-east Asia when they venture abroad. She explained how this could blind them to their neighbours’ hidden strengths. Prof Kong also shared that SMU has sought to actively vest in its students a sound appreciation of growth in Asia. To support this endeavour, the University is launching a series of overseas centres in selected South-east Asian …

Deliberate Errors Promote Meaningful Learning, Sarah Shi Hui Wong, Stephen Wee Hun Lim

Research Collection School of Social Sciences

Our civilization recognizes that errors can be valuable learning opportunities, but for decades, they have widely been avoided or, at best, allowed to occur as serendipitous accidents. The present research tested whether greater learning success could paradoxically be achieved through making errors by intentional design, relative to traditional errorless learning methods. We show that deliberately committing and correcting errors even when one knows the correct answers enhances learning—a counterintuitive phenomenon that we termed the derring effect. Across two experiments (N = 160), learners engaged in open-book study of scientific expository texts and were then tested on their retention and higher-order …

Personal Comfort Models Based On A 6‐Month Experiment Using Environmental Parameters And Data From Wearables, Federico Tartarini, Stefano Schiavon, Matias Quintana, Clayton Miller

Research Collection College of Integrative Studies

Personal thermal comfort models are a paradigm shift in predicting how building occupants perceive their thermal environment. Previous work has critical limitations related to the length of the data collected and the diversity of spaces. This paper outlines a longitudinal field study comprising 20 participants who answered Right-Here-Right-Now surveys using a smartwatch for 180 days. We collected more than 1080 field-based surveys per participant. Surveys were matched with environmental and physiological measured variables collected indoors in their homes and offices. We then trained and tested seven machine learning models per participant to predict their thermal preferences. Participants indicated 58% of …

Inhibition Of Cyclin Dependent Kinase 4/6 Overcomes Primary Resistance To Programmed Cell Death 1 Blockade In Malignant Mesothelioma, Hee-Jin Jang, Cynthia Y Truong, Eric M Lo, Hudson M Holmes, Daniela Ramos, Maheshwari Ramineni, Ju-Seog Lee, Daniel Y Wang, Massimo Pietropaolo, R Taylor Ripley, Bryan M Burt, Hyun-Sung Lee

Faculty, Staff and Student Publications

BACKGROUND: Despite the profound number of malignant pleural mesothelioma (MPM) patients now treated with programmed cell death 1 (PD-1) blockade, insight into the underpinnings of rational therapeutic strategies to treat resistance to checkpoint immunotherapy remains unrealized. Our objective was to develop a novel therapeutic approach to overcome primary resistance to PD-1 blockade in MPM.

METHODS: We generated a transcriptome signature of resistance to PD-1 blockade in MPM patients treated with nivolumab (4 responders and 4 nonresponders). We used The Cancer Genome Atlas MPM cohort (n = 73) to determine what genomic alterations were associated with the resistance signature. We tested …

A Semi-Mechanistic Dose-Finding Design In Oncology Using Pharmacokinetic/Pharmacodynamic Modeling, Xiao Su, Yisheng Li, Peter Müller, Chia-Wei Hsu, Haitao Pan, Kim-Anh Do

Faculty, Staff and Student Publications

While a number of phase I dose-finding designs in oncology exist, the commonly used ones are either algorithmic or empirical model-based. We propose a new framework for modeling the dose-response relationship, by systematically incorporating the pharmacokinetic (PK) data collected in the trial and the hypothesized mechanisms of the drug effects, via dynamic PK/PD modeling, as well as modeling of the relationship between a latent cumulative pharmacologic effect and a binary toxicity outcome. This modeling framework naturally incorporates the information on the impact of dose, schedule and method of administration (e.g., drug formulation and route of administration) on toxicity. The resulting …

Development And Validation Of A Population-Based Anatomical Colorectal Model For Radiation Dosimetry In Late Effects Studies Of Survivors Of Childhood Cancer, Constance A Owens, Bastien Rigaud, Ethan B Ludmir, Aashish C Gupta, Suman Shrestha, Arnold C Paulino, Susan A Smith, Christine B Peterson, Stephen F Kry, Choonsik Lee, Tara O Henderson, Gregory T Armstrong, Kristy K Brock, Rebecca M Howell

Faculty, Staff and Student Publications

Purpose: The purposes of this study were to develop and integrate a colorectal model that incorporates anatomical variations of pediatric patients into the age-scalable MD Anderson Late Effects (MDA-LE) computational phantom, and validate the model for pediatric radiation therapy (RT) dose reconstructions.

