Digital Commons Network^™

Validity And Reliability Of Inertial Measurement System For Linear Movement Velocity In Flywheel Squat Exercise, Sergio Maroto-Izquierdo, Kazunori Nosaka, Jesús Alarcón-Gómez, Fernando Martín-Rivera

Research outputs 2022 to 2026

The aim of this study was to examine the validity and reliability of an Inertial Measurement System integrated into a secondary pulley (IMS) for determining linear velocity during flywheel squat exercises. Thirty-one male participants who were highly experienced in a flywheel resistance exercise training performed flywheel squat exercises with three incremental loads, and mean velocity (MV), mean propulsive velocity (MPV) and max velocity (Vmax) of the exercises were simultaneously recorded with a validated linear encoder and the IMS, in two different sessions. Validity was analyzed using ordinary least products regression (OLP), Lin’s concordance correlation coefficient (CCC), and Hedge’s g for …

Search For Gamma-Ray And Neutrino Coincidences Using Hawc And Antares Data, H. A. Ayala Solares, S. Coutu, D. Cowen, D. B. Fox, T. Grégoire, F. Mcbride, M. Mostafá, K. Murase, S. Wissel, A. Albert, S. Alves, M. André, M. Ardid, S. Ardid, J. J. Aubert, J. Aublin, B. Baret, S. Basa, B. Belhorma, M. Bendahman, F. Benfenati, V. Bertin, S. Biagi, M. Bissinger, J. Boumaaza, M. Bouta, M. C. Bouwhuis, H. Branzas, R. Bruijn, J. Brunner, J. Busto, B. Caiffi, D. Calvo, A. Capone, L. Caramete, J. Carr, V. Carretero, S. Celli, M. Chabab, T. N. Chau, R. Cherkaoui El Moursli, T. Chiarusi, M. Circella, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. F. Diaz, G. De Wasseige, B. De Martino, C. Distefano, I. Di Palma, A. Domi, C. Donzaud, D. Dornic, D. Drouhin, T. Eberl, T. Van Eeden, D. Van Eijk, N. El Khayati, A. Enzenhofer, P. Fermani, G. Ferrara, F. Filippini, L. Fusco, J. Garcia, P. Gay, H. Glotin, R. Gozzini, R. Gracia Ruiz, K. Graf, C. Guidi, S. Hallmann, H. Van Haren, A. J. Heijboer, Y. Hello, J. J. Hernandez-Rey, J. Hobl, J. Hofestadt, F. Huang, G. Illuminati, C. W. James, B. Jisse-Jung, M. De Jong, P. De Jong, M. Kadler, O. Kalekin, U. Katz, A. Kouchner, I. Kreykenbohm, V. Kulikovskiy, R. Lahmann, M. Lamoureux, R. Le Breton, D. Lefevre, E. Leonora, G. Levi, S. Le Stum, D. Lopez-Coto, S. Loucatos, L. Maderer, J. Manczak, M. Marcelin, A. Margiotta, A. Marinelli, J. A. Martinez-Mora, K. Melis, P. Migliozzi, A. Moussa, R. Muller, L. Nauta, S. Navas, E. Nezri, B. O Fearraigh, A. Paun, G. E. Pavalas, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, C. Piore, V. Popa, T. Pradier, N. Randazzo, D. Real, S. Reck, G. Riccobene, A. Romanov, A. Sanchez-Losa, D. F. E. Samtleben, M. Sanguineti, P. Sapienza, J. Schnabel, J. Schumann, F. Schussler, J. Seneca, M. Spurio, Th. Stolarczyk, M. Taiuti, Y. Tayalati, S. J. Tingay, B. Vallage, V. Van Elewyck, F. Versari, S. Viola, D. Vivolo, J. Wilms, S. Zavatarelli, A. Zegarelli, J. D. Zornoza, J. Zuniga, A. Albert, C. Alvarez, J. C. Arteaga-Velazquez, R. Babu, E. Belmont-Moreno, K. S. Caballero-Mora, T. Capistran, A. Carraminana, S. Casanova, U. Cotti, O. Chaparro-Amaro, J. Cotzomi, S. Coutino De Leon, E. De La Fuenta, C. De Leon, R. Diaz Hernandez, M. A. Duvernois, M. Durocher, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, M. Fernandez Alonso, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, S. Kaufmann, A. Lara, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, I. Martinez-Castellanos, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, A. Nayerhoda, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, F. Salesa Greus, A. Sandoval, M. Schneider, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Varela, Xiaojie Wang, K. Whitaker, E. Willox, A. Zepeda, H. Zhou

