Digital Commons Network^™

Prospective In Silico Evaluation Of Cone-Beam Computed Tomography-Guided Stereotactic Adaptive Radiation Therapy (Ct-Star) For The Ablative Treatment Of Ultracentral Thoracic Disease, Joshua P Schiff, Eric Laugeman, Hayley B Stowe, Xiaodong Zhao, Jessica Hilliard, Ellie Hawk, Jesiah Watkins, Casey Hatscher, Shahed N Badiyan, Pamela P Samson, Geoffrey D Hugo, Clifford G Robinson, Alex T Price, Lauren E Henke

2020-Current year OA Pubs

PURPOSE: We conducted a prospective, in silico study to evaluate the feasibility of cone-beam computed tomography (CBCT)-guided stereotactic adaptive radiation therapy (CT-STAR) for the treatment of ultracentral thoracic cancers (NCT04008537). We hypothesized that CT-STAR would reduce dose to organs at risk (OARs) compared with nonadaptive stereotactic body radiation therapy (SBRT) while maintaining adequate tumor coverage.

METHODS AND MATERIALS: Patients who were already receiving radiation therapy for ultracentral thoracic malignancies underwent 5 additional daily CBCTs on the ETHOS system as part of a prospective imaging study. These were used to simulate CT-STAR, in silico

RESULTS: Seven patients were accrued, 6 with …

Phantom-Based Quality Assurance Of A Clinical Dose Accumulation Technique Used In An Online Adaptive Radiation Therapy Platform, Borna Maraghechi, Thomas Mazur, Dao Lam, Alex Price, Lauren Henke, Hyun Kim, Geoffrey D Hugo, Bin Cai

2020-Current year OA Pubs

PURPOSE: This study aimed to develop a routine quality assurance method for a dose accumulation technique provided by a radiation therapy platform for online treatment adaptation.

METHODS AND MATERIALS: Two commonly used phantoms were selected for the dose accumulation QA: Electron density and anthropomorphic pelvis. On a computed tomography (CT) scan of the electron density phantom, 1 target (gross tumor volume [GTV]; insert at 6 o'clock), a subvolume within this target, and 7 organs at risk (OARs; other inserts) were contoured in the treatment planning system (TPS). Two adaptation sessions were performed in which the GTV was recontoured, first at …

Status, Subject, And Agency In Innovation, Kali Murray

Emory Law Journal Online

The Inequalities of Innovation will be rightly understood as a major scholarly assessment in intellectual property and innovation law for its naming of three key inequalities: the inequality of wealth and income, the inequality of opportunity to innovate, and the inequality of access to innovation. This Essay complicates the triadic framework discussed in The Inequalities of Innovation by interrogating its relationship to status harm and social identity and its relationship to broader discussions of social identities such as race and the law.

Book Review, Tang (Cindy) Tian

Journal Articles

Reviewing:

Strum, Philippa. On Account of Sex: Ruth Bader Ginsburg and the Making of Gender Equality Law. Lawrence, Kansas: University Press of Kansas, 2022. 206p. $21.95.

The Secret Sauce: Examining Law Schools That Overperform On The Bar Exam, Derek T. Muller, Christopher J. Ryan Jr.

Journal Articles

Since 2010, law schools have faced declining enrollment and entering classes with lower predictors of success despite recent signs of improvement. At least partly as a result, rates at which law school graduates pass the bar exam have declined and remain at historic lows. Yet, during this time, many schools have improved their graduates' chances of success on the bar exam, and some schools have dramatically outperformed their predicted bar exam passage rates. This Article examines which schools do so and why.

