Digital Commons Network^™

Spatial Heterogeneity Of Infiltrating T Cells In High-Grade Serous Ovarian Cancer Revealed By Multi-Omics Analysis, Bin Yang, Xiong Li, Wei Zhang, Junpeng Fan, Yong Zhou, Jingjing Yin, Ensong Guo, Xi Li, Yu Fu, Si Liu, Dianxing Hu, Xu Qin, Yingyu Dou, Rourou Xiao, Funian Lu, Zizhuo Wang, Tianyu Qin, Wei Wang, Qinghua Zhang, Shuaicheng Li, Ding Ma, Gordon B Mills, Gang Chen, Chaoyang Sun

Faculty, Staff and Student Publications

Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, represent a favorable prognostic factor in high-grade serous ovarian cancer (HGSOC) and other tumor lineages. Here, we analyze the spatial heterogeneity of different TIL subtypes in HGSOC. We integrated RNA sequencing, whole-genome sequencing, bulk T cell receptor (TCR) sequencing, as well as single-cell RNA/TCR sequencing to investigate the characteristics and differential composition of TILs across different HGSOC sites. Two immune "cold" patterns in ovarian cancer are identified: (1) ovarian lesions with low infiltration of mainly dysfunctional T cells and immunosuppressive Treg cells and (2) omental lesions infiltrated with non-tumor-specific bystander cells. Exhausted CD8 T …

Relative Importance Of Radar Variables For Nowcasting Heavy Rainfall: A Machine Learning Approach, Yi Victor Wang, Seung Hee Kim, Geunsu Lyu, Choeng-Lyong Lee, Gyuwon Lee, Ki-Hong Min, Menas C. Kafatos

Institute for ECHO Articles and Research

Highly short-term forecasting, or nowcasting, of heavy rainfall due to rapidly evolving mesoscale convective systems (MCSs) is particularly challenging for traditional numerical weather prediction models. To overcome such a challenge, a growing number of studies have shown significant advantages of using machine learning (ML) modeling techniques with remote sensing data, especially weather radar data, for high-resolution rainfall nowcasting. To improve ML model performance, it is essential first and foremost to quantify the importance of radar variables and identify pertinent predictors of rainfall that can also be associated with domain knowledge. In this study, a set of MCS types consisting of …

Menstrual Health Among Adolescents And Young Adults In Rural Haiti., Emily R. Rupe, Jonathan Rodean, Emily A. Hurley, Melissa K. Miller, Marie Daphnee Boncoeur, Abbey R. Masonbrink

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Adolescent and young adult (AYA) females in low- and middle-income countries often face disparities in menstrual health (MH). Poor MH and lack of sexual and reproductive health education leads to school absenteeism, increasing risk for adverse psychosocial and educational outcomes. Further, disasters (e.g., earthquakes) are linked with unsafe living environments and sanitation facilities for women. We sought to describe MH perspectives and practices among AYAs in rural Haiti.

METHODS: We conducted a cross-sectional survey in two rural communities in Haiti. AYA females aged 14-24 years completed questions on demographics, the Menstrual Practice Needs Scale (36 items; MPNS-36) and the …

Rhetoric And Affect In Undergraduate Research: A Diary Study, Kristine Johnson, J. Michael Rifenburg

University Faculty Publications and Creative Works

In this article, we examine undergraduate research as a site of rhetorical development by listening to undergraduate researchers narrate and reflect upon their work as it unfolds. We draw from diary entries and follow-up interviews with eighteen undergraduate researchers at two different institutions, analyzing the rhetorical and affective elements of undergraduate research. Connecting undergraduate research with the concept of meaningful writing, we conclude by offering recommendations for teachers, mentors, and administrators.

Cardiac Physical Exam Skills And Auscultation Session For Pediatric Interns, Christopher A Sumski, Anoop Singh, Amanda Rogers, Robert Treat, Charles Bergstrom

2020-Current year OA Pubs

INTRODUCTION: Physicians need adequate physical exam skills. Unfortunately, interns have variable physical exam skills, and teaching is often limited to rounds, an inconsistent setting. Physical exam skills, particularly those involving auscultation, require practice. Our goal was to create a cardiac physical exam workshop for pediatric interns that would improve their performance on an interactive assessment of their ability and understanding in physical exam and murmur interpretation.

