Digital Commons Network^™

The Experience Of The Expectant Mother Following A Diagnosis Of A Fetal Anomaly, Janet A. Tucker

Dissertations

The experience of pregnancy complicated by a fetal anomaly diagnosis is comprised of many concepts: uncertainty, information needs, stress and anxiety, waiting, decision-making dilemmas, isolation, fragmented health care, multiple losses and grief, foreknowledge, acceptance and adaptation. There is great variance in what is understood about each concept. The purpose of this study was to explore uncertainty and waiting among expectant mothers from the time period of a prenatal diagnosis of a fetal anomaly through the post-partum period.

Editorial: Special Issue “Protein Modeling And Simulation: Selected Articles From The Computational Structural Bioinformatics Workshop 2021”, Negin Forouzesh, Kamal Ai Nasr

Computer Science Faculty Research

No abstract provided.

Hemodynamic Investigations In Intracranial Aneurysms: A Commentary, Hang Yi, Mark Johnson, Luke Bramlage, Zifeng Yang, Bryan Ludwig

Mechanical and Materials Engineering Faculty Publications

Intracranial aneurysms (IAs) are abnormal bulges in a blood vessel in the brain that have a potential to rupture and even causing a stroke, which can lead to lasting brain damage, long-term disability, or even loss of life. It has been widely acknowledged that hemodynamic factors, e.g., instantaneous wall shear stress, time-averaged wall shear stress, wall shear stress gradient, gradient oscillatory number, oscillatory shear index, pulsatile blood flow waveform (flow rate magnitude and shape, physical flow period), relative residence time/turnover time, blood pressure, and vortex (i.e., size, location, and numbers), have a close relationship with the pathobiology (i.e., initiation, growth, …

2023-February-22-Rotation Spotlight- Meredith Reeder ('23), Mental Health Focus, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

Meet Meredith Reeder (’23) from Maryville, Tennessee, who experienced a rotation at ETSU Health Internal Medicine and ETSU Center of Excellence for HIV/AIDs in Johnson City with Dr. Sarah Melton, Preceptor and Professor/Vice Chair of Pharmacy Practice.

What did your day look like on rotation?

A typical day on a psychiatry rotation with Dr. Melton involves looking up new and existing patients before their appointment in the internal medicine clinic or the infectious disease clinic. Once the patient arrives, the pharmacy team conducts an interview that involves a medication reconciliation, medication assessment, monitoring, and therapeutic adjustments if needed. We get …

Soybean Seed Protein Concentration Is Limited By Nitrogen Supply In Tropical And Subtropical Environments In Brazil, E. H. Figueiredo Moura Da Silva, N. Cafaro La Menza, G. G. Munareto, A. J. Zanon, Santos Carvalho, F. R. Marin

Department of Agronomy and Horticulture: Faculty Publications

Soybean production contributes to ca. 60% of global plant-based protein used for food and feed. Brazil is the largest soybean producer and exporter, with 60% from tropical and 40% from subtropical environments. Nitrogen (N) can play an essential role in the storage of proteins in seeds; thus, it could be a key factor in increasing the quantity and quality of seeds in high-yielding soybean crops. Unlike in temperate environments, there is a gap of knowledge on whether soybean grown under tropical and subtropical climates are limited by N-fertilization to sustain the seed yield increase without detriments in seed protein concentration. …

Student Advocacy As A Catalyst For Sustainable And Social Change, Joshua Filer

Sustainability Research & Practice Seminar Presentations

Joshua Filer, Finance ‘23 - Student Advocacy as a Catalyst for Sustainable and Social Change

Fs Transcript 2023-02-22, Northern Illinois University

Faculty Senate Archives

No abstract provided.

Spring Gbm, Cardozo Sports Law Society

2022–2023 Flyers

No abstract provided.

