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Ethical Leadership And Funding Strategies In Nonprofit Organizations, George Edward Walker Mar 2026

Ethical Leadership And Funding Strategies In Nonprofit Organizations, George Edward Walker

Walden Dissertations and Doctoral Studies

A lack of effective funding strategies can negatively affect nonprofit program sustainability and growth. Nonprofit leaders are concerned with inadequate funding practices as they lessen organizational sustainability, donor trust, and reliable program delivery. Grounded in deontological ethical theory, the purpose of this qualitative pragmatic inquiry was to explore funding strategies nonprofit leaders use to expand and sustain programs and services. The participants were eight nonprofit leaders from the West Coast of the United States with 10+ years of leadership experience. Data were collected using semistructured interviews and peer-reviewed journals. Through thematic analysis, five themes were identified: (a) research and data …


Food Insecurity’S Influence On Obesity, Hypertension, And Diabetes In Rural Vermont And Adirondack New York, Lindsay Morse Mar 2026

Food Insecurity’S Influence On Obesity, Hypertension, And Diabetes In Rural Vermont And Adirondack New York, Lindsay Morse

Walden Dissertations and Doctoral Studies

Food insecurity (FI) is a persistent public health challenge in the United States and disproportionately affects rural communities. Guided by syndemic theory, this quantitative cross-sectional study examined associations between FI and chronic disease outcomes among rural residents of Vermont and the Adirondack region of New York. Social determinants of health screenings and electronic medical records from 35 rural primary care sites were analyzed. Secondary data from n = 72,505 adults were used to evaluate these relationships. Binary logistic regression models assessed obesity, hypertension (HTN), and diabetes (DM), and a multinomial logistic regression model evaluated the combined presence of obesity and …


Polθ Activity Modulates Sensitivity To Standard Therapies In Dnmt3a-Deficient Leukemia, Bac Viet Le, Umeshkumar Vekariya, Monika M. Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, Malgorzata Gozdecka, Zayd Haydar, Martin Walsh, Jayashri Ghosh, Elaine Vaughan-Williams, Paulina Podszywalow-Bartnicka, Anna-Mariya Kukuyan, Sylwia Ziolkowska, Jessica Atkins, Emir Hadzijusufovic, Gurushankar Chandramouly, Reza Nejati, Katarzyna Piwocka, Richard T. Pomerantz, George S. Vassiliou, Brian J.P. Huntly, Peter Valent, Mariusz Wasik, Alfonso Bellacosa, Jean-Yves Masson, Gaorav P. Gupta, Grant A. Challen, Tomasz Skorski Mar 2026

Polθ Activity Modulates Sensitivity To Standard Therapies In Dnmt3a-Deficient Leukemia, Bac Viet Le, Umeshkumar Vekariya, Monika M. Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, Malgorzata Gozdecka, Zayd Haydar, Martin Walsh, Jayashri Ghosh, Elaine Vaughan-Williams, Paulina Podszywalow-Bartnicka, Anna-Mariya Kukuyan, Sylwia Ziolkowska, Jessica Atkins, Emir Hadzijusufovic, Gurushankar Chandramouly, Reza Nejati, Katarzyna Piwocka, Richard T. Pomerantz, George S. Vassiliou, Brian J.P. Huntly, Peter Valent, Mariusz Wasik, Alfonso Bellacosa, Jean-Yves Masson, Gaorav P. Gupta, Grant A. Challen, Tomasz Skorski

Department of Biochemistry and Molecular Biology Faculty Papers

Myeloid malignancies carrying somatic DNMT3A mutations (DNMT3Amut) are refractory to standard therapy. DNMT3Amut leukemia cells accumulate toxic DNA double-strand breaks (DSBs) and stalled replication forks, rendering them dependent on DNA damage response (DDR). We report here that DNA polymerase theta (Polθ), a key element in DSB repair by end-joining (Polθ-mediated end-joining [TMEJ]) and in fork restarting, promotes survival and proliferation of DNMT3Amut leukemia cells. Polθ is overexpressed in DNMT3Amut leukemia cells due to abrogation of PARP1 PARylation-dependent UBE2O E3 ligase-mediated ubiquitination and proteasomal degradation of Polθ. In addition, PARP1-mediated recruitment of the SMARCAD1-MSH2/MSH3 repressive complex to DSBs is diminished in …


Front Matter, New Mexico Law Review Mar 2026

Front Matter, New Mexico Law Review

New Mexico Law Review

No abstract provided.