Physics Faculty Research & Creative Works

In the quest for high-energy neutrino sources, the Astrophysical Mult messenger Observatory Network has implemented a new search by combining data from the High-Altitude Water Cherenkov (HAWC) Observatory and the Astronomy with a Neutrino Telescope and Abyss environmental RESearch (ANTARES) neutrino telescope. Using the same analysis strategy as in a previous detector combination of HAWC and IceCube data, we perform a search for coincidences in HAWC and ANTARES events that are below the threshold for sending public alerts in each individual detector. Data were collected between 2015 July and 2020 February with a live time of 4.39 yr. Over this …

Glass-Based Biodegradable Pressure Sensor Toward Biomechanical Monitoring With A Controllable Lifetime, Devdatt Chattopadhyay, Jonghyun Park, Chang-Soo Kim

Mechanical and Aerospace Engineering Faculty Research & Creative Works

A New Class of Potentially Implantable Solid-State Sensors is Demonstrated Utilizing Biodegradable Glass as the Main Structural Material. the Device Behavior is Manipulated Via Chemical Decomposition, and Then Physically Disintegrated in a Controlled Manner. It is based on the Capacitive Sensing Mechanism, Comprising an Elastic Insulator between Two Borate-Rich Glass Substrates. This Mesoscale Pressure Sensor is Characterized by a Range of Pressure of Up to 14 MPa in a Phosphate Buffer Solution Environment. the Sensor Exhibits Good Sensitivity and Reversibility Responding to Compressive Pressures and Remains Fully Functional Before a Desired, Sudden Failure Caused by Dissolution. the Operational Lifetime Can …

Selection Of Solidification Pathway In Rapid Solidification Processes, Nima Najafizadeh, Men G. Chu, Yijia Gu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Rapid Solidification Processing of Alloys Enables the Formation of Exotic Nonequilibrium Microstructures. However, the Interrelationship between the Processing Parameters and the Resulting Microstructure is Yet to Be Fully Understood. in Melt Spinning (MS) and Additive Manufacturing (AM) of Rapidly Solidified Alloys, Opposite Microstructure Development Sequences Were Observed. a Fine-To-Coarse Microstructural Transition is Typically Observed in Melt-Spun Ribbons, Whereas Melt Pools in AM Exhibit a Coarse-To-Fine Transition. in This Paper, the Microstructural Evolutions during These Two Processes Are Investigated using Phase-Field Modeling. the Variation of All Key Variables of the Solid-Liquid Interface (Temperature, Composition, and Velocity) throughout the Entire Rapid Solidification …

Biostimulation Of Petroleum-Contaminated Soil Using Organic And Inorganic Amendments, Ogochukwu A. Udume, Gideon O. Abu, Herbert O. Stanley, Ijeoma F. Vincent-Akpu, Yusuf Momoh, Michael O. Eze

Chemistry Faculty Research & Creative Works

The most common approaches for the in-situ bioremediation of contaminated sites worldwide are bioaugmentation and bio stimulation. Bio stimulation has often proved more effective for chronically contaminated sites. This study examined the effectiveness of optimized water hyacinth compost in comparison with other organic and inorganic amendments for the remediation of crude oil-polluted soils. Water hyacinth was found to be rich in nutrients necessary to stimulate microbial growth and activity. an organic geochemical analysis revealed that all amendments in this study increased total petroleum hydrocarbon (TPH) biodegradation by ≥75% within 56 days, with the greatest biodegradation (93%) occurring in sterilized soil …

Correlated Dynamics Of Collective Droplet Excitations In A One-Dimensional Harmonic Trap, I. A. Englezos, Simeon I. Mistakidis, P. Schmelcher

