Digital Commons Network^™

[18f]Tosyl Fluoride As A Versatile [18f]Fluoride Source For The Preparation Of 18f-Labeled Radiopharmaceuticals, Dong Zhou, Wenhua Chu, Jinbin Xu, Sally Schwarz, John A Katzenellenbogen

2020-Current year OA Pubs

Positron emission tomography (PET) is an in vivo imaging technology that utilizes positron-emitting radioisotope-labeled compounds as PET radiotracers that are commonly used in clinic and in various research areas, including oncology, cardiology, and neurology. Fluorine-18 is the most widely used PET-radionuclide and commonly produced by proton bombardment of

Lies,Damn Lies, And Kamikaze Lies: Protecting Falsehoods In The Name Of Truth, Doris Deltosto Brogan

Faculty Publications

Despite calls to reverse New York Times v. Sullivan and abandon the reckless disregard standard for public figure defamation cases--calls offered by two Supreme Court Justices, a number of legal scholars and some members of the popular press-- this article demonstrates that Sullivan’s protections have never been more relevant or more necessary, particularly in light of an epidemic of malicious, often strategic falsity, as well as overt assaults on the institutional press by powerful actors. We need Sullivan now more than ever. Further, for Sullivan to do its work effectively, it must be reinforced by two other legal protections: robust …

The Chanticleer, 2023-02-23, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Prenatal Detection Of A Foxf1 Deletion In A Fetus With Acdmpv And Hydronephrosis, Izabela Plaskota, Marta Smyk, Magdalena Niemiec, Artur Barczyk, Ewa Obersztyn, Jan Modzelewski, Iwona Lipska, Paweł Stankiewicz, Marzena Gajecka, Małgorzata Rydzanicz, Rafał Płoski, Tomasz Szczapa, Justyna A Karolak

Faculty, Staff and Students Publications

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by the arrest of fetal lung formation, resulting in neonatal death due to acute respiratory failure and pulmonary arterial hypertension. Heterozygous single-nucleotide variants or copy-number variant (CNV) deletions involving the FOXF1 gene and/or its lung-specific enhancer are found in the vast majority of ACDMPV patients. ACDMPV is often accompanied by extrapulmonary malformations, including the gastrointestinal, cardiac, or genitourinary systems. Thus far, most of the described ACDMPV patients have been diagnosed post mortem, based on histologic evaluation of the lung tissue and/or genetic testing. Here, …

Addressing Barriers In Fair Data Practices For Biomedical Data, Thomas D Horvath, Luke V Rasmussen, Tor C Savidge, Thomas Stoeger, Serdar Turkarslan, Qinglong Wu, Chunlei Wu, Andrew I Su, Lars Pache, Niaid Systems Biology Data Dissemination Working Group

Faculty, Staff and Students Publications

No abstract provided.

Developing A Standardized But Extendable Framework To Increase The Findability Of Infectious Disease Datasets, Candice Czech, Mengjia Kang, Lars Pache, Luke V Rasmussen, Tor C Savidge, Justin Starren, Qinglong Wu, Jiwen Xin, Michael R Yeaman, Xinghua Zhou, Andrew I Su, Chunlei Wu, Liliana Brown, Reed S Shabman, Laura D Hughes

Faculty, Staff and Students Publications

Biomedical datasets are increasing in size, stored in many repositories, and face challenges in FAIRness (findability, accessibility, interoperability, reusability). As a Consortium of infectious disease researchers from 15 Centers, we aim to adopt open science practices to promote transparency, encourage reproducibility, and accelerate research advances through data reuse. To improve FAIRness of our datasets and computational tools, we evaluated metadata standards across established biomedical data repositories. The vast majority do not adhere to a single standard, such as Schema.org, which is widely-adopted by generalist repositories. Consequently, datasets in these repositories are not findable in aggregation projects like Google Dataset Search. …

Macroh2a Histone Variants Modulate Enhancer Activity To Repress Oncogenic Programs And Cellular Reprogramming, Jagneet Kaur, Manvir Bains, Amik Munankarmy, Monique S Bagwell, Stephanie L Safgren, John Moore-Weiss, Marina Buciuc, Lynzie Shimp, Kelsey A Leach, Luis F Duarte, Chandandeep S Nagi, Saul Carcamo, Chi-Yeh Chung, Dan Hasson, Neda Dadgar, Jian Zhong, Jeong-Heon Lee, Fergus J Couch, Alexander Revzin, Tamas Ordog, Emily Bernstein, Alexandre Gaspar-Maia

