Digital Commons Network^™

Metabolic Pathways Enriched According To Erg Status Are Associated With Biochemical Recurrence In Hispanic/Latino Patients With Prostate Cancer, Natalia L. Acosta-Vega, Rodolfo Varela, Jorge Andrés Mesa, Jone Garai, Melody C. Baddoo, Alberto Gómez-Gutiérrez, Silvia J. Serrano-Gómez, Marcela Nuñez Lemus, Martha Lucía Serrano, Jovanny Zabaleta, Alba L. Combita, María Carolina Sanabria-Salas

School of Medicine Faculty Publications

Background: The role of ERG-status molecular subtyping in prognosis of prostate cancer (PCa) is still under debate. In this study, we identified differentially expressed genes (DEGs) according to ERG-status to explore their enriched pathways and implications in prognosis in Hispanic/Latino PCa patients. Methods: RNA from 78 Hispanic PCa tissues from radical prostatectomies (RP) were used for RNA-sequencing. ERGhigh/ERGlow tumor groups were determined based on the 1.5-fold change median expression in non-tumor samples. DEGs with a False Discovery Rate (FDR) < 0.01 and a fold change >2 were identified between ERGhigh and ERGlow tumors and submitted to enrichment analysis in MetaCore. Survival and association analyses were performed …

Analyzing Audio/Visual Data In The Digital Humanities, Taylor B. Arnold, Lauren Tilton

Department of Math & Statistics Faculty Publications

The Bloomsbury Handbook to the Digital Humanities reconsiders key debates, methods, possibilities, and failings from across the digital humanities, offering a timely interrogation of the present and future of the arts and humanities in the digital age.

Comprising 43 essays from some of the field's leading scholars and practitioners, this comprehensive collection examines, among its many subjects, the emergence and ongoing development of DH, postcolonial digital humanities, feminist digital humanities, race and DH, multilingual digital humanities, media studies as DH, the failings of DH, critical digital humanities, the future of text encoding, cultural analytics, natural language processing, open access and …

Positive And Negative Actions Early In The Relationship Predict Later Interactions Among Toddlers, Ayelet Lahat, Zhangling Lou, Michal Perlman, Nina Howe, Jonathan Santo, Holly E. Recchia, William M. Bukowski, Hildy S. Ross

Psychology Faculty Publications

Very little is known about the role of early interactions in the development of peer relationships among toddlers. The present study examined whether behaviors early in the formation of toddler relationships predict interactions later in their relationships. Twenty-eight unfamiliar 20- and 30-month-old toddlers from a predominately European background met separately with each of two other toddlers for 18 playdates. Both positive and negative behaviors at the beginning of the relationship predicted a higher frequency of games later in the relationship. Positive behaviors at the beginning of the relationship predicted fewer conflicts later in the relationship. Negative behaviors at the beginning …

University Welcomes 13 Stamps Scholars For 2022, Erin Garrett

University of Mississippi News

New cohort exemplifies academic excellence, leadership and exceptional character

2022-11-03 Message From The President, Morehead State University. Office Of The President.

Staff Congress Records

A message sent on November 3, 2022 by the President of Morehead State University to the campus community regarding upcoming dates and events, the Centennial of the University, and construction work to be conducted to building on campus.

The Importance Of Library Assessment In Hr: A Case Study Of Transitioning To A Hybrid Work Environment After The Covid-19 Pandemic, Sally Bowler-Hill

Posters and Presentations

Purpose & Goals: The purpose of this study was to explore and understand employee perceptions of remote work as a potential option for normal operations, based on experiences from the COVID-19 pandemic. The goals were to obtain feedback from library faculty and staff about remote work and telecommuting in order to develop a guideline, and to measure satisfaction with the hybrid work environment several months after the guideline was implemented.

Design & Methodology: Two web-based surveys were sent to all library faculty and staff, one in April 2021 and the other in March 2022. The first survey included multiple-choice and …

New Times, New Terms, Grace Huffman, Jill Crane

University Libraries Blog Archive

This Native American Heritage Month, read how library catalogers implemented less harmful terminology surrounding Indigenous communities.

