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Titan Success: Faculty Behind The Scenes, February, Thorpe Center

Publications from the Associate Deans

No abstract provided.

Understanding And Improving Older People’S Well-Being Through Social Prescribing Involving The Cultural Sector: Interviews From A Realist Evaluation, Jordan Gorenberg, Stephanie Tierney, Geoff Wong, Amadea Turk, Sebastien Libert, Caroline Potter, Kathryn Eccles, Shona Forster, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth Mcdougall, Harriet Warburton, Lucy Shaw, Kamal R. Mahtani

Peninsula Medical School

Social prescribing is a non-clinical approach to addressing social, environmental, and economic factors affecting how people feel physical and/or emotionally. It involves connecting people to ?community assets? (e.g., local groups, organizations, and charities) that can contribute to positive well-being. We sought to explain in what ways, for whom, and why the cultural sector can support social prescribing with older people. We conducted semi-structured interviews with 28 older people (aged 60+) and 25 cultural sector staff. The following nine concepts, developed from interview data, progressed the understanding of tailoring cultural offers, which came from our previous realist review?immersion, buddying, café culture, …

Forgotten Brother Reuben Lewis: Missouri River Fur Trader And Indian Agent For The Arkansas Cherokees, Jay H. Buckley, Deveney Reber

Faculty Publications

Reuben Lewis was born in 1777, the fourth and youngest child of William Lewis and Lucy Meriwether. Their oldest child, Jane, married and lived out her days at Locust Hill, the family estate in Virginia. The Lewis’ second child, baby Lucinda, died in infancy. Their third child, Meriwether – the closest in age and friendship to Reuben – became the famous first half of the Lewis and Clark Expedition which explored the uncharted West before he met his tragic and mysterious death on the Natchez Trace in Tennessee. While Reuben’s life has been rightly overshadowed by his older brother Meriwether’s …

Da Principio: Ancorando L'Etica All'evento Della Creazione, Davide Sciarabba

Faculty Publications

No abstract provided.

Ash Aerosol Particle Size Distribution, Composition, And Deposition Behavior While Co-Firing Coal And Steam-Exploded Biomass In A 1.5 Mwth Combustor, Rajarshi Roy, Brian Schooff, Xiaolong Li, Scott Montgomery, Jacob Tuttle, Jost O.L. Wendt, Kingsley Dickson, Brian Iverson, Andrew R. Fry

Faculty Publications

Five different blends of Utah bituminous coal and steam-exploded pine (100/0, 75/25, 50/50, 25/75, 0/100 by mass) were fired in a 1.5 MWth combustor. Primary objectives were to understand mineral matter behavior by analyzing aerosol size distribution, aerosol size-segregated composition, ash deposition mass, and ash composition. For particle size < 0.1 μm, pure coal had the lowest aerosol concentration and pure biomass showed the highest (higher nucleation of potassium salts), a trend which reversed for particles >0.1 μm. During pure biomass combustion, aerosol particles >15 μm contained higher mass fractions of potassium (+126%), calcium (+132%), and iron (+115%) and lower fractions of aluminum (−49%) and silicon (−29%) than pure coal. Ash deposition mass decreased with increasing biomass blends. …

Minerals And Memories: Ireland's Ballrooms Of Romance, Tanya Dean

Articles

No abstract provided.

Overexpression Of Both Human Sodium Iodide Symporter (Nis) And Brg1-Bromodomain Synergistically Enhances Radioiodine Sensitivity By Stabilizing P53 Through Npm1 Expression, J Na, C-H Lee, J-K Chung, H Youn

Peninsula Medical School

Improved therapeutic strategies are required to minimize side effects associated with radioiodine gene therapy to avoid unnecessary damage to normal cells and radiation-induced secondary malignancies. We previously reported that codon-optimized sodium iodide symporter (oNIS) enhances absorption of I-131 and that the brahma-associated gene 1 bromodomain (BRG1-BRD) causes inefficient DNA damage repair after high-energy X-ray therapy. To increase the therapeutic effect without applying excessive radiation, we considered the combination of oNIS and BRG1-BRD as gene therapy for the most effective radioiodine treatment. The antitumor effect of I-131 with oNIS or oNIS+BRD expression was examined by tumor xenograft models along with functional …

