Digital Commons Network^™

Molecular Classification And Biomarkers Of Clinical Outcome In Breast Ductal Carcinoma In Situ: Analysis Of Tbcrc 038 And Rahbt Cohorts, Siri H Strand, Deborah J Veis, Katherine Deschryver, Jen Tappenden, Jingqin Luo, Shu Jiang, Graham A Colditz, Et Al.

2020-Current year OA Pubs

Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression …

Mendelian Randomization And Genetic Colocalization Infer The Effects Of The Multi-Tissue Proteome On 211 Complex Disease-Related Phenotypes, Chengran Yang, Anne M Fagan, Richard J Perrin, Herve Rhinn, Oscar Harari, Carlos Cruchaga

2020-Current year OA Pubs

BACKGROUND: Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR) studies have been mainly focused on plasma proteomes. Previous MR studies using the brain proteome only reported protein effects on a set of pre-selected tissue-specific diseases. No studies, however, have used high-throughput proteomics from multiple tissues to perform MR on hundreds of phenotypes.

METHODS: Here, we performed MR and colocalization analysis using multi-tissue (cerebrospinal fluid (CSF), plasma, and brain from pre- and post-meta-analysis of several …

The Hypertension Cascade Of Care In The Midst Of Conflict: The Case Of The Gaza Strip, Bassam A. Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P. Vamos, Sanjay Basu, John S. Yudkin, Mohammed Jawad, Christopher Millett, Hala Ghattas Ph.D.

Faculty Publications

Although hypertension constitutes a substantial burden in conflict-affected areas, little is known about its prevalence, control, and management in Gaza. This study aims to estimate the prevalence and correlates of hypertension, its diagnosis and control among adults in Gaza. We conducted a representative, cross-sectional, anonymous, household survey of 4576 persons older than 40 years in Gaza in mid-2020. Data were collected through face-to-face interviews, anthropometric, and blood pressure measurements. Hypertension was defined in anyone with an average systolic blood pressure ≥140 mmHg or average diastolic blood pressure ≥90 mmHg from two consecutive readings or a hypertension diagnosis. The mean age …

Social Behavior And Youth Psychopathology During The Covid-19 Pandemic: A Longitudinal Study, Alexandra M. Rodman, Maya L. Rosen, Steven W. Kasparek, Makeda Mayes, Liliana Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin

Neuroscience: Faculty Publications

The early stages of the COVID-19 pandemic and associated stay-at-home orders resulted in a stark reduction in daily social interactions for children and adolescents. Given that peer relationships are especially important during this developmental stage, it is crucial to understand the impact of the COVID-19 pandemic on social behavior and risk for psychopathology in children and adolescents. In a longitudinal sample (N=224) of children (7-10y) and adolescents (13-15y) assessed at three strategic time points (before the pandemic, during the initial stay-at-home order period, and six months later after the initial stay-at-home order period was lifted), we examine whether certain social …

Evaluation Of Simvastatin As A Disease-Modifying Treatment For Patients With Parkinson Disease: A Randomized Clinical Trial, Kara N. Stevens, Siobhan Creanor, Alison Jeffery, Alan Whone, John Zajicek, Andy Foggo, Ben Jones, Rebecca Chapman, Laura Cocking, Jonny Wilks, Doug Webb, Camille Carroll

Peninsula Medical School

Importance: Current treatments manage symptoms of Parkinson disease (PD), but no known treatment slows disease progression. Preclinical and epidemiological studies support the potential use of statins as disease-modifying therapy. Objective: To determine whether simvastatin has potential as a disease-modifying treatment for patients with moderate PD. Design, Setting, and Participants: This randomized clinical trial, a double-blind, parallel-group, placebo-controlled futility trial, was conducted between March 2016 and May 2020 within 23 National Health Service Trusts in England. Participants aged 40 to 90 years with a diagnosis of idiopathic PD, with a modified Hoehn and Yahr stage of 3.0 or less while taking …

F-Box Receptor Mediated Control Of Substrate Stability And Subcellular Location Organizes Cellular Development Of Aspergillus Nidulans, Bayram Ö Sarikaya, Ö Bayram, B Karahoda, C Meister, Am Köhler, S Thieme, N Elramli, D Frawley, J Mcgowan, Da Fitzpatrick, K Schmitt, Leandro Jose De Assis, O Valerius, Gh Goldman, Gh Braus