Episode 20: Anne Prucha, Christina Torres

Futures in Languages Transcripts

No abstract provided.

Toward An Asian American Antiracist Pedagogy For First Year Writing, Dorothy Margaret Stone

Theses and Dissertations

This thesis seeks to demonstrate a need for an antiracist writing curriculum in light of the COVID-19 pandemic, which contributed to an upswing of violent acts against Asians and Asian Americans living in the United States. Asian Americans have faced fluctuating status over the course of this country’s history, yet these stories are hardly represented by the canon and are instead misconstrued by hegemonic narratives. I seek to speak back against these narratives by designing a writing course based on critical race counterstory—those lived experiences that conflict with mainstream perceptions. By designing a methodological framework for teaching first-year writing through …

Heyman Center Book Talk: Going Public, Heyman Center On Corporate Governance, Rachel Landy, Dakin Campbell, Megan Baier

2022–2023 Flyers

No abstract provided.

Physician Predicts Severe Flu Season, Erin Garrett

University of Mississippi News

University Health Services offers vaccines for prevention, antivirals for treatment

Industry Expert Plans Update For Sports And Rec Administration Program, Cameron Smith

University of Mississippi News

Brennan Berg brings experience from academia, NBA to Ole Miss

The Content Of Covid-19 Information Searches And Vaccination Intention: An Implication For Risk Communication, Ayokunle A. Olagoke, Brenikki Floyd, Comfort T. Adebayo, Ayomide Owoyemi, Ashley M. Hughes

Health and Kinesiology Faculty Publications

Objective:

The main objective of this study was to examine the association between COVID-19 information search activities and vaccination intention.

Methods:

Cross-sectional data were collected using online surveys. Independent variables included COVID-19 information search on the (1) science of viral effects of COVID-19 on the body, (2) origin of COVID-19, (3) symptoms and outcomes, (4) transmission and prevention, (5) future outbreak, and (6) policies/procedures to follow. The outcome variable was vaccination intention. A multivariable regression analysis was conducted.

Results:

Participants (N = 501) had a mean age of 32.44 ± 11.94 years, were 55.3% female, and 67.9% were white. Most …

Wmu Board Of Trustees Formal Session November 3, 2022, Western Michigan University

WMU Board of Trustees Meetings

Acceptance of the Agenda

Approval of the Minutes (September 15, 2022 Meeting)

Remarks by the Chair

Remarks by the President

Updates by the Faculty Senate President

Updates by the Western Student Association President

Updates by the Graduate Student Association President

Bronco Connect: Discovering Success

Public Comments Regarding Action Items

Action Items

• Sale of Kalamazoo Downtown Property
• Western Michigan University External Audit
• Changes to the Student Code of Conduct

Consent Items

• Curriculum Proposals
• Personnel Report
• Revised Bylaws for the Paper Technology Foundation
• Revised Western Michigan University Board of Trustees Meeting Dates for 2023
• Annuity and Life Income Funds Performance Report
• Operating …

An Autoencoder-Based Deep Learning Method For Genotype Imputation, Meng Song, Jonathan Greenbaum, Joseph Luttrell Iv, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan-Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong-Wen Deng, Chaoyang Zhang

Faculty Publications

Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with fine-mapping. In recent years, deep learning (DL) based methods, such as sparse convolutional denoising autoencoder (SCDA), have been developed for genotype imputation. However, it remains a challenging task to optimize the learning process in DL-based methods to achieve high imputation accuracy. To address this challenge, we have developed a convolutional autoencoder (AE) model for genotype imputation and implemented a customized training loop by modifying the training process with a …

November 2022 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

St. Norbert College Rotc Cadets Shine At Army Ranger Challenge, St. Norbert College

Press Releases 2022

No abstract provided.