Methods: Colorectal contours were manually derived from whole-body non-contrast computed tomography (CT) scans of 114 pediatric patients (age range: 2.1-21.6 years, 74 males, 40 females). One contour was used for an anatomical template, 103 for training and 10 for testing. Training contours were used to create a colorectal principal component analysis (PCA)-based statistical shape model (SSM) to extract …

Molecular Map Of Chronic Lymphocytic Leukemia And Its Impact On Outcome, Binyamin A Knisbacher, Ziao Lin, Cynthia K Hahn, Ferran Nadeu, Martí Duran-Ferrer, Kristen E Stevenson, Eugen Tausch, Julio Delgado, Alex Barbera-Mourelle, Amaro Taylor-Weiner, Pablo Bousquets-Muñoz, Ander Diaz-Navarro, Andrew Dunford, Shankara Anand, Helene Kretzmer, Jesus Gutierrez-Abril, Sara López-Tamargo, Stacey M Fernandes, Clare Sun, Mariela Sivina, Laura Z Rassenti, Christof Schneider, Shuqiang Li, Laxmi Parida, Alexander Meissner, François Aguet, Jan A Burger, Adrian Wiestner, Thomas J Kipps, Jennifer R Brown, Michael Hallek, Chip Stewart, Donna S Neuberg, José I Martín-Subero, Xose S Puente, Stephan Stilgenbauer, Catherine J Wu, Elias Campo, Gad Getz

Faculty, Staff and Student Publications

Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymphocytic leukemia (CLL), a B cell neoplasm with variable natural history that is conventionally categorized into two subtypes distinguished by extent of somatic mutations in the heavy-chain variable region of immunoglobulin genes (IGHV). To build the 'CLL map,' we integrated genomic, transcriptomic and epigenomic data from 1,148 patients. We identified 202 candidate genetic drivers of CLL (109 new) and refined the characterization of IGHV subtypes, which revealed distinct genomic landscapes and leukemogenic trajectories. …

An Automated Treatment Planning Framework For Spinal Radiation Therapy And Vertebral-Level Second Check, Tucker J Netherton, Callistus Nguyen, Carlos E Cardenas, Caroline Chung, Ann H Klopp, Lauren E Colbert, Dong Joo Rhee, Christine B Peterson, Rebecca Howell, Peter Balter, Laurence E Court

Faculty, Staff and Student Publications

Purpose: Complicating factors such as time pressures, anatomic variants in the spine, and similarities in adjacent vertebrae are associated with incorrect level treatments of the spine. The purpose of this work was to mitigate such challenges by fully automating the treatment planning process for diagnostic and simulation computed tomography (CT) scans.

Methods and materials: Vertebral bodies are labeled on CT scans of any length using 2 intendent deep-learning models-mirroring 2 different experts labeling the spine. Then, a U-Net++ architecture was trained, validated, and tested to contour each vertebra (n = 220 CT scans). Features from the CT and auto-contours were …

Monkeypox Prevention And Protecting Sex Workers: A Call To Action, Randi Beth Singer, Amy K. Johnson, Jessica L. Zemlak, Ariel Shensa, Rebecca M. Singer, Cocoa Costales, Kathleen Chiu, Jahari Stamps

College of Nursing Faculty Research and Publications

No abstract provided.

Cry Wolf, Olivia Claire Acosta

Electronic Theses and Dissertations

Cry Wolf is a confessional poetry collection told in three sections about at-work stalking. This collection also alludes to the Brothers Grimm fairytale, The Little Red Riding Hood. The sections of Cry Wolf include “The Wolf,” which introduces the speaker’s discovery of work-related stalking. The second section, entitled “The Fur,” is where the speaker empowers themselves to file a Title IX report about this dilemma, and Red cloaks herself in the wolf’s skin. The final portion of the collection, entitled “Red’s Home,” gives the audience a view of the speaker's self-love as they maintain it through trauma. This section also …

Targeted Temperature Management Using Esophageal Cooling, Cedar Morrow Anderson, Christopher Joseph, Rick Fisher, Donald Berry, J Brad Diestelhorst, Christine Kulstad, Marvin Wayne

Faculty, Staff and Student Publications

Although specific temperature targets are debated, targeted temperature management (TTM) is a common treatment for postcardiac arrest patients. However, consistently implementing a TTM protocol is challenging, especially in a community hospital. Often, the protocols described in the literature include labor- and cost-intensive methods that are not feasible or sustainable in many health care settings. Esophageal temperature management (ETM) is a TTM method that can be easily utilized alone or combined with surface methods. We sought to evaluate ETM in a cohort of patients treated with TTM after cardiac arrest. Chart reviews were conducted of all patients treated with ETM after …

