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Afghan Refugees Engagement Journalism, Angrej Singh

Capstones

My community of focus is Afghan refugees who came to the U.S. after Aug. 15, 2021. Since mid-Aug. of 2021, nearly 76,000 Afghan refugees came to the U.S. after living across eight U.S. military bases for a few months — with the help of resettlement agencies — they have resettled to 48 states in which they are starting to rebuild their lives. During the uncertainty of their legal status, multiple Afghan led organizations have been calling on Congress to pass an Afghan Adjustment Act. This legislation would create a pathway for permanent status to the thousands that were granted entry …

Back To The Roots: Black Veganism, Kiara R. Thomas

Capstones

Only 3% of Americans in general, but 8% of Black Americans are strict vegan or vegetarian. Whether it’s to reduce animal cruelty, manage a chronic illness, or connect with their heritage and build a social movement, Black people are embracing plant-based diets. https://kiarathomas429.github.io/portfolio/

Scientists And Activists Work To Save The Planet, Myriam G. Vidal Valero

Capstones

Climate change and human intervention in nature are affecting people, ecosystems and ways of living all over the world. This portfolio of environmental pieces showcases the dire consequences of not addressing these issues, how solutions can be reached and the challenges facing those who try to change things.

More Muslim, Salman Ahad Khan

Capstones

More Muslim is a show that explores the Muslim experience, with all its messiness.

Each episode is a narrative, transhistorical journey into one aspect of the Muslim experience that defined or is being defined by the modern world. This capstone forms the first two episodes of the series. Episode 1, "When Memes Meet Sufis," explores the question of how Rumi, a Muslim scholar from the 13th century, became the best-selling poet in the US. Episode 2, "The Halal Meat Conundrum," is a firsthand journey into the American halal meat industry and attempts to understand how halal became a $20 billion …

Wage Theft In Construction Is The Greatest Form Of Theft And We Do Nothing About It, Alexandra B. O'Connor

Capstones

I looked at the construction industry in New York City and state to analyze the prevalence of wage theft. The unaccounted and accounted for wage theft in the industry directly correlates with its low-wage and immigrant workforce.

Representation In Animation — Bringing Diversity Behind The Screen, Elizabeth Short

Capstones

Animation is an extremely popular form of media, particularly for children who grow up with the influence of cartoon television shows and films. As long-standing discussions on representation in media expand, the evolution of diversity in animated characters grows as well. Examining the history of animation as an art form and its changes over the years is important, but it is also essential to ask — does representation on-screen match representation behind the scenes? If not, how does that change?

https://medium.com/@liz.short31/representation-in-animation-bringing-diversity-behind-the-screen-3033f06632b6

Review Of Disinformation: The Nature Of Facts And Lies In The Post-Truth Era, Taylor J. Greene

Library Articles and Research

A review of Donald A. Barclay's Disinformation: The Nature of Facts and Lies in the Post-Truth Era.

25 Years Of Garage Review – Music Documentary Falls Prey To The Same Mistakes That Killed The Scene, Monique Charles

Sociology Faculty Articles and Research

"A host of veterans from the heyday of the UK’s garage scene (including Heartless Crew, Dane Bowers and members of So Solid Crew) star in 25 Years of Garage, a new documentary co-directed by former promoter Terry Stone.

As an academic who specialises in Black music and advocates for its serious intellectual study, I find it encouraging to see active members of the garage scene documenting the culture.

UK garage was a genre of electronic dance music, which peaked between the late 1990s and early 2000s. Incorporating elements of R&B, jungle and pop, its sound was marked by pitch-shifted vocal …

Asian Powers And A Transitioning Gulf Order, Jonathan Fulton

All Works

The Gulf regional security complex is shaped by intense competition between regional states and US military preponderance. American security cooperation with the Gulf Cooperation Council member states has sustained a status quo that has allowed the Asian countries studied in this Special Issue – China, India, Japan, Singapore, and South Korea – to advance their interests without significant contributions to regional stability. As the US signals intentions to reduce its security commitments to the region, the perception of hegemonic retreat will influence the external partnerships Gulf states choose as well as the regional policies that these Asian countries will adopt. …

The Effectiveness Of Project-Based Learning On Emirati Undergraduate Students In A Microbiology Course, Carole Ayoub Moubareck

All Works

Purpose: A composting project was introduced into an undergraduate microbiology course, to evaluate its efficacy against traditional lecturing for teaching environmental sustainability. Design/methodology/approach: The research project was a semester-long intervention. Three groups of students participated in the study: a group of 47 female undergraduate students were involved in a composting project, a group of 43 female students were exposed to a traditional lecture and a group of 34 students were the control group. A pretest and a posttest were used, along with poster presentations for the composting project students. In addition, a questionnaire was used to examine students' attitudes toward …

Uab Political Science Major Laura Nell Walker Wins Award At Connecther Film Festival, Micah Hardge

Browse All News

No abstract provided.

