Digital Commons Network^™

Association Of Igg N-Glycomics With Prevalent And Incident Type 2 Diabetes Mellitus From The Paradigm Of Predictive, Preventive, And Personalized Medicine Standpoint, Xiaoni Meng, Fei Wang, Xiangyang Gao, Biyan Wang, Xizhu Xu, Youxin Wang, Wei Wang, Qiang Zeng

Research outputs 2022 to 2026

Objectives: Type 2 diabetes mellitus (T2DM), a major metabolic disorder, is expanding at a rapidly rising worldwide prevalence and has emerged as one of the most common chronic diseases. Suboptimal health status (SHS) is considered a reversible intermediate state between health and diagnosable disease. We hypothesized that the time frame between the onset of SHS and the clinical manifestation of T2DM is the operational area for the application of reliable risk assessment tools, such as immunoglobulin G (IgG) N-glycans. From the viewpoint of predictive, preventive, and personalized medicine (PPPM/3PM), the early detection of SHS and dynamic monitoring by glycan biomarkers …

Ranking The Risk Of Co2 Emissions From Seagrass Soil Carbon Stocks Under Global Change Threats, Martin Dahl, Kathryn Mcmahon, Paul S. Lavery, Serena H. Hamilton, Catherine E. Lovelock, Oscar Serrano

Research outputs 2022 to 2026

Seagrass meadows are natural carbon storage hotspots at risk from global change threats, and their loss can result in the remineralization of soil carbon stocks and CO2 emissions fueling climate change. Here we used expert elicitation and empirical evidence to assess the risk of CO2 emissions from seagrass soils caused by multiple human-induced, biological and climate change threats. Judgments from 41 experts were synthesized into a seagrass CO2 emission risk score based on vulnerability factors (i.e., spatial scale, frequency, magnitude, resistance and recovery) to seagrass soil organic carbon stocks. Experts perceived that climate change threats (e.g., gradual ocean warming and …

Novel Insights Into Potential Cannabis-Related Cancerogenesis From Recent Key Whole Epigenome Screen Of Cannabis Dependence And Withdrawal: Epidemiological Commentary And Explication Of Schrott Et Al., Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Whilst the cannabis-cancer link has been traditionally described as controversial recent whole nation and whole continent studies have demonstrated that well documented laboratory-based multimodal cannabinoid genotoxicity is indeed reflected in numerous cancer types in larger epidemiological series. A recent longitudinal human sperm epigenome-wide DNA methylation screen in both cannabis dependence and cannabis withdrawal has revealed remarkable insights into the manner in which widespread perturbations of DNA methylation may lead to cancerogenic changes in both the exposed and subsequent generations as a result of both cannabis exposure and withdrawal. These results therefore powerfully strengthen and further robustify the causal nature of …

Responsive, Adaptive, And Future-Centred Leadership In Response To Crisis: Findings From Australia, Fiji, And New Zealand, Michelle Striepe, Pauline Thompson, Sylvia Robertson, Mohini Devi, David Gurr, Fiona Longmuir, Adam Taylor, Christine Cunningham

Research outputs 2022 to 2026

The COVID-19 pandemic has caused major disruption to education and highlighted the importance of effective leadership during times of crisis. This paper considers the impact of the pandemic on school leaders in Australia, Fiji, and New Zealand. A secondary analysis of data from five interpretivist, qualitative studies was conducted. The aim of the study was to investigate the similarities and differences between the leaders’ experiences across school settings, states/provinces, and countries. Our findings place renewed importance on understanding the role of schools within the community and the vital role school leaders play in helping schools respond to volatile and dynamic …

A New Augmented Reality System For Calculating Social Distancing Between Children At School, Omar Alshaweesh, Mohammad Wedyan, Moutaz Alazab, Bilal Abu-Salih, Adel Al-Jumaily