T Cells Specific For Α-Myosin Drive Immunotherapy-Related Myocarditis, Margaret L Axelrod, Wouter C Meijers, Elles M Screever, Juan Qin, Mary Grace Carroll, Xiaopeng Sun, Elie Tannous, Yueli Zhang, Ayaka Sugiura, Brandie C Taylor, Ann Hanna, Shaoyi Zhang, Kaushik Amancherla, Warren Tai, Jordan J Wright, Spencer C Wei, Susan R Opalenik, Abigail L Toren, Jeffrey C Rathmell, P Brent Ferrell, Elizabeth J Phillips, Simon Mallal, Douglas B Johnson, James P Allison, Javid J Moslehi, Justin M Balko

Faculty, Staff and Student Publications

Immune-related adverse events, particularly severe toxicities such as myocarditis, are major challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy1. The pathogenesis of ICI-associated myocarditis (ICI-MC) is poorly understood. Pdcd1-/-Ctla4+/- mice recapitulate clinicopathological features of ICI-MC, including myocardial T cell infiltration2. Here, using single-cell RNA and T cell receptor (TCR) sequencing of cardiac immune infiltrates from Pdcd1-/-Ctla4+/- mice, we identify clonal effector CD8+ T cells as the dominant cell population. Treatment with anti-CD8-depleting, but not anti-CD4-depleting, antibodies improved the survival of Pdcd1-/-Ctla4+/- mice. Adoptive transfer of immune cells from mice with myocarditis induced fatal myocarditis in recipients, …

Celebration Of Life - Chamber Singers

Bailey School of Music Concert Programs

Program for the November 1 Chamber Singers performance

Americana Festival

Bailey School of Music Concert Programs

Kennesaw State University’s Bailey School of Music, a unit of the College of the Arts, will present the Americana Festival from Nov. 7-11. Four diverse concerts will focus on American composers and patriotic songs to celebrate Veterans Day.

The Equilibrium Of Tumor Suppression: Dubs As Active Regulators Of Pten, Audrey Christine, Mi Kyung Park, Su Jung Song, Min Sup Song

Faculty, Staff and Student Publications

PTEN is among the most commonly lost or mutated tumor suppressor genes in human cancer. PTEN, a bona fide lipid phosphatase that antagonizes the highly oncogenic PI3K-AKT-mTOR pathway, is considered a major dose-dependent tumor suppressor. Although PTEN function can be compromised by genetic mutations in inherited syndromes and cancers, posttranslational modifications of PTEN may also play key roles in the dynamic regulation of its function. Notably, deregulated ubiquitination and deubiquitination lead to detrimental impacts on PTEN levels and subcellular partitioning, promoting tumorigenesis. While PTEN can be targeted by HECT-type E3 ubiquitin ligases for nuclear import and proteasomal degradation, studies have …

Antibody Therapeutics For Epithelial Ovarian Cancer, Mason Ruiz, Ningyan Zhang, Anil K Sood, Zhiqiang An

Faculty, Staff and Student Publications

INTRODUCTION: High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. A lack of effective and tolerable therapeutic options and nonspecific symptoms at presentation with advanced stage of disease are among the challenges in the management of the disease.

AREAS COVERED: An overview of ovarian cancer, followed by a discussion of the current therapeutic regimes and challenges that arise during and after the treatment of EOC. We discuss different formats of antibody therapeutics and their usage in targeting validated targets implicated in ovarian cancer, as well as three emerging …

Comparison Of Setup Accuracy And Efficiency Between The Klarity System And Bodyfix System For Spine Stereotactic Body Radiation Therapy, Enzhuo Quan, Shane P Krafft, Tina M Briere, Marissa J Vaccarelli, Amol J Ghia, Andrew J Bishop, Debra N Yeboa, Todd A Swanson, Eun Young Han

Faculty, Staff and Student Publications

BACKGROUND: Spine stereotactic body radiation therapy (SBRT) uses highly conformal dose distributions and sharp dose gradients to cover targets in proximity to the spinal cord or cauda equina, which requires precise patient positioning and immobilization to deliver safe treatments.

AIMS: Given some limitations with the BodyFIX system in our practice, we sought to evaluate the accuracy and efficiency of the Klarity SBRT patient immobilization system in comparison to the BodyFIX system.