Faithful Listening In An Age Of Noise, Charles Veenstra Mar 2026

Faithful Listening In An Age Of Noise, Charles Veenstra

Faculty Work Comprehensive List

"True listening opens the door to understanding, builds relationships, fosters cooperation instead of conflict, and allows God’s love and reconciliation to work through us."

Posting about barriers to healthy communication from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Faithful Listening in an Age of Noise


The False Promise Of Progressive Originalism, Michael Smith Mar 2026

The False Promise Of Progressive Originalism, Michael Smith

New Mexico Law Review

As the conservative-dominated Supreme Court continues to accrue its power, commentators on both the political right and left suggest that those pursuing progressive policy goals would do well to turn to originalist methodology. Many of the Justices on the Court purport to be originalists, and progressive originalist arguments are more likely to appeal to this otherwise tough crowd. Haven’t progressives heard that we’re all originalists now? I argue that originalism’s appeal to progressives is largely illusory. Originalism is unlikely to make a difference before a Court controlled by a supermajority of conservative Justices who exercise discretion over the interpretive methodology …


Underruling Voting Rights, Michael Pitts Mar 2026

Underruling Voting Rights, Michael Pitts

New Mexico Law Review

An “underrule” occurs when the Supreme Court renders a decision diametrically opposed to a prior case without explicitly overruling the prior case. With the decision in Alexander v. South Carolina State Conference NAACP in 2024, the Court has now issued two underrules during the development of its racial gerrymandering jurisprudence. These underrules, particularly in a politically sensitive area such as racial gerrymandering, undermine confidence in the judiciary. But underrules are nothing new to doctrinal development in the realm of race and redistricting. The Court also issued two underrules as it developed vote dilution jurisprudence during the mid-1970s to the early …


Bad Men In The Bordertown: Confronting Police Violence Against Native Americans With The Bad Men Treaty Clauses, Taylor Graham Mar 2026

Bad Men In The Bordertown: Confronting Police Violence Against Native Americans With The Bad Men Treaty Clauses, Taylor Graham

New Mexico Law Review

In nine treaties signed by Tribal Nations and the United States between 1867 and 1868, the United States promised redress to Native Americans for wrongs committed against them by “bad men among the whites.” Today, Native Americans are more likely to be killed by police than any other group, with much of this violence concentrated near the borders of Tribal Nations. Although claims brought under the “bad men” treaty clauses offer an avenue for combatting this epidemic of violence, courts have begun interpreting the clauses to apply only when “wrongs” occur within Tribal boundaries. This article argues that the territoriality …


Weakening The Reasonable Efforts Requirement In New Mexico Termination Of Parental Rights Cases, Monika Myers Mar 2026

Weakening The Reasonable Efforts Requirement In New Mexico Termination Of Parental Rights Cases, Monika Myers

New Mexico Law Review

Parents’ right to control the upbringing of their own children is long-established in the United States. However, in the case of child abuse, neglect, or abandonment, a state can terminate parental rights, permanently severing the legal relationship between a parent and a child. In New Mexico, to terminate parental rights for abuse or neglect the State must prove three elements by clear and convincing evidence: (1) the child is abused or neglected; (2) the conditions that brought the child into care are unlikely to change in the foreseeable future and (3) this is the case despite reasonable efforts by the …


The Barrier And The Burden: How Flawed Interpretations Of The New Mexico Human Rights Act Have Relegated Disability To Second-Class Status, Ellen Caroline Sherman Rabin Mar 2026

The Barrier And The Burden: How Flawed Interpretations Of The New Mexico Human Rights Act Have Relegated Disability To Second-Class Status, Ellen Caroline Sherman Rabin

