Digital Commons Network^™

Clinical Epigenomic Explanation Of The Epidemiology Of Cannabinoid Genotoxicity Manifesting As Transgenerational Teratogenesis, Cancerogenesis And Aging Acceleration, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

As global interest in the therapeutic potential of cannabis and its’ derivatives for the management of selected diseases increases, it is increasingly imperative that the toxic profile of cannabinoids be thoroughly understood in order to correctly assess the balance between the therapeutic risks and benefits. Modern studies across a number of jurisdictions, including Canada, Australia, the US and Europe have confirmed that some of the most worrying and severe historical reports of both congenital anomalies and cancer induction following cannabis exposure actually underestimate the multisystem thousand megabase-scale transgenerational genetic damage. These findings from teratogenic and carcinogenic literature are supported by …

Corticospinal And Intracortical Responses From Both Motor Cortices Following Unilateral Concentric Versus Eccentric Contractions, Onno Van Der Groen, Christopher Latella, Kazunori Nosaka, Dylan Edwards, Wei Peng Teo, Janet L. Taylor

Research outputs 2022 to 2026

Cross-education is the phenomenon where training of one limb can cause neuromuscular adaptations in the opposite untrained limb. This effect has been reported to be greater after eccentric (ECC) than concentric (CON) strength training; however, the underpinning neurophysiological mechanisms remain unclear. Thus, we compared responses to transcranial magnetic stimulation (TMS) in both motor cortices following single sessions of unilateral ECC and CON exercise of the elbow flexors. Fourteen healthy adults performed three sets of 10 ECC and CON right elbow flexor contractions at 75 % of respective maximum on separate days. Elbow flexor maximal voluntary isometric contraction (MVIC) torques were …

Search For Gamma-Ray And Neutrino Coincidences Using Hawc And Antares Data, H. A. Ayala Solares, S. Coutu, D. Cowen, D. B. Fox, T. Grégoire, F. Mcbride, M. Mostafá, K. Murase, S. Wissel, A. Albert, S. Alves, M. André, M. Ardid, S. Ardid, J. J. Aubert, J. Aublin, B. Baret, S. Basa, B. Belhorma, M. Bendahman, F. Benfenati, V. Bertin, S. Biagi, M. Bissinger, J. Boumaaza, M. Bouta, M. C. Bouwhuis, H. Branzas, R. Bruijn, J. Brunner, J. Busto, B. Caiffi, D. Calvo, A. Capone, L. Caramete, J. Carr, V. Carretero, S. Celli, M. Chabab, T. N. Chau, R. Cherkaoui El Moursli, T. Chiarusi, M. Circella, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. F. Diaz, G. De Wasseige, B. De Martino, C. Distefano, I. Di Palma, A. Domi, C. Donzaud, D. Dornic, D. Drouhin, T. Eberl, T. Van Eeden, D. Van Eijk, N. El Khayati, A. Enzenhofer, P. Fermani, G. Ferrara, F. Filippini, L. Fusco, J. Garcia, P. Gay, H. Glotin, R. Gozzini, R. Gracia Ruiz, K. Graf, C. Guidi, S. Hallmann, H. Van Haren, A. J. Heijboer, Y. Hello, J. J. Hernandez-Rey, J. Hobl, J. Hofestadt, F. Huang, G. Illuminati, C. W. James, B. Jisse-Jung, M. De Jong, P. De Jong, M. Kadler, O. Kalekin, U. Katz, A. Kouchner, I. Kreykenbohm, V. Kulikovskiy, R. Lahmann, M. Lamoureux, R. Le Breton, D. Lefevre, E. Leonora, G. Levi, S. Le Stum, D. Lopez-Coto, S. Loucatos, L. Maderer, J. Manczak, M. Marcelin, A. Margiotta, A. Marinelli, J. A. Martinez-Mora, K. Melis, P. Migliozzi, A. Moussa, R. Muller, L. Nauta, S. Navas, E. Nezri, B. O Fearraigh, A. Paun, G. E. Pavalas, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, C. Piore, V. Popa, T. Pradier, N. Randazzo, D. Real, S. Reck, G. Riccobene, A. Romanov, A. Sanchez-Losa, D. F. E. Samtleben, M. Sanguineti, P. Sapienza, J. Schnabel, J. Schumann, F. Schussler, J. Seneca, M. Spurio, Th. Stolarczyk, M. Taiuti, Y. Tayalati, S. J. Tingay, B. Vallage, V. Van Elewyck, F. Versari, S. Viola, D. Vivolo, J. Wilms, S. Zavatarelli, A. Zegarelli, J. D. Zornoza, J. Zuniga, A. Albert, C. Alvarez, J. C. Arteaga-Velazquez, R. Babu, E. Belmont-Moreno, K. S. Caballero-Mora, T. Capistran, A. Carraminana, S. Casanova, U. Cotti, O. Chaparro-Amaro, J. Cotzomi, S. Coutino De Leon, E. De La Fuenta, C. De Leon, R. Diaz Hernandez, M. A. Duvernois, M. Durocher, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, M. Fernandez Alonso, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, S. Kaufmann, A. Lara, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, I. Martinez-Castellanos, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, A. Nayerhoda, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, F. Salesa Greus, A. Sandoval, M. Schneider, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Varela, Xiaojie Wang, K. Whitaker, E. Willox, A. Zepeda, H. Zhou