Research outputs 2022 to 2026

Social distancing is one of the most important ways to prevent many diseases, especially the respiratory system, where the latest internationally spread is coronavirus disease, and it will not be the last. The spreading of this pandemic has become a major threat to human life, especially to the elderly and people suffering from chronic diseases. During the Corona pandemic, medical authorities were keen to control the spread through social distancing and monitoring it in markets, universities, and schools. This monitoring was mostly used to estimate the distance with the naked eye and interfere with estimating the distance on the observer …

Sprint Cycling Rate Of Torque Development Associates With Strength Measurement In Trained Cyclists, Shannon Connolly, Peter Peeling, Martyn J. Binnie, Paul S. R. Goods, Christopher Latella, Janet L. Taylor, Anthony J. Blazevich, Wouter P. Timmerman, Chris R. Abbiss

Research outputs 2022 to 2026

Purpose:

A cyclist’s rate of force/torque development (RFD/RTD) and peak force/torque can be measured during single-joint or whole-body isometric tests, or during cycling. However, there is limited understanding of the relationship between these measures, and of the mechanisms that contribute to each measure. Therefore, we examined the: (i) relationship between quadriceps central and peripheral neuromuscular function with RFD/RTD in isometric knee extension, isometric mid-thigh pull (IMTP), and sprint cycling; and (ii) relationship among RFD/RTD and peak force/torque between protocols.

Methods:

Eighteen trained cyclists completed two familiarisation and two experimental sessions. Each session involved an isometric knee extension, IMTP, and sprint …

Creativity And Initial Teacher Education: Reflections Of Secondary Visual Arts Teachers In Ghana, Enock Swanzy-Impraim, Julia E. Morris, Geoffrey W. Lummis, Andrew Jones

Research outputs 2022 to 2026

The development of creativity through learning is a significant part of Ghana's pre-tertiary education system framework. Achieving the successful implementation of creativity from policy to practice in schools relies on teachers in the local school system, who are shaped by their past teaching experiences and the training they have received during initial teacher education (ITE). Using interviews and observation data, this case study explored 16 secondary visual arts teachers' experiences and reflections on their training in relation to creativity and its impact on their current practice. Five themes emerged from an inductive analysis: containment, free expression, self-directed learning, replication of …

Fabrication And Optimization Of Nafion As A Protective Membrane For Tin-Based Ph Sensors, Shimrith P. Shylendra, Magdalena Wajrak, Kamal Alameh

Research outputs 2022 to 2026

In this study, a solid-state modified pH sensor with RF magnetron sputtering technology was developed. The sensor consists of an active electrode consisting of a titanium nitride (TiN) film with a protective membrane of Nafion and a reference glass electrode of Ag/AgCl. The sensitivity of the pH sensor was investigated. Results show a sensor with excellent characteristics: sensitivity of 58.6 mV/pH for pH values from 2 to 12, very short response time of approximately 12 s in neutral pH solutions, and stability of less than 0.9 mV in 10 min duration. Further improvement in the performance of the TiN sensor …

Integrative Review: Factors Impacting Effective Delegation Practices By Registered Nurses To Assistants In Nursing, Carol Crevacore, Elisabeth R. Jacob, Linda L. Coventry, Christine Duffield

Research outputs 2022 to 2026

Aim

To identify the evidence on factors that impact delegation practices by Registered Nurses to Assistants in Nursing in acute care hospitals.

Design

An integrative review.

Data Sources

Database searches were conducted between July 2011 and July 2021.

Review Methods

We used the 12-step approach by Kable and colleagues to document the search strategy. The (Whittemore & Knafl. 2005. Journal of Advanced Nursing, 52(5), 546–553) integrative review framework method was adopted and the methodological quality of the studies was assessed using Joanna Briggs critical appraisal instruments.