New Mexico Law Review

Plaintiffs alleging disability discrimination under New Mexico law face significantly higher barriers than plaintiffs alleging other types of discrimination. The plain text of the New Mexico Human Rights Act (“NMHRA”) provides equal protections against discrimination based on characteristics such as race, gender, pregnancy, and disability. However, by relying on federal disability law to guide the interpretation of the NMHRA in cases of disability discrimination, New Mexico courts have effectively created a two-tiered system in which claims of disability discrimination face higher barriers to prevail in an administrative adjudication and survive summary judgment than other discrimination claims. This two-tiered system not …


Predicting The Future Past: Human Cognitive Limits And Proximate Cause Determinations In Civil Actions, Dr. Molly Wilson, Helen Webster Mar 2026

Predicting The Future Past: Human Cognitive Limits And Proximate Cause Determinations In Civil Actions, Dr. Molly Wilson, Helen Webster

New Mexico Law Review

Juror decision-making is inherently influenced by psychological biases, which pose a significant challenge to the fairness and accuracy of proximate cause determinations in tort cases. This Article explores the cognitive and social biases—such as hindsight bias, primacy, anchoring, belief in a just world, and moral outrage—that affect jurors as they engage in the complex reasoning required to assess foreseeability and causation. Given that jurors must disregard their knowledge of actual harm and set aside emotional responses to tragic injuries, the risk of bias is substantial. Traditional jury instructions have proven insufficient in mitigating these effects. As a solution, this Article …


Spirituality In Abstraction: The Female Future In 20th-Century Art, Lauren T. Sargent Mar 2026

Spirituality In Abstraction: The Female Future In 20th-Century Art, Lauren T. Sargent

Epochs Art History Journal

No abstract provided.


Redesigning Outpatient Chemotherapy Scheduling: A Management Approach To Site-Integrated Operations, Dominick J. Morrone Mar 2026

Redesigning Outpatient Chemotherapy Scheduling: A Management Approach To Site-Integrated Operations, Dominick J. Morrone

MUSC Theses and Dissertations

Outpatient infusion centers face persistent scheduling complexity driven by variable treatment durations, coordination between clinics, pharmacy lead times, and constrained staffing. This doctoral project develops and reviews a comprehensive framework for infusion scheduling transformation that integrates workforce role redesign, site‑level communication pathways, and data‑informed workqueue governance. Using a multi‑phase case at a large cancer center as an anchor, the framework specifies responsibilities across central schedulers, on‑site teams, medical coordinators, and nursing; details communication and escalation design (secure messaging and in‑basket use); and outlines training and proficiency tiers. The project synthesizes evidence from scheduling science and time-driven activity-based costing principles to …


Fungal Meningitis In Us Patients Who Received Epidural Anesthesia In Matamoros, Mexico, Dallas J Smith, Elizabeth Misas, Jeremy A W Gold, Nicole Evert, Thi Dang, Emilie Prot, Simone Godwin, Julieanna Rivas, Jessica Pearson, Lori Koenecke, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Irma López-Martínez, Caitlyn Lutfy, Samantha Williams, Axel A Vazquez Deida, Katrina M Byrd, Julian A Villalba, Sarah Reagan-Steiner, Lindsay Parnell, Lalitha Gade, Romney M Humphries, Nathan P Wiederhold, Charles Y Chiu, Joshua A Lieberman, Anastasia P Litvintseva, Tom Chiller, Luis Ostrosky-Zeichner, Fungal Meningitis Response Team Mar 2026

Fungal Meningitis In Us Patients Who Received Epidural Anesthesia In Matamoros, Mexico, Dallas J Smith, Elizabeth Misas, Jeremy A W Gold, Nicole Evert, Thi Dang, Emilie Prot, Simone Godwin, Julieanna Rivas, Jessica Pearson, Lori Koenecke, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Irma López-Martínez, Caitlyn Lutfy, Samantha Williams, Axel A Vazquez Deida, Katrina M Byrd, Julian A Villalba, Sarah Reagan-Steiner, Lindsay Parnell, Lalitha Gade, Romney M Humphries, Nathan P Wiederhold, Charles Y Chiu, Joshua A Lieberman, Anastasia P Litvintseva, Tom Chiller, Luis Ostrosky-Zeichner, Fungal Meningitis Response Team

Faculty, Staff and Student Publications

Background: Fungal meningitis outbreaks are rare and entail high mortality rates. Beginning May 2023, we investigated fungal meningitis caused by Fusarium solani species complex occurring in US patients who received epidural anesthesia in Matamoros, Mexico.