Physics Faculty Research & Creative Works

In the quest for high-energy neutrino sources, the Astrophysical Mult messenger Observatory Network has implemented a new search by combining data from the High-Altitude Water Cherenkov (HAWC) Observatory and the Astronomy with a Neutrino Telescope and Abyss environmental RESearch (ANTARES) neutrino telescope. Using the same analysis strategy as in a previous detector combination of HAWC and IceCube data, we perform a search for coincidences in HAWC and ANTARES events that are below the threshold for sending public alerts in each individual detector. Data were collected between 2015 July and 2020 February with a live time of 4.39 yr. Over this …

Glass-Based Biodegradable Pressure Sensor Toward Biomechanical Monitoring With A Controllable Lifetime, Devdatt Chattopadhyay, Jonghyun Park, Chang-Soo Kim

Mechanical and Aerospace Engineering Faculty Research & Creative Works

A New Class of Potentially Implantable Solid-State Sensors is Demonstrated Utilizing Biodegradable Glass as the Main Structural Material. the Device Behavior is Manipulated Via Chemical Decomposition, and Then Physically Disintegrated in a Controlled Manner. It is based on the Capacitive Sensing Mechanism, Comprising an Elastic Insulator between Two Borate-Rich Glass Substrates. This Mesoscale Pressure Sensor is Characterized by a Range of Pressure of Up to 14 MPa in a Phosphate Buffer Solution Environment. the Sensor Exhibits Good Sensitivity and Reversibility Responding to Compressive Pressures and Remains Fully Functional Before a Desired, Sudden Failure Caused by Dissolution. the Operational Lifetime Can …

Selection Of Solidification Pathway In Rapid Solidification Processes, Nima Najafizadeh, Men G. Chu, Yijia Gu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Rapid Solidification Processing of Alloys Enables the Formation of Exotic Nonequilibrium Microstructures. However, the Interrelationship between the Processing Parameters and the Resulting Microstructure is Yet to Be Fully Understood. in Melt Spinning (MS) and Additive Manufacturing (AM) of Rapidly Solidified Alloys, Opposite Microstructure Development Sequences Were Observed. a Fine-To-Coarse Microstructural Transition is Typically Observed in Melt-Spun Ribbons, Whereas Melt Pools in AM Exhibit a Coarse-To-Fine Transition. in This Paper, the Microstructural Evolutions during These Two Processes Are Investigated using Phase-Field Modeling. the Variation of All Key Variables of the Solid-Liquid Interface (Temperature, Composition, and Velocity) throughout the Entire Rapid Solidification …

Biostimulation Of Petroleum-Contaminated Soil Using Organic And Inorganic Amendments, Ogochukwu A. Udume, Gideon O. Abu, Herbert O. Stanley, Ijeoma F. Vincent-Akpu, Yusuf Momoh, Michael O. Eze

Chemistry Faculty Research & Creative Works

The most common approaches for the in-situ bioremediation of contaminated sites worldwide are bioaugmentation and bio stimulation. Bio stimulation has often proved more effective for chronically contaminated sites. This study examined the effectiveness of optimized water hyacinth compost in comparison with other organic and inorganic amendments for the remediation of crude oil-polluted soils. Water hyacinth was found to be rich in nutrients necessary to stimulate microbial growth and activity. an organic geochemical analysis revealed that all amendments in this study increased total petroleum hydrocarbon (TPH) biodegradation by ≥75% within 56 days, with the greatest biodegradation (93%) occurring in sterilized soil …