Results

Nine studies were included. Delegation between the Registered Nurse and the …

Communety: Deep Learning-Based Face Recognition System For The Prediction Of Cohesive Communities, Syed Afaq Ali Shah, Weifeng Deng, Muhammad Aamir Cheema, Abdul Bais

Research outputs 2022 to 2026

Effective mining of social media, which consists of a large number of users is a challenging task. Traditional approaches rely on the analysis of text data related to users to accomplish this task. However, text data lacks significant information about the social users and their associated groups. In this paper, we propose CommuNety, a deep learning system for the prediction of cohesive networks using face images from photo albums. The proposed deep learning model consists of hierarchical CNN architecture to learn descriptive features related to each cohesive network. The paper also proposes a novel Face Co-occurrence Frequency algorithm to quantify …

Covid-19 Two Years On: A Review Of Covid-19-Related Empirical Research In Major Tourism And Hospitality Journals, Songshan (Sam) Huang, Xuequn Wang

Research outputs 2022 to 2026

Purpose: This study aims to provide a timely review of the COVID-19-related empirical research published in 19 quartile one (Q1) and quartile two (Q2) tourism and hospitality journals in social science citation index (SSCI).

Design/methodology/approach: A total of 407 COVID-19-related empirical papers were collected from the 19 SSCI Q1 and Q2 tourism and hospitality journals via Scopus database. Thematic content analysis was supplemented with Leximancer software to identify the research themes/subthemes, research methods and countries/regions of research.

Findings: The study found studies of COVID-19’s impact on consumer behaviour predominate in number, followed by studies on response actions and recovery strategies, …

Royal Panda Bites, Grayson Briggs

Student Publications

No abstract provided.

Examining Incivility Through A Moral Lens: Coworker Morality Appraisals, Other-Condemning Emotions, And Instigated Incivility, Gerardo A. Miranda, Jennifer L. Welbourne

Management Faculty Publications

While much is known about the prevalence and impact of incivility in the workplace, relatively less is known about those who instigate workplace incivility. This research aims to investigate incivility instigation through a moral lens by examining the roles of other-condemning moral emotions (contempt, disgust, and anger) and appraisals of coworkers’ morality as predictors of this behavior at work. In Study 1, we used structural equation modeling to analyze two waves of self-report data collected from a sample of 447 full-time United States (U.S.) working adults. Findings from this study indicate that appraising coworkers as low in morality elicited feelings …

Tools, Tips, And Tricks For Beginning Teachers, Kimberly Lilley, Regina Lineback, Brad Rhew, Elia Spencer

Instructional Modules for Professional learning Responding to Opportunities and Valuing Educators (IMPROVE)

Tools, Tips, and Tricks for Beginning Teachers is a professional learning module (PLM) that supports the growth and development of beginning teachers. The topics reviewed in this PLM include classroom management, collaboration, instructional strategies, and student engagement. The strategies included in this PLM are research-based and support the Beginning Teacher Standards, Professional Teaching Standards, and Beginning Teacher Standards for Science Education. As you proceed through the PLM, you will have opportunities to consider your current or planned practices in each of the focus areas and select new tools, tips, or tricks that can be applied to your classroom practices.

View …

Battling Burnout Zombies In High School English, Jennifer Gribben, Michelle Nelson

Instructional Modules for Professional learning Responding to Opportunities and Valuing Educators (IMPROVE)

This PLM was created to support secondary education English teachers who are struggling to prevent student disengagement in ELA classrooms. This PLM was based on John Hattie's 10 habits. The creators of this PLM also used Explicit DIRECT Instruction and Rigorous curriculum design to ground their ideas in proven RESEARCH. This PLM will give teachers a place to find ideas and strategies to help make their classrooms a successful learning environment.

View professional learning module.

Cultural Responsibility: Whose Job Is It Anyway?, Shannon Coleman, Siobhan Cooke, Yu'vonne James, Elizabeth Younger

Instructional Modules for Professional learning Responding to Opportunities and Valuing Educators (IMPROVE)

This professional learning module (PLM) on cultural responsibility in the school setting is rooted in the recognition of the importance of creating an inclusive and equitable learning environment for all students and staff. This PLM module was designed to help teachers, and those working within the school setting, understand, appreciate, and effectively address cultural diversity and its impact on students’ learning experiences.