The Impact Of Covid-19 On Women And Work: Career Advancement Challenges, Sara Lafkas, Marin Christensen, Susan R. Madsen

Social Work Faculty Publications

The COVID-19 pandemic upended countless lives all over the world. Considerable research has shown that women’s career progression has been more negatively impacted by the pandemic than men’s, especially in the wake of school closures and increased childcare responsibilities. In order to understand more deeply the impact of the pandemic on women’s careers, a large mixed-method survey was conducted in Utah, a western state in the United States. This article reports on the responses of 2564 respondents to one of three open-ended questions taken from the overall survey, namely: “How has the pandemic impacted your career advancement experiences and opportunities …

Boron Nitride Nanotubes: Force Field Parameterization, Epoxy Interactions, And Comparison With Carbon Nanotubes For High-Performance Composite Materials, Swapnil S. Bamane, Michael B. Jakubinek, Krishan Kanhaiya, Behnam Ashrafi, Hendrik Heinz, Gregory Odegard

Michigan Tech Publications, Part 1

Boron nitride nanotubes (BNNTs) are a very promising reinforcement for future high-performance composites because of their excellent thermo-mechanical properties. To take full advantage of BNNTs in composite materials, it is necessary to have a comprehensive understanding of the wetting characteristics of various high-performance resins. Molecular dynamics (MD) simulations provide an accurate and efficient approach to establish the contact angle values of engineering polymers on reinforcement surfaces, which offers a measure for the interaction between the polymer and reinforcement. In this research, MD simulations and experiments are used to determine the wettability of various epoxy systems on BNNT surfaces. The reactive …

Portrait De La Santé Et De La Sécurité Agricole Au Québec : Le Cas Des Éleveurs De Porcs, Nancy Beauregard, Alain Marchand, Philippe Fravalo, Marie Archambault, Pascal Thériault, Philippe Roy, Heather Burnett, Pierre Durand

Rapports de recherche scientifique

Pourquoi l’étude Éleveurs de porcs en santé ?

Le secteur agricole au Canada possède un bilan préoccupant en matière de santé et de sécurité du travail. Bien qu’une réduction importante des décès liés à l’agriculture ait été observée ces dernières années, la preuve empirique cumulée montre que ce secteur d’activités demeure à risque eut égard à d’autres indicateurs d’intérêt (p. ex. : santé physique, santé mentale, pratiques de travail sécuritaires). Or, peu d’études en contexte canadien ont cherché à examiner une pluralité de déterminants individuels et environnementaux (c.-à-d. environnement immédiat de travail et son interface avec la famille, contexte lié …

Gardner-Webb Undergraduate And Graduate Students Present Research In Annual Event, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University students will present their undergraduate and graduate research on March 4 at the annual Life of the Scholar-Multidisciplinary Conference (LOTS-MC). The event begins at 8:30 in Stewart Hall, Tucker Student Center, with remarks by Professor of English and Director of Undergraduate Research Dr. June Hobbs, Digital Scholarship and User Experience Librarian Holly Mabry and Professor of English Dr. Shea Stuart.

The Lumberjack, February 22, 2023

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Of Boys And Men: Why The Modern Male Is Struggling, Why It Matters, And What To Do About It, Richard Reeves

Brookings Scholar Lecture Series

Boys and men are struggling. Profound economic and social changes of recent decades have many losing ground in the classroom, the workplace, and in the family. While the lives of women have changed, the lives of many men have remained the same or even deteriorated. Our attitudes, our institutions, and our laws have failed to keep up. Conservative and progressive politicians, mired in their own ideological warfare, fail to provide thoughtful solutions.

The father of three sons, a journalist, and a Brookings Institution scholar, Richard V. Reeves has spent twenty-five years worrying about boys both at home and work. His …

Lindenwood Digest, February 22, 2023, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

The Trade Impact Of Economic Integration Agreements, Byungyul Park, John C. Beghin

Cornhusker Economics

A year ago, Cornhusker Economics reported on the substantial trade integration that has been taking place globally in recent decades (see Beghin, 2022). With this proliferation of Economic Integration Agreements (EIAs) through regional and bilateral trade agreements and customs unions since the 1990s, many economists have investigated the effect of these agreements on merchandise trade. Early investigations struggled to find robust findings. They reached two opposite conclusions, with an eventual rejoinder on their limitations. Some investigations found statistically insignificant or negligible effects of EIAs on trade flows. Other investigations found significant effects, sometimes negative, of EIAs on trade. See Park …

February 22, 2023 (Vol. 107, No. 21), Daily Eastern News

Daily Eastern News: 2022-2023

No abstract provided.