Correlated Dynamics Of Collective Droplet Excitations In A One-Dimensional Harmonic Trap, I. A. Englezos, Simeon I. Mistakidis, P. Schmelcher

Physics Faculty Research & Creative Works

We Address The Existence And Dynamics Of One-Dimensional Harmonically Confined Quantum Droplets Appearing In Two-Component Mixtures By Deploying A Nonperturbative Approach. We Find That, In Symmetric Homonuclear Settings, Beyond-Lee-Huang-Yang Correlations Result In Flat-Top Droplet Configurations For Either Decreasing Intercomponent Attraction Or Larger Atom Number. Asymmetric Mixtures Feature Spatial Mixing Among The Involved Components With The More Strongly Interacting Or Heavier One Exhibiting Flat-Top Structures. Applying Quenches On The Harmonic Trap We Trigger The Lowest-Lying Collective Droplet Excitations. The Interaction-Dependent Breathing Frequency, Being Slightly Reduced In The Presence Of Correlations, Shows A Decreasing Trend For Stronger Attractions. Semianalytical Predictions Are Also …

Curcumin Release From Biomaterials For Enhanced Tissue Regeneration Following Injury Or Disease, Adelle E. Hamilton, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin's effectiveness as a treatment and restricts its use in clinical applications. Furthermore, to achieve beneficial, clinically relevant results, high doses of curcumin are required for systemic administration. Many researchers have utilized biomaterial carriers, including electrospun fibers, nanoparticles, hydrogels, and composite scaffolds, to overcome curcumin's principle therapeutic limitation of low bioavailability. By using biomaterials to deliver curcumin directly …

Mathematical Modeling Of Microscale Biology: Ion Pairing, Spatially Varying Permittivity, And Born Energy In Glycosaminoglycan Brushes, William J. Ceely, Marina Chugunova, Ali Nadim, James D. Sterling

Business and Information Technology Faculty Research & Creative Works

Biological macromolecules including nucleic acids, proteins, and glycosaminoglycans are typically anionic and can span domains of up to hundreds of nanometers and even micron length scales. The structures exist in crowded environments that are dominated by multivalent electrostatic interactions that can be modeled using mean-field continuum approaches that represent underlying molecular nanoscale biophysics. We develop such models for glycosaminoglycan brushes using steady state modified Poisson-Boltzmann models that incorporate important ion-specific (Hofmeister) effects. The results quantify how electroneutrality is attained through ion electrophoresis, spatially varying permittivity hydration forces, and ion-specific pairing. Brush-salt interfacial profiles of the electrostatic potential as well as …

Salt Doping Of Hyaluronic Acid Glycopolymer Biocondensates, James D. Sterling, Lu Fu, Kenisha Pudun, Shenda Baker, Megan Lord, Henry E. Riggs

Business and Information Technology Faculty Research & Creative Works

Biocondensates are largely studied with regard to intracellular components, while recognition of the formation of extracellular biocondensates are emerging, such as for cell surface heparan sulfate binding with basic fibroblast growth factor. This study analyzed the formation of biocondensates in vitro between the ubiquitous extracellular component, hyaluronan an anionic glycosaminoglycan, and cationic derivitized polyglucosamines known to bind to mucosal interfaces. The effect of molecular weight and net charge ratio was studied using a combination of microscopy, turbidity, laser diffraction particle sizing and zeta potential measurements. These analyses revealed that molecular weight affected the ability to form biocondensates while the surface …

Rheological Characterization Of Ultra-High Performance Concrete For 3d Printing, Arun R. Arunothayan, Behzad Nematollahi, Kamal Khayat, Akilesh Ramesh, Jay G. Sanjayan

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The authors recently developed a 3D-printable ultra-high performance fiber-reinforced concrete (3DP-UHPFRC) for additive construction of structural members with significantly reduced reliance on steel bars. This study investigates the rheological behavior of the developed 3DP-UHPFRC. The effects of two major factors affecting the performance of 3DP-UHPFRC, namely steel fiber volume (0, 1%, and 2%) and nano-clay (NC) content (0, 0.1%, and 0.2% by binder mass) on workability, static yield stress, dynamic yield stress, and apparent viscosity were determined. Test results showed that the inclusion of steel fibers and NC reduced the workability and led to a significant increase in the static …