Editorial: The Biology And Management Of Chronic Diseases In Mexican Americans, Eron G. Manusov, Belinda M. Reininger, Alfredo Ulloa-Aguirre, John Blangero

School of Medicine Publications

No abstract provided.

Association Of Sepsis-Induced Cardiomyopathy And Mortality: A Systematic Review And Meta-Analysis, Yu-Min Lin, Mei-Chuan Lee, Han Siong Toh, Wei-Ting Chang, Sih-Yao Chen, Fang-Hsiu Kuo, Hsin-Ju Tang, Yi-Ming Hua, Dongmei Wei, Jesus D. Melgarejo, Zhen-Yu Zhang, Chia-Te Liao

School of Medicine Publications

Background

The implication of sepsis-induced cardiomyopathy (SIC) to prognosis is controversial, and its association with mortality at different stages remains unclear. We conducted a systematic review and meta-analysis to understand the association between SIC and mortality in septic patients.

Methods

We searched and appraised observational studies regarding the mortality related to SIC among septic patients in PubMed and Embase from inception until 8 July 2021. Outcomes comprised in-hospital and 1-month mortality. We adopted the random-effects model to examine the mortality risk ratio in patients with and without SIC. Meta-regression, subgroup, and sensitivity analyses were applied to examine the outcome’s heterogeneity. …

Consensus Opinion From An International Group Of Experts On Measurable Residual Disease In Hairy Cell Leukemia, Farhad Ravandi, Robert J Kreitman, Enrico Tiacci, Leslie Andritsos, Versha Banerji, Seema A Bhat, Alessandro Broccoli, Timothy Call, Dai Chihara, Claire Dearden, Judit Demeter, Sasha Dietrich, Monica Else, Narendranath Epperla, Brunangelo Falini, Francesco Forconi, Douglas E Gladstone, Alessandro Gozzetti, Sunil Iyengar, James B Johnston, Jeffrey Jorgensen, Gunnar Juliusson, Francesco Lauria, Gerard Lozanski, Sameer A Parikh, Jae H Park, Aaron Polliack, Graeme Quest, Tadeusz Robak, Kerry A Rogers, Alan Saven, John F Seymour, Tamar Tadmor, Martin S Tallman, Constantine S Tam, Philip A Thompson, Xavier Troussard, Clive S Zent, Thorsten Zenz, Pier Luigi Zinzani, Bernhard Wörmann, Kanti Rai, Michael Grever

Faculty, Staff and Student Publications

A significant body of literature has been generated related to the detection of measurable residual disease (MRD) at the time of achieving complete remission (CR) in patients with hairy cell leukemia (HCL). However, due to the indolent nature of the disease as well as reports suggesting long-term survival in patients treated with a single course of a nucleoside analog albeit without evidence of cure, the merits of detection of MRD and attempts to eradicate it have been debated. Studies utilizing novel strategies in the relapse setting have demonstrated the utility of achieving CR with undetectable MRD (uMRD) in prolonging the …

Hypermethylation Of Nc886 In Hpv-Positive Oropharyngeal Cancer And Its Clinical Implications: An Epigenome-Wide Association Study, Yifan Xu, Ziqiao Wang, Peng Wei, Richa Gairola, Karl T Kelsey, Guojun Li

Faculty, Staff and Student Publications

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased rapidly in the United States, driven by rising human papillomavirus (HPV) infections in the U.S. population. HPV-positive OPSCC patients have a better prognosis than HPV-negative patients. To gain insights into the unique biology of HPV(+) OPSCC that may contribute to its clinical behaviors, we performed a multi-stage epigenome-wide methylation profiling of leukocyte and tumor DNA in OPSCC patients and compared the methylation levels of CpG sites between HPV(+) and HPV(-) OPSCC patients. We identified and validated a significantly differentially methylated region (DMR) of 1,355 bp encompassing non-coding RNA 886 ( …