Methods: Early epidemiological information suggested US patients with suspected fungal meningitis had undergone mostly cosmetic procedures under epidural anesthesia performed in 2 Matamoros clinics. US patients known to have received surgery at these clinics during 1 January-13 May 2023 (clinic closures date) were identified and notified by public health officials. Epidemiological and clinical data were used to update diagnostic and clinical guidance for outbreak response, …


Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago Mar 2026

Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago

Faculty Publications

Introduction: Physical activity is fundamental for children’s health and well-being, yet most children are not active enough. School-based interventions aiming to increase children’s physical activity have largely been ineffective, perhaps due to a lack of consideration of the unique culture within each school. The aim of this paper is to understand the key aspects of physical activity culture in English primary schools using the organizational culture framework.

Methods: A four-month rapid ethnography study was conducted within three primary schools in Bristol, UK, between March and July 2024. The findings draw on observations, interviews, documentary data, photo elicitation, informal conversations and …


Generalizing Networks To Address Data Imbalance For Facial Action Unit Recognition, Andrew W. Sumsion Mar 2026

Generalizing Networks To Address Data Imbalance For Facial Action Unit Recognition, Andrew W. Sumsion

Theses and Dissertations

Facial action unit (AU) recognition is used in a variety of downstream applications, including sign language translation, dementia detection, pain detection, and other high-impact tasks that require understanding facial motion. Although AU recognition is a well-established field, a number of unresolved issues remain. An initial problem is the need to improve overall performance on the benchmark datasets, as measured by the average F1 score. Also, the performance across all individual AUs, not just the average F1 score, needs to be increased. Recently, the field has shifted its attention towards ensuring that AU recognition models generalize beyond the distributions represented in …


Exploring The Influence Of Environmental Motivations On Consumer Attitudes And Purchase Intentions Toward Upcycled Foods, Peng Lu, Jennifer Waldeck, Keith Weber, Hualu Zhou Mar 2026

Exploring The Influence Of Environmental Motivations On Consumer Attitudes And Purchase Intentions Toward Upcycled Foods, Peng Lu, Jennifer Waldeck, Keith Weber, Hualu Zhou

Communication Faculty Articles and Research

Food loss and waste (FLW) present pressing environmental and economic challenges. Upcycling technologies provide a sustainable pathway by transforming food by-products into value-added products; however, consumer acceptance remains a critical barrier. Guided by Self-Determination Theory (SDT), this study investigates how environmental motivations influence consumers’ attitudes and purchase intentions toward milk enriched with upcycled peanut skins. Data were collected from a nationally representative sample of 1488 U.S. adults. Structural equation modeling (SEM) was employed to test hypothesized relationships among motivational constructs, and cluster analysis was used to identify consumer segments based on motivational profiles. The results show that intrinsic motivation and …


2026 March 17 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University Mar 2026

2026 March 17 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.


From Flat To Form- Shoulder Cluster Darts, Lauryn White Mar 2026

From Flat To Form- Shoulder Cluster Darts, Lauryn White

SPARK Symposium Presentations

This design explores the transformation of a basic bodice by relocating the waist dart to the shoulder to create a clustered effect of three smaller darts. The method used to achieve this is the slashing technique, which allows for controlled redistribution of dart intake. By closing the original waist dart, three evenly distributed darts are opened at the shoulder. This approach enhances both the visual interest and structural design of the garment.


Equity And Diversity Minutes 03/17/2026, Equity And Diversity Committee Mar 2026

Equity And Diversity Minutes 03/17/2026, Equity And Diversity Committee

Equity and Diversity Committee

No abstract provided.