Effect Of Additional Water Or Superplasticizer On Key Characteristics Of Cement Paste Made With Superabsorbent Polymer And Other Shrinkage Mitigating Materials, Kamran Aghaee, Ricarda Sposito, Karl Christian Thienel, Kamal Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The use of superabsorbent polymer (SAP) coupled with expansive agent (EA) or shrinkage-reducing admixture (SRA) can effectively reduce shrinkage of cement-based materials. However, SAP particles at high contents can adversely affect rheological and mechanical properties. Securing proper workability can be accomplished by additional water or adjusting the superplasticizer (SP) demand. There is an uncertainty about the efficiency of these approaches to workability compensation. This study evaluates the effect of additional water or SP on key properties of cement paste made with SAP and relatively high content of EA or SRA. Macro and micro mechanisms underlying the effect of combined shrinkage …

Homogeneous Flow Performance Of Steel-Fiber Reinforced Self-Consolidating Concrete For Repair Application: A Biphasic Approach, Naimeh Nouri, Masoud Hosseinpoor, Ammar Yahia, Kamal Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

In this study, fiber-reinforced self-consolidating concrete (FR-SCC) was considered as a diphasic suspension of fiber and coarse aggregate (F-A ≥ 5 mm) skeleton in mortar suspension with solid particles finer than 5 mm. The coupled effect of the volumetric content of fibers, coarse aggregate particle-size distribution, and rheological properties of the mortar on the passing ability and dynamic stability of various FR-SCC mixtures was investigated. Nine high-strength and 10 conventional-strength FR-SCC mixtures for repair application were proportioned with water-to-binder ratios (W/B) of 0.35 and 0.42, respectively, and macro steel fibers of 0.1%–0.5% volumetric contents. The dosages of high-range water-reducer (HRWR) …

Student Voices That Resonate – Constructing Composite Narratives That Represent Students’ Classroom Experiences, Olivia Johnston, Helen Wildy, Jennifer Shand

Research outputs 2014 to 2021

Words and stories have the power to resonate with people. Composite narratives can be constructed using multiple participant accounts, representing their experiences while also capturing the properties and categories of qualitative research findings. The ability of composite narratives to represent the multiple facets of theory construction through a singular narrative point-of-view is unique and provides a concise and credible method to present research findings. This paper explains how composite narratives can be constructed to present the research data that findings are built upon through an illustrative example of the process. The example of a composite narrative presented in this article …

أثر استخدام تقنیة الاتصال عن بعد في المحاكمات الجزائیة على ضمانتي العلنیة والشفویة: دراسة مقارنة, الیازیة راشد السبوسي

Theses

Remote litigation is an application of modern technology that countries have established and added to the judicial system. Remote attendance appeared more at the time of the Corona pandemic, as the countries that had not previously used modern means in their judicial system have begun to advance it, and this is in contrast to the countries that used this system before the emergence of this pandemic. Among the pioneering countries in using remote communication technology is the UAE, where it started using this technology in 2017, that is three years before the pandemic, when the legislator enacted a special law. …

First-Principles Calculations On The Electronic Structure, Mechanical, Vibrational, And Thermal Properties Of The Ca₃Bin Antiperovskite Alloy, Reem Maher Mohamad

Theses

Antiperovskites are the counterparts of perovskites. They have diverse properties that make them physically rich and technologically relevant. In the recent years, the alkaline earth based antiperovskites, especially the ones with small semiconductor bandgap, have captured tremendous attention due to their properties which make them efficient to be used in optoelectronic and thermoelectric applications. In this thesis, we are shading light on the alkaline antiperovskite ����₃������ due to its narrow bandgap. Thus, it can be considered as a promising candidate for thermoelectric and optoelectronic applications. Specifically, it is used to harvest waste thermal energy into electricity at low …

Heat Transfer In Mini-Channel Heat Exchanger With Smooth And Pin-Fins Surfaces, Mohammed Molham Daadoua