METHODS: We completed a targeted needs assessment and then developed a 2-hour workshop on the pediatric cardiac physical exam targeted to pediatrics residents. The workshop included didactics, group discussion, and practice interpreting common pediatric …

Type Iv Pili Are A Critical Virulence Factor In Clinical Isolates Of Paenibacillus Thiaminolyticus, Christine Hehnly, Petra Erdmann Gilmore, R. Reid Townsend, David D. Limbrick, Et Al.

2020-Current year OA Pubs

Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hydrocephalus in these areas. Since many children with hydrocephalus suffer poor long-term outcomes despite surgical intervention, prevention of hydrocephalus remains paramount. Our previous studies implicated a novel bacterial pathogen, Paenibacillus thiaminolyticus, as a causal agent of neonatal sepsis and postinfectious hydrocephalus in Uganda. Here, we report the isolation of three

Quality Assessment And Refinement Of Chromatin Accessibility Data Using A Sequence-Based Predictive Model, Seong Kyu Han, Yoshiharu Muto, Parker C Wilson, Benjamin D Humphreys, Matthew G Sampson, Aravinda Chakravarti, Dongwon Lee

2020-Current year OA Pubs

Chromatin accessibility assays are central to the genome-wide identification of gene regulatory elements associated with transcriptional regulation. However, the data have highly variable quality arising from several biological and technical factors. To surmount this problem, we developed a sequence-based machine learning method to evaluate and refine chromatin accessibility data. Our framework, gapped k-mer SVM quality check (gkmQC), provides the quality metrics for a sample based on the prediction accuracy of the trained models. We tested 886 DNase-seq samples from the ENCODE/Roadmap projects to demonstrate that gkmQC can effectively identify "high-quality" (HQ) samples with low conventional quality scores owing to marginal …

Restoring Mitochondrial Cardiolipin Homeostasis Reduces Cell Death And Promotes Recovery After Spinal Cord Injury, Nai-Kui Liu, Chunyan Wang, Et Al.

2020-Current year OA Pubs

Alterations in phospholipids have long been associated with spinal cord injury (SCI). However, their specific roles and signaling cascades in mediating cell death and tissue repair remain unclear. Here we investigated whether alterations of cardiolipin (CL), a family of mitochondrion-specific phospholipids, play a crucial role in mitochondrial dysfunction and neuronal death following SCI. Lipidomic analysis was used to determine the profile of CL alteration in the adult rat spinal cord following a moderate contusive SCI at the 10th thoracic (T10) level. Cellular, molecular, and genetic assessments were performed to determine whether CL alterations mediate mitochondrial dysfunction and neuronal death after …

Caregiver Perceptions Of Change In Pediatric Asthma Control During The Covid-19 Pandemic, Gabrielle Pogge, Erika A Waters, Gregory D Webster, Sreekala Prabhakaran, Jean M Hunleth, David A Fedele, James A Shepperd

2020-Current year OA Pubs

PURPOSE: Although several indicators suggest that pediatric asthma control in the United States improved early in the pandemic, other indicators suggest not. Missing are reports from caregivers of the experiences of their children with asthma early in the pandemic.

METHODS: Using the PP-ACT and other measures that we specifically constructed for our research, we conducted a cross-sectional national survey of US caregivers of children with asthma (N=595) to examine perceived change in their child's asthma control and changes in reports of ED visits and use of emergency relief medicine and controller medicine pre-pandemic (January to March 2020) versus early-pandemic (June …

A Unique High-Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance In Cantu Syndrome, Gautam K Singh, Conor Mcclenaghan, Manish Aggarwal, Hongjie Gu, Maria S Remedi, Dorothy K Grange, Colin G Nichols