Phenomics Enables Measurement Of Complex Responses Of Developing Animals To Global Environmental Drivers, Oliver Tills, Luke A. Holmes, Elliot Quinn, Tony Everett, Manuela Truebano, John I. Spicer

School of Biological and Marine Sciences

Phenomics offers technological advances for high-dimensional phenotyping, facilitating rapid, high-throughput assessment of physiological performance and has proven invaluable in global research challenges including drug discovery and food security. However, this rapidly growing discipline has remained largely inaccessible to the increasingly urgent challenge of assessing organismal functional sensitivity to global change drivers. Here, we investigate the response of an ecologically important marine invertebrate to multiple environmental drivers using Energy Proxy Traits (EPTs), a new approach for measuring complex phenotypes captured on video as a spectrum of energy levels across different temporal frequencies in fluctuating pixel values. We imaged three developmental stages …

Real-World Covid-19 Vaccine Effectiveness Against The Omicron Ba.2 Variant In A Sars-Cov-2 Infection-Naive Population, Jonathan J Lau, Chao Wu, Gaya K Amarasinghe, Et Al.

2020-Current year OA Pubs

The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and escape of vaccine-derived immunity. Although first-generation vaccines remain effective against severe disease and death, robust evidence on vaccine effectiveness (VE) against all Omicron infections, irrespective of symptoms, remains sparse. We used a community-wide serosurvey with 5,310 subjects to estimate how vaccination histories modulated risk of infection in infection-naive Hong Kong during a large wave of Omicron BA.2 epidemic in January-July 2022. We estimated that Omicron infected 45% (41-48%) of the local population. Three and four doses of BNT162b2 or CoronaVac were effective against Omicron infection 7 days after vaccination (VE of …

Navigating Care For Rare Diseases: Caregiver And Patient Advice For Families And Clinicians Managing Care For Vascular Malformations, Anna M Kerr, Christine Bereitschaft, Kayla M Duty, Bryan A Sisk

2020-Current year OA Pubs

OBJECTIVE: Families affected by rare diseases face many challenges finding adequate care and often report poor communication with clinicians. In the current study, we explore patient and caregiver advice for families and clinicians in the context of complex vascular malformations (VMs), a condition that is frequently misunderstood and misdiagnosed.

METHODS: We performed semi-structured interviews with 21 adult patients with complex VMs and 24 caregivers of children with VMs. We analyzed the transcripts using thematic analysis.

RESULTS: Participants advised patients and caregivers to advocate for care, address mental and emotional well-being, seek social support, and promote self-management and self-care. Participants advised …

Citation Impact And Reach Of The Ioc Sport And Exercise Medicine Consensus Statements, Lauren V. Fortington, Rebecca N. Handcock, Wayne Derman, Carolyn A. Emery, Kati Pasanen, Martin Schwellnus, Evert Verhagen, Caroline F. Finch

Research outputs 2022 to 2026

Background: Research evidence is commonly compiled into expert-agreed consensus statements or guidelines, with an increasing trend towards their publication in peer-reviewed journals. Prominent among these has been the publication of several International Olympic Committee (IOC) tatements to help inform sport and exercise medicine (SEM) practice. This study aimed to assess the citation impact and reach of the IOC statements published between 2003 and 2020. Method: Bibliometric analysis focused on identifying core publications (original statement and linked publications) and quantifying their academic citations (number and Field-Weighted Citation Impact (FWCI)) in journal articles up to February 2022. The analysis includes descriptive data …