General Review Of Elements Quiz For "Write Or Left" Textbook, Kylee C. Pastore

Open Educational Resources

General Review of Elements Quiz for Write or Left: An OER Textbook for Creative Writing Courses. This quiz assesses students' knowledge of the key terms employed in the textbook and is intended for the opening weeks of the semester. Includes quiz questions and answer key.

Final 2021 Insufficiently Reclaimed Sites Sampling Bres No. 154 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Office Of Research, Economic Engagement And Outreach Update, February 22, 2023, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Setd2 Regulates Chromatin Accessibility And Transcription To Suppress Lung Tumorigenesis, Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M. Nargund, Shaoyuan Yang, Yang Lyu, James J. Hsieh, Christina S. Leslie, Emily H. Cheng

2020-Current year OA Pubs

SETD2, a H3K36 trimethyltransferase, is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. However, how SETD2 loss of function promotes tumorigenesis remains unclear. Using conditional Setd2-KO mice, we demonstrated that Setd2 deficiency accelerated the initiation of KrasG12D-driven lung tumorigenesis, increased tumor burden, and significantly reduced mouse survival. An integrated chromatin accessibility and transcriptome analysis revealed a potentially novel tumor suppressor model of SETD2 in which SETD2 loss activates intronic enhancers to drive oncogenic transcriptional output, including the KRAS transcriptional signature and PRC2-repressed targets, through regulation of chromatin accessibility and histone chaperone recruitment. …

Identifying Factors Which Influence Eating Disorder Risk During Behavioral Weight Management: A Consensus Study, Hiba Jebeile, Caitlin M Mcmaster, Brittany J Johnson, Sarah P Garnett, Susan J Paxton, Anna L Seidler, Rebecca A Jones, Andrew J Hill, Sarah Maguire, Caroline Braet, Genevieve Dammery, Denise E Wilfley, Louise A Baur, Natalie B Lister, On Behalf Of The Eating Disorders In Weight-Related Therapy (Edit) Collaboration

2020-Current year OA Pubs

This study aimed to understand clinician, researcher and consumer views regarding factors which influence eating disorder (ED) risk during behavioral weight management, including individual risk factors, intervention strategies and delivery features. Eighty-seven participants were recruited internationally through professional and consumer organizations and social media and completed an online survey. Individual characteristics, intervention strategies (5-point scale) and delivery features (important/unimportant/unsure) were rated. Participants were mostly women (n = 81), aged 35-49 y, from Australia or United States, were clinicians and/or reported lived experience of overweight/obesity and/or ED. There was agreement (64% to 99%) that individual characteristics were relevant to ED risk, …

The Toxoplasma Micropore Mediates Endocytosis For Selective Nutrient Salvage From Host Cell Compartments, Wenyan Wan, Hui Dong, De-Hua Lai, Jiong Yang, Kai He, Xiaoyan Tang, Qun Liu, Geoff Hide, Xing-Quan Zhu, L David Sibley, Zhao-Rong Lun, Shaojun Long

2020-Current year OA Pubs

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a dense neck, termed the micropore, on the surface of intracellular parasites. However, the function of this structure remains unknown. Here we validate the micropore as an essential organelle for endocytosis of nutrients from the host cell cytosol and Golgi in the model apicomplexan Toxoplasma gondii. Detailed analyses demonstrated that Kelch13 is localized at the dense neck of the organelle and functions as …

Uncovering The Complex Genetic Architecture Of Human Plasma Lipidome Using Machine Learning Methods, Miikael Lehtimäki, Binisha H Mishra, Coral Del-Val, Leo-Pekka Lyytikäinen, Mika Kähönen, C Robert Cloninger, Olli T Raitakari, Reijo Laaksonen, Igor Zwir, Terho Lehtimäki, Pashupati P Mishra

2020-Current year OA Pubs

Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of plasma lipidome profiled from 1,426 Finnish individuals aged 30-45 years. PGMRA involves biclustering genotype and lipidome data independently followed by their inter-domain integration based on hypergeometric tests of the number of shared individuals. Pathway enrichment analysis was performed on the SNP sets to identify their associated biological processes. We identified 93 statistically significant (hypergeometric p-value < 0.01) lipidome-genotype relations. Genotype biclusters in these 93 relations contained 5977 SNPs across 3164 genes. Twenty nine of the 93 relations contained genotype biclusters with more than 50% unique SNPs and participants, thus representing most distinct subgroups. We identified 30 significantly enriched biological processes among the SNPs involved in 21 of these 29 most distinct genotype-lipidome subgroups through which the identified genetic variants can influence and regulate plasma lipid related metabolism and profiles. This study identified 29 distinct genotype-lipidome subgroups in the studied Finnish population that may have distinct disease trajectories and therefore could be useful in precision medicine research.