Research for this Article began by accounting for law schools' incoming class credentials to predict an expected bar …

The Rural Enterprise Crime Complex: ‘Undefendable Rural Space’ And The Threat From The Fortress Farm, Orlando Goodall

School of Law, Humanities and Social Sciences

In response to the concept of the ‘fortress farm’ and its appropriation of traditional defensible space theory, this article introduces the conditions of undefendable rural space and the rural enterprise crime complex. Perspectives that invert traditional theory to determine contexts conducive to the incidence of rural enterprise crime. Empirical data from extensive fieldwork on crimes against wild animals in rural England is used to argue that the fortress and undefendable rural space can in effect serve to ‘design-out’ crime control and lock crime in. A dichotomous outcome, which creates a fortress for relatively powerful human insiders and a rural enterprise …

Evaluating The Implementation Of A ‘Child First’ Approach Within Plymouth’S Youth Justice Multi-Agency Diversion Scheme., Emma Taylor, Patricia Gray, Katie Mcbride, Zoe James

School of Law, Humanities and Social Sciences

This is the final report from the evaluation of the Plymouth Youth Justice Service (PYJS) multi-agency ‘child first’ diversion scheme, known as Outcome 22. Baselineand first-year interim reports have also been produced, with this final evaluation aiming to examine the effectiveness of this diversion scheme in reducing first time entrants and recidivism in the city of Plymouth, whilst adhering to a Child First approach

The ‘People’S War On Terror’ In Xinjiang: A Model For China?, Hannah Theaker

School of Law, Humanities and Social Sciences

No abstract provided.

The Impact Of Myosteatosis On Outcomes Following Surgery For Gastrointestinal Malignancy: A Meta-Analysis, A Maccormick, A Streeter, M Puckett, Somaiah Aroori

Peninsula Medical School

INTRODUCTION: The aim of this review was to evaluate the impact of preoperative myosteatosis on long-term outcomes following surgery for gastrointestinal malignancy.

METHODS: We conducted a systematic search of the electronic information sources, including PubMed MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL and AMED. Studies were included if they reported the impact of preoperatively defined myosteatosis, or a similar term, on long-term survival outcomes following surgery for gastrointestinal malignancy. A subgroup analysis was performed for those studies reporting outcomes for colorectal cancer patients only.

FINDINGS: Thirty-nine full-text articles were reviewed for inclusion, with 19 being retained after …

Dietary Patterns And Practices And Leucocyte Telomere Length: Findings From The Uk Biobank, Vasiliki Bountziouka, Christopher P. Nelson, Qingning Wang, Crispin Musicha, Veryan Codd, Nilesh J. Samani

Peninsula Medical School

BACKGROUND: Shorter telomere length (TL) is associated with risk of several age-related diseases and decreased life span, but the extent to which dietary patterns and practices associate with TL is uncertain. OBJECTIVE: This study aimed to investigate the association of dietary patterns and practices and leucocyte TL (LTL). DESIGN: This was a cross-sectional study. PARTICIPANTS AND SETTING: Data collected voluntarily from up to 422,797 UK Biobank participants, during 2006-2010. MAIN OUTCOME MEASURES: LTL was measured as a ratio of the telomere repeat number to a single-copy gene and was loge-transformed and standardized (z-LTL). STATISTICAL ANALYSES PERFORMED: Adherence a priori to …

Hmp-Reader: Menpa Guidelines For Designing And Reporting Research On Holistic Movement Practices, Including Yoga, Tai Chi, Qigong, And Conscious Dance, Ineke Vergeer, Adrian Taylor, Mats Hallgren, Stuart J.H. Biddle

Peninsula Medical School

No abstract provided.