Peninsula Medical School

Fungal growth and development are coordinated with specific secondary metabolism. This coordination requires 8 of 74 F-box proteins of the filamentous fungus Aspergillus nidulans. F-box proteins recognize primed substrates for ubiquitination by Skp1-Cul1-Fbx (SCF) E3 ubiquitin RING ligases and degradation by the 26S proteasome. 24 F-box proteins are found in the nuclear fraction as part of SCFs during vegetative growth. 43 F-box proteins interact with SCF proteins during growth, development or stress. 45 F-box proteins are associated with more than 700 proteins that have mainly regulatory roles. This corroborates that accurate surveillance of protein stability is prerequisite for organizing multicellular …

Place Cells Dynamically Refine Grid Cell Activities To Reduce Error Accumulation During Path Integration In A Continuous Attractor Model

Faculty, Staff and Students Publications

Navigation is one of the most fundamental skills of animals. During spatial navigation, grid cells in the medial entorhinal cortex process speed and direction of the animal to map the environment. Hippocampal place cells, in turn, encode place using sensory signals and reduce the accumulated error of grid cells for path integration. Although both cell types are part of the path integration system, the dynamic relationship between place and grid cells and the error reduction mechanism is yet to be understood. We implemented a realistic model of grid cells based on a continuous attractor model. The grid cell model was …

A Path To Translation: How 3d Patient Tumor Avatars Enable Next Generation Precision Oncology, Hans Clevers, Elena Elez, Salma Kaochar, Scott E Kopetz, Xiao-Nan Li, Funda Meric-Bernstam, Clifford A Meyer, Haiwei Mou, Kristen M Naegle, Martin F Pera, Zinaida Perova, Katerina A Politi, Benjamin J Raphael, Paul Robson, Rosalie C Sears, Josep Tabernero, David A Tuveson, Alana L Welm, Bryan E Welm, Christopher D Willey, Konstantin Salnikow, Jeffrey H Chuang, Xiling Shen

Faculty, Staff and Students Publications

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.

Applications Of A Superposed Ornstein-Uhlenbeck Type Processes, Santatriniaina Avotra Randrianambinina, Julius Esunge

Journal of Stochastic Analysis

No abstract provided.

Serving What’S Served: A Survey Of Scholarly Dishonesty And Plagiarism Awareness Of Research Scholars Of Babasaheb Bhimrao Ambedkar University, Lucknow, Manoj Kumar Pant Mr., Udita Negi Mrs

Library Philosophy and Practice (e-journal)

The present study is inclined towards identifying the cause and awareness of the scholarly community in institutes of higher education toward the issue of academic dishonesty. A questionnaire was distributed to research scholars pertaining to the faculty of science and social science of Babasaheb Bhimrao Ambedkar University, Lucknow. The results show that the students are aware of the issue of plagiarism and academic dishonesty. However, due to lack of encouragement to be fair and thorough system they do not consider it to be a big challenge. The author recommends mission mode action for awareness of students and faculty towards the …

Information Needs And Seeking Pattern Of Children In Public Libraries: A Case Study Of Kwara State Library, Nigeria, Ronke Oyetunji, Michael Chinweike Chigbundu, David Azeez Olokode

Library Philosophy and Practice (e-journal)

The continuous advancement of children in sizes and knowledge, influences their curiosity and need for information which in turn precedes their information seeking patterns. The Children’s section in public libraries saddled with the responsibilities of meeting the information needs of children ensures that there are adequate information resources available for children. This study was carried out in Kwara State Library, Nigeria, with the aim of identifying the information seeking patterns and needs of children in Kwara State Library. To achieve this aim, four objectives were formulated. Which are; to identify the sources of information available to children in Kwara state …

Food And Beverage Bots – An Exploration Of The Relationship Between Marketing Automation And Grocery E-Commerce, David Joel

Student Work - Business

Chatbot technology holds immense potential to profitably upgrade the digital presence of food and beverage brands when properly applied to their online sales, marketing, and customer service strategies. This paper helps these brands in realizing the potential of this technology and prepares them to put themselves at the forefront digitally at a time when we are seeing a huge move towards online sales from businesses in this industry. It does this by examining the current relationship between chatbot technology and increases in revenue for grocery brands that are using e-commerce to grow their business online. This was accomplished through interviewing …

Conscious Capitalism: An Emerging Economic Philosophy For Higher Purpose In Business, Molly Wickam

Graduate School Faculty Publications

An enhanced economic philosophy, conscious capitalism, is ascending in the United States and gaining traction in helping corporations redefine their approach to business. This article analyzes and evaluates conscious capitalism, integrates it with biblical economics and the social justice faith tradition, and explores its relationship to business education. Business education researchers have the opportunity to integrate conscious capitalism ideas into business curriculum to give students ideas that broaden their understanding of an enhanced model of capitalism and the ways capitalism can do good. Additionally, there is opportunity for Christian business professors to integrate the social justice themes of mishpat, hesed …

Beatrice Crawford Concert - University Symphony Orchestra, John J. Cali School Of Music

2022-2023

For our fifth Crawford concert offering, the Symphony Orchestra is joined by renowned cellist Seth Parker Woods for an evening of music for cello and orchestra.