Racial/Ethnic Disparities Of Cancer, Metabolic Syndrome, And Lifestyle Behaviors In People Under 50: A Cross-Sectional Study Of Data From The National Health And Nutrition Examination Survey, Lin Zhu, Areebah Rahman, Ming-Chin Yeh, Grace X. Ma

Publications and Research

Introduction: Recent epidemiological studies have suggested a trend of increasing preva- lence of metabolic syndrome (MetS) and certain types of cancer among adults under age 50. How MetS is associated with cancer in adults under the age of 50, however, remains unclear. Furthermore, it remains unknown whether associations between MetS and cancer vary by racial/ethnic group and whether modifiable lifestyle factors influence MetS–cancer relationships. Methods: We used data from the 2011–2018 National Health and Nutrition Examination Survey (NHANES) to define a case-control sample to examine potential racial/ethnic disparities associated with MetS and cancer of any type. We used a chi-square …

Characterization Of Bcma Expression In Circulating Rare Single Cells Of Patients With Plasma Cell Neoplasms, Libere J Ndacayisaba, Kate E Rappard, Stephanie N Shishido, Sonia M Setayesh, Guilin Tang, Pei Lin, Nicholas Matsumoto, Ching-Ju Hsu, Rafael Nevarez, Carmen Ruiz Velasco, Amin Naghdloo, Eric Yang, Kevin Kelly, James Hicks, Jeremy Mason, Robert Z Orlowski, Elisabet E Manasanch, Peter Kuhn

Faculty, Staff and Student Publications

B-cell maturation antigen (BCMA), a key regulator of B-cell proliferation and survival, is highly expressed in almost all cases of plasma cell neoplasms and B-lymphoproliferative malignancies. BCMA is a robust biomarker of plasma cells and a therapeutic target with substantial clinical significance. However, the expression of BCMA in circulating tumor cells of patients with hematological malignancies has not been validated for the detection of circulating plasma and B cells. The application of BCMA as a biomarker in single-cell detection and profiling of circulating tumor cells in patients' blood could enable early disease profiling and therapy response monitoring. Here, we report …

Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response In Msi-H/Dmmr Metastatic Colorectal Cancer: A Single-Center Experience, Victoria Serpas Higbie, Jane Rogers, Hyunsoo Hwang, Wei Qiao, Lianchun Xiao, Arvind Dasari, Kerri Mola-Rudd, Van K Morris, Robert A Wolff, Kanwal Raghav, Ryan Huey, Christine Parseghian, Jason Willis, Scott Kopetz, Michael J Overman, Benny Johnson

Faculty, Staff and Student Publications

BACKGROUND: Immune checkpoint blockade (ICB) has improved outcomes for patients with microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) tumors. However, not all MSI-H/dMMR patients will exhibit the same ICB efficacy. Previous studies suggest that concomitant antibiotic use while receiving ICB may result in poorer outcomes. We aimed to evaluate this association in patients with MSI-H/dMMR metastatic colorectal cancer (mCRC).

MATERIALS AND METHODS: A single-site, retrospective review of 57 patients with MSI-H/dMMR mCRC that received ICB was completed. Data collected included patient demographics, ICB information, and antibiotic use. Antibiotic exposure was considered from 90 days prior to ICB through 6 weeks …

Role Of Cd38 In Pulmonary Host Defense Against Gram-Negative Pneumonia, Xiaoqian Shan

LSU Master's Theses

The Gram-negative bacterium, Klebsiella pneumoniae, is a major cause of hospital-acquired pneumonia in the U.S. In particular, the dramatic increase in carbapenem-resistant K. pneumoniae infections poses a serious threat to the public health both in the United States and worldwide. Clearance of bacteria in the lungs depends on effective pulmonary immune response. It may be possible to design improved therapies that augment host immune responses while attenuating excessive pulmonary inflammation through modulation of key innate immunity molecules during pneumonic infections. Cluster differentiation CD38 (CD38) has been detected on the surface of many immune cells or intracellular compartments, acting as …

Enabling The Human Perception Of A Working Camera In Web Conferences Via Its Movement, Anish Shrestha

LSU Master's Theses

In recent years, video conferencing has seen a significant increase in its usage due to the COVID-19 pandemic. When casting user’s video to other participants, the videoconference applications (e.g. Zoom, FaceTime, Skype, etc.) mainly leverage 1) webcam’s LED-light indicator, 2) user’s video feedback in the software and 3) the software’s video on/off icons to remind the user whether the camera is being used. However, these methods all impose the responsibility on the user itself to check the camera status, and there have been numerous cases reported when users expose their privacy inadvertently due to not realizing that their camera is …