National Study Of Nafld Management Identifies Variation In Delivery Of Care In The Uk Between 2019 To 2022, Wenhao Li, David Sheridan, Stuart Mcpherson, William Alazawi, Kush Abeysekera, Tom Marjot, Paul Brennan, Sara Mahgoub, Tessa Cacciottolo, Theresa Hydes, Tim Hardy, Gio Mcginty, Oliver Tavabie, Jennifer Cathcart, Chirantha Premathilaka, Ashis Mukhopadhya, Arshiya Bhat, Shahnaz Begum, Bashar Abushaban, Meha Bhuva, Sophie Sinclair, Damien Leith, Cullen Mcculloch, Joanna Leithead, Richard Fox, Mh Shah, Eugene Campbell, Edward Brown, Dina Mansour, F Shah, Michael Allison, Jonathan Chan, Victoria Roberts, Gautham Appanna, Mandour Omer Mandour, Georgina Slee, Vicki Wong, Sreelakshmi Kotha, Katrina Pekarska, Richard Parker, Cyril Sieberhagen, Thomas Ngan, Esra Asilmaz, Hamish Miller, Jeremy Cobbold, Dom Crocombe, Manolis Tsochatzis, Sudeep Tanwar, Aruna Dias, Gurmit Singh, S Agrawal, P Chhabra, A Gurung, R Veettil, Rd Abeles, D Chatterjee, M Carbonell, Z Mohamed, A El-Sayed, A Johnson, Damien Leith, S Barclay, K Kelly, J Munonye, D Coates, O Bamidele, T Johnston, D Samuel, B Ball, R Arscott-Samuel, P Hams, M Armstrong, A Elkhol, K Shailesh, V Bains, P Manousou, T Gupta, S Than, E Unitt, V Gordon, A Wakefield, S Gilchrist, I Cozma, S Saeed, S Umrani, K Olsen

Peninsula Medical School

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with liver and cardiovascular morbidity and mortality. Recently published NAFLD Quality Standards include 11 key performance indicators (KPIs) of good clinical care. This national study, endorsed by British Association for the Study of the Liver (BASL) and British Society of Gastroenterology (BSG), aimed to benchmark NAFLD care in UK hospitals against these KPIs. Methods: This study included all new patients with NAFLD reviewed in the outpatient clinic in the months of March 2019 and March 2022. Participating UK hospitals self-registered for the study through BASL/BSG. KPI outcomes were compared using …

Motivational Support Intervention To Reduce Smoking And Increase Physical Activity In Smokers Not Ready To Quit: The Tars Rct, Adrian H. Taylor, Tom P. Thompson, Adam Streeter, Jade Chynoweth, Tristan Snowsill, Wendy Ingram, Michael Ussher, Paul Aveyard, Rachael L. Murray, Tess Harris, Colin Green, Jane Horrell, Lynne Callaghan, Colin J. Greaves, Lisa Price, Lucy Cartwright, Jonny Wilks, S Campbell, Dan Preece, Siobhan Creanor

Peninsula Medical School

No abstract provided.

Strategies Are Needed To Support People With Alcohol Use Disorder And Alcohol-Related Liver Disease To Take Part In Randomised Clinical Trials: Results From The Mirage Pilot Trial Of Functional Imagery Training, A Dhanda, V Allgar, J Andrade, L Callaghan, B Hudson, W Ingram, A King, V Lavers, J Lomax, A Mccune, C Musicha, R Parker, C Rollinson, S Creanor

Peninsula Medical School

No abstract provided.

Not Hearing, Not Engaging, And Not Happening: Elusive Inclusive Higher Education, It Is Time To Reconsider Sector Practices In Partnership With Disabled Student Expertise, Suanne Gibson, Zeta Williams-Brown, Jen Shute, Mette Westander

School of Law, Humanities and Social Sciences

This paper focuses on inclusive higher education in the United Kingdom. It details international literature, research studies and national reports, including findings from the authors’ study, ‘Working with disabled students to address unequal outcomes in UK HE during the pandemic’ where we critically explored inclusive practice in Higher Education (HE) and disabled students’ learning experiences. Our national study was carried out as a collaboration between the University of Plymouth, University of Wolverhampton, and Disabled Students UK (DSUK). Data collection took place in 2021 with an extensive literature-based investigation alongside the dissemination of a questionnaire to DSUK members resulting in 14 …