Physics Faculty Research & Creative Works

We Address The Existence And Dynamics Of One-Dimensional Harmonically Confined Quantum Droplets Appearing In Two-Component Mixtures By Deploying A Nonperturbative Approach. We Find That, In Symmetric Homonuclear Settings, Beyond-Lee-Huang-Yang Correlations Result In Flat-Top Droplet Configurations For Either Decreasing Intercomponent Attraction Or Larger Atom Number. Asymmetric Mixtures Feature Spatial Mixing Among The Involved Components With The More Strongly Interacting Or Heavier One Exhibiting Flat-Top Structures. Applying Quenches On The Harmonic Trap We Trigger The Lowest-Lying Collective Droplet Excitations. The Interaction-Dependent Breathing Frequency, Being Slightly Reduced In The Presence Of Correlations, Shows A Decreasing Trend For Stronger Attractions. Semianalytical Predictions Are Also …

Curcumin Release From Biomaterials For Enhanced Tissue Regeneration Following Injury Or Disease, Adelle E. Hamilton, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin's effectiveness as a treatment and restricts its use in clinical applications. Furthermore, to achieve beneficial, clinically relevant results, high doses of curcumin are required for systemic administration. Many researchers have utilized biomaterial carriers, including electrospun fibers, nanoparticles, hydrogels, and composite scaffolds, to overcome curcumin's principle therapeutic limitation of low bioavailability. By using biomaterials to deliver curcumin directly …

Mathematical Modeling Of Microscale Biology: Ion Pairing, Spatially Varying Permittivity, And Born Energy In Glycosaminoglycan Brushes, William J. Ceely, Marina Chugunova, Ali Nadim, James D. Sterling

Business and Information Technology Faculty Research & Creative Works

Biological macromolecules including nucleic acids, proteins, and glycosaminoglycans are typically anionic and can span domains of up to hundreds of nanometers and even micron length scales. The structures exist in crowded environments that are dominated by multivalent electrostatic interactions that can be modeled using mean-field continuum approaches that represent underlying molecular nanoscale biophysics. We develop such models for glycosaminoglycan brushes using steady state modified Poisson-Boltzmann models that incorporate important ion-specific (Hofmeister) effects. The results quantify how electroneutrality is attained through ion electrophoresis, spatially varying permittivity hydration forces, and ion-specific pairing. Brush-salt interfacial profiles of the electrostatic potential as well as …

Salt Doping Of Hyaluronic Acid Glycopolymer Biocondensates, James D. Sterling, Lu Fu, Kenisha Pudun, Shenda Baker, Megan Lord, Henry E. Riggs

Business and Information Technology Faculty Research & Creative Works

Biocondensates are largely studied with regard to intracellular components, while recognition of the formation of extracellular biocondensates are emerging, such as for cell surface heparan sulfate binding with basic fibroblast growth factor. This study analyzed the formation of biocondensates in vitro between the ubiquitous extracellular component, hyaluronan an anionic glycosaminoglycan, and cationic derivitized polyglucosamines known to bind to mucosal interfaces. The effect of molecular weight and net charge ratio was studied using a combination of microscopy, turbidity, laser diffraction particle sizing and zeta potential measurements. These analyses revealed that molecular weight affected the ability to form biocondensates while the surface …

Rheological Characterization Of Ultra-High Performance Concrete For 3d Printing, Arun R. Arunothayan, Behzad Nematollahi, Kamal Khayat, Akilesh Ramesh, Jay G. Sanjayan

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The authors recently developed a 3D-printable ultra-high performance fiber-reinforced concrete (3DP-UHPFRC) for additive construction of structural members with significantly reduced reliance on steel bars. This study investigates the rheological behavior of the developed 3DP-UHPFRC. The effects of two major factors affecting the performance of 3DP-UHPFRC, namely steel fiber volume (0, 1%, and 2%) and nano-clay (NC) content (0, 0.1%, and 0.2% by binder mass) on workability, static yield stress, dynamic yield stress, and apparent viscosity were determined. Test results showed that the inclusion of steel fibers and NC reduced the workability and led to a significant increase in the static …

