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Novel Therapeutic Approaches In Neoplastic Meningitis, Manmeet Ahluwalia, Shreya Saxena, Atulya Khosla, Ahmad Ozair

All Publications

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Promoting Rigor And Sustainment In Implementation Science Capacity Building Programs: A Multi-Method Study., Amy G Huebschmann, Shelly Johnston, Rachel Davis, Bethany M Kwan, Elvin Geng, Debra Haire-Joshu, Brittney Sandler, Demetria M Mcneal, Ross C Brownson, Borsika A Rabin

2020-Current year OA Pubs

BACKGROUND: The field of Implementation science (IS) continues to evolve, and the number and type of IS capacity building Programs (ISCBPs) are in flux. These changes push the field to revisit the accepted IS competencies and to guide sustainment of ISCBPs. Our objectives were: (1) compare characteristics of current ISCBPs; (2) identify recommendations to support ISCBP sustainment; (3) measure how often ISCBPs address IS competencies; (4) identify novel and important IS competencies for the field.

METHOD: This multi-method study included ISCBPs delivering structured, longitudinal IS training, excluding single courses and brief workshops. We used three complementary methods to meet our …

Mechanical Ventilation In Patients With Cardiogenic Pulmonary Edema: A Sub-Analysis Of The Lung Safe Study, Laura Amado-Rodríguez, Raquel Rodríguez-Garcia, Giacomo Bellani, Tài Pham, Eddy Fan, John G Laffey, Lung Safe Investigators

Faculty, Staff and Student Publications

BACKGROUND: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality.

METHODS: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model.

RESULTS: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, …

Suitability Of Current Single-Cylinder Diesel Engines Available In Indonesia With New Indonesian National Standard (Sni 119:2020), Sukra Kurnia Fajar Adhi, Setiapraja Hari, Soewono Respatya Teguh, Sumartono Hari

ASEAN Journal on Science and Technology for Development

Diesel engines have been utilized for various purposes in Indonesia. Diesel engine manufacturers have developed designs and competed with each other to win the market in Indonesia. Nationally and internationally recognized standards are required to ensure the quality of products for Indonesia and the international market. The Indonesian National Standard (SNI) 119 is one of the recognized standards for single-cylinder diesel engine in Indonesia. Compared with the previous SNI 0119:2012, SNI 119:2020 has revised the limits of some parameters. This study evaluated the passing data of SNI test results from 2015 to 2020 and then analyzed the distribution of engines …

Analysis Of Surface Water Availability To Meet Agricultural Water Demands In Kediri Regency, Indonesia, Sekaranom Andung Bayu, Purnama I.G. Setyawan, Cahyadi Ahmad, Andika Neil, Febriarta Erik, Nurjani Emilya, Firmansyah Anugrah Jorgi, Maghfiroh, Larasati Chafda, Septyo Novanna Dwi

ASEAN Journal on Science and Technology for Development

This study aims to analyze the potential of surface water to meet agricultural water needs in Kediri Regency, Indonesia. Data from government agencies (i.e., Indonesian Bureau of Meteorology, Climatology, and Geophysics and Kediri Agriculture Office) and fieldwork were analyzed to achieve the research objectives. The data obtained consisted of rainfall, temperature, infiltration capacity, soil texture, root depth, and agricultural land area. The potential of surface water resources was calculated by using the Thornthwaite–Mather water balance method. The water balance results were compared with agricultural water demands, which were calculated on the basis of the area of agricultural land and type …

Manuka Honey Reduces The Virulence Of Pectobacterium Brasiliense By Suppressing Genes That Encode Plant Cell Wall-Degrading Enzymes, Ava Sheila, Subandiyah Siti, Rohman Muhammad Saifur, Ogawa Naoto, Joko Tri

ASEAN Journal on Science and Technology for Development

The primary virulence of soft rot pectobacteria, including Pectobacterium brasiliense, is mainly determined by the massive production of plant cell wall-degrading enzymes (PCWDEs), which promote plant tissue maceration in many crops. The antibiotic treatment to treat bacterial soft rot causes environmental problems and potentially affects resistance. Antibiotic resistance is driving interest in antimicrobial treatments, and no organism has been reported to have acquired resistance to honey. However, the use of honey as a therapeutic agent for plant bacterial pathogens has rarely been studied. Therefore, this study was undertaken to determine the in vitro effect of Manuka honey against P. brasiliense …