Prediction Models Of Shielding Effectiveness Of Carbon Fibre Reinforced Cement-Based Composites Against Electromagnetic Interference, Shilpa Narayanan, Yifan Zhang, Farhad Aslani

Research outputs 2022 to 2026

With the rapid development of communication technology as well as a rapid rise in the usage of electronic devices, a growth of concerns over unintentional electromagnetic interference emitted by these devices has been witnessed. Pioneer researchers have deeply studied the relationship between the shielding effectiveness and a few mixed design parameters for cementitious composites incoporating carbon fibres by conducting physical experiments. This paper, therefore, aims to develop and propose a series of prediction models for the shielding effectiveness of cementitious composites involving carbon fibres using frequency and mixed design parameters, such as the water-to-cement ratio, fibre content, sand-to-cement ratio and …

Site Selection Of Combined Offshore Wind And Wave Energy Farms: A Systematic Review, Shabnam Hosseinzadeh, Amir Etemad-Shahidi, Rodney A. Stewart

Research outputs 2022 to 2026

Growing energy demand worldwide and onshore limitations have increased interest in offshore renewable energy exploitation. A combination of offshore renewable energy resources such as wind and wave energy can produce stable power output at a lower cost compared to a single energy source. Consequently, identifying the best locations for constructing combined offshore renewable energy farms is crucial. This paper investigates the technical, economic, social, and environmental aspects of Combined Offshore Wind and Wave Energy Farm (COWWEF) site selection. Past literature was evaluated using a systematic review method to synthesize, criticize, and categorize study regions, dataset characteristics, constraints, evaluation criteria, and …

Machine Learning Approximations To Predict Epigenetic Age Acceleration In Stroke Patients, Isabel Fernández-Pérez, Joan Jiménez-Balado, Uxue Lazcano, Eva Giralt-Steinhauer, Lucía Rey Álvarez, Elisa Cuadrado-Godia, Ana Rodríguez-Campello, Adrià Macias-Gómez, Antoni Suárez-Pérez, Anna Revert-Barberá, Isabel Estragués-Gázquez, Carolina Soriano-Tarraga, Jaume Roquer, Angel Ois, Jordi Jiménez-Conde

2020-Current year OA Pubs

Age acceleration (Age-A) is a useful tool that is able to predict a broad range of health outcomes. It is necessary to determine DNA methylation levels to estimate it, and it is known that Age-A is influenced by environmental, lifestyle, and vascular risk factors (VRF). The aim of this study is to estimate the contribution of these easily measurable factors to Age-A in patients with cerebrovascular disease (CVD), using different machine learning (ML) approximations, and try to find a more accessible model able to predict Age-A. We studied a CVD cohort of 952 patients with information about VRF, lifestyle habits, …

Autophagy Requirements For Eye Lens Differentiation And Transparency, Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A Sue Menko, S Amer Riazuddin, Alan Shiels, Marc Kantorow

2020-Current year OA Pubs

Recent evidence points to autophagy as an essential cellular requirement for achieving the mature structure, homeostasis, and transparency of the lens. Collective evidence from multiple laboratories using chick, mouse, primate, and human model systems provides evidence that classic autophagy structures, ranging from double-membrane autophagosomes to single-membrane autolysosomes, are found throughout the lens in both undifferentiated lens epithelial cells and maturing lens fiber cells. Recently, key autophagy signaling pathways have been identified to initiate critical steps in the lens differentiation program, including the elimination of organelles to form the core lens organelle-free zone. Other recent studies using ex vivo lens culture …

Identification Of Bradycardia Following Remdesivir Administration Through The Us Food And Drug Administration American College Of Medical Toxicology Covid-19 Toxic Pharmacovigilance Project, Jason M Devgun, Rongmei Zhang, Jeffrey Brent, Paul Wax, Keith Burkhart, Alison Meyn, Sharan Campleman, Stephanie Abston, Kim Aldy, Toxicology Investigators Consortium Fact Study Group

2020-Current year OA Pubs

IMPORTANCE: The rapid spread and mortality associated with COVID-19 emphasized a need for surveillance system development to identify adverse events (AEs) to emerging therapeutics. Bradycardia is a remdesivir infusion-associated AE listed in the US Food and Drug Administration-approved prescribing information.

