Digital Commons Network^™

Leukocytoclastic Vasculitis: A Peculiar Presentation Of Scrub Typhus, Anila Vasireddy, Kanthilatha Pai, Varsha M. Shetty, Raviraja V. Acharya, Ramamoorthi Kusugodlu, Akhila Doddamani, Sharath P. Madhyastha

Sultan Qaboos University Medical Journal

Scrub typhus is a disease endemic to the Indian subcontinent caused by the obligate intracellular pleomorphic organism, Orientia tsutsugamushi. Scrub typhus, among other acute febrile illnesses, manifests as prodromal symptoms of fever, malaise, myalgia and anorexia followed by a distinct maculopapular rash, hepatosplenomegaly and lymphadenopathy. We report the case of a patient presenting to tertiary care hospital in southern India in 2021 who developed a rare cutaneous vasculitis secondary to infection with Orientia tsutsugamushi. After performing the Weil-Felix test, a diagnostic titre of >1:640 against OXK was obtained. Furthermore, a skin biopsy was carried out which confirmed the diagnosis of …

20230223_Hslic's Biomedical Informatics Seminar Series Presents- Glyneva Bradley-Ridout, Ba, Mi, And Elena Springall, Bsc, Mlis, Brandon Carroll

HSLIC Blog Post

No abstract provided.

3 Honored As Emeritus Faculty, Linda Gunter

Browse All News

No abstract provided.

The Patent Law Clinic At Nyls Helps A Nonprofit’S Efforts To Change Lives In Central Africa, Shahrokh Falati

NYLS Community News

No abstract provided.

February 23, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

February 23, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Lecture Series | Toward A Treaty On Crimes Against Humanity, Center For International Law

Center for International Law

February 23, 2023

The Crafting Of Pre-Service Special Education Teachers’ Perceptions Of Problem Behavior: A Post-Intentional Phenomenological Study, Jamillah Gilbert

Theses and Dissertations

A disproportionate number of Black students with disabilities experience exclusionary discipline practices (e.g., suspensions and expulsions) in K-12 public schools. This disparity persists, regardless of the severity of identified problem behavior, the school’s average socio-economic status, or the type of public school attended. Given that teacher education programs (TEPs) are pivotal training grounds for pedagogical and philosophical formation, it is crucial for TEPs to demonstrate accountability for building critical consciousness of the factors that produce and perpetuate this disparity. Gaining a fuller understanding of how pre-service special education teachers craft their perceptions of problem behavior during their TEPs may help …

Richard Whately's Revitalization Of Syllogistic Logic, Calvin Jongsma

Faculty Work Comprehensive List

This is an expanded version of the first chapter Richard Whately’s Revitalization of Syllogistic Logic in Aristotle’s Syllogism and the Creation of Modern Logic edited by Lukas M. Verburgt and Matteo Cosci (Bloomsbury, 2023). Drawing upon the author’s 1982 Ph. D. dissertation (https://digitalcollections.dordt.edu/faculty_work/230/ ) and more current scholarship, this essay traces the critical historical background to Whately’s work in more detail than could be done in the published version.

Application Of E-Learning In The Smart City Projects, Asma Ghanim Al Arai

Theses

The concept of smart city is getting popular over time. It uses communication of technology and information to maximize operational organization. It shares information among the public to improve citizen welfare and the services of the government. Smart learning or E-learning is also one of the components of a smart city. Cities are the crucible hub of human innovation. Through smart cities, the community strives to integrate and cover environmental, bio, digital and financial technologies to solve urban problems. The E-learning process is based on formalized teaching, and it enhances with the help of electronic resources. Internet and computers play …

Legal Geographies, Caroline Griffith, Sarah Klosterkamp, Alida Cantor, Austin Kocher

Geography Faculty Publications and Presentations

This encyclopedia entry defines and discusses legal geography. Legal geography is an interdisciplinary area of scholarship that focuses on the intersections and co-constitution between law and space and place: that is, how law and legal processes produce space/place, and how particular places in turn influence law. Rather than thinking of law as an abstract, universal, a-spatial set of rules, legal geography examines the ways in which law is situated in place, and how places are shaped by legal practices and processes.