Steering Minutes 03/17/2026, Steering Committee Mar 2026

Steering Minutes 03/17/2026, Steering Committee

Steering Committee

No abstract provided.


Student Affairs Minutes 03/17/2026, Student Affairs Committee Mar 2026

Student Affairs Minutes 03/17/2026, Student Affairs Committee

Student Affairs Committee

No abstract provided.


Geology Lab Activities An Open Educational Resource For Community College Students And Instructors, Rondi Davies, Ari Nakamura Mar 2026

Geology Lab Activities An Open Educational Resource For Community College Students And Instructors, Rondi Davies, Ari Nakamura

Open Educational Resources

I'm delighted to present the updated version of Geology Lab Activities, initially developed during the COVID-19 pandemic for online learning. As we have returned to the classroom, this revised edition remains a versatile educational tool for community college students, adaptable for both online and in-person classes.

This manual combines my preferred open-access materials with my own contributions, forming a cohesive resource for non-major geology students. Thanks to a CUNY OER grant, I partnered with graphic designer Ari Nakamura, whose innovative and elegant design has truly elevated the book.

Our labs are crafted to be engaging and relevant for non-major …


Southgate Owners Corp. V. Esposito Mar 2026

Southgate Owners Corp. V. Esposito

All Decisions

The Appellate Division affirmed the Supreme Court's dismissal of a cooperative landlord's action seeking to retroactively collect 30 years of maintenance fees for additional shares allocated to a tenant. The court found that the proprietary lease's plain language only allowed maintenance collection from the date of issuance, not retroactively. The landlord's claim was also time-barred. Additionally, the court affirmed the grant of attorneys' fees to the tenant under the proprietary lease's reciprocal provision, Real Property Law § 234, because the tenant successfully defended the action to enforce purported obligations.


Tet Cpg Sequence-Context-Specific Dna Demethylation Shapes Progression Of Idh-Mutant Gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi Van Hijfte, Rania Head, Iris De Heer, Marta Padovan, Maurice De Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J Van Den Bent, Pieter Wesseling, Pim J French Mar 2026

Tet Cpg Sequence-Context-Specific Dna Demethylation Shapes Progression Of Idh-Mutant Gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi Van Hijfte, Rania Head, Iris De Heer, Marta Padovan, Maurice De Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J Van Den Bent, Pieter Wesseling, Pim J French

Faculty Research 2026

Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. We collect 302 primary and recurrent resections from oligodendrogliomas and perform Ki-67 staining, proteomics, and DNA methylation profiling. During tumor progression, DNA methylation of oligodendrogliomas changes along a continuum. This continuum is linked to increased epigenetic aging, methylation of transcription factors and Ki-67+ cell density, and large-scale DNA demethylation. Demethylation correlates with CpG flanking sequences preferred by TET enzymes. We confirm these findings in previously profiled astrocytomas, indicating IDH-mutant gliomas progress along a shared epigenetic axis. We develop an …


Rethinking Ratio-Based Normalization Towards Model-Based Approaches In Heart Weight Analysis., Manuela A Oestereicher, Patricia Da Silva-Buttkus, Valérie Gailus-Durner, Susan Marschall, Helmut Fuchs, Impc Consortium, Martin Hrabě De Angelis, Elida Schneltzer, Nadine Spielmann Mar 2026

Rethinking Ratio-Based Normalization Towards Model-Based Approaches In Heart Weight Analysis., Manuela A Oestereicher, Patricia Da Silva-Buttkus, Valérie Gailus-Durner, Susan Marschall, Helmut Fuchs, Impc Consortium, Martin Hrabě De Angelis, Elida Schneltzer, Nadine Spielmann

Faculty Research 2026

Heart weight (HW) is a critical parameter in cardiology and mouse research, commonly normalized to body weight (BW) or tibia length (TL) to account for size differences. Ratio-based normalization, however, assumes strict proportionality between variables, an assumption that is rarely tested and may bias group comparisons. We analysed HW, BW, and TL measurements from over 25,000 C57BL/6N wildtype mice generated by the International Mouse Phenotyping Consortium. Sex- and age-stratified analyses were combined with simulation-based modelling to evaluate empirical scaling relationships and the statistical behaviour of ratio-based normalization. Across all age and sex groups, correlations between HW, BW, and TL were …