OBJECTIVE: To evaluate the magnitude and duration of bradycardic events following remdesivir administration.

DESIGN, SETTING, AND PARTICIPANTS: A multicenter cohort study of patients with recorded heart rate less than 60 beats per minute within 24 hours after administration of a remdesivir dose was conducted between November 23, 2020, and October 31, 2021. Participants included patients hospitalized with COVID-19 at 15 …

Transeuntis Mundi, A Nomadic Artistic Practice, Cândida Luiza Borges Da Silva

School of Law, Humanities and Social Sciences Theses

In this practice-led Ph.D. research, I investigate how an artistic practice can respond to the migration phenomena performed by human beings across the planet over millennia ¬– what I refer to as the millennial global human journey. Based on the idea of mobility, I chose to frame this research in the articulation of concepts deriving from the prefix trans: transculture, transhumance and transmediality. This research contributes to studies in art composition by developing the processes and concept of transmedial composition, mainly contributing to the field of New Media Art. This investigation resulted in the work Transeuntis Mundi (TM) Project – …

The Effects Of Robot Voices And Appearances On Users' Emotion Recognition And Subjective Perception, Sangjin Ko, Jaclyn A. Barnes, Jiayuan Dong, Chung Hyuk Park, Ayanna Howard, Myounghoon Jeon

Michigan Tech Publications, Part 1

As the influence of social robots in people's daily lives grows, research on understanding people's perception of robots including sociability, trust, acceptance, and preference becomes more pervasive. Research has considered visual, vocal, or tactile cues to express robots' emotions, whereas little research has provided a holistic view in examining the interactions among different factors influencing emotion perception. We investigated multiple facets of user perception on robots during a conversational task by varying the robots' voice types, appearances, and emotions. In our experiment, 20 participants interacted with two robots having four different voice types. While participants were reading fairy tales to …

Selectively Modified Lactose And N-Acetyllactosamine Analogs At Three Key Positions To Afford Effective Galectin-3 Ligands †, Shuay Abdullayev, Priyanka Dipak Kadav, Purnima Bandyopadhyay, Francisco Javier Medrano, Gabriel A. Rabinovich, Tarun K. Dam, Antonio Romero, René Roy

Michigan Tech Publications, Part 1

Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in inflammatory diseases. Lactose ((β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose, Lac) and N-Acetyllactosamine (2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose, LacNAc) have been widely exploited as ligands for a wide range of galectins, sometimes with modest selectivity. Even though several chemical modifications at single positions of the sugar rings have been applied to these ligands, very few examples combined the simultaneous modifications at key positions known to increase both affinity and selectivity. We report herein combined modifications at the anomeric position, C-2, and O-3′ of each of the two …

Fibroblast-Generated Extracellular Matrix Guides Anastomosis During Wound Healing In An Engineered Lymphatic Skin Flap, Alvis Chiu, Wenkai Jia, Yumeng Sun, Jeremy Goldman, Feng Zhao

Michigan Tech Publications, Part 1

A healthy lymphatic system is required to return excess interstitial fluid back to the venous circulation. However, up to 49% of breast cancer survivors eventually develop breast cancer-related lymphedema due to lymphatic injuries from lymph node dissections or biopsies performed to treat cancer. While early-stage lymphedema can be ameliorated by manual lymph drainage, no cure exists for late-stage lymphedema when lymph vessels become completely dysfunctional. A viable late-stage treatment is the autotransplantation of functional lymphatic vessels. Here we report on a novel engineered lymphatic flap that may eventually replace the skin flaps used in vascularized lymph vessel transfers. The engineered …