Theses

This research aims to investigate heat transfer of single-phase and two-phase fluids in mini-channel heat exchanger with smooth and pin-fins surfaces. The main goal of the study is to develop a high-performance heat exchanger for thermal management in various processing applications. This research is carried out using computational fluid dynamics (CFD) modeling and experimentations. The proposed method is to use enhanced structured pin-fins surfaces in a mini-channel heat exchanger to improve heat transfer. The pin-fin microchannel heat exchanger is investigated using a CFD method with single-phase fluid (water, air). The experimental investigations are conducted using single-phase and two-phase fluid involving …

The Impact Of School-Based Intervention For Overweight And Obese 9-13-Year-Olds On Anthropometry, Nutrition Knowledge, Attitudes, Selfefficacy And Dietary Behaviors, Sara Zuarub

Dissertations

Childhood obesity has emerged as a significant public health concern in the United Arab Emirates (UAE). The study evaluated the effects of school-based nutrition education on knowledge, attitude, dietary practices, self-efficacy, and anthropometric measurements of overweight and obese school children aged 9-13 years. Additionally, the parents' perceptions on factors contributing to childhood obesity were examined. A 6-month intervention program based on Social Cognitive Theory (SCT) was undertaken by children from 36 public schools located in Dubai and Sharjah emirates, UAE. The overweight/obese school children (n = 403) were classified into three categories, including two intervention groups (1 and 2) and …

Practical Led-Based Spectral Imaging For Cultural Heritage Studio Photography, Olivia R. Kuzio

Theses

"Wouldn't it be better if 99% of institutions were working toward 99% accuracy, rather than 1% of institutions working toward 100% accuracy?" — John Barrett (Senior Photographer, Bodleian Libraries) during the AHFAP panel discussion "The Practical Implementation of Imaging Standards" in February 2022. In an increasingly virtual world, cultural heritage collections are more frequently experienced on a screen than in person. For especially precious or ephemeral works, reproductions may serve as the primary means of interacting with them. Often, series of works or related pieces are held in different collections, and it may be logistically complicated to exhibit them together …

Sex-Specific Hypnotic Effects Of The Neuroactive Steroid (3Β,5Β,17Β)-3-Hydroxyandrostane-17-Carbonitrile Are Mediated By Peripheral Metabolism Into An Active Hypnotic Steroid, Francesca M Manzella, Omar H Cabrera, Davis Wilkey, Brier Fine-Raquet, Jelena Klawitter, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic

2020-Current year OA Pubs

BACKGROUND: The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate neuronal γ-aminobutyric acid type A (GABA

METHODS: We used a combination of behavioural loss of righting reflex, neuroendocrine, pharmacokinetic, in vitro patch-clamp electrophysiology, and in vivo electrophysiological approaches in wild-type mice and in genetic knockouts of the Ca

RESULTS: Adult male mice were less sensitive to the hypnotic effects of 3β-OH compared with female mice, and these differences appeared during development. Adult males had higher 3β-OH brain concentrations despite being less sensitive to its hypnotic effects. Females metabolised 3β-OH into the active GABA …

Potassium Fertilizer Rate Recommendations: Does Accounting For Soil Stock Of Potassium Matter?, Kimberly B. Oliver, Michael P. Popp, Di Fang, John D. Anderson, Nathan A. Slaton, Gerson L. Drescher, Trenton L. Roberts, Jada Thompson

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Profitability, yield, and fertilizer use are compared across three different potassium (K) fertilizer rate recommendation ideologies. Existing agronomic, “build and maintain” rate recommendations (KE) are compared to profit-maximizing rates with and without taking long-run soil-test K (STK) implications into account. Regardless of starting STK, K use equilibrated over the course of 3 years irrespective of ideology. Since taking long-run STK into account did not alter ending STK and only led to a miniscule yield effect, we encourage producers to use annual profit-maximizing K rates that were 3–11% lower than KE rates and generated more profit with minimal yield loss.