Metformin Increases Natural Killer Cell Functions In Head And Neck Squamous Cell Carcinoma Through Cxcl1 Inhibition, Mckenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A. Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M. Wise-Draper

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

BACKGROUND: Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial (NCT02325401). Metformin is also postulated to activate an antitumor immune response. Here, we investigate immunologic effects of metformin on natural killer (NK) and natural killer T cells, including results from two phase I open-label studies in patients with HNSCC treated with metformin (NCT02325401, NCT02083692).

METHODS: Peripheral blood was collected before and after metformin treatment or from newly diagnosed patients with HNSCC. Peripheral immune cell …

Toward A Safer Transportation System For Senior Road Users, Saba Doulabi

LSU Doctoral Dissertations

Senior pedestrians and drivers (65 years and older) are among the most vulnerable road users. As the population of seniors rise, concerns regarding older adults' traffic safety are growing. The advantages of using autonomous vehicles, innovative vehicle technologies, and active transportation are becoming more widely recognized to improve seniors' mobility and safety. This behooves researchers to further investigate senior road users’ safety challenges and countermeasures. This study contributes to the literature by achieving two main goals. First, to explore contributing factors affecting the safety of older pedestrians and drivers in the current transportation system. Second, to examine seniors’ perceptions, preferences, …

Fish And Invertebrate Community And Trophic Structure In The Gulf Of Mexico Coastal Plains Watersheds Across Varying Hydrologic Connectivity., Erin Elizabeth Thayer

LSU Doctoral Dissertations

Subtropical Northern Gulf of Mexico coastal plains watersheds tend to have mild seasonal temperature, low topography, and fine, mostly homogenous substrate sizes; these watersheds may not follow fish and invertebrate community patterns predicted by established lotic paradigms because those paradigms tend to describe communities in either temperate or tropical regions. However, the bases of most generally accepted lotic paradigms involve evaluation of allochthonous and autochthonous contributions to lotic ecosystems via three hydrologic connectivity dimensions including vertical (hyporheic and shallow groundwater), lateral (floodplain), and longitudinal (upstream and downstream). My dissertation goals were to explore these three dimensions within Louisiana coastal plains …

Deepdemod: Bpsk Demodulation Using Deep Learning Over Software-Defined Radio, Arhum Ahmad, Satyam Agarwal, Sam Darshi, Sumit Chakravarty

Open Access Publishing Fund Collection

In wireless communication, signal demodulation under non-ideal conditions is one of the important research topic. In this paper, a novel non-coherent binary phase shift keying demodulator based on deep neural network, namely DeepDeMod, is proposed. The proposed scheme makes use of neural network to decode the symbols from the received sampled signal. The proposed scheme is developed to demodulate signal under fading channel with additive white Gaussian noise along with hardware imperfections, such as phase and frequency offset. The time varying nature of hardware imperfections and channel poses a additional challenge in signal demodulation. In order to address this issue, …

Climate Change In The Midterms: Where Do Candidates Stand?, Julie Bobyock

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

New Hampshire Rates Highest For Student Indebtedness. Where Do The Candidates Stand On Student Loans And Debt?, Melanie Matts

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Marjorie Smith, Self-Described Policy Wonk, Eyes A Return To Nh House, Max Scheinblum

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Building The Foundation For A Trauma Responsive School, Katie Berger, Takeisha Rheams

Staff Publications & Research

The social emotional health of gifted students continues to be a priority for counselors, faculty, residence life staff and administrators. This session will provide an overview of the trauma responsive schools designation pilot that IMSA participated in with Ann & Robert H. Lurie Children’s Hospital of Chicago, with the purpose of identifying an effective, sustainable and scalable model of consultation to determine the optimal support for students. Participants will gain resources to build an interdisciplinary trauma responsive school team, develop a trauma responsive action plan, and understand metrics for success to become a trauma informed and trauma responsive school.