Faculty, Staff and Students Publications

Considerable efforts have been made to characterize active enhancer elements, which can be annotated by accessible chromatin and H3 lysine 27 acetylation (H3K27ac). However, apart from poised enhancers that are observed in early stages of development and putative silencers, the functional significance of cis-regulatory elements lacking H3K27ac is poorly understood. Here we show that macroH2A histone variants mark a subset of enhancers in normal and cancer cells, which we coined 'macro-Bound Enhancers', that modulate enhancer activity. We find macroH2A variants localized at enhancer elements that are devoid of H3K27ac in a cell type-specific manner, indicating a role for macroH2A at …

Natural Killer T Cells And Other Innate-Like T Lymphocytes As Emerging Platforms For Allogeneic Cancer Cell Therapy

Faculty, Staff and Students Publications

T cells expressing chimeric antigen receptors (CARs) have achieved major clinical success in patients with hematologic malignancies. However, these treatments remain largely ineffective for solid cancers and require significant time and resources to be manufactured in an autologous setting. Developing alternative immune effector cells as cancer immunotherapy agents that can be employed in allogeneic settings is crucial for the advancement of cell therapy. Unlike T cells, Vα24-invariant natural killer T cells (NKTs) are not alloreactive and can therefore be generated from allogeneic donors for rapid infusion into numerous patients without the risk of graft-versus-host disease. Additionally, NKT cells demonstrate inherent …

Banking On Virus-Specific T Cells To Fulfill The Need For Off-The-Shelf Cell Therapies

Faculty, Staff and Students Publications

Adoptively transferred virus-specific T cells (VSTs) have shown remarkable safety and efficacy for the treatment of virus-associated diseases and malignancies in hematopoietic stem cell transplant (HSCT) recipients, for whom VSTs are derived from the HSCT donor. Autologous VSTs have also shown promise for the treatment of virus-driven malignancies outside the HSCT setting. In both cases, VSTs are manufactured as patient-specific products, and the time required for procurement, manufacture, and release testing precludes their use in acutely ill patients. Further, Good Manufacturing Practices-compliant products are expensive, and failures are common in virus-naive HSCT donors and patient-derived VSTs that are rendered anergic …

Textile Printing: Design And Process, Richard Malachowski

Seminar in Textiles and Clothing

Richard Malachowski has an eclectic background in textiles with decades of experience as a textile chemist and director of research and engineering at Cranston Print Works. Using that experience, he described how a textile print is created from design concept through production. Showing physical textile samples, he explained the process of rotary screen printing, flat bed screen printing, and ink jet printing.

Intellectual Disability Related To De Novo Germline Loss Of The Distal End Of The P-Arm Of Chromosome 17: A Case Report, Eden Pope, Matthew Huertas, Amar Paul, Braden Cunningham, Matthew Jennings, Ryan Perry, Stephanie Chavez, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Hypothesis/Purpose: In this report we present a case of a 20-year-old female with congenital intellectual disability, stunted growth, and hypothyroidism. Competitive genetic hybridization (CHG) revealed a loss of 17p13.3, and the deletion was not present in either parent. This deletion has not previously been characterized, but mutations on the p-arm of chromosome 17 are responsible for Miller-Dieker Syndrome and Isolated Lissencephaly Sequence, both of which share symptoms in common with the patient.

Methods: Peripheral mononuclear cells (PBMCs) were used for karyotyping and competitive genetic hybridization (CHG). Bioinformatic analysis was carried out using the Genome Data Viewer (ncbi.nlm.nih.gov/genome/gdv).

Results: Karyotype was …

The Malliavin-Stein Method For Normal Random Walks With Dependent Increments, Ian Flint, Nicolas Privault, Giovanni Luca Torrisi

Journal of Stochastic Analysis

No abstract provided.