Mechanical And Thermal Load Effect On Piston Crown Of A Biogas Engine: A Simulation Approach, Truc Nguyen The, Anh Duc Tran, Cam Van Nguyen, Khac Tung Nguyen, Dinh Long Hoang, Xuan Phong Trinh, Nguyen Duc Khanh

ASEAN Journal on Science and Technology for Development

This paper presents the study results on stress and deformation of the piston crown of a biogas engine converted from a conventional diesel engine using dedicated software. The original diesel engine was modified to reduce the compression ratio to suit biogas fuel. The original engine's combustion chamber and compression ratio were changed by modifying the piston crown to a heron type. The parameters of in-cylinder pressure and temperature were determined by the thermodynamic simulation software AVL Boost. Research results show that the in-cylinder pressure decreased compared to diesel when using biogas fuel, but the temperature increased. The infinite element method-based …

Determining Kinetic Parameters Of Cellulose And Lignin Pyrolysis By Gaussian Process Regression (Gpr) Method, Pichayaporn Viriya-Amornkij, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

The ignition and flame-spread processes in the forest and urban fires involve the pyrolysis reactions of biomass materials. One of the most common methods for estimating the fire performance of a material is the evaluation of kinetic parameters, i.e., activation energy (𝐸), pre-exponential factor (𝐴), and reaction model (𝑓(𝛼)), from thermogravimetric analysis (TG) data. Typically, 𝐸 is estimated based on an Arrhenius-type equation such as Kissinger, Kissinger-Akahira-Sunose (KAS), and Friedman equations. Then, its value is adjusted along with other parameters by assuming a reaction model, e.g., the 𝑛-order model. This study proposes a Gaussian process regression (GPR) method to determine …

A Systematic Review Of The Effects Of Meditative And Mindful Walking On Mental And Cardiovascular Health, Dustin W. Davis, Bryson Carrier, Kyle Cruz, Brenna Barrios, Merrill Russen Landers, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 1692-1734, 2022. Meditative and mindful exercise are types of physical exercise during which people pay attention, on purpose, to each new present moment without judging their experience. The goal is to apply an accepting awareness of the environment, bodily sensations, thoughts, and emotions without labeling them (e.g., good or bad). The literature centers on qigong, tai chi, and yoga, which are types of mindful exercise that improve mental and cardiovascular health. It is unclear if meditative and mindful walking also improve these health domains. To the authors’ knowledge, this question has not been addressed …

Influence Of Wire Arc Additive Manufacturing Beads’ Geometry And Building Strategy: Mechanical And Structural Behavior Of Er70s-6 Prismatic Blocks, Ahmed Elsokaty, Omar Oraby, Sameha Sadek, Hanadi G. Salem

Faculty Journal Articles

No abstract provided.

Fire-Resistance Testing Procedures For Construction Elements—A Review, Shashikant Chaturvedi, Ajitanshu Vedrtnam, Maged A. Youssef, Martin T. Palou, Gonzalo Barluenga, Kishor Kalauni

Civil and Environmental Engineering Publications

Fire accidents are a significant risk to human life and civil infrastructure. As a countermeasure, the regulatory bodies of different countries have established standards for evaluating the performance of construction elements during fire exposure. ISO 834 is the globally accepted fire-resistance testing standard. Other standards include ASTM E119, BS 476, IS 3809, JIS A 1304, AS 1503, EN 1363, and GB/T 9978, which are utilized by the US, Britain, India, Japan, Australia, Europe, and China, respectively. This article presents a summary and comparison of the fire-resistance testing standards. In reality, standard tests for isolated structural members may not efficiently portray …

The Wonder And Faith Of A Child, Eric F. Spina

President's Blog: From the Heart

"I wish you the miracle of Christmas," University of Dayton President Eric F. Spina wrote to the campus community in his annual message. "The story of Christ's birth — and the way we give of ourselves to others in return — bring hope to our world."