Utilization Of Mechanically Recycled Carbon Fibers In Vinyl Ester Composites, Khaled Alharmoodi, Amir Hussain Idrisi, Abdel Hamid Ismail Mourad, Basim Abu-Jdayil

Michigan Tech Publications, Part 1

As we enter the twenty-first century, the aviation sector is expected to thrive as flying becomes the primary mode of transportation between states or nations. With such a demand, there is a corresponding need to manufacture aircraft components. The study focused on recycling carbon fiber composites received from the STRATA company, which were cut-off/waste material generated during the manufacture of airplane components. The cut-offs were then reduced to powder form using a standard face milling machine in three sizes (90, 150, and 250 µm). After, the powder was utilized to fabricate vinyl ester composites with four weight percentages (10%, 20%, …

A Catalog Of The Highest-Energy Cosmic Rays Recorded During Phase I Of Operation Of The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, P. Allison, K. Almeida Cheminant, J. Chirinos, B. Fick, D. Nitz, I. Norwood, A. Puyleart, Et Al.

Michigan Tech Publications, Part 1

A catalog containing details of the highest-energy cosmic rays recorded through the detection of extensive air showers at the Pierre Auger Observatory is presented with the aim of opening the data to detailed examination. Descriptions of the 100 showers created by the highest-energy particles recorded between 2004 January 1 and 2020 December 31 are given for cosmic rays that have energies in the range 78-166 EeV. Details are also given on a further nine very energetic events that have been used in the calibration procedure adopted to determine the energy of each primary. A sky plot of the arrival directions …

An Assessment Of Blood Vessel Remodeling Of Nanofibrous Poly(Ε-Caprolactone) Vascular Grafts In A Rat Animal Model, Jana Horakova, Tereza Blassova, Zbynek Tonar, Connor Mccarthy, Katerina Strnadova, David Lukas, Petr Mikes, Patrick Bowen, Roger J. Guillory Ii, Megan C. Frost, Jeremy Goldman

Michigan Tech Publications, Part 1

The development of an ideal vascular prosthesis represents an important challenge in terms of the treatment of cardiovascular diseases with respect to which new materials are being considered that have produced promising results following testing in animal models. This study focuses on nanofibrous polycaprolactone-based grafts assessed by means of histological techniques 10 days and 6 months following suturing as a replacement for the rat aorta. A novel stereological approach for the assessment of cellular distribution within the graft thickness was developed. The cellularization of the thickness of the graft was found to be homogeneous after 10 days and to have …

Wildfire Risk Zone Mapping In Contrasting Climatic Conditions: An Approach Employing Ahp And F-Ahp Models, Aishwarya Sinha, Suresh Nikhil, Rajendran Shobha Ajin, Jean Homian Danumah, Sunil Saha, Romulus Costache, Ambujendran Rajaneesh, Kochappi Sathyan Sajinkumar, Kolangad Amrutha, Alfred Johny, Fahad Marzook, Pratheesh Chacko Mammen, Kamal Abdelrahman, Mohammed S. Fnais, Mohamed Abioui

Michigan Tech Publications, Part 1

Wildfires are one of the gravest and most momentous hazards affecting rich forest biomes worldwide; India is one of the hotspots due to its diverse forest types and human-induced reasons. This research aims to identify wildfire risk zones in two contrasting climate zones, the Wayanad Wildlife Sanctuary in the Western Ghats and the Kedarnath Wildlife Sanctuary in the Himalayas, using geospatial tools, analytical hierarchy process (AHP), and fuzzy-AHP models to assess the impacts of various conditioning factors and compare the efficacy of the two models. Both of the wildlife sanctuaries were severely battered by fires in the past, with more …

The Phangs-Jwst Treasury Survey: Star Formation, Feedback, And Dust Physics At High Angular Resolution In Nearby Galaxies, Janice C. Lee, Karin M. Sandstrom, Adam K. Leroy, David A. Thilker, Eva Schinnerer, Erik Rosolowsky, Judy Schmidt, Et Al.