Beatrice Crawford memorial concert: This concert is a free public performance supported by a generous grant from the Keating Crawford Foundation. It is presented at Montclair State University in memory of Beatrice Crawford, a Montclair musician who was the director of two choral groups, "The Madrigals" and "The Choraliers".

Polymer Reaction Engineering Xi, Timothy Mckenna, Markus Busch, Jay Reimers, Brian Greenhalgh, Claudia Sayer, Robin Hutchinson, Joe Schork, Jose Ramon Leiza, John Tsavalas

Polymer Reaction Engineering XI (2022)

No abstract provided.

Therapeutic Approaches Applied To A Middle School Art Unit, Alisa Burggraff

Art 895 Research Papers

This case study begins with a brief description of my circumstances as a middle school art teacher, Social and Emotional Learning (SEL), the Collaborative for Academic, Social, and Emotional Learning (CASEL), and my research questions: How can art educators adapt CASEL/SEL within their art curriculum to improve students’ mental health and abilities to cope with stress and trauma? What specific therapeutic and CASEL Model procedures can be applied to an art curriculum that aids in the development of a child’s social and emotional development or learning? SEL and CASEL are defined and compared to art therapy/art therapy practices. A rationale …

Learning Through Social Media: A Case Study Of The Getty Center, Regan Fisher

Art 895 Research Papers

Social media is a powerful tool that allows for massive connectivity across the globe and is integral to how young people interact with each other and make sense of their world. During the COVID19 pandemic of 2020, social media was instrumental in connecting communities to museums and providing access during closures. This case study examines how The Getty Center in Los Angeles utilized social media with innovative, strategic thinking and engaging content to achieve their mission of educating the public and increasing awareness about the artifacts housed in their collection.

Art And Its Importance To Social-Emotional Learning And Behavior Management In The Classroom, Ashley Joustra

Art 895 Research Papers

This case study examines the association between an arts education and social-emotional learning (SEL) and attempts to identify if an increased social competence positively affects behavior in the classroom. Education policies are explored as well as outcomes of SEL through art programs. Organizations promoting the SEL such as CASEL and educational plans highlighting art/SEL integration from the UChicago Consortium of School Research are studied. Behavior data from CUSD 300 in northwestern Illinois is examined in relation to art and SEL education.

A Blockchain-Based Regulatory Framework For Mhealth, Dounia Marbouh, Mecit Can Emre Simsekler, Khaled Salah, Raja Jayaraman, Samer Ellahham

Industrial Engineering: Faculty & Staff Publications

Mobile health (mHealth) is playing a key role in facilitating health services for patients. Such services may include remote diagnostics and monitoring, chronic conditions management, preventive medicine, and health promotion. While mHealth has gained significant traction during the COVID-19 pandemic, they may pose safety risks to patients. This entails regulations and monitoring of shared data and management of potential safety risks of all mHealth applications continuously and systematically. In this study, we propose a blockchain-based framework for regulating mHealth apps and governing their safe use. We systematically identify the needs, stakeholders, and requirements of the current mHealth practices and regulations …

Encouraging Confident Art Making In The Primary Elementary Art Room, Morgan Hagan

Art 895 Research Papers

This action research study observes artistic outcomes from students in kindergarten through third grade who display a range of artistic skill levels, and backgrounds. The purpose of this study is to explore what confidence looks like in student artwork and what pedagogical practices art teachers can use to help encourage that confidence by answering two central questions. What does confidence look like in student artwork? What pedagogical practices can art teachers use to encourage students to have confidence in art making?

Ken Moon, Oral History Interview, 2022, Chyelle Pitts-Chatman, Matt Jones

Oral Histories

In the Fall of 2022, Matt Jones’s Oral History Techniques class conducted a set of interviews documenting the stories behind the student unrest on Eastern Michigan University’s campus from 1966-1972. Ken Moon was a Black administrator at EMU during the lates 1960s and early 1970s, and an important mediator between the students and the administration. Moon was an influential figure on campus and supported students academically and personally.

Uni Suzuki School Presents: Northern Iowa Youth Orchestra, December 11, 2022 [Program], University Of Northern Iowa. School Of Music.