2020-Current year OA Pubs

Background Cardiomegaly caused by left ventricular hypertrophy is a risk factor for development of congestive heart failure, classically associated with decreased systolic and/or diastolic ventricular function. Less attention has been given to the phenotype of left ventricular hypertrophy with enhanced ventricular function and increased cardiac output, which is potentially associated with high-output heart failure. Lack of recognition may pose diagnostic ambiguity and management complexities. Methods and Results We sought to systematically characterize high-output cardiac hypertrophy in subjects with Cantu syndrome (CS), caused by gain-of-function variants in

Morphologic Design Of Nanostructures For Enhanced Antimicrobial Activity, Fatma Al-Zahraa Sayed, Noura G Eissa, Yidan Shen, David A Hunstad, Karen L Wooley, Mahmoud Elsabahy

2020-Current year OA Pubs

Despite significant progress in synthetic polymer chemistry and in control over tuning the structures and morphologies of nanoparticles, studies on morphologic design of nanomaterials for the purpose of optimizing antimicrobial activity have yielded mixed results. When designing antimicrobial materials, it is important to consider two distinctly different modes and mechanisms of activity-those that involve direct interactions with bacterial cells, and those that promote the entry of nanomaterials into infected host cells to gain access to intracellular pathogens. Antibacterial activity of nanoparticles may involve direct interactions with organisms and/or release of antibacterial cargo, and these activities depend on attractive interactions and …

Perspectives On Joint Eanm/Snmmi/Anzsnm Practice Guidelines/Procedure Standards For [18f]Fdg Pet/Ct Imaging During Immunomodulatory Treatments In Patients With Solid Tumors, E Lopci, R L Wahl, Et Al.

2020-Current year OA Pubs

Response assessment in the context of immunomodulatory treatments represents a major challenge for the medical imaging community and requires a multidisciplinary approach with involvement of oncologists, radiologists, and nuclear medicine specialists. There is evolving evidence that [

Offline Payments Using Printed Qr Codes, Arunkumar Rajendran

Defensive Publications Series

Mobile payment applications cannot be used to make payments if a person does not have a mobile device or if no data connectivity is available. This disclosure describes techniques to enable a user to make a payment even if the user does not have a mobile device or if their device does not have data connectivity. Per the techniques, a user can carry a printed QR code that includes information about the user’s payment account, e.g., a payment wallet, a bank account, etc. that serves as the source of payment. The code can be scanned by a merchant (or other …

Human-Machine Communication: Complete Volume 5. Gender And Human-Machine Communication

Human-Machine Communication

This is the complete volume of HMC Volume 5

Ivf So White, So Medical: Digital Normativity And Algorithm Bias In Infertility On Instagram, Caitlyn M. Jarvis, Margaret M. Quinlan

Human-Machine Communication

Increasingly, women experiencing infertility are turning online to social media platforms, like Instagram, to engage with a support network and foster empathy. However, Instagram is also noted for its augmentation of White, cis, and heteronormative femininity through a process of silencing and minoritizing alternative, non-White voices. Through an inductive analysis of the most frequently used infertility hashtags, we collected and analyzed 252 Instagram posts to investigate how these algorithmic practices may socially construct the idealized IVF experience through communicating normative expectations. We identify predominant patterns of use that reinforce stratification within infertility treatments as primarily accessible to White women and …

Designing A Loving Robot: A Social Construction Analysis Of A Sex Robot Creator’S Vision, Annette Masterson

Human-Machine Communication

In 2018, one of the world’s first sex robots was released by CEO Matt McMullen and his company, RealDoll. With artificial intelligence capabilities, the Harmony model is meant to support and converse with users. Using a social construction of technology theory lens, this study develops the theory’s fourth level of analysis, emphasizing mass media’s construction abilities. A critical discourse analysis of 38 publicity interviews found a tendency to emphasize the companionship of sex robots while envisioning a future where integration is normalized, and a sentient robot is possible. As the creator, McMullen’s vision could determine the future of robotic design, …

The Evolution Of Gendered Software: Products, Scientific Reasoning, Criticism, And Tools, Victoria A. E. Kratel