Abdominal Aortic Calcification, Cardiac Troponin I And Atherosclerotic Vascular Disease Mortality In Older Women, Ryan Teh, Richard L. Prince, Marc Sim, John T. Schousboe, Warren Raymond, Pawel Szulc, Wai Lim, Jonathan M. Hodgson, Kun Zhu, Douglas P. Kiel, Carl Schultz, Peter L. Thompson, Joshua Lewis

Research outputs 2014 to 2021

Objective: Examine if two inexpensive measures of atherosclerotic vascular diseases (ASVD), abdominal aortic calcification (AAC) and high-sensitivity cardiac troponin I (hs-cTnI) provide complementary information for 10-year ASVD mortality and all-cause mortality risk in older women.

Methods: 908 community-dwelling women without prevalent ASVD ( ≥ 75 years) were followed-up between 2003 and 2013. AAC and plasma hs-cTnI measures were obtained in 2003. AAC was assessed on lateral spine images using a semiquantitative method (AAC24). Linked health records were used for mortality outcomes.

Results: Mean±SD age was 79.9±2.6 years. 276 (30.4%) women died during follow-up, including 138 (15.2%) ASVD-related deaths. AAC24 and …

Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective Of Chronological Age, Joan Jiménez-Balado, Carolina Soriano-Tárraga, Et Al.

2020-Current year OA Pubs

In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively …

Association Of Gulf War Illness With Characteristics In Deployed Vs Non-Deployed Gulf War Era Veterans In The Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis, Linh M Duong, Alice B S Nono Djotsa, Jacqueline Vahey, Lea Steele, Rachel Quaden, Kelly M Harrington, Sarah T Ahmed, Renato Polimanti, Elani Streja, John Michael Gaziano, John Concato, Hongyu Zhao, Krishnan Radhakrishnan, Elizabeth R Hauser, Drew A Helmer, Mihaela Aslan, Elizabeth J Gifford

Center for Medical Ethics and Health Policy Staff Publications

Gulf War Illness (GWI), a chronic multisymptom illness with a complex and uncertain etiology and pathophysiology, is highly prevalent among veterans deployed to the 1990-1991 GW. We examined how GWI phenotypes varied by demographic and military characteristics among GW-era veterans. Data were from the VA's Cooperative Studies Program 2006/Million Veteran Program (MVP) 029 cohort, Genomics of GWI. From June 2018 to March 2019, 109,976 MVP enrollees (out of a total of over 676,000) were contacted to participate in the 1990-1991 GW-era Survey. Of 109,976 eligible participants, 45,169 (41.1%) responded to the 2018-2019 survey, 35,902 respondents met study inclusion criteria, 13,107 …

Rolling Up Single Layer Polymer, Xiaoyuan Huang

Mechanical Engineering and Materials Science Independent Study

This report introduces two way of rolling up materials and conclude a reasonable two ways to roll up a single layer of polymer. Four experiment procedures are described, and three of them were finished during the Fall 2022 semester.

Safety Related Hvac Systems In Pwr Nuclear Power Plants, Florie Markwell

Mechanical Engineering and Materials Science Independent Study

This paper is for the completion of MEMS 500 - Independent Study at Washington University in St. Louis. The materials and coursework are based off MEMS 5420 HVAC Analysis and Design I. This course covered readings and problems from chapters 1-8 of Heating, Ventilating, and Air-Conditioning Design and Analysis - sixth edition by McQuiston, Parker, and Spitler. Topics included moist air prop- erties, indoor environmental quality (comfort and health), heat transmission in building structures, space heating loads, and cooling loads. This paper focuses on a few of the safety related HVAC systems found in PWR or pressurized water reactor type …

Global South Research Collaboration: A Comparative Perspective, Abdoulaye Gueye, Edward Choi, Carolina Guzmán-Valenzuela, Gustavo Gregorutti

Faculty Publications

Research collaboration has become a major research topic in the social sciences. While this literature has mainly focused on collaborative dynamics in the Global North, more recent studies have examined these dynamics within the Global South. This article expands the scope of analysis by comparing the level of co-publications by Global South-based scholars with Global South-based colleagues and that between academics at Global South institutions and researchers in Global North universities. It shows that academic partnerships within the Global South are less common than instances of collaboration between the Global South and Global North. The relatively weak Global South collaborative …

Reducing Disparities In Postpartum Care Utilization: Development Of A Clinical Risk Assessment Tool, Sandi Tenfelde, Cara Joyce, Dina Tell, Lisa Masinter, Jena Wallander-Gemkow, Lindsey Garfield Dr.