Prenatal Detection Of A Foxf1 Deletion In A Fetus With Acdmpv And Hydronephrosis, Izabela Plaskota, Marta Smyk, Magdalena Niemiec, Artur Barczyk, Ewa Obersztyn, Jan Modzelewski, Iwona Lipska, Paweł Stankiewicz, Marzena Gajecka, Małgorzata Rydzanicz, Rafał Płoski, Tomasz Szczapa, Justyna A Karolak

Faculty, Staff and Students Publications

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by the arrest of fetal lung formation, resulting in neonatal death due to acute respiratory failure and pulmonary arterial hypertension. Heterozygous single-nucleotide variants or copy-number variant (CNV) deletions involving the FOXF1 gene and/or its lung-specific enhancer are found in the vast majority of ACDMPV patients. ACDMPV is often accompanied by extrapulmonary malformations, including the gastrointestinal, cardiac, or genitourinary systems. Thus far, most of the described ACDMPV patients have been diagnosed post mortem, based on histologic evaluation of the lung tissue and/or genetic testing. Here, …

Addressing Barriers In Fair Data Practices For Biomedical Data, Thomas D Horvath, Luke V Rasmussen, Tor C Savidge, Thomas Stoeger, Serdar Turkarslan, Qinglong Wu, Chunlei Wu, Andrew I Su, Lars Pache, Niaid Systems Biology Data Dissemination Working Group

Faculty, Staff and Students Publications

No abstract provided.

Developing A Standardized But Extendable Framework To Increase The Findability Of Infectious Disease Datasets, Candice Czech, Mengjia Kang, Lars Pache, Luke V Rasmussen, Tor C Savidge, Justin Starren, Qinglong Wu, Jiwen Xin, Michael R Yeaman, Xinghua Zhou, Andrew I Su, Chunlei Wu, Liliana Brown, Reed S Shabman, Laura D Hughes

Faculty, Staff and Students Publications

Biomedical datasets are increasing in size, stored in many repositories, and face challenges in FAIRness (findability, accessibility, interoperability, reusability). As a Consortium of infectious disease researchers from 15 Centers, we aim to adopt open science practices to promote transparency, encourage reproducibility, and accelerate research advances through data reuse. To improve FAIRness of our datasets and computational tools, we evaluated metadata standards across established biomedical data repositories. The vast majority do not adhere to a single standard, such as Schema.org, which is widely-adopted by generalist repositories. Consequently, datasets in these repositories are not findable in aggregation projects like Google Dataset Search. …

Macroh2a Histone Variants Modulate Enhancer Activity To Repress Oncogenic Programs And Cellular Reprogramming, Jagneet Kaur, Manvir Bains, Amik Munankarmy, Monique S Bagwell, Stephanie L Safgren, John Moore-Weiss, Marina Buciuc, Lynzie Shimp, Kelsey A Leach, Luis F Duarte, Chandandeep S Nagi, Saul Carcamo, Chi-Yeh Chung, Dan Hasson, Neda Dadgar, Jian Zhong, Jeong-Heon Lee, Fergus J Couch, Alexander Revzin, Tamas Ordog, Emily Bernstein, Alexandre Gaspar-Maia

Faculty, Staff and Students Publications

Considerable efforts have been made to characterize active enhancer elements, which can be annotated by accessible chromatin and H3 lysine 27 acetylation (H3K27ac). However, apart from poised enhancers that are observed in early stages of development and putative silencers, the functional significance of cis-regulatory elements lacking H3K27ac is poorly understood. Here we show that macroH2A histone variants mark a subset of enhancers in normal and cancer cells, which we coined 'macro-Bound Enhancers', that modulate enhancer activity. We find macroH2A variants localized at enhancer elements that are devoid of H3K27ac in a cell type-specific manner, indicating a role for macroH2A at …

Natural Killer T Cells And Other Innate-Like T Lymphocytes As Emerging Platforms For Allogeneic Cancer Cell Therapy

Faculty, Staff and Students Publications

T cells expressing chimeric antigen receptors (CARs) have achieved major clinical success in patients with hematologic malignancies. However, these treatments remain largely ineffective for solid cancers and require significant time and resources to be manufactured in an autologous setting. Developing alternative immune effector cells as cancer immunotherapy agents that can be employed in allogeneic settings is crucial for the advancement of cell therapy. Unlike T cells, Vα24-invariant natural killer T cells (NKTs) are not alloreactive and can therefore be generated from allogeneic donors for rapid infusion into numerous patients without the risk of graft-versus-host disease. Additionally, NKT cells demonstrate inherent …

Textile Printing: Design And Process, Richard Malachowski

Seminar in Textiles and Clothing

Richard Malachowski has an eclectic background in textiles with decades of experience as a textile chemist and director of research and engineering at Cranston Print Works. Using that experience, he described how a textile print is created from design concept through production. Showing physical textile samples, he explained the process of rotary screen printing, flat bed screen printing, and ink jet printing.