Mir21 Modulates The Hippo Signaling Pathway Via Interference With Pp2a Bβ To Inhibit Trophoblast Invasion And Cause Preeclampsia, Mingyu Hu, Yangxi Zheng, Jiujiang Liao, Li Wen, Juan Cheng, Biao Huang, Yao Long, Yue Wu, Xuan Ye, Yong Fu, Hongbo Qi, Philip N Baker, Chao Tong

Faculty, Staff and Student Publications

Preeclampsia (PE) is a pregnancy-specific disorder attributed to deficient extravillous trophoblast (EVT) invasion into the uterus, but the mechanism of EVT invasion remains unclear. In this study, we found significantly elevated expression of microRNA 21 (miR21), which negatively regulates trophoblast invasion and migration, in preeclamptic placentae. Whole-genome RNA sequencing revealed that PPP2R2B, which encodes PP2A Bβ, and the Hippo pathway are downstream targets of miR21. The effects of miR21 on trophoblast mobility were abolished in LATS1T1079A/S909A and YAP-5SA mutants. Moreover, we found that PP2A Bβ dephosphorylates LATS1 via direct protein-protein interactions and thus modulates the phosphorylation and subcellular distribution …

Using Patient Flow Analysis With Real-Time Patient Tracking To Optimize Radiation Oncology Consultation Visits, Shane Mesko, Julius Weng, Prajnan Das, Albert C Koong, Joseph M Herman, Ashley Kerr, John Frenzel, Katy E French, Wendi Martinez, Iris Recinos, Abdulaziz Alshaikh, Utpala Daftary, Amy C Moreno, Quynh-Nhu Nguyen

Faculty, Staff and Student Publications

PURPOSE: Clinical efficiency is a key component of the value-based care model and a driver of patient satisfaction. The purpose of this study was to identify and address inefficiencies at a high-volume radiation oncology clinic.

METHODS AND MATERIALS: Patient flow analysis (PFA) was used to create process maps and optimize the workflow of consultation visits in a gastrointestinal radiation oncology clinic at a large academic cancer center. Metrics such as cycle times, waiting times, and rooming times were assessed by using a real-time patient status function in the electronic medical record for 556 consults and compared between before vs after …

A Computational Method For Estimating Trunk Muscle Activations During Gait Using Lower Extremity Muscle Synergies, Payam Zandiyeh, Ata Babazadeh-Naseri, Andrew J Baines, Benjamin J Fregly

Faculty, Staff and Student Publications

One of the surgical treatments for pelvic sarcoma is the restoration of hip function with a custom pelvic prosthesis after cancerous tumor removal. The orthopedic oncologist and orthopedic implant company must make numerous often subjective decisions regarding the design of the pelvic surgery and custom pelvic prosthesis. Using personalized musculoskeletal computer models to predict post-surgery walking function and custom pelvic prosthesis loading is an emerging method for making surgical and custom prosthesis design decisions in a more objective manner. Such predictions would necessitate the estimation of forces generated by muscles spanning the lower trunk and all joints of the lower …

Egfr-Phosphorylated Gdh1 Harmonizes With Rsk2 To Drive Creb Activation And Tumor Metastasis In Egfr-Activated Lung Cancer, Jihoon Kang, Jaemoo Chun, Jung Seok Hwang, Chaoyun Pan, Jie Li, Isabelle Young, Yibin Kang, Don L Gibbons, Gabriel Sica, Haian Fu, Suresh S Ramalingam, Lingtao Jin, Sumin Kang

Faculty, Staff and Student Publications

The cancer metastasis process involves dysregulated oncogenic kinase signaling, but how this orchestrates metabolic networks and signal cascades to promote metastasis is largely unclear. Here we report that inhibition of glutamate dehydrogenase 1 (GDH1) and ribosomal S6 kinase 2 (RSK2) synergistically attenuates cell invasion, anoikis resistance, and immune escape in lung cancer and more evidently in tumors harboring epidermal growth factor receptor (EGFR)-activating or EGFR inhibitor-resistant mutations. Mechanistically, GDH1 is activated by EGFR through phosphorylation at tyrosine 135 and, together with RSK2, enhances the cAMP response element-binding protein (CREB) activity via CaMKIV signaling, thereby promoting metastasis. Co-targeting RSK2 and GDH1 …