METHODS: Twenty-three patients with 26 metastatic spinal lesions (78 fractions) were enrolled in this prospective observational study with one of two systems - BodyFIX (n = 11) or Klarity …

Molecular Mechanisms Of Resistance To Kinase Inhibitors And Redifferentiation In Thyroid Cancers, Marie-Claude Hofmann, Muthusamy Kunnimalaiyaan, Jennifer R Wang, Naifa L Busaidy, Steven I Sherman, Stephen Y Lai, Mark Zafereo, Maria E Cabanillas

Faculty, Staff and Student Publications

Protein kinases play critical roles in cell survival, proliferation and motility. Their dysregulation is therefore a common feature in the pathogenesis of a number of solid tumors, including thyroid cancers. Inhibiting activated protein kinases has revolutionized thyroid cancer therapy, offering a promising strategy in treating tumors refractory to radioactive iodine treatment or cytotoxic chemotherapies. However, despite satisfactory early responses, these drugs are not curative and most patients inevitably progress due to drug resistance. This review summarizes up-to-date knowledge on various mechanisms that thyroid cancer cells develop to bypass protein kinase inhibition and outlines strategies that are being explored to overcome …

Differential Integrated Stress Response And Asparagine Production Drive Symbiosis And Therapy Resistance Of Pancreatic Adenocarcinoma Cells, Christopher J Halbrook, Galloway Thurston, Seth Boyer, Cecily Anaraki, Jennifer A Jiménez, Amy Mccarthy, Nina G Steele, Samuel A Kerk, Hanna S Hong, Lin Lin, Fiona V Law, Catherine Felton, Lorenzo Scipioni, Peter Sajjakulnukit, Anthony Andren, Alica K Beutel, Rima Singh, Barbara S Nelson, Fran Van Den Bergh, Abigail S Krall, Peter J Mullen, Li Zhang, Sandeep Batra, Jennifer P Morton, Ben Z Stanger, Heather R Christofk, Michelle A Digman, Daniel A Beard, Andrea Viale, Ji Zhang, Howard C Crawford, Marina Pasca Di Magliano, Claus Jorgensen, Costas A Lyssiotis

Faculty, Staff and Student Publications

The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate. Pancreatic cancer subtypes have been characterized by transcriptional and functional differences, with subtypes reported to exist within the same tumor. However, it remains unclear if this diversity extends to metabolic programming. Here, using metabolomic profiling and functional interrogation of metabolic dependencies, we identify two distinct metabolic subclasses among neoplastic populations within individual human and mouse tumors. Furthermore, these populations are poised for metabolic cross-talk, and in examining this, we find an unexpected role for asparagine supporting proliferation during limited respiration. Constitutive …

Flow Cytometry Immunophenotypic Features Of Pure Erythroid Leukemia And The Distinction From Reactive Erythroid Precursors, Hong Fang, Sa A Wang, M James You, Shimin Hu, Roberto N Miranda, Zhenya Tang, Pei Lin, Jeffrey L Jorgensen, Jie Xu, Beenu Thakral, Ellen J Schlette, Siba El Hussein, Carlos Bueso-Ramos, L Jeffrey Medeiros, Wei Wang

Faculty, Staff and Student Publications

BACKGROUND: The immunophenotype of pure erythroid leukemia (PEL) as determined by flow cytometry immunophenotypic analysis is not well characterized. The immunophenotypic difference between PEL and reactive conditions is under-explored.

METHODS: We assessed and compared the immunophenotype of 24 PEL cases and 28 reactive cases containing early erythroid precursors by flow cytometry.

RESULTS: The neoplastic erythroid cells in all PEL cases were positive for CD36 and CD71. CD45 was also positive in all cases, but the expression level was often dimmer than granulocytes. CD117 expression ranged from partial to uniform, and CD235a was often only positive in the CD117-dim to negative …

Outpatient Surgery For Rib Fracture Fixation: A Report Of Three Cases., Daniel T Degenova, Nolan P Schmitz, Jia Bao Lin, Travis J Jones, Benjamin C Taylor

Surgery Articles

Rib fractures are common injuries observed in trauma patients that will often heal without operative intervention. However, patients can infrequently have continued pain. Operative fixation of these symptomatic rib fractures has traditionally led to the patient requiring hospital admission for observation and pain control. The purpose of this study was to review three cases of outpatient rib fracture, open reduction and internal fixation (ORIF) surgery. Three patients with symptomatic rib fractures treated with ORIF at a single urban level one trauma center underwent outpatient same-day surgery. Pertinent demographic, clinical, radiographic, and surgical data were collected. All patients had decreased preoperative …