Intellectual Disability Related To De Novo Germline Loss Of The Distal End Of The P-Arm Of Chromosome 17: A Case Report, Eden Pope, Matthew Huertas, Amar Paul, Braden Cunningham, Matthew Jennings, Ryan Perry, Stephanie Chavez, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Hypothesis/Purpose: In this report we present a case of a 20-year-old female with congenital intellectual disability, stunted growth, and hypothyroidism. Competitive genetic hybridization (CHG) revealed a loss of 17p13.3, and the deletion was not present in either parent. This deletion has not previously been characterized, but mutations on the p-arm of chromosome 17 are responsible for Miller-Dieker Syndrome and Isolated Lissencephaly Sequence, both of which share symptoms in common with the patient.

Methods: Peripheral mononuclear cells (PBMCs) were used for karyotyping and competitive genetic hybridization (CHG). Bioinformatic analysis was carried out using the Genome Data Viewer (ncbi.nlm.nih.gov/genome/gdv).

Results: Karyotype was …

The Malliavin-Stein Method For Normal Random Walks With Dependent Increments, Ian Flint, Nicolas Privault, Giovanni Luca Torrisi

Journal of Stochastic Analysis

No abstract provided.

The Heart Rates And Movement Speed Of Specialist Tactical Police During A Multistorey Active Shooter Training Scenario, Jeremy Robinson, Mihajlo Micovic, Ben Schram, Alexander Leroux, Robin Marc Orr

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 281-292, 2023. Specialist police tactical groups (PTGs) are involved in situations that extend beyond the capability of general duties police and can include responding to active shooter incidents. Due to the nature of their tasks, these officers typically carry and wear additional equipment which can impart an increased physical cost, for which the officers must be prepared. The aim of this study was to examine the heart rate responses and movement speeds of specialist PTG officers during a multistorey active shooter scenario. Eight PTG officers completed an active shooter scenario within a multistorey office …

Neuromuscular Responses To Failure Vs Non-Failure During Blood Flow Restriction Training In Untrained Females, Christopher E. Proppe, Taylor M. Aldeghi, Paola Rivera, David H. Gonzalez-Rojas, Ethan C. Hill Phd

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 293-303, 2023. Applying blood flow restriction (BFR) during resistance exercise is a potent stimulus of muscular adaption, but there is little direct comparison of its effect on neuromuscular function. The purpose of this investigation was to compare surface electromyography amplitude and frequency responses during a 75 (1 × 30, 3 × 15) repetition bout (BFR-75) of BFR to 4 sets to failure (BFR-F). Twelve women (mean ± SD age = 22 ± 4 years; body mass = 72 ± 14.4 kg; height = 162.1 ± 4.0 cm) volunteered for the investigation. One leg was …

Dead Front Display With Adjustable Cover-Glass Gap, Jose Madrid

Defensive Publications Series

A dead front display is a type of display that disappears, e.g., blends with the background, when turned off. A tradeoff exists between the sharpness of the display in the ON state and the effectiveness of hiding the black state of the display behind the diffuser in the OFF state. The closer the display is to the diffuser, the sharper the ON state but the more visible the black in the OFF state. This disclosure describes a mechanism to dynamically adjust the air gap between the top diffuser layer and the display of a dead front display for different display …

Can Multidetector Ct Scan Replace Mri For Evaluation Of Mesorectal Fasca In Rectal Cancer?, Maryam Farghdani, Mehdi Karami, Amirafraz Fallah

BioMedicine

Abstract

Background

Colorectal cancer is the 4th leading cause of cancer mortality.

Aim

This study aimed to can multidetector CT scan (MDCT) replace Magnetic resonance imaging (MRI) for mesorectal fasca in rectal cancer?

Methods

This cross-sectional was conducted on patients with rectal cancer in Alzahra and Seyed-Shohada hospitals. MRI, mesorectal fascia (MPR), and axial MDCT were provided from patients to assess the involvement of mesorectal fascia. Sensitivity, specificity, positive and negative predictive values were assessed in these patients. Kappa coefficient agreement was used for analysis. Patients were also divided into different subgroups based on gender, tumoral location, nodal involvement, and …

A1 Adenosine Receptor Antagonist Induces Cell Apoptosis In Kyse-30 And Ym-1 Esophageal Cancer Cell Lines, Parisa Zeynali, Marie Saghaeian Jazi, Jahanbakhsh Asadi, Seyyed Mehdi Jafari

BioMedicine

Background and Aim: Adenosine A1 receptor (AA1R) has been shown to have an inhibitory effect on cell growth in several cancers; however, its function in esophageal cancer is still unclear. In this study, we examined the effect of AA1R on cell growth and apoptosis in esophageal cancer cells. Materials and methods: In this study, YM-1 and KYSE-30 esophageal cancer cell lines were cultured. AA1R gene expression was determined by quantitative Real-time Polymerase Chain Reaction (qRT-PCR). As well, the AA1R antagonist (DPCPX) effect on cell viability was evaluated by the MTT assay. Moreover, apoptosis was assessed by annexin-V and propidium iodide …