New Viability Assays For Acanthamoeba Castellanii Trophozoites And Cysts Allow Rapid Assessment Of Drug Activity., Carrie A Flynn, Rebecca I Colón-Ríos, Andrew Harmez, William F Flynn, Barbara I Kazmierczak Mar 2026

New Viability Assays For Acanthamoeba Castellanii Trophozoites And Cysts Allow Rapid Assessment Of Drug Activity., Carrie A Flynn, Rebecca I Colón-Ríos, Andrew Harmez, William F Flynn, Barbara I Kazmierczak

Faculty Research 2026

Pathogenic free-living amoebae such as Acanthamoeba castellanii are present in soil and water worldwide. A. castellanii causes systemic infections with very high mortality rates, yet drugs specifically targeting this pathogen are not available. Methods to reliably generate and assay cysts, which drive infection recurrence and drug resistance, are unavailable in a high-throughput format suitable for drug screening and testing. In this study, we developed a robust and reproducible protocol for encysting A. castellanii as well as a high-throughput, quantitative cyst viability assay using fluorescent live/dead staining coupled with microscopy and automated image analysis. These methods, coupled with optimized techniques for …


Tet Cpg Sequence-Context-Specific Dna Demethylation Shapes Progression Of Idh-Mutant Gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi Van Hijfte, Rania Head, Iris De Heer, Marta Padovan, Maurice De Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J Van Den Bent, Pieter Wesseling, Pim J French Mar 2026

Tet Cpg Sequence-Context-Specific Dna Demethylation Shapes Progression Of Idh-Mutant Gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi Van Hijfte, Rania Head, Iris De Heer, Marta Padovan, Maurice De Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J Van Den Bent, Pieter Wesseling, Pim J French

Faculty Research 2026

Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. We collect 302 primary and recurrent resections from oligodendrogliomas and perform Ki-67 staining, proteomics, and DNA methylation profiling. During tumor progression, DNA methylation of oligodendrogliomas changes along a continuum. This continuum is linked to increased epigenetic aging, methylation of transcription factors and Ki-67+ cell density, and large-scale DNA demethylation. Demethylation correlates with CpG flanking sequences preferred by TET enzymes. We confirm these findings in previously profiled astrocytomas, indicating IDH-mutant gliomas progress along a shared epigenetic axis. We develop an …


Petroleum Potential Of The Middle–Late Jurassic Source Rocks (Sargelu And Naokelekan Formations) In The Kurdistan Region, Northern Iraq., Karwan Taha Chicho Zebari, Ayad Nuri Faqi Edilbi, Azad Tahir Saeed Mar 2026

Petroleum Potential Of The Middle–Late Jurassic Source Rocks (Sargelu And Naokelekan Formations) In The Kurdistan Region, Northern Iraq., Karwan Taha Chicho Zebari, Ayad Nuri Faqi Edilbi, Azad Tahir Saeed

Polytechnic Journal

This study evaluates the petroleum generating potential of the Middle-Late Jurassic Sargelu and Naokelekan Formations across distinct tectonic zones in the Kurdistan Region, Iraq. Source rock quality is assessed through geochemical analyses of organic matter (OM) quantity, type, thermal maturity, and key factors influencing hydro-carbon generation. Rock-Eval pyrolysis was performed on outcrop samples from five sections located within the Imbricated and High Folded Zones of the Zagros Fold-Thrust Belt. Results demonstrate significant variability in total organic carbon (TOC) content, hydro-carbon generation potential (as reflected by S1, S2, and genetic potential values.), and kerogen types across these zones. The Sargelu and …


Presidential Search Committee Minutes, Clemson University Board Of Trustees, 2026 March 17, Clemson University Board Of Trustees Mar 2026

Presidential Search Committee Minutes, Clemson University Board Of Trustees, 2026 March 17, Clemson University Board Of Trustees

Minutes

No abstract provided.