Biostatistics Collaborative Core: Faculty Publications and Other Works

Introduction: Patients receiving care at Federally Qualified Health Centers (FQHCs) have low postpartum care attendance. Perinatal morbidity and mortality disproportionately affect patients with low-income and are potentially preventable. The purpose of this study was to develop a clinical decision support tool to identify FQHC patients less likely to return for postpartum care. To accomplish this purpose, we evaluated established predictors and novel risk factors in our patient population.

Methods: This is a retrospective, secondary data analysis of 50,022 patients who received prenatal care past 24 weeks’ gestation in FQHCs between 2012 and 2017. The postpartum visit was defined using Healthcare …

Exome Array Analysis Of 9721 Ischemic Stroke Cases From The Sign Consortium, Wei Zhao, O Colin Stine, Kathleen A Ryan, Megan Lynch, Jennifer A Smith, Jessica D Faul, Yao Hu, Jeffrey W Haessler, Myriam Fornage, Charles Kooperberg, On Behalf Of The Trans-Omics For Precision Medicine Topmed Stroke Working Group, James A Perry, Charles C Hong, John W Cole, Elizabeth Pugh, Kimberly Doheny, Sharon L R Kardia, David R Weir, Braxton D Mitchell, Sign Consortium

Faculty, Staff and Student Publications

Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we performed an exome array analysis on 106,101 SNPs for 9721 ischemic stroke cases from the SiGN Consortium, and 12,345 subjects with no history of stroke from the Health Retirement Study and SiGN consortium. We identified 15 coding variants significantly associated with all ischemic stroke at array-wide threshold (i.e., p < 4.7 × 10-7), including two common SNPs in ABO that have previously been associated with stroke. Twelve of the remaining 13 variants were extremely rare …

New Semi-Dwarfing Alleles With Increased Coleoptile Length By Gene Editing Of Gibberellin 3-Oxidase 1 Using Crispr-Cas9 In Barley (Hordeum Vulgare L.), Jingye Cheng, Camilla Hill, Yong Han, Tianhua He, Xingguo Ye, Sergey Shabala, Ganggang Guo, Meixue Zhou, Ke Wang, Chengdao Li

Grain and Other Field Crops Research Articles

The green revolution was based on genetic modification of the gibberellin (GA) hormone system with “dwarfing” gene mutations that reduces GA signals, conferring shorter stature, thus enabling plant adaptation to modern farming conditions. Strong GA-related mutants with shorter stature often have reduced coleoptile length, discounting yield gain due to their unsatisfactory seedling emergence under drought conditions. Here we present gibberellin (GA) 3-oxidase1 (GA3ox1) as an alternative semi-dwarfing gene in barley that combines an optimal reduction in plant height without restricting coleoptile and seedling growth. Using large-scale field trials with an extensive collection of barley accessions, we showed that a natural …

Glutamine Produces Ammonium To Tune Lysosomal Ph And Regulate Lysosomal Function, Jian Xiong, Thi Thu Trang Luu, Kartik Venkatachalam, Guangwei Du, Michael X Zhu

Faculty, Staff and Student Publications

Glutamine is one of the most abundant amino acids in the cell. In mitochondria, glutaminases 1 and 2 (GLS1/2) hydrolyze glutamine to glutamate, which serves as the precursor of multiple metabolites. Here, we show that ammonium generated during GLS1/2-mediated glutaminolysis regulates lysosomal pH and in turn lysosomal degradation. In primary human skin fibroblasts BJ cells and mouse embryonic fibroblasts, deprivation of total amino acids for 1 h increased lysosomal degradation capacity as shown by the increased turnover of lipidated microtubule-associated proteins 1A/1B light chain 3B (LC3-II), several autophagic receptors, and endocytosed DQ-BSA. Removal of glutamine but not any other amino …