Jugular Foramen Versus Hypoglossal Canal In Axial Ct Scan, Maryam Mohammadzadeh, Reza Erfanian, Saman Rezaeian, Nasim Batavani, Behrooz Amirzargar

BioMedicine

Background: Differentiating jugular foramen from hypoglossal canal in computed tomography (CT) scan is vital for correct diagnosis of posterior fossa pathologies; however, it has been shown that the ability for differentiating these skull base elements is limited. The purpose of this study was to produce a simple algorithm for differentiating the jugular foramen from the hypoglossal canal in axial CT scan on two levels (top level where bony carotid canal is evident and lower level where bony carotid canal is not evident). Methods: Data derived from axial CT scan of 250 patients (500 sides) were used for producing algorithm. At …

The Impact Of Procalcitonin In Assessing Outcomes In Pediatrics Severe Trauma Cases: A Three-Year Experience From A Tertiary Hospital, Waleed H. Albuali

BioMedicine

Background Although procalcitonin levels are raised in patients with systemic inflammation, its usage in pediatric patients, particularly those in the intensive care unit who are most susceptible to sepsis. Methods It is a retrospective research study that included pediatric patients aged more than two weeks who were brought to the King Fahd Hospital of the University's PICU owing to serious trauma or post-acute postoperative occurrences from January 2017 to December 2019. At 24 hours after admission, data such as age, gender, comorbidities, trauma severity as measured by the Injury Severity Score, and PRISM III score were collected. Results Following a …

High Levels Of Histone H3 K27 Acetylation And Tri-Methylation Are Associated With Shorter Survival In Oral Squamous Cell Carcinoma Patients, Akram Shahhosseini, Ekaterina Bourova-Flin, Samira Derakhshan, Pouyan Aminishakib, Afsaneh Goudarzi

BioMedicine

Background: Acetylation and trimethylation of histone H3 lysine 27 (H3K27ac and H3K27me3) generally activate and repress transcription, respectively. Concurrent activation of H3K27ac and H3K27me3 has been reported to correlate with poor prognosis in hepatocellular carcinoma. A high level of H3K27me3 has been shown to be associated with advanced oral squamous cell carcinoma (OSCC) tumour stage, but prognostic impact of H3K27ac level alone/or in combination with H3K27me3 in OSCC patients had not yet been reported. Material and Methods: In this study, immunohistochemistry using specific antibodies against H3K27ac and H3K27me3 was performed on a series of 72 OSCC samples to investigate the …

Effects Of Hepatocyte Growth Factor On Porcine Mammary Cell Growth And Senescence, Chi-Ping Huang, Liang-Chih Liu, Hsin-Ling Lu, Chih-Rong Shyr

BioMedicine

Background: The porcine mammary glands share morphological and physiological similarities with human ones, making primary porcine mammary cells (PMC) suitable for biomedical research and a potential cellular therapeutic for breast cancer xenogeneic cell immunotherapy. Primary cells isolated from tissues remain the physiological functions of origin tissues but their self-renewal ability is restricted and cells acquire senescence during in vitro expansion. To overcome these drawbacks, here we sought to establish an approach to efficiently increase PMC’s in vitro growth. We studied the effects of the hepatocyte growth factor (HGF) to maintain the expansion capacity of porcine mammary cells and identify the …

New-Onset Diabetes In Covid-19: The Molecular Pathogenesis, Desak Made Wihandani, Made Lady Adelaida Purwanta, W. Riski Widya Mulyani, I Wayan Ardyan Sudharta Putra, I Gede Putu Supadmanaba

BioMedicine

Diabetes mellitus (DM) is still a challenging metabolic disease worldwide. In the current situation, the world is facing a COVID-19 pandemic due to SARS-CoV-2 infection. DM is one of comorbid that can worsen the severity of the COVID-19 condition. Surprisingly, SARS-CoV-2 infection can induce new-onset diabetes, a condition in which acute hyperglycemia occurs and may potentially develop into a complication in non-diabetic patients. Angiotensin-converting enzyme 2 (ACE2) is a crucial entry factor of SARS-CoV-2 infection. ACE2 will bind to the spike protein of SARS-CoV-2, making its entrance to the potentially damaging process of many tissues in the human body, including …

Beyond Mental Stress-Induced Myocardial Ischemia Following The Covid-19 Vaccine, Chih-Cheng Lai, Po-Ren Hsueh

BioMedicine

No abstract provided.