The Heart Rates And Movement Speed Of Specialist Tactical Police During A Multistorey Active Shooter Training Scenario, Jeremy Robinson, Mihajlo Micovic, Ben Schram, Alexander Leroux, Robin Marc Orr

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 281-292, 2023. Specialist police tactical groups (PTGs) are involved in situations that extend beyond the capability of general duties police and can include responding to active shooter incidents. Due to the nature of their tasks, these officers typically carry and wear additional equipment which can impart an increased physical cost, for which the officers must be prepared. The aim of this study was to examine the heart rate responses and movement speeds of specialist PTG officers during a multistorey active shooter scenario. Eight PTG officers completed an active shooter scenario within a multistorey office …

Neuromuscular Responses To Failure Vs Non-Failure During Blood Flow Restriction Training In Untrained Females, Christopher E. Proppe, Taylor M. Aldeghi, Paola Rivera, David H. Gonzalez-Rojas, Ethan C. Hill Phd

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 293-303, 2023. Applying blood flow restriction (BFR) during resistance exercise is a potent stimulus of muscular adaption, but there is little direct comparison of its effect on neuromuscular function. The purpose of this investigation was to compare surface electromyography amplitude and frequency responses during a 75 (1 × 30, 3 × 15) repetition bout (BFR-75) of BFR to 4 sets to failure (BFR-F). Twelve women (mean ± SD age = 22 ± 4 years; body mass = 72 ± 14.4 kg; height = 162.1 ± 4.0 cm) volunteered for the investigation. One leg was …

Dead Front Display With Adjustable Cover-Glass Gap, Jose Madrid

Defensive Publications Series

A dead front display is a type of display that disappears, e.g., blends with the background, when turned off. A tradeoff exists between the sharpness of the display in the ON state and the effectiveness of hiding the black state of the display behind the diffuser in the OFF state. The closer the display is to the diffuser, the sharper the ON state but the more visible the black in the OFF state. This disclosure describes a mechanism to dynamically adjust the air gap between the top diffuser layer and the display of a dead front display for different display …

Can Multidetector Ct Scan Replace Mri For Evaluation Of Mesorectal Fasca In Rectal Cancer?, Maryam Farghdani, Mehdi Karami, Amirafraz Fallah

BioMedicine

Abstract

Background

Colorectal cancer is the 4th leading cause of cancer mortality.

Aim

This study aimed to can multidetector CT scan (MDCT) replace Magnetic resonance imaging (MRI) for mesorectal fasca in rectal cancer?

Methods

This cross-sectional was conducted on patients with rectal cancer in Alzahra and Seyed-Shohada hospitals. MRI, mesorectal fascia (MPR), and axial MDCT were provided from patients to assess the involvement of mesorectal fascia. Sensitivity, specificity, positive and negative predictive values were assessed in these patients. Kappa coefficient agreement was used for analysis. Patients were also divided into different subgroups based on gender, tumoral location, nodal involvement, and …

A1 Adenosine Receptor Antagonist Induces Cell Apoptosis In Kyse-30 And Ym-1 Esophageal Cancer Cell Lines, Parisa Zeynali, Marie Saghaeian Jazi, Jahanbakhsh Asadi, Seyyed Mehdi Jafari

BioMedicine

Background and Aim: Adenosine A1 receptor (AA1R) has been shown to have an inhibitory effect on cell growth in several cancers; however, its function in esophageal cancer is still unclear. In this study, we examined the effect of AA1R on cell growth and apoptosis in esophageal cancer cells. Materials and methods: In this study, YM-1 and KYSE-30 esophageal cancer cell lines were cultured. AA1R gene expression was determined by quantitative Real-time Polymerase Chain Reaction (qRT-PCR). As well, the AA1R antagonist (DPCPX) effect on cell viability was evaluated by the MTT assay. Moreover, apoptosis was assessed by annexin-V and propidium iodide …

Jugular Foramen Versus Hypoglossal Canal In Axial Ct Scan, Maryam Mohammadzadeh, Reza Erfanian, Saman Rezaeian, Nasim Batavani, Behrooz Amirzargar

BioMedicine

Background: Differentiating jugular foramen from hypoglossal canal in computed tomography (CT) scan is vital for correct diagnosis of posterior fossa pathologies; however, it has been shown that the ability for differentiating these skull base elements is limited. The purpose of this study was to produce a simple algorithm for differentiating the jugular foramen from the hypoglossal canal in axial CT scan on two levels (top level where bony carotid canal is evident and lower level where bony carotid canal is not evident). Methods: Data derived from axial CT scan of 250 patients (500 sides) were used for producing algorithm. At …

The Impact Of Procalcitonin In Assessing Outcomes In Pediatrics Severe Trauma Cases: A Three-Year Experience From A Tertiary Hospital, Waleed H. Albuali

BioMedicine

Background Although procalcitonin levels are raised in patients with systemic inflammation, its usage in pediatric patients, particularly those in the intensive care unit who are most susceptible to sepsis. Methods It is a retrospective research study that included pediatric patients aged more than two weeks who were brought to the King Fahd Hospital of the University's PICU owing to serious trauma or post-acute postoperative occurrences from January 2017 to December 2019. At 24 hours after admission, data such as age, gender, comorbidities, trauma severity as measured by the Injury Severity Score, and PRISM III score were collected. Results Following a …