Tokenization Ticket Master, Christopher O'Kane, Patrick Hutchinson

Defensive Publications Series

The present invention discloses a tokenization ticket master system where in which a consumer 101 enters sensitive data into an event checkout page which is displayed/presented on a user device 102. The event checkout page presented/displayed on the user device 102 posts the sensitive data to an event server 103. The sensitive data is then sent to a tokenization server 104, where the data is securely stored, and a token is created to represent the sensitive data. A token ID is returned to the event server 103 and the token ID is encoded as a QR code. The token may …

Preparing Future School Counselors To Work With English Language Learners, Jennifer S. Watkinson, Qi Shi, Hope Slezak, Rachel Litvin

Journal of Counselor Preparation and Supervision

English Language Learners (ELLs) are one of the fastest growing student groups in the United States, yet school counselors often feel unprepared to address their unique needs. To better prepare school counselors to work with ELLs, counselor educators can integrate experiential learning activities that are grounded practice. Yet, little is known about the types of work experiences school counselors encounter when working with ELL students. This phenomenological study described the experiences of eight, first year school counselors who work with ELLs. Findings inform the types of training scenarios counselor educators can use to prepare school counselors-in-training (SCIT) to work with …

Exploring The Training And Practice Experiences Of Male School Counselors, Eric S. Davis, Michele Pinellas, Sarah Putnam, Rosemarie Beahm

Journal of Counselor Preparation and Supervision

Males are underrepresented as school counselors and may experience stigma associated with being viewed as less masculine, sexual deviants, or unqualified. Despite these aspects, research has shown benefits for school stakeholders based in the diverse perspectives male school counselors can provide. The purpose of this phenomenological qualitative research study was to understand the lived experiences of 25 male school counselors from across the United States. Based on the thematic analysis findings, we will discuss specific implications and recommendations for male school counselor training, supervision, and practice.

School Counseling Site Supervision: Training Recommendations To Benefit School Counselor Interns And Site Supervisors, Chris R. Wilder, Atiya R. Smith, Jennifer Money-Brady, Denise B. Ebersole, Abraham Cazares-Cervantes, Teshaunda L. Hannor-Walker, Judith Justice

Journal of Counselor Preparation and Supervision

The importance of supervision is supported in the research literature. Site supervision in school counseling does not require formal training. The absence of formal training has potential implications for the novice school counselor, the P-12 students they serve, and future school counseling supervisees. The authors compare current training models and explore best practices to improve site supervision for school counseling interns. accreditation, ethics, and current needs in school counseling for the school counselor intern and the site supervisor. Finally, the authors review supervision training and models, accreditation, ethics, and current needs for the school counselor intern and the site supervisor, …

Supervision In Schools: A Developmental Approach, Jessica Miserentino, Michael D. Hannon

Journal of Counselor Preparation and Supervision

School counselor supervision has been identified as both integral to effective school counseling practice and significantly underrepresented in counseling research. We provide a critical review of school counseling supervision literature and provide a rationale for using the Integrated Developmental Model for supervising school counselors through a case study. We conclude with recommendations for counselor preparation programs to integrate sustainable practices to help advocate for more frequent supervision support for school counselors.

Counseling Children And Adolescents: A Call To Action, Rebekah Byrd, Chad Luke, Sonya Lorelle, Emily Donald, Jillian Blueford, Charmayne Adams, Edward (Franc) Hudspeth

Journal of Counselor Preparation and Supervision

The ACA 2014 Code of Ethics clearly states the mandate for counselor competence in C.2.a. It is noted that “Counselor practice only within the boundaries of their competence, based on their education, training, supervised experience, state and national credentials, and appropriate professional experience” (p. 8). Given the importance of competencies, ethical standards, and the emphasis on best practice, the paucity of these factors in regard to training and supervision for counselors working with child and adolescent populations is concerning. This article offers a conceptualization of the culture of childhood leading to the need for cultural competency. It outlines information specific …

Letter From The Editor: Special Issue On School Counseling, Rebekah Reysen

Journal of Counselor Preparation and Supervision

No abstract provided.

Runge-Kutta Methods For Rough Differential Equations, Martin Redmann, Sebastian Riedel

Journal of Stochastic Analysis

No abstract provided.