Michigan Tech Publications, Part 1

The PHANGS collaboration has been building a reference data set for the multiscale, multiphase study of star formation and the interstellar medium (ISM) in nearby galaxies. With the successful launch and commissioning of JWST, we can now obtain high-resolution infrared imaging to probe the youngest stellar populations and dust emission on the scales of star clusters and molecular clouds (∼5-50 pc). In Cycle 1, PHANGS is conducting an eight-band imaging survey from 2 to 21 μm of 19 nearby spiral galaxies. Optical integral field spectroscopy, CO(2-1) mapping, and UV-optical imaging for all 19 galaxies have been obtained through large programs …

Proposal For And Validation Of Novel Risk-Based Process To Reduce The Risk Of Construction Site Fatalities (Major Accident Prevention (Map) Program), Roberta Selleck, Marcus Cattani, Maureen Hassall

Research outputs 2022 to 2026

Despite developments in the prevention of fatalities in the construction industry, fatalities resulting from well-known hazards continue at an unacceptable rate. Construction fatality prevention literature describes risk management techniques to provide ‘early warning’ of potential events. In dynamic construction project environments, these ‘early warnings’ are missed resulting in serious and fatal events. Critical Control Risk Management (CCRM) provides an alternative strategy to prevent fatal events in the construction industry. However, no research exists that explores the application of CCRM to actual construction projects. This study aims to design, develop, and validate a construction fatality prevention program using CCRM principles through …

Editorial: Green Chemistry Biocatalysis, Barry J. Ryan, Gary T. Henehan, Bekir E. Eser, Ning Li, Zheng Guo, Gemma K. Kinsella

Articles

Editorial on the Research Topic: Green chemistry biocatalysis

Geospatiotemporal And Causal Inferential Study Of European Epidemiological Patterns Of Cannabis- And Substance-Related Congenital Orofacial Anomalies, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Introduction:

Since high rates of congenital anomalies (CAs), including facial CAs (FCAs), causally attributed to antenatal and community cannabis use have been reported in several recent series, it was of interest to examine this subject in detail in Europe.

Methods:

CA data were taken from the EUROCAT database. Drug exposure data were downloaded from the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Income was taken from the World Bank’s online sources.

Results:

On the bivariate maps of both orofacial clefts and holoprosencephaly against resin, the Δ9-tetrahydrocannabinol concentration rates of both covariates increased together in France, Bulgaria, and the …

An Examination Of Primary Health Care Nursing Service Evaluation Using The Donabedian Model: A Systematic Review, Kylie Mccullough, Lesley Andrew, Angela Genoni, Melissa Dunham, Lisa Whitehead, Davina Porock

Research outputs 2022 to 2026

Nurses are key to the delivery of global primary health care services. However, there appears to be a lack of evaluation of primary health care nursing delivery models in the published literature. This evaluation is vital to the improvement of patient experiences, national and global health outcomes, and the justification of future investment in primary health care nursing services. The purpose of this review was to explore and analyze the literature that reports on the evaluation of primary health care nursing services, to ascertain the nature and utility of these evaluation methods, and identify opportunities for future research in this …

Behaviour And Material Properties Of Versaloc Semi-Interlocking Mortarless Masonry, Sonam Dorji, Hossein Derakhshan, David P. Thambiratnam, Tatheer Zahra, Alireza Mohyeddin

Research outputs 2022 to 2026

Masonry construction is popular around the world, but the use of mortared masonry presents numerous challenges. In recent decades, masonry construction systems incorporating interlocking masonry units have been proposed to eliminate mortar. The interlocking between masonry units can be achieved using specially shaped units. This paper presents a comprehensive experimental study to determine the behaviour as well as basic material properties of one such semi-interlocking mortarless masonry. The experiments included testings of ungrouted masonry units, prisms, and wallets. In addition, masonry prisms and wallets with grouted cores were also investigated to study the effect of grouting. A detailed description of …