The Tetraspanin Transmembrane Protein Cd53 Mediates Dyslipidemia And Integrates Inflammatory And Metabolic Signaling In Hepatocytes, Cassandra B Higgins, Joshua A Adams, Matthew H Ward, Zev J Greenberg, Małgorzata Milewska, Jiameng Sun, Yiming Zhang, Luana Chiquetto Paracatu, Qian Dong, Samuel Ballentine, Weikai Li, Ilona Wandzik, Laura G Schuettpelz, Brian J Debosch

2020-Current year OA Pubs

Tetraspanins are transmembrane signaling and proinflammatory proteins. Prior work demonstrates that the tetraspanin, CD53/TSPAN25/MOX44, mediates B-cell development and lymphocyte migration to lymph nodes and is implicated in various inflammatory diseases. However, CD53 is also expressed in highly metabolic tissues, including adipose and liver; yet its function outside the lymphoid compartment is not defined. Here, we show that CD53 demarcates the nutritional and inflammatory status of hepatocytes. High-fat exposure and inflammatory stimuli induced CD53 in vivo in liver and isolated primary hepatocytes. In contrast, restricting hepatocyte glucose flux through hepatocyte glucose transporter 8 deletion or through trehalose treatment blocked CD53 induction …

Estimating The Demand For Groundwater: A Second-Stage Hedonic Land Price Analysis For The Lower Mississippi River Alluvial Plain, Arkansas, Kent Kovacs, Sheby Rider

Agricultural Economics and Agribusiness Faculty Publications and Presentations

We estimate the benefits of the saturated thickness (water-bearing porous material) of the alluvial aquifer in Arkansas through an application of the hedonic price model to the sale of agricultural land. There is evidence from the first-stage analysis of diminishing returns from increasing saturated thickness. Using a survey of farmer operators’ preferences and socioeconomic characteristics, we recover the underlying demand function for saturated thickness in a second-stage analysis. Shifts in the demand function reveal that produced/social capital can be a substitute or a complement to saturated thickness, and human capital is a substitute for saturated thickness.

Is A Genetic Diathesis For Poor Nutrition Becoming More Crucial Due To The Uniformity Of Covid Social Stress?, M. Catherine Desoto

Faculty Publications

The important role of nutrition in proper neural functioning and mental health has seen wider acceptance, but is still sadly under recognized given the existent body of research. This Special Issue was designed to unite authoritative information on this topic in one volume. This editorial provides an overview of the issue, and suggests that the combination of social isolation, lack of exercise, and remaining indoors that overtook industrialized societies during 2020 are specific factors expected to change the Gene × Environment interactions for anxiety and depression. Importantly, the recent environmental changes may make biological diatheses for nutritional deficiencies even more …

Comparison Of Percentile Tables And Algorithm-Based Calculators For Classification Of Blood Pressures In Children And Adolescents With Obesity: A Secondary Analysis Of A Clinical Trial, William J Pitts, Tami L Cave, Alana Cavadino, Roman J Shypailo, Sarah E Maessen, Paul L Hofman, William Wong, Yvonne C Anderson

Faculty, Staff and Students Publications

AIM: Obesity as a major risk factor for childhood hypertension necessitates careful blood pressure (BP) monitoring of those affected. This study aimed to compare BP classification in a cohort of children affected by obesity using tables versus digital calculations in two sets of guidelines.

METHODS: This study was a secondary analysis of data collected from a randomised clinical trial of a multidisciplinary life-style assessment and intervention program. Baseline data from 237 children with a body mass index >99th percentile or >91st percentile with weight-related comorbidities and available BP measurements were analysed. We assessed agreement between tables and algorithms in classification …

The Behavioral Assessment Screening Tool For Mobile Health (Bastmhealth): Development And Compliance In Two Weeks Of Daily Reporting In Chronic Traumatic Brain Injury, Shannon B Juengst, Brittany Wright, Angelle M Sander, Samuel Preminger, Andrew Nabasny, Lauren Terhorst

Faculty, Staff and Students Publications

Objectives:

To develop and evaluate the feasibility of a short form of the Behavioral Assessment Screening Tool (BAST_mHealth) for high frequency in situ self-reported assessment of neurobehavioral symptoms using mobile health technology for community-dwelling adults with traumatic brain injury (TBI).

Design:

Prospective, repeated measures study of mHealth assessment of self-reported neurobehavioral symptoms in adults with and without a lifetime history of TBI over a two-week period.

Setting:

Community

Participants:

Community-dwelling adults with (n=52) and without (n=12) a lifetime TBI history consented to the study.