Effect Of Additional Water Or Superplasticizer On Key Characteristics Of Cement Paste Made With Superabsorbent Polymer And Other Shrinkage Mitigating Materials, Kamran Aghaee, Ricarda Sposito, Karl Christian Thienel, Kamal Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The use of superabsorbent polymer (SAP) coupled with expansive agent (EA) or shrinkage-reducing admixture (SRA) can effectively reduce shrinkage of cement-based materials. However, SAP particles at high contents can adversely affect rheological and mechanical properties. Securing proper workability can be accomplished by additional water or adjusting the superplasticizer (SP) demand. There is an uncertainty about the efficiency of these approaches to workability compensation. This study evaluates the effect of additional water or SP on key properties of cement paste made with SAP and relatively high content of EA or SRA. Macro and micro mechanisms underlying the effect of combined shrinkage …

Homogeneous Flow Performance Of Steel-Fiber Reinforced Self-Consolidating Concrete For Repair Application: A Biphasic Approach, Naimeh Nouri, Masoud Hosseinpoor, Ammar Yahia, Kamal Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

In this study, fiber-reinforced self-consolidating concrete (FR-SCC) was considered as a diphasic suspension of fiber and coarse aggregate (F-A ≥ 5 mm) skeleton in mortar suspension with solid particles finer than 5 mm. The coupled effect of the volumetric content of fibers, coarse aggregate particle-size distribution, and rheological properties of the mortar on the passing ability and dynamic stability of various FR-SCC mixtures was investigated. Nine high-strength and 10 conventional-strength FR-SCC mixtures for repair application were proportioned with water-to-binder ratios (W/B) of 0.35 and 0.42, respectively, and macro steel fibers of 0.1%–0.5% volumetric contents. The dosages of high-range water-reducer (HRWR) …

Bzip Transcription Factors Repress The Expression Of Wheat (Triticum Aestivum L.) High Molecular Weight Glutenin Subunit Genes In Vegetative Tissues, Csaba Éva, Blanka Moncsek, Kitti Szőke-Pázsi, Viola Kunos, Klára Mészáros, Szabolcs Makai, László Sági, Angéla Juhász

Research outputs 2022 to 2026

High molecular weight glutenin subunits (HMW GS) represent an important fraction of endosperm-specific seed-storage proteins that provide elasticity to bread dough. Previously, the second cis-regulatory module (CRM2) was found to be one of the most conserved part of HMW GS promoters, which indicated its pre-eminent role in their gene regulation. Here, we observed that deletion of CRM2 from the promoters of the Bx7 and By8 HMW GS genes increased the leakage of their transient expression in wheat leaf tissue. The effect of a VP1, an Myb and an antisense bZIP transcription factor (TF)-binding site, potentially involved in endosperm-specific regulation within …

Keeping The Family: A Socio-Ecological Perspective On The Challenges Of Child Removal And Reunification For Mothers Who Have Experienced Substance-Related Harms, Julie Dare, Celia Wilkinson, Shantha P. Karthigesu, David A. Coall, Ruth Marquis

Research outputs 2022 to 2026

The challenges and experiences associated with child removal and reunification from the perspective of mothers experiencing substance-related harms is under-researched in Australia. Our qualitative study employed a socio-ecological model to better understand the background to child removal, and perceived barriers and facilitators to achieving reunification of mother and child. In-depth interviews were conducted with 16 women, 8 of whom self-identified as Australian First Nations People. At the time of the interviews, these women were either living in substance use rehabilitation facilities, their own home or with relatives. Findings highlighted a history of complex disadvantage and trauma among the women, along …

Student Voices That Resonate – Constructing Composite Narratives That Represent Students’ Classroom Experiences, Olivia Johnston, Helen Wildy, Jennifer Shand

Research outputs 2014 to 2021

Words and stories have the power to resonate with people. Composite narratives can be constructed using multiple participant accounts, representing their experiences while also capturing the properties and categories of qualitative research findings. The ability of composite narratives to represent the multiple facets of theory construction through a singular narrative point-of-view is unique and provides a concise and credible method to present research findings. This paper explains how composite narratives can be constructed to present the research data that findings are built upon through an illustrative example of the process. The example of a composite narrative presented in this article …

أثر استخدام تقنیة الاتصال عن بعد في المحاكمات الجزائیة على ضمانتي العلنیة والشفویة: دراسة مقارنة, الیازیة راشد السبوسي