Nonaligned Modernism: Socialist Postcolonial Aesthetics In Yugoslavia, 1945–1985. By Bojana Videkanić. Montreal: Mcgill-Queen's University Press, 2019. 304 Pages. Notes. Illustrations. Figures. £99.00, Hard Bound; £33.00, Paper; $31.35, Ebook., N Bobic

School of Art, Design and Architecture

Book review

Comprehensive Measurement Of The Prevalence Of Dementia In Low- And Middle-Income Countries: Stride Methodology And Its Application In Indonesia And South Africa, Nicolas Farina, Roxanne Jacobs, Yuda Turana, Fasihah Irfani Fitri, Marguerite Schneider, Imelda Theresia, Sumaiyah Docrat, Tara Puspitarini Sani, Lydia Augustina, Emiliano Albanese, Adelina Comas-Herrera, Toit P Du, Cleusa P. Ferri, Ishtar Govia, Aliaa Ibnidris, Martin Knapp, Sube Banerjee

Peninsula Medical School

Background A core element of the Strengthening Responses to Dementia in Developing Countries (STRiDE) programme was to generate novel data on the prevalence, cost and impact of dementia in low- and middle-income countries, to build better health policy. Indonesia and South Africa are two middle-income countries in need of such data. Aims To present the STRiDE methodology and generate estimates of dementia prevalence in Indonesia and South Africa. Method We conducted community-based, single-phase, cross-sectional studies in Indonesia and South Africa, randomly sampling participants aged 65 years or older in each country. Dementia prevalence rates for each country were generated by …

How To … Define Clinical Education Research Terminology: A Glossary, Gabrielle M. Finn, Ben Charmer, Oliver E. Burton, Aqua Asif, Matthew H.V. Byrne, Nicola Brennan, Megan E.L. Brown

Peninsula Medical School

Clinical education research (ClinEdR) utilises diverse terminology, which can lead to confusion. A common language is essential for enhancing impact. An expert panel drawn from various workstreams within the National Institute for Health and Care Research (NIHR) Incubator for Clinical Education Research was tasked with reviewing an initial list of terms for the development of a glossary of terms in the field of ClinEdR. The glossary was populated with terms, definitions and foundational papers by the authors and peer-reviewed for accuracy. The glossary of terms developed for ClinEdR should enable researchers to use a common language, promoting consistency and improving …

A Pragmatic, Multicentre, Double-Blind, Placebo-Controlled Randomised Trial To Assess The Safety, Clinical And Cost-Effectiveness Of Mirtazapine And Carbamazepine In People With Alzheimer’S Disease And Agitated Behaviours: The Hta-Symbad Trial, Sube Banerjee, Nicolas Farina, Catherine Henderson, Juliet High, Susan Stirling, Lee Shepstone, Julia Fountain, Clive Ballard, Peter Bentham, Alistair Burns, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O’Brien, Annabel Price, Alan J. Thomas, Ann Marie Swart, Tanya Telling, Naji Tabet

Peninsula Medical School

No abstract provided.

Monitoring Of Drying Kinetics Evolution And Hygrothermal Properties Of New Earth-Based Materials Using Climatic Chamber Simulation, Athmane Azil, Karim Touati, Nassim Sebaibi, Malo Le Guern, Francois Streiff, S Goodhew, Moussa Gomina, M Boutouil

School of Art, Design and Architecture

This study focuses on the drying kinetics of cob and light-earth layers comprising a hybrid walling system. Volumetric water content sensors are immersed and placed at different positions on the walls of a building to measure the drying kinetics. In addition, an experimental analysis of the effect of temperature, relative humidity (RH), and wind velocity variations on thermal conductivity in a climatic chamber under winter and summer conditions was conducted. The analysis of samples in laboratory aims to investigate the hygrothermal properties of cob and light-earth materials, and their dependency on the aforementioned parameters. The in situ drying kinetics of …

Developing Sustainable Makers, Polly Macpherson

School of Art, Design and Architecture

This essay will discuss my developed professional and teaching knowledge of sustainable making processes and how I have used this to focus creative learners on how to explore personal values and strengthen their sustainable making practices.