High Levels Of Histone H3 K27 Acetylation And Tri-Methylation Are Associated With Shorter Survival In Oral Squamous Cell Carcinoma Patients, Akram Shahhosseini, Ekaterina Bourova-Flin, Samira Derakhshan, Pouyan Aminishakib, Afsaneh Goudarzi

BioMedicine

Background: Acetylation and trimethylation of histone H3 lysine 27 (H3K27ac and H3K27me3) generally activate and repress transcription, respectively. Concurrent activation of H3K27ac and H3K27me3 has been reported to correlate with poor prognosis in hepatocellular carcinoma. A high level of H3K27me3 has been shown to be associated with advanced oral squamous cell carcinoma (OSCC) tumour stage, but prognostic impact of H3K27ac level alone/or in combination with H3K27me3 in OSCC patients had not yet been reported. Material and Methods: In this study, immunohistochemistry using specific antibodies against H3K27ac and H3K27me3 was performed on a series of 72 OSCC samples to investigate the …

Effects Of Hepatocyte Growth Factor On Porcine Mammary Cell Growth And Senescence, Chi-Ping Huang, Liang-Chih Liu, Hsin-Ling Lu, Chih-Rong Shyr

BioMedicine

Background: The porcine mammary glands share morphological and physiological similarities with human ones, making primary porcine mammary cells (PMC) suitable for biomedical research and a potential cellular therapeutic for breast cancer xenogeneic cell immunotherapy. Primary cells isolated from tissues remain the physiological functions of origin tissues but their self-renewal ability is restricted and cells acquire senescence during in vitro expansion. To overcome these drawbacks, here we sought to establish an approach to efficiently increase PMC’s in vitro growth. We studied the effects of the hepatocyte growth factor (HGF) to maintain the expansion capacity of porcine mammary cells and identify the …

New-Onset Diabetes In Covid-19: The Molecular Pathogenesis, Desak Made Wihandani, Made Lady Adelaida Purwanta, W. Riski Widya Mulyani, I Wayan Ardyan Sudharta Putra, I Gede Putu Supadmanaba

BioMedicine

Diabetes mellitus (DM) is still a challenging metabolic disease worldwide. In the current situation, the world is facing a COVID-19 pandemic due to SARS-CoV-2 infection. DM is one of comorbid that can worsen the severity of the COVID-19 condition. Surprisingly, SARS-CoV-2 infection can induce new-onset diabetes, a condition in which acute hyperglycemia occurs and may potentially develop into a complication in non-diabetic patients. Angiotensin-converting enzyme 2 (ACE2) is a crucial entry factor of SARS-CoV-2 infection. ACE2 will bind to the spike protein of SARS-CoV-2, making its entrance to the potentially damaging process of many tissues in the human body, including …

Beyond Mental Stress-Induced Myocardial Ischemia Following The Covid-19 Vaccine, Chih-Cheng Lai, Po-Ren Hsueh

BioMedicine

No abstract provided.

Selenium Nanoparticles Attenuate Bleomycin-Induced Pulmonary Oxidative Stress And Fibrosis In Rats, Azza M A. Abouelella, Bahig A. El Deeb, Eman Mohammed Ali

Bulletin of Faculty of Pharmacy Cairo University

Pulmonary fibrosis is a fatal progressive lung disorder. Bleomycin (BLM) has been used for induction of experimental pulmonary fibrosis. Selenium nanoparticles (SeNPs) have been synthesized and investigated for their ability to ameliorate BLM-induced pulmonary fibrosis. SeNPs (0.5 mg⁄kg. ip) were administered for four weeks; two weeks pre and two weeks post BLM (2.5 U⁄kg. ip). BLM induced biochemical and histological deterioration of lungs. SeNPs induced significant histopathological and biochemical improvement of oxidative stress (MDA, SOD and GSH), inflammatory (IL6 and IL10) and fibrotic markers (hydroxyproline). In conclusion; SeNPs has potential therapeutic rather than protective effect on management of pulmonary damage.