Theses

Remote litigation is an application of modern technology that countries have established and added to the judicial system. Remote attendance appeared more at the time of the Corona pandemic, as the countries that had not previously used modern means in their judicial system have begun to advance it, and this is in contrast to the countries that used this system before the emergence of this pandemic. Among the pioneering countries in using remote communication technology is the UAE, where it started using this technology in 2017, that is three years before the pandemic, when the legislator enacted a special law. …

First-Principles Calculations On The Electronic Structure, Mechanical, Vibrational, And Thermal Properties Of The Ca₃Bin Antiperovskite Alloy, Reem Maher Mohamad

Theses

Antiperovskites are the counterparts of perovskites. They have diverse properties that make them physically rich and technologically relevant. In the recent years, the alkaline earth based antiperovskites, especially the ones with small semiconductor bandgap, have captured tremendous attention due to their properties which make them efficient to be used in optoelectronic and thermoelectric applications. In this thesis, we are shading light on the alkaline antiperovskite ����₃������ due to its narrow bandgap. Thus, it can be considered as a promising candidate for thermoelectric and optoelectronic applications. Specifically, it is used to harvest waste thermal energy into electricity at low …

Heat Transfer In Mini-Channel Heat Exchanger With Smooth And Pin-Fins Surfaces, Mohammed Molham Daadoua

Theses

This research aims to investigate heat transfer of single-phase and two-phase fluids in mini-channel heat exchanger with smooth and pin-fins surfaces. The main goal of the study is to develop a high-performance heat exchanger for thermal management in various processing applications. This research is carried out using computational fluid dynamics (CFD) modeling and experimentations. The proposed method is to use enhanced structured pin-fins surfaces in a mini-channel heat exchanger to improve heat transfer. The pin-fin microchannel heat exchanger is investigated using a CFD method with single-phase fluid (water, air). The experimental investigations are conducted using single-phase and two-phase fluid involving …

The Impact Of School-Based Intervention For Overweight And Obese 9-13-Year-Olds On Anthropometry, Nutrition Knowledge, Attitudes, Selfefficacy And Dietary Behaviors, Sara Zuarub

Dissertations

Childhood obesity has emerged as a significant public health concern in the United Arab Emirates (UAE). The study evaluated the effects of school-based nutrition education on knowledge, attitude, dietary practices, self-efficacy, and anthropometric measurements of overweight and obese school children aged 9-13 years. Additionally, the parents' perceptions on factors contributing to childhood obesity were examined. A 6-month intervention program based on Social Cognitive Theory (SCT) was undertaken by children from 36 public schools located in Dubai and Sharjah emirates, UAE. The overweight/obese school children (n = 403) were classified into three categories, including two intervention groups (1 and 2) and …

Models Of School Breakfast Program Implementation In Western Australia And The Implications For Supporting Disadvantaged Students, Susan M. Hill, Matthew F. Byrne, Elizabeth Wenden, Amanda Devine, Margaret Miller, Henrietta Quinlan, Donna Cross, Judy Eastham, Miranda Chester

Research outputs 2022 to 2026

A substantial body of literature points to the educational and social benefits of school breakfast programs. Most high-income countries provide free or subsidized school breakfasts to support disadvantaged children. Australia does not have a nationally-funded school meal program. Instead, charitable organizations offer school breakfast programs on a voluntary basis, often with funding support from state/territory governments. Decisions about participating in a school breakfast program (SBP), which students to support, and the degree of integration with other strategies to support disadvantaged students are made at the school level. This large-scale, multi-year study examined models of SBP implementation in Western Australian (WA) …

Woman-Centred Ethics: A Feminist Participatory Action Research [Journal Article], Kate Buchanan, Sadie Geraghty, Lisa Whitehead, Elizabeth Newnham

Research outputs 2022 to 2026

Introduction: Contemporary ethical issues in the maternity system are nuanced, complex and layered. Medicalisation and the reported rise in incidence of mistreatment and birth trauma, has been described as unethical. Some authors suggest bioethical principles are limited in terms of guiding everyday care of pregnancy and birth. There is currently no known published research which explores what birthing people say is ethical. Aims: This study sought to explore women's experience of maternity care from an ethical perspective. Method: A Feminist Participatory Action Research (FPAR) was conducted over three years, in two phases. A Community Action Research Group (CARG) was formed …