A Novel 3d Volumetric Method For Directly Quantifying Porosity And Pore Space Morphology In Flocculated Suspended Sediments, Tj Lawrence, Sj Carr, Aj Manning, Jat Wheatland, Aj Bushby, Kl Spencer

School of Biological and Marine Sciences

No abstract provided.

At What Scale Should We Assess The Health Of Pelagic Habitats? Trade-Offs Between Small-Scale Manageable Pressures And The Need For Regional Upscaling, C. A. Graves, M. Best, A. Atkinson, B. Bear, E. Bresnan, M. Holland, D. G. Johns, M. Machairopoulou, A. Mcquatters-Gollop, A. Mellor, C. Ostle, K. Paxman, S. Pitois, P. Tett, M. Devlin

School of Biological and Marine Sciences

Major planktonic lifeforms such as diatoms, dinoflagellates, meroplankton and holoplankton have recently shown significant and alarming changes in abundance - mainly downwards trends - around the northwest European shelf. This has major implications for food web connections and for ecosystem services including seafood provision and carbon storage. We have quantified these changes in abundance for 2006–2019/20 using a Plankton Index (PI) and show that the scale of spatial aggregation is critical to the ability of the PI to detect change, understand causal mechanisms, and provide advice to policymakers. We derived PI statistics in the Celtic and North Seas from data …

Nutrient Dynamics, Carbon Storage And Community Composition On Artificial And Natural Reefs In Bali, Indonesia, Zach Boakes, I. Gusti Ngurah A. Suryaputra, Alice E. Hall, Daniel J. Franklin, Richard Stafford

School of Biological and Marine Sciences

Artificial reefs are now commonly used as a tool to restore degraded coral reefs and have a proven potential to enhance biodiversity. Despite this, there is currently a limited understanding of ecosystem functioning on artificial reefs, and how this compares to natural reefs. We used water sampling (bottom water sampling and pore water sampling), as well as surface sediment sampling and sediment traps, to examine the storage of total organic matter (as a measure of total organic carbon) and dynamics of dissolved inorganic nitrate, nitrite, phosphate and ammonium. These biogeochemical parameters were used as measures of ecosystem functioning, which were …

Intraspecific Differences In Short- And Long-Term Foraging Strategies Of Reef Manta Ray (Mobula Alfredi) In The Chagos Archipelago, Joanna L. Harris, Clare B. Embling, Genevieve Alexander, David Curnick, Ronan Roche, Niv Froman, Marleen Stuhr, Elaine S. Fileman, Simon Hilbourne, Rebecca Carter, Annie Murray, Jessica Savage, Guy M.W. Stevens

School of Biological and Marine Sciences

Assessing the foraging ecology of a threatened species is necessary to understand their movement behaviour and habitat use patterns, which are essential for developing effective protection strategies. Here, the foraging ecology of reef manta rays (Mobula alfredi) in the Chagos Archipelago, a region encompassed by a vast no-take marine protected area (MPA), was investigated using stable isotope analysis of skin and muscle tissue. Enriched δ13C values suggest the population predominantly forages in nearshore environments. Skin δ13C values increased with increased rainfall, likely associated with the boosts in primary production and zooplankton biomass due to the coastal advection of seabird guano. …

Can Coral Reef Restoration Programmes Facilitate Changes In Environmental Attitudes? A Case Study On A Rural Fisher Community In North Bali, Indonesia, Zach Boakes, Luh Putu Mahyuni, Alice E. Hall, Marin Cvitanovic, Richard Stafford