Human-Machine Communication

Over the past 7 decades, gendered software has become globally established. In this theoretical distribution, I outline the evolution of gendered software. The journey of gendered software started with the raw idea fueled by Alan Turing’s imitation game in the 1950s. And only shortly thereafter, in the 1960s and 1970s, the first gendered software products like Joseph Weizenbaum’s ELIZA were developed. Thus, academia took its time to not only explore technological aspects, but to further investigate the matter of gender in the 1990s CASA-paradigm (Nass et al., 1994) and Media Equation (Reeves & Nass, 1996). As these theories reasoned the …

Do People Perceive Alexa As Gendered? A Cross-Cultural Study Of People’S Perceptions, Expectations, And Desires Of Alexa, Leopoldina Fortunati, Autumn P. Edwards, Anna Maria Manganelli, Chad Edwards, Federico De Luca

Human-Machine Communication

Mainly, the scholarly debate on Alexa has focused on sexist/anti-woman gender representations in the everyday life of many families, on a cluster of themes such as privacy, insecurity, and trust, and on the world of education and health. This paper takes another stance and explores via online survey methodology how university student respondents in two countries (the United States, n = 333; and Italy, n = 322) perceive Alexa’s image and gender, what they expect from this voice-based assistant, and how they would like Alexa to be. Results of a free association exercise showed that Alexa’s image was scarcely embodied …

Gender Ambiguity In Voice-Based Assistants: Gender Perception And Influences Of Context, Sandra Mooshammer, Katrin Etzrodt

Human-Machine Communication

Recently emerging synthetic acoustically gender-ambiguous voices could contribute to dissolving the still prevailing genderism. Yet, are we indeed perceiving these voices as “unassignable”? Or are we trying to assimilate them into existing genders? To investigate the perceived ambiguity, we conducted an explorative 3 (male, female, ambiguous voice) × 3 (male, female, ambiguous topic) experiment. We found that, although participants perceived the gender-ambiguous voice as ambiguous, they used a profoundly wide range of the scale, indicating tendencies toward a gender. We uncovered a mild dissolve of gender roles. Neither the listener’s gender nor the personal gender stereotypes impacted the perception. However, …

Gender And Human-Machine Communication: Where Are We?, Leopoldina Fortunati, Autumn P. Edwards

Human-Machine Communication

In this introduction to the fifth volume of the journal Human-Machine Communication, we present and discuss the five articles focusing on gender and human-machine communication. In this essay, we will analyze the theme of gender, including how this notion has historically and politically been set up, and for what reasons. We will start by considering gender in in-person communication, then we will progress to consider what happens to gender when it is mediated by the most important ICTs that preceded HMC: the telephone, mobile phone, and computer-mediated communication (CMC). We outline the historical framework necessary to analyze the last section …

Physical Activity Independently Predicts Perceived Stress During The Covid-19 Pandemic In Private University Students, Curtis W. Brownell, Laura S. Kabiri, Cassandra S. Diep, Heidi Y. Perkins, Amanda M. Perkins-Ball, Augusto X. Rodriguez

International Journal of Exercise Science

International Journal of Exercise Science 15(7): 1680-1691, 2022. Physical activity has significantly declined during the COVID-19 pandemic. Declines in physical activity have correlated with increased levels of perceived stress, though studies examining physical activity and stress have failed to account for critical confounds. The present study aims to determine whether physical activity independently predicts perceived stress in students attending private four-year universities. Physical activity, socioeconomic status, resilience, gender, and perceived stress data were collected from 85 students and used in a multiple linear regression analysis. The regression model accounted for 43.5% of the variance in perceived stress (R2 = .462, …

Muscle Architecture And Strength Changes Induced By Different Resistance Training Frequencies And Detraining, Tiago Volpi Braz, Felipe Brigatto, Danilo Rodrigues Batista, Wellington Gonçalves Dias, Luan Oenning Col, Guilherme Borsetti Businari, Jhenipher Rosolem, Julio Benvenutti Bueno De Camargo, Paulo Henrique Barbosa, Charles Ricardo Lopes

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 1661-1679, 2022. The purpose of the present study was to investigate muscle thickness and strength outcomes of the quadriceps femoris induced by different resistance training (RT) frequencies and detraining. In addition, muscle architecture (MA) parameters were also assessed. Twenty-seven healthy resistance-trained subjects (men, n = 17; women, n = 10; 20.8 ± 1.9 years; RT experience = 3.3 ± 1.6 years) volunteered to participate in this study. One leg of each subject was randomly allocated into the 2 sessions per week condition (2x) and the contralateral leg was then placed in the 4 sessions …