Music Recital Programs

Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.

Certification Basis For A Fully Autonomous Uncrewed Passenger Carrying Urban Air Mobility Aircraft, Steve Price

Student Works

The Urban Air Mobility campaign has set a goal to efficiently transport passengers and cargo in urban areas of operation with autonomous aircraft. This concept of operations will require aircraft to utilize technology that currently does not have clear regulatory requirements. This report contains a comprehensive analysis and creation of a certification basis for a fully autonomous uncrewed passenger carrying rotorcraft for use in Urban Air Mobility certified under Title 14 Code of Federal Regulations Part 27. Part 27 was first analyzed to determine the applicability of current regulations. The fully electric propulsion system and fully autonomous flight control system …

Saint Jude's, December 11, 2022

Saint Jude's

A newsletter published for Deaf Catholics in Waltham, MA

Saint Jude's Finding Aid

Heterogeneous Strain Distribution & The Effects Of High Frequency Climate Change On The Evolution Of Early-Stage Rift Systems: Case Studies From Lakes Tanganyika And Malawi (Nyasa), East Africa, Lachlan Wright

Dissertations - ALL

The break-up of the earth’s crust through the formation of continental rift basins is a fundamental aspect of plate-tectonics and the first step that ultimately leads to plate-spreading, new continent formation, and the creation of ocean basins. Within continental rifts, processes associated with extensional faulting drive uplift and subsidence of the landscapes forming rift valleys, and climatically influenced processes act upon these transient landscapes, erode them, modify relief, and produce sediments that infill the rift valleys creating the stratigraphic record. Continental rifts are highly sensitive to the interplay between extensional faulting, sedimentary processes, and climate change, and variations in the …

A Robust Random Forest Prediction Model For Mother-To-Child Hiv Transmission Based On Individual Medical History, Rebecca Chaula

Tanzania Journal of Engineering and Technology (TJET)

Human Immunodeficiency Virus (HIV) continues to be a leading cause of mortality and reduces manpower throughout the world. HIV transmission from mother to child is still a global challenge in health research. According to UNAIDS, in every 7 girls, 6 are found to be newly infected among adolescents whereby 15-24 years are likely to be living with HIV which is the maternal age and likely to transfer to the child. Machine learning methods have been used to predict HIV/AIDS transmission from mother to child but left behind some important considerations including the use of patient-level information and techniques in balancing …

Review Of Educational Psychology- Second Edition, Seokmin Kang

Open Educational Resources - Reviews

No abstract provided.

The Use Of Online Social Media Platforms By Tanzania Journalists To Produce And Disseminate Development News, Elisha Magolanga

Tanzania Journal of Engineering and Technology (TJET)

Advancement in Information and Communication Technologies (ICT) are revolutionizing Development Journalism (DJ) into an effective strategy for building competitive economies globally. However, many countries in Africa including Tanzania are slow in tapping potentials of ICT for development journalism. Digital penetration in the form of the Internet and social media are changing the way in which journalists are mobilizing and engaging communities in journalism practises, a key strategy for a competitive digitalised economy. This paper was guided by Development Communication Theory and Diffusion of Innovation Theory to explore the use of online social media by journalists in Tanzania to practice development …

Television White Space Based Broadband Network’S Coverage And Capex Performance For Rural Areas Connectivity In Tanzania, Moses Ismail

Tanzania Journal of Engineering and Technology (TJET)

This study compared the CAPEX requirements for a television white space (TVWS) based broadband network and that of deploying the UMTS based mobile broadband networks to deliver broadband connectivity in areas with sparse population which characterize most of Tanzania rural. Like many developing countries, Tanzania has low Internet penetration, with penetration of just over 46% when multiple subscriptions are taken into account. The affected communities are mostly rural due to low population densities which make deployment of the mobile broadband to be much expensive in terms of costs. This limits the economic development potential in these areas given that the …

Isolation Of Ddos Attacks And Flash Events In Internet Traffic Using Deep Learning Techniques, Alex Frank Mongi

Tanzania Journal of Engineering and Technology (TJET)

The adoption of network function visualization (NFV) and software defined radio (SDN) has created a tremendous increase in Internet traffic due to flexibility brought in the network layer. An increase in traffic flowing through the network poses a security threat that becomes tricky to detect and hence selects an appropriate mitigation strategy. Under such a scenario occurrence of the distributed denial of service (DDoS) and flash events (FEs) affect the target servers and interrupt services. Isolating the attacks is the first step before selecting an appropriate mitigation technique. However, detecting and isolating the DDoS attacks from FEs when happening simultaneously …