Histopathological Tumour Response Scoring In Resected Pancreatic Cancer Following Neoadjuvant Therapy: International Interobserver Study (Isgpp-1), Boris V Janssen, Stijn Van Roessel, Susan Van Dieren, Onno De Boer, Volkan Adsay, Lodewijk Brosens, Deyali Chatterjee, Angela Chou, Claudio Doglioni, Irene Esposito, Roger Feakins, Talia L Fuchs, Noriyoshi Fukushima, Anthony J Gill, Seung-Mo Hong, Ralph H Hruban, Jeffrey Kaplan, Alyssa Krasinkas, Claudio Luchini, Chanjuan Shi, Aatur Singhi, Elizabeth Thompson, Marie-Louise F Velthuysen, Marc G Besselink, Joanne Verheij, Huamin Wang, Caroline Verbeke, Arantza Fariña

Faculty, Staff and Student Publications

Background: Most tumour response scoring systems for resected pancreatic cancer after neoadjuvant therapy score tumour regression. However, whether treatment-induced changes, including tumour regression, can be identified reliably on haematoxylin and eosin-stained slides remains unclear. Moreover, no large study of the interobserver agreement of current tumour response scoring systems for pancreatic cancer exists. This study aimed to investigate whether gastrointestinal/pancreatic pathologists can reliably identify treatment effect on tumour by histology, and to determine the interobserver agreement for current tumour response scoring systems.

Methods: Overall, 23 gastrointestinal/pancreatic pathologists reviewed digital haematoxylin and eosin-stained slides of pancreatic cancer or treated tumour bed. The …

Defining Cellular Population Dynamics At Single-Cell Resolution During Prostate Cancer Progression, Alexandre A Germanos, Sonali Arora, Ye Zheng, Erica T Goddard, Ilsa M Coleman, Scott Wilkinson, Nicholas J Brady, Robert A Amezquita, Michael Zager, Annalysa Long, Yu Chi Yang, Jason H Bielas, Raphael Gottardo, David S Rickman, Franklin W Huang, Cyrus M Ghajar, Peter S Nelson, Adam G Sowalsky, Manu Setty, Andrew C Hsieh

Faculty, Staff and Student Publications

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution from disease onset to the development of androgen independence in an in vivo murine model. We observe an expansion of a castration-resistant intermediate luminal cell type that correlates with treatment resistance and poor prognosis in human patients. Moreover, transformed epithelial cells and associated fibroblasts create a microenvironment conducive to pro-tumorigenic immune infiltration, which is partially androgen responsive. Androgen-independent prostate cancer leads to significant diversification of …

Lipid-Nanoparticle-Mediated Delivery Of Docetaxel Prodrug For Exploiting Full Potential Of Gold Nanoparticles In The Treatment Of Pancreatic Cancer, Ingrid Barta, Sunil Krishnan, Devika B Chithrani

Faculty, Staff and Student Publications

Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, we explored the effect of a DTX prodrug encapsulated in lipid nanoparticles (LNP_DTX-P) on GNP uptake in pancreatic cancer models in vitro and in vivo. For the in vitro experiment, a pancreatic cancer cell line, MIA PaCa-2, was cultured and dosed with 1 nM GNPs and 45 nM free DTX or an equivalent dose of LNP_DTX-P. For the in vivo experiment, MIA PaCa-2 cells were implanted subcutaneously …

Use Of An Interactive Obesity Treatment Approach In Individuals With Severe Mental Illness: Feasibility, Acceptability, And Proposed Engagement Criteria, Ginger Nicol, Madeline Jansen, Rita Haddad, Amanda Ricchio, Michael D Yingling, Julia A Schweiger, Katie Keenoy, Bradley A Evanoff, John W Newcomer

2020-Current year OA Pubs

BACKGROUND: Digital and mobile health interventions are increasingly being used to support healthy lifestyle change, including in certain high-risk populations such as those with severe mental illnesses (SMIs). Life expectancy in this population lags 15 years behind counterparts in the general population, primarily due to obesity-related health conditions.

OBJECTIVE: We tested the feasibility and usability of a 12-week interactive obesity treatment approach (iOTA) to adults with chronic SMIs (depression, bipolar disorder and schizophrenia spectrum disorder) receiving treatment in community settings. The iOTA incorporates short message service (SMS) text messages to supplement monthly in-person health coaching.