Episodic Memory Dysfunction And Hypersynchrony In Brain Functional Networks In Cognitively Intact Subjects And Mci: A Study Of 379 Individuals, Brenda Chino, Pablo Cuesta, Javier Pacios, Jaisalmer De Frutos-Lucas, Lucía Torres-Simón, Sandra Doval, Alberto Marcos, Ricardo Bruña, Fernando Maestú

Research outputs 2022 to 2026

Delayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer’s disease (AD). Changes in brain functional connectivity (FC) could accompany this decline in the DR performance even in a resting state condition from the preclinical stages to the diagnosis of AD itself, so the characterization of the relationship between the two phenomena has attracted increasing interest. Another aspect to contemplate is the potential moderator role of the APOE genotype in this association, considering the evidence about their implication for the disease. 379 subjects (118 mild cognitive impairment (MCI) and 261 cognitively intact …

Practical Led-Based Spectral Imaging For Cultural Heritage Studio Photography, Olivia R. Kuzio

Theses

"Wouldn't it be better if 99% of institutions were working toward 99% accuracy, rather than 1% of institutions working toward 100% accuracy?" — John Barrett (Senior Photographer, Bodleian Libraries) during the AHFAP panel discussion "The Practical Implementation of Imaging Standards" in February 2022. In an increasingly virtual world, cultural heritage collections are more frequently experienced on a screen than in person. For especially precious or ephemeral works, reproductions may serve as the primary means of interacting with them. Often, series of works or related pieces are held in different collections, and it may be logistically complicated to exhibit them together …

Sex-Specific Hypnotic Effects Of The Neuroactive Steroid (3Β,5Β,17Β)-3-Hydroxyandrostane-17-Carbonitrile Are Mediated By Peripheral Metabolism Into An Active Hypnotic Steroid, Francesca M Manzella, Omar H Cabrera, Davis Wilkey, Brier Fine-Raquet, Jelena Klawitter, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic

2020-Current year OA Pubs

BACKGROUND: The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate neuronal γ-aminobutyric acid type A (GABA

METHODS: We used a combination of behavioural loss of righting reflex, neuroendocrine, pharmacokinetic, in vitro patch-clamp electrophysiology, and in vivo electrophysiological approaches in wild-type mice and in genetic knockouts of the Ca

RESULTS: Adult male mice were less sensitive to the hypnotic effects of 3β-OH compared with female mice, and these differences appeared during development. Adult males had higher 3β-OH brain concentrations despite being less sensitive to its hypnotic effects. Females metabolised 3β-OH into the active GABA …

Modulation Of Trpv4 Protects Against Degeneration Induced By Sustained Loading And Promotes Matrix Synthesis In The Intervertebral Disc, Garrett W D Easson, Alireza Savadipour, Akila Anandarajah, Leanne E Iannucci, Spencer P Lake, Farshid Guilak, Simon Y Tang

2020-Current year OA Pubs

While it is well known that mechanical signals can either promote or disrupt intervertebral disc (IVD) homeostasis, the molecular mechanisms for transducing mechanical stimuli are not fully understood. The transient receptor potential vanilloid 4 (TRPV4) ion channel activated in isolated IVD cells initiates extracellular matrix (ECM) gene expression, while TRPV4 ablation reduces cytokine production in response to circumferential stretching. However, the role of TRPV4 on ECM maintenance during tissue-level mechanical loading remains unknown. Using an organ culture model, we modulated TRPV4 function over both short- (hours) and long-term (days) and evaluated the IVDs' response. Activating TRPV4 with the agonist GSK101 …

The Ntpase Activity Of The Double Fyve Domain-Containing Protein 1 Regulates Lipid Droplet Metabolism., Victoria A. Ismail, Teri Naismith, David J. Kast

2020-Current year OA Pubs

Lipid droplets (LDs) are transient lipid storage organelles that can be readily tapped to resupply cells with energy or lipid building blocks and therefore play a central role in cellular metabolism. However, the molecular factors and underlying mechanisms that regulate the growth and degradation of LDs are poorly understood. It has emerged that proteins that establish contacts between LDs and the endoplasmic reticulum play a critical role in regulating LD metabolism. Recently, the autophagy-related protein, double FYVE domain-containing protein 1 (DFCP1/ZFYVE1) was shown to reside at the interface of the endoplasmic reticulum and LDs, however, little is known about the …