Review Of A Revolution In Canvas: The Rise Of Women Artists In Britain And France, 1760-1830, By Paris A. Spies-Gans, Gabrielle Stecher

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Paris A. Spies-Gans, A Revolution on Canvas: The Rise of Women Artists in Britain and France, 1760-1830 by Gabrielle Stecher

Review Of Placing Charlotte Smith, Eds Elizabeth A. Dolan And Jacqueline M. Labbe, Heather Heckman-Mckenna

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Placing Charlotte Smith edited by Elizabeth A. Dolan and Jacqueline M. Labbe, written by Heather Heckman-McKenna

Review Of Female Husbands: A Trans History, By Jen Manion, Jeremy Chow

ABO: Interactive Journal for Women in the Arts, 1640–1830

This review evaluates Jen Manion's Female Husbands: A Trans History.

Review Of The Life And Legend Of Catterina Vizzani: Sexual Identity, Science And Sensationalism In Eighteenth-Century Italy And England, By Clorinda Donato, Ula E. Lukszo Klein

ABO: Interactive Journal for Women in the Arts, 1640–1830

Review of The Life and Legend of Catterina Vizzani: Sexual Identity, Science and Sensationalism in Eighteenth-Century Italy and England, by Clorinda Donato, written by Ula Lukszo Klein. Oxford University Studies in the Enlightenment, Liverpool University Press, 2020, 347 pp., 3 b/w images. ISBN: 978-1-789-62221-8

Review Of The Novel Stage: Narrative Form From The Restoration To Jane Austen, By Marcie Frank, Kathleen E. Urda

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Marcie Frank's The Novel Stage: Narrative Form from the Restoration to Jane Austen by Kathleen E. Urda

Negotiating Gender, Representing Landscape: Teaching Lady Anne Lindsay Barnard’S Letters, Journals And Watercolours From The Cape Colony (1797–1801), Lenka Filipova

ABO: Interactive Journal for Women in the Arts, 1640–1830

The article focuses on Lady Anne Lindsay Barnard’s letters, journals and watercolours that she produced during her stay at the Cape Colony (1797–1801). Combining a series of tasks focused on close reading of Barnard’s work and a critical discussion of the historical context, the article provides a teaching strategy to examine her work with respect to the gendered discourse of the eighteenth century, and her approach to the Cape landscape and its inhabitants which both employs and, significantly, subverts contemporaneous conventions. More specifically, the tasks draw attention to Barnard’s use of ‘the modesty topos’ and the way she uses rhetorical …

Teaching Mary Wollstonecraft's Travelogue Of Historical Trauma, Annette Hulbert

ABO: Interactive Journal for Women in the Arts, 1640–1830

Abstract: I teach Mary Wollstonecraft’s Letters Written During a Short Residence in Sweden, Norway, and Denmark (1796) in an undergraduate English literature course on “Survival Narratives of the Eighteenth Century” at the University of California, Davis. The aim of this course is to show how significant perilous voyages were to the ways in which writers in eighteenth-century Britain imagined and interpreted their world. The course draws from the burst of new scholarship on rethinking the traditional “rise of the novel” narrative in imperial, oceanic, and global contexts and develops interpretive frameworks for the eighteenth century’s changing relationship to commerce and …

Ripped From The Headlines: Teaching Lady Mary Wortley Montagu's Turkish Letters In The Context Of 21st-Century Controversies, Susan Spencer

ABO: Interactive Journal for Women in the Arts, 1640–1830

In the long shadow of 9/11 and the ongoing COVID pandemic, Lady Mary Wortley Montagu’s Turkish Embassy Letters connect with the lived experience of today’s students, especially the cluster of eight letters dated 1 April 1717. By emphasizing parallels between Montagu’s observations and the students’ own lives, The Turkish Embassy Letters can add a modern dimension to the eighteenth century in general, challenges of gender, and texts written in and about the Muslim world.