Digital Commons Network^™

Missed Opportunities In The Diagnosis Of Tuberculosis Meningitis, Niamh Simmons, Margaret A Olsen, Joanna Buss, Thomas C Bailey, Carlos Mejia-Chew

2020-Current year OA Pubs

BACKGROUND: Tuberculosis meningitis (TBM) has high mortality and morbidity. Diagnostic delays can impact TBM outcomes. We aimed to estimate the number of potentially missed opportunities (MOs) to diagnose TBM and determine its impact on 90-day mortality.

METHODS: This is a retrospective cohort of adult patients with a central nervous system (CNS) TB

RESULTS: Of 893 patients with TBM, median age at diagnosis was 50 years (interquartile range, 37-64), 61.3% were male, and 35.2% had Medicaid as primary payer. Overall, 407 (45.6%) had a prior hospital or ED visit with an MO code. In-hospital 90-day mortality was not different between those …

Biallelic Variants In Ogdh Encoding Oxoglutarate Dehydrogenase Lead To A Neurodevelopmental Disorder Characterized By Global Developmental Delay, Movement Disorder, And Metabolic Abnormalities, Ella F Whittle, Madison Chilian, Ehsan Ghayoor Karimiani, Helga Progri, Daniela Buhas, Melis Kose, Rebecca D Ganetzky, Mehran Beiraghi Toosi, Paria Najarzadeh Torbati, Reza Shervin Badv, Ivan Shelihan, Hui Yang, Houda Zghal Elloumi, Sukyeong Lee, Yalda Jamshidi, Alan M Pittman, Henry Houlden, Erika Ignatius, Shamima Rahman, Reza Maroofian, Wan Hee Yoon, Christopher J Carroll

Faculty, Staff and Students Publications

PURPOSE: This study aimed to establish the genetic cause of a novel autosomal recessive neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.

METHODS: We performed a detailed clinical characterization of 4 unrelated individuals from consanguineous families with a neurodevelopmental disorder. We used exome sequencing or targeted-exome sequencing, cosegregation, in silico protein modeling, and functional analyses of variants in HEK293 cells and Drosophila melanogaster, as well as in proband-derived fibroblast cells.

RESULTS: In the 4 individuals, we identified 3 novel homozygous variants in oxoglutarate dehydrogenase (OGDH) (NM_002541.3), which encodes a subunit of the tricarboxylic acid cycle enzyme …

A Review Of Stellate Ganglion Block As An Adjunctive Treatment Modality, Kennedy Kirkpatrick, Mashfee H Khan, Yi Deng, Krishna B Shah

Faculty, Staff