View professional learning module.

Editorial: Peripheral Stimulation: Neuromodulation Of The Central Nervous System Through Existing Pathways, Jose L Pons, Ilknur Telkes, Arjun Tarakad

Faculty, Staff and Students Publications

No abstract provided.

Versican Provides The Provisional Matrix For Uterine Spiral Artery Dilation And Fetal Growth, Tsutomu Ohara, Baku Nakakita, Yoshimi Kitawaki, Asuka Okunomiya, Hirohiko Tani, Ken Yamaguchi, Junzo Hamanishi, John P Lydon, Takiko Daikoku, Hideto Watanabe, Masaki Mandai

Faculty, Staff and Students Publications

The extracellular matrix (ECM) in the endometrium plays a crucial role in mammalian pregnancy. We have shown that versican secreted from the endometrial epithelium promotes embryo implantation. Versican is a proteoglycan, a major player in the provisional matrix, and versikine, its N-terminal fragment cleaved by ADAMTS proteinases, serves as a bioactive molecule. Here, since versican expression in the placenta was dynamically altered in humans and mice, we investigated the role of versican in pregnancy using uterine-specific Vcan deletion mice (uKO mice) and ADAMTS-resistant versican expressing mice (V1R mice). uKO mice exhibited insufficient spiral artery dilation, followed by fetal growth restriction …

Astrocytic-Based Controller Shifts Epileptic Activity To The Chaotic State

Faculty, Staff and Students Publications

Introduction: Investigating an effective controller to shift hippocampal epileptic periodicity to normal chaotic behavior will be new hope for epilepsy treatment. Astrocytes nourish and protect neurons and maintain synaptic transmission and network activity. Therefore, this study explored the ameliorating effect of the astrocyte computational model on epileptic periodicity.

Methods: Modified Morris-Lecar equations were used to model the hippocampal CA3 network. Network inhibitory parameters were employed to generate oscillation-induced epileptiform periodicity. The astrocyte controller was based on a functional dynamic mathematical model of brain astrocytic cells.

Results: Results demonstrated that the synchronization of two neural networks shifted the brain's chaotic state …

Engaging Patients In Antimicrobial Stewardship: Co-Designed Educational Tool To Improve Periprocedural Care Through De-Implementation Of Guideline-Discordant Antimicrobial Use, Tyler Thompson, Isabella Epshtein, Hillary Mull, Dipandita Basnet Thapa, Dimitri Drekonja, Maria C Rodriguez-Barradas, Teena Huan Xu, Howard Gold, A Rani Elwy, Judy Strymish, Westyn Branch-Elliman

Faculty, Staff and Students Publications

Effective de-implementation models often include replacement of an ineffective practice with an alternative. We co-developed patient education materials as a replacement strategy for inappropriate post-procedural antibiotics in cardiac device procedures. Lessons learned and developed materials may be used to promote infection prevention in other periprocedural settings.

Toward More Rigorous And Informative Nutritional Epidemiology: The Rational Space Between Dismissal And Defense Of The Status Quo, Rafael Ferreira Da Silva, Adam Hoover, David M Klurfeld, Eric Loken, Evan Mayo-Wilson, Nir Menachemi, Greg Pavela, Patrick D Quinn, Dale Schoeller, Carmen Tekwe, Danny Valdez, Colby J Vorland, Leah D Whigham, David B Allison

Faculty, Staff and Students Publications

To date, nutritional epidemiology has relied heavily on relatively weak methods including simple observational designs and substandard measurements. Despite low internal validity and other sources of bias, claims of causality are made commonly in this literature. Nutritional epidemiology investigations can be improved through greater scientific rigor and adherence to scientific reporting commensurate with research methods used. Some commentators advocate jettisoning nutritional epidemiology entirely, perhaps believing improvements are impossible. Still others support only normative refinements. But neither abolition nor minor tweaks are appropriate. Nutritional epidemiology, in its present state, offers utility, yet also needs marked, reformational renovation. Changing the status quo …

Acute Liver Failure And Unique Challenges Of Pediatric Liver Transplantation Amidst A Worldwide Cluster Of Adenovirus-Associated Hepatitis, Luz Helena Gutierrez Sanchez, Moreshwar S Desai, Dana Cerminara, Flor M Munoz, Leanne M Buffaloe, Kristen G Valencia-Deray, N Thao N Galvan, Julu Bhatnagar, Lindsey Estetter, Negar Rassaei, Sarah Reagan-Steiner, Jason Wicker, James J Dunn, Carl E Allen, Kalyani R Patel, Sanjiv Harpavat, John A Goss, Daniel H Leung

Faculty, Staff and Students Publications

Investigation into a recent cluster of acute hepatitis in children from the southeastern United States identified human adenovirus (HAdV) DNAemia in all 9 cases. Molecular genotyping in 5 of 9 (56%) children identified HAdV type 41 in all cases (100%). Importantly, 2 children from this cluster progressed rapidly to pediatric acute liver failure (PALF) and required liver transplantation. HAdV type 41, a known cause of self-limited gastroenteritis, has not previously been associated with severe cholestatic hepatitis and liver failure in healthy children. Adenovirus polymerase chain reaction assay and sequencing of amplicons performed on DNA extracted from formalin-fixed, paraffin-embedded liver tissue …

Can Mild Traumatic Brain Injury Alter Cognition Chronically? A Limbic-Cenc Multicenter Study, Terri K Pogoda, Heather G Belanger, Randall S Scheibel, Angela P Presson, Shannon R Miles, Elisabeth A Wilde, David F Tate, Maya Troyanskaya, Mary Jo Pugh, Amy Jak, David X Cifu

Faculty, Staff and Students Publications

Objective: While outcome from mild traumatic brain injury (mTBI) is generally favorable, concern remains over potential negative long-term effects, including impaired cognition. This study examined the link between cognitive performance and remote mTBIs within the Long-term Impact of Military-relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) multicenter, observational study of Veterans and service members (SMs) with combat exposure.

Method: Baseline data of the participants passing all cognitive performance validity tests (n = 1,310) were used to conduct a cross-sectional analysis. Using multivariable regression models that adjusted for covariates, including age and estimated preexposure intellectual function, positive mTBI history …

The Tmem106b T186s Coding Variant Increases Neurite Arborization And Synaptic Density In Primary Hippocampal Neurons, Joanna L Jankowsky

Faculty, Staff and Students Publications

The lysosomal protein TMEM106B was identified as a risk modifier of multiple dementias including frontotemporal dementia and Alzheimer’s disease. The gene comes in two major haplotypes, one associated with disease risk, and by comparison, the other with resilience. Only one coding polymorphism distinguishes the two alleles, a threonine-to-serine substitution at residue 185 (186 in mouse), that is inherited in disequilibrium with multiple non-coding variants. Transcriptional studies suggest synaptic, neuronal, and cognitive preservation in human subjects with the protective haplotype, while murine in vitro studies reveal dramatic effects of TMEM106B deletion on neuronal development. Despite this foundation, the field has not …

Case Report: Artemis Deficiency And 3m Syndrome-Coexistence Of Two Distinct Genetic Disorders, Ivan Kingyue Chinn, Jordan Scott Orange, Hasibe Artac

Faculty, Staff and Students Publications

The presence of two different genetic conditions in the same individual is possible, especially in populations with consanguinity. In this case report, we present the coexistence of Artemis deficiency (OMIM 602450) and Three M (3M) syndrome (OMIM 273750). A 10-months-old male patient with neuromotor developmental delay was evaluated for immunodeficiency due to recurrent respiratory infections diarrhea and oral moniliasis from the age of 1.5 months. He had facial dysmorphism with rotated ears, flat nose and hypertelorism. Neurological examination revealed generalized hypotonia and mental motor delay. Immunological screening of the patient demonstrated mild lymphopenia, hypogammaglobulinemia, reduced number of CD3

Using Oer In Tenure Narratives: Conversations With Tenure Experts, Stephen Craig Finlay, Isabel Soto-Luna

Criss Library Faculty Publications

We conducted 16 interviews with unit heads at UNO who have experience with mentoring and reviewing tenure-track faculty and, from these interviews, articulated a number of strategies for using OERs work in tenure packets.

“I Am Not A Good Woman?” Exploring The Views And Challenges Of Nurses When Discussing Hpv Testing And Associated Cervical Screening With Women In Iraq, Suhailah M. Ali, Rebecca Lawes, Ayla Khedher Ghalib

School of Nursing and Midwifery

Introduction: Cervical cancer is mostly caused by high-risk Human papillomavirus HPV, with an estimation prevalence of HPV of 99.7% worldwide. The US Food and Drug Administration (FDA) approved an HPV test for primary cervical screening in 2014. An HPV-DNA test, which provides higher protection against invasive cervical carcinomas, is replacing the long-standing Pap smear as the primary method of cervical cancer screening. Objective: To explore nurses’ experience and knowledge of HPV DNA testing and how screening impacts on women's health through increasing awareness and proposing actions for health education strategies. Method: A qualitative exploratory study was conducted on a purposeful …

Corporations And Abortion Rights In A Post-Dobbs World, Jennifer S. Fan

Law Faculty Research and Publications

When the U.S. Supreme Court issued its decision on Dobbs v. Jackson Women’s Health Organization, it eliminated the constitutional right to abortion, overturning nearly fifty years of precedent. Although there were those who celebrated the decision, there were also those who were dismayed and angry about its consequences. As a result, many groups mobilized into action, but the vast majority of corporations were not among them. Unlike other social issues, companies were largely silent on the issue of abortion. Using shareholder proposal data from a ten-year period and reproductive health benefits offered by companies, this Article examines how corporations addressed …

Woke Capital Revisited, Jennifer S. Fan

Law Faculty Research and Publications

Inclusive corporate leadership is now at the forefront of discussions related to corporate governance. Two corporate theories help to explain the rise in prominence of diversity, equity, and inclusion (“DEI”) efforts in corporate leadership. First, an expanded definition of corporate purpose which elevated the idea of the importance of stakeholders, contributed to the momentum from business and legal quarters for broader corporate inclusion. Second, the increasing publicness of corporations—the social expectation of how large, typically public corporations should act given their position of power—also led to corporations becoming more active in the DEI space. It is against this backdrop that …

Goal-Directed Haemodynamic Therapy Improves Patient Outcomes In Kidney Transplantation, J Fabes, Midani A Al, As Sarna, Dh Hadi, Sa Naji, Nr Banga, Gl Jones, Pd Berry, Md Wittenberg

Peninsula Medical School

Introduction: Kidney transplant graft function depends on optimised haemodynamics. However, high fluid volumes risk hypervolaemic complications. The Edwards Lifesciences ClearSight™ device permits fluid titration through markers of preload and beat-to-beat blood pressure monitoring. We evaluated the implementation of a novel goal-directed haemodynamic therapy protocol to determine whether patient outcomes had improved. Design: A retrospective evaluation of standard care versus goal-directed haemodynamic therapy in adults undergoing kidney transplantation was performed in a single centre between April 2016 and October 2019. Twenty-eight standard-of-care patients received intraoperative fixed-rate infusion and 28 patients received goal-directed haemodynamic therapy. The primary outcome was volume of fluid …