Shatt Al-Arab River And The Seawater Intrusion: Causes And Solutions, Havan H. Salman, Hamdiea Skheel Jazaa

Al-Bahir

. The scarcity and pollution of water resources led to environmental deterioration in Iraq, where the water needs for agricultural purposes are estimated at about 51 billion m3 annually to irrigate 11.3 million dunums and about 10 billion m3 annually for social health needs and 5 billion m3 annually for industrial, oil needs and electricity production. This paper addresses another factor exacerbating the crisis and posing another challenge to competition, which is pollution from seawater intrusion. Take the Shatt al-Arab as a case study. Shatt al-Arab is the main water source for the city of Basra in southern Iraq, where …

The Effect Of Using Drta Strategy On Developing Reading Comprehension Skills For Seventh Graders In Gaza Governorates, Mohammed Al-Nahhal

Hebron University Research Journal-B (Humanities) - (مجلة جامعة الخليل للبحوث- ب (العلوم الانسانيه

This research aimed to investigate the effect of employing the DRTA as a strategy to develop the reading comprehension skills among seventh-graders in Gaza governorates. The quasi-experimental approach was used on a sample of (80) female students divided into two equivalent groups. The experimental group included (44) female students, while the control one included (36) female students. The tools of data collection were a checklist of reading comprehension skills and a reading comprehension test. To analyze the collected data, a t-test was conducted. Furthermore, to examine the effectiveness of the DRTA strategy in developing reading comprehension skills, the effect size …

Staying Tuned To Umm Kulthum: On The Voyage With The Sinbad And Ulysses In Jabra’S The Ship, Ahmad Qabaha

Hebron University Research Journal-B (Humanities) - (مجلة جامعة الخليل للبحوث- ب (العلوم الانسانيه

By drawing on recent approaches to music listening, spatial and postcolonial theories, this paper examines the significance of various instances of intertextuality in Jabra Ibrahim Jabra’s The Ship. It argues that intertextuality in the novel enables the characters to sustain a sense of community and national solidarity immune to closure and disintegration in exile. This paper shows that the intertexts in the novel are resources of power, strength and agency necessary to fend off alienation and loss, and the intertextual fabric functions as a transformational space from denial into presence, from helplessness into determination. The paper concludes that (inter)textuality in …

Semiotic Manifestations In Novel Bilal's Code By Ahmed Khairy Al-Omari, Khader Abu Jahjouh, Shimaa Abu Shaqra

Hebron University Research Journal-B (Humanities) - (مجلة جامعة الخليل للبحوث- ب (العلوم الانسانيه

Semiotic analysis is concerned with monitoring the signs that reveal the components of text. This study aims to highlight the defining semiotic features included in Ahmed Al-Omari's Bilal's Code with particular reference to semiotic features including title, cover, dedication, preface, semiotics of colors, body language, characters, and time and place components. Using the descriptiveanalytical method based on the mechanisms of semiotic analysis, the study tries to highlight the features of the semiotic formation that has played an important role in the foundation of the novel's aesthetic and narrative structure.The study came up with a number of results. The cover of …

Online Learning Challenges For Students With Disabilities: Digital Accessibility And Universal Design For Learning Solutions, Khalid Khadr, Abdulnaser Abdulraheem Fakhrou, Rehab Dirgham, Riyad Ayyash, Hana Khalily

Hebron University Research Journal-B (Humanities) - (مجلة جامعة الخليل للبحوث- ب (العلوم الانسانيه

This study aimed to investigate the challenges faced by students with disabilities in online education and to review scientific solutions, digital access solutions and assistive technology for these challenges in higher education institutions. This study analyzed and compared more than seventy references from recent studies that reviewed the challenges and technological solutions available to students with disabilities in some higher education institutions in the United States of America, Australia and the United Kingdom; The aim is to benefit from these experiences in developing support for students with disabilities in online education at Qatar University. It was found throughout the literatures …

The Corona Virus Pandemic Psychological Effect And Its Relationship To Future Anxiety Among Teachers, Ahmad Al- Shraifin, Ali Jarwan, Mu’Ayyad Megdadi

Hebron University Research Journal-B (Humanities) - (مجلة جامعة الخليل للبحوث- ب (العلوم الانسانيه

The study aimed at revealing the relation between Corona virus pandemic psychological effect and future anxiety among teachers considering some variables (i.e., gender, social status, and school type). To achieve the aims of the study, the Impact of Event Scale-Revised IES-R scale and the future anxiety scale were utilized, after examining their validity and reliability. The sample consisted of 254 teachers from public and private schools in Irbid. The results show that there are statistically significant differences in the means of corona virus pandemic psychological effect scale due to the type of school; private school teachers were more affected by …