Potassium Fertilizer Rate Recommendations: Does Accounting For Soil Stock Of Potassium Matter?, Kimberly B. Oliver, Michael P. Popp, Di Fang, John D. Anderson, Nathan A. Slaton, Gerson L. Drescher, Trenton L. Roberts, Jada Thompson

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Profitability, yield, and fertilizer use are compared across three different potassium (K) fertilizer rate recommendation ideologies. Existing agronomic, “build and maintain” rate recommendations (KE) are compared to profit-maximizing rates with and without taking long-run soil-test K (STK) implications into account. Regardless of starting STK, K use equilibrated over the course of 3 years irrespective of ideology. Since taking long-run STK into account did not alter ending STK and only led to a miniscule yield effect, we encourage producers to use annual profit-maximizing K rates that were 3–11% lower than KE rates and generated more profit with minimal yield loss.

The Tetraspanin Transmembrane Protein Cd53 Mediates Dyslipidemia And Integrates Inflammatory And Metabolic Signaling In Hepatocytes, Cassandra B Higgins, Joshua A Adams, Matthew H Ward, Zev J Greenberg, Małgorzata Milewska, Jiameng Sun, Yiming Zhang, Luana Chiquetto Paracatu, Qian Dong, Samuel Ballentine, Weikai Li, Ilona Wandzik, Laura G Schuettpelz, Brian J Debosch

2020-Current year OA Pubs

Tetraspanins are transmembrane signaling and proinflammatory proteins. Prior work demonstrates that the tetraspanin, CD53/TSPAN25/MOX44, mediates B-cell development and lymphocyte migration to lymph nodes and is implicated in various inflammatory diseases. However, CD53 is also expressed in highly metabolic tissues, including adipose and liver; yet its function outside the lymphoid compartment is not defined. Here, we show that CD53 demarcates the nutritional and inflammatory status of hepatocytes. High-fat exposure and inflammatory stimuli induced CD53 in vivo in liver and isolated primary hepatocytes. In contrast, restricting hepatocyte glucose flux through hepatocyte glucose transporter 8 deletion or through trehalose treatment blocked CD53 induction …

The Insurance Landscape For Implant- And Autologous-Based Breast Reconstruction In The United States, Louisa C. Boyd, Jason A. Greenfield, Sravya S. Ainapurapu, Rachel Skladman, Gary Skolnick, Durai Sundaramoorthi, Justin M. Sacks

2020-Current year OA Pubs

UNLABELLED: Insurance coverage of postmastectomy breast reconstruction is mandated in America, regardless of reconstructive modality. Despite enhanced patient-reported outcomes, autologous reconstruction is utilized less than nonautologous reconstruction nationally. Lower reimbursement from Medicare and Medicaid may disincentivize autologous-based reconstruction. This study examines the impact of insurance and sociodemographic factors on breast reconstruction.

METHODS: A retrospective analysis of the Healthcare Cost and Utilization Project National Inpatient Sample Database from 2014 to 2017 was performed. International Classification of Diseases Clinical Modification and Procedure Coding System codes were used to identify patients for inclusion. De-identified sociodemographic and insurance data were analyzed using

RESULTS: In …

Estimating The Demand For Groundwater: A Second-Stage Hedonic Land Price Analysis For The Lower Mississippi River Alluvial Plain, Arkansas, Kent Kovacs, Sheby Rider

Agricultural Economics and Agribusiness Faculty Publications and Presentations

We estimate the benefits of the saturated thickness (water-bearing porous material) of the alluvial aquifer in Arkansas through an application of the hedonic price model to the sale of agricultural land. There is evidence from the first-stage analysis of diminishing returns from increasing saturated thickness. Using a survey of farmer operators’ preferences and socioeconomic characteristics, we recover the underlying demand function for saturated thickness in a second-stage analysis. Shifts in the demand function reveal that produced/social capital can be a substitute or a complement to saturated thickness, and human capital is a substitute for saturated thickness.