METHODS: Factors hypothesized to be …

Recurrent Switch 2 Domain Rac2 Mutations In Intravascular Large B-Cell Lymphoma, Rohan Kodgule, Jie Chen, Pooja Khonde, Joshua Robinson, Amy D'Albora, Lisa Cook, Catrina C Fronick, Robert Fulton, Sridhar Nonavinkere Srivatsan, Patrick J Cimino, Eric J Duncavage

2020-Current year OA Pubs

No abstract provided.

A Survey Of Mental Wellbeing And Stress Among Dental Therapists And Hygienists In South West England, Georgia Hallett, Robert Witton, Ian Mills

Peninsula Dental School

Introduction Mental health and wellbeing of the dental team has been brought into sharp focus during the COVID-19 pandemic. Despite this renewed interest, there has been longstanding issues with poor mental health and wellbeing in the dental profession for some time. While there is some evidence that documents poor mental wellbeing amongst dentists, there appears to be a lack of evidence concerning dental care professionals. Aims To explore the level of mental wellbeing and stress amongst dental hygienists and therapists (DHTs) in South West England. Method An online survey was distributed to DHTs in South West England via two professional …

Condensates Formed By Prion-Like Low-Complexity Domains Have Small-World Network Structures And Interfaces Defined By Expanded Conformations, Mina Farag, Samuel R Cohen, Wade M Borcherds, Anne Bremer, Tanja Mittag, Rohit V Pappu

2020-Current year OA Pubs

Biomolecular condensates form via coupled associative and segregative phase transitions of multivalent associative macromolecules. Phase separation coupled to percolation is one example of such transitions. Here, we characterize molecular and mesoscale structural descriptions of condensates formed by intrinsically disordered prion-like low complexity domains (PLCDs). These systems conform to sticker-and-spacers architectures. Stickers are cohesive motifs that drive associative interactions through reversible crosslinking and spacers affect the cooperativity of crosslinking and overall macromolecular solubility. Our computations reproduce experimentally measured sequence-specific phase behaviors of PLCDs. Within simulated condensates, networks of reversible inter-sticker crosslinks organize PLCDs into small-world topologies. The overall dimensions of PLCDs …

Topics And Sentiment Surrounding Vaping On Twitter And Reddit During The 2019 E-Cigarette And Vaping Use-Associated Lung Injury Outbreak: Comparative Study, Dezhi Wu, Erin Kasson, Avineet Kumar Singh, Yang Ren, Nina Kaiser, Ming Huang, Patricia A Cavazos-Rehg

2020-Current year OA Pubs

BACKGROUND: Vaping or e-cigarette use has become dramatically more popular in the United States in recent years. e-Cigarette and vaping use-associated lung injury (EVALI) cases caused an increase in hospitalizations and deaths in 2019, and many instances were later linked to unregulated products. Previous literature has leveraged social media data for surveillance of health topics. Individuals are willing to share mental health experiences and other personal stories on social media platforms where they feel a sense of community, reduced stigma, and empowerment.

OBJECTIVE: This study aimed to compare vaping-related content on 2 popular social media platforms (ie, Twitter and Reddit) …

Stat3 Gain-Of-Function Mutations Connect Leukemia With Autoimmune Disease By Pathological Nkg2dhi Cd8+ T Cell Dysregulation And Accumulation, Etienne Masle-Farquhar, Megan A Cooper, Tiphanie P Vogel, Et Al.

2020-Current year OA Pubs

The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8

Rapid Astrocyte-Dependent Facilitation Amplifies Multi-Vesicular Release In Hippocampal Synapse, Jongyun Myeong, Vitaly A Klyachko

2020-Current year OA Pubs

Synaptic facilitation is a major form of short-term plasticity typically driven by an increase in residual presynaptic calcium. Using near-total internal reflection fluorescence (near-TIRF) imaging of single vesicle release in cultured hippocampal synapses, we demonstrate a distinctive, release-dependent form of facilitation in which probability of vesicle release is higher following a successful glutamate release event than following a failure. This phenomenon has an onset of ≤500 ms and lasts several seconds, resulting in clusters of successful release events. The release-dependent facilitation requires neuronal contact with astrocytes and astrocytic glutamate uptake by EAAT1. It is not observed in neurons grown alone …