Skeletal Dysplasia-Causing Trpv4 Mutations Suppress The Hypertrophic Differentiation Of Human Ipsc-Derived Chondrocytes, Amanda R Dicks, Grigory I Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy Steward, Wolfgang Liedtke, Colin G Nichols, Chia-Lung Wu, Farshid Guilak

2020-Current year OA Pubs

Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent stem cells (hiPSCs) harboring either the mild V620I or lethal T89I mutations to elucidate the differential effects on channel function and chondrogenic differentiation. We found that hiPSC-derived chondrocytes with the V620I mutation exhibited increased basal currents through TRPV4. However, both mutations showed more rapid calcium signaling with a reduced overall magnitude in response to TRPV4 agonist GSK1016790A compared to wildtype (WT). There were no differences in …

Asprosin Promotes Feeding Through Sk Channel-Dependent Activation Of Agrp Neurons, Clemens Duerrschmid, Peiyu Gao, Pingwen Xu, Chunmei Wang, Yanlin He

Faculty, Staff and Students Publications

Asprosin, a recently identified adipokine, activates agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARH) via binding to protein tyrosine phosphatase receptor δ (Ptprd) to increase food intake. However, the intracellular mechanisms responsible for asprosin/Ptprd-mediated activation of AgRPARH neurons remain unknown. Here, we demonstrate that the small-conductance calcium-activated potassium (SK) channel is required for the stimulatory effects of asprosin/Ptprd on AgRPARH neurons. Specifically, we found that deficiency or elevation of circulating asprosin increased or decreased the SK current in AgRPARH neurons, respectively. AgRPARH-specific deletion of SK3 (an SK channel subtype highly expressed in AgRPARH neurons) blocked asprosin-induced …

Policy Stringency, Political Conditions, And Public Performances Of Pandemic Control: An International Comparison, Dan Chen, Yong Li, Jiebing Wu

Political Science Faculty Publications

What factors might explain the cross-country variations in COVID-19 public performances and what lessons can be drawn to be better-prepared for future pandemics? This study focuses on the effects of policy stringency on COVID-19 public health outcomes to gain insights into national-level state responses to COVID-19 and the conditions for their effectiveness. Using data from 136 countries comprising 91.4% of the global population, we find that more stringent policies lead to lower infection and death rates. More importantly, the negative effects of restrictive policies on infection and death rates are moderated by political trust and democracy levels, possibly through the …

Hand In Hand, Spring 2023

Hand in Hand

A newsletter published for Deaf Catholics in Milwaukee, WI

Hand in Hand Finding Aid

The Independent Contractor Workforce: New Evidence On Its Size And Composition And Ways To Improve Its Measurement In Household Surveys, Katharine G. Abraham, Brad J. Hershbein, Susan N. Houseman, Beth Truesdale

Upjohn Institute Working Papers

Good data on the size and composition of the independent contractor workforce are elusive, with household survey and administrative tax data often disagreeing on levels and trends. We carried out a series of focus groups to learn how self-employed independent contractors speak about their work. Based on these findings, we designed and fielded a large-scale telephone survey to elicit more accurate and complete information on independent contractors, including those who may be coded incorrectly as employees in conventional household survey data and those who are independent contractors in a secondary work activity. We find that, upon probing, roughly one in …

Evaluating Progress In The Pandemic, Tomi Schwandt

Times Talk Archive & ADP Projects

Times Talk: Education: Evaluating Progress in the Pandemic

Wednesday, February 22, 2023

12:00-1:00pm

Forsyth Library, South Study Area

Speaker(s): Tomi Schwandt, Political Science