Interventions:

Not applicable

Main Outcome Measures:

BAST_mHealth subscales (2-items each): Negative Affect, Fatigue, …

A Case Report Of Subacute Combined Degeneration Due To Nitrous Oxide-Induced Vitamin B12 Deficiency, Jorge Nadal Bosch, Javier Malcolm, Mario Moya, Michael Menowsky, Roberto A. Cruz

School of Medicine Publications

Nitrous oxide, also known as “laughing gas,” is a naturally occurring gas that is colorless, odorless, nonflammable, and nontoxic. It has been used as an inhalant anesthetic in the medical field for more than 150 years for dental and surgical procedures. Due to its wide availability and ability to cause euphoria, its recreational use is on the rise. We present a case of subacute combined degeneration (SCD) due to nitrous oxide-induced vitamin B12 deficiency. The patient presented with bilateral lower extremity paresthesia, weakness, and ataxic gait. The patient was found to have vitamin B12 deficiency. An MRI of the cervical …

Toxin Induced Parkinsonism And Hospitalization Related Adverse Outcome Mitigation For Parkinson’S Disease: A Comprehensive Review, Kenneth R. Dalton, Charles J. Kidd, Nawaz Hack

School of Medicine Publications

Patients with Parkinson’s disease admitted to the hospital have unique presentations. This unique subset of patients requires a multidisciplinary approach with a knowledge-based care team that can demonstrate awareness of complications specific to Parkinson’s disease to reduce critical care admissions, morbidity, and mortality. Early recognition of toxic exposures, medication withdrawals, or medication-induced symptoms can reduce morbidity and mortality. This review can assist in the critical assessment of new or exacerbating Parkinson’s disease symptoms.

Association Of Lifestyle Behaviors With Non-Alcoholic Fatty Liver Disease And Advanced Fibrosis Detected By Transient Elastography Among Hispanic/Latinos Adults In The Us, Natalia I Heredia, Xiaotao Zhang, Maya Balakrishnan, Jessica P Hwang, Aaron P Thrift

Faculty, Staff and Students Publications

OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent liver disease, with the highest prevalence observed in the U.S. among Hispanic/Latino adults. While physical activity and dietary behaviors have established protective associations with NAFLD and its severity, these associations have not been well-characterized in Hispanic/Latino adults. The purpose of this study was to assess the association of lifestyle behaviors with NAFLD and advanced fibrosis in US Hispanic/Latino adults.

DESIGN: We selected all Hispanic/Latino adults from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). NAFLD was defined as CAP ≥285 dB/m, and advanced fibrosis as liver stiffness measurements ≥8.6 …

Genotype-Phenotype Relationships Of Truncating Mutations, Pe297g And Pd482g In Bile Salt Export Pump Deficiency, Antonia Felzen, Daan B E Van Wessel, Emmanuel Gonzales, Richard J Thompson, Irena Jankowska, Benjamin L Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Björn Fischler, Jan B F Hulscher, Daniele Serranti, Cigdem Arikan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Muñoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsőfi, Pier Luigi Calvo, Enke Grabhorn, Steffen Hartleif, Wendy J Van Der Woerd, Binita M Kamath, Jian-She Wang, Liting Li, Özlem Durmaz, Nanda Kerkar, Marianne Hørby Jørgensen, Ryan Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Noemie Laverdure, Cristina Targa Ferreira, Felipe Ordoñez Guerrero, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey-Ling Chen, Elisa De Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Aglaia Zellos, Estella M Alonso, Ronald J Sokol, Frederick J Suchy, Kathleen M Loomes, Patrick J Mckiernan, Philip Rosenthal, Yumirle Turmelle, Simon Horslen, Kathleen Schwarz, Jorge A Bezerra, Kasper Wang, Bettina E Hansen, Henkjan J Verkade, Natural Course And Prognosis Of Pfic And Effect Of Biliary Diversion (Napped) Consortium

Faculty, Staff and Students Publications

BACKGROUND & AIMS: Bile salt export pump (BSEP) deficiency frequently necessitates liver transplantation in childhood. In contrast to two predicted protein truncating mutations (PPTMs), homozygous p.D482G or p.E297G mutations are associated with relatively mild phenotypes, responsive to surgical interruption of the enterohepatic circulation (siEHC). The phenotype of patients with a compound heterozygous genotype of one p.D482G or p.E297G mutation and one PPTM has remained unclear. We aimed to assess their genotype-phenotype relationship.

METHODS: From the NAPPED database, we selected patients with homozygous p.D482G or p.E297G mutations (BSEP1/1; n = 31), with one p.D482G or p.E297G, and one PPTM (BSEP1/3; n …