School of Biological and Marine Sciences

There is currently limited research assessing the ecological potential of coral restoration programmes of habitat enhancement and restoration of benthic and mobile populations for influencing the attitudes (and subsequent behaviours) of the communities where they are based. Our qualitative study investigated the impact of a coral reef restoration programmes on local environmental attitudes in a rural fishing community in north Bali, Indonesia. We conducted semi-structured interviews with individuals and multi-stakeholder focus groups (n = 31) in Tianyar Village, where the NGO ‘North Bali Reef Conservation’ (‘Yowana Bhakti Segara’) was based. Our results highlight several factors that influenced environmental behaviours, including …

Three-Layer Model With Absorption For Conservative Estimation Of The Maximum Acoustic Transmission Coefficient Through The Human Skull For Transcranial Ultrasound Stimulation, David Attali, Thomas Tiennot, Mark Schafer, Elsa Fouragnan, Jérôme Sallet, Charles F. Caskey, Robert Chen, Ghazaleh Darmani, Ellen J. Bubrick, Christopher Butler, Charlotte J. Stagg, Miriam Klein-Flügge, Lennart Verhagen, Seung Schik Yoo, Kim Butts Pauly, Jean Francois Aubry

School of Psychology

Transcranial ultrasound stimulation (TUS) has been shown to be a safe and effective technique for non-invasive superficial and deep brain stimulation. Safe and efficient translation to humans requires estimating the acoustic attenuation of the human skull. Nevertheless, there are no international guidelines for estimating the impact of the skull bone. A tissue independent, arbitrary derating was developed by the U.S. Food and Drug Administration to take into account tissue absorption (0.3 dB/cm-MHz) for diagnostic ultrasound. However, for the case of transcranial ultrasound imaging, the FDA model does not take into account the insertion loss induced by the skull bone, nor …

Unlocking Social Innovation In Xr For Healthcare In Coastal Communities, Alejandro Veliz Reyes, Marius N. Varga, Hannah Bradwell, Rory Baxter

School of Art, Design and Architecture

This position paper reconsiders the 'social' aspect of XR systems for healthcare, often developed following a 'problem-solution' approach that neglects sociocultural factors affecting their codesign and successful adoption. Focusing on coastal and rural communities, we review and present key principles to consider when codesigning XR systems with marginalised groups. Our work stems from two projects funded by UK Research & Innovation that aim to promote healthy ageing in coastal communities.

Investigating The Role Of Action-Contingent Expectancy Biases In Dysphoria-Linked Activity Engagement Behavioural Choice, Julie L. Ji, Colin Macleod

School of Psychology

Reduced tendency to engage in potentially rewarding activities is a hallmark of depression. The present study investigated the role of future expectancy biases in depression-linked behavioural choice, in participants varying in self-reported depression symptoms (dysphoria). A novel laboratory paradigm was developed to test the hypotheses that the degree to which higher dysphoria is associated with reduced tendency to engage in a potentially rewarding activity is dependent on the presence of negative biases in the expected outcomes of activity engagement. Specifically, two types of expectancy biases were distinguished: a) the expected likelihood of a negative rather than positive outcome, and b) …

Anticipatory Reward Dysfunction In Alcohol Dependence: An Electroencephalography Monetary Incentive Delay Task Study, Mica Komarnyckyj, Chris Retzler, Robert Whelan, Oliver Young, Elsa Fouragnan, Anna Murphy

School of Psychology

A wealth of functional magnetic resonance imaging monetary incentive delay task (MIDT) research has shown alcohol dependency is associated with a hypoactive striatal response during gain anticipation (gain > neutral) and loss anticipation (loss > neutral). Electroencephalography (EEG) holds clinical advantages over fMRI (high temporal resolution, low cost, portable) however its use to study reward processing in alcohol dependence is limited. We aimed to carry out the first EEG MIDT (eMIDT) study in alcohol dependence. 21 abstinent alcohol dependent individuals and 26 controls performed an MIDT while neural activity was recorded using 64-channel EEG. Trial averaged event-related potentials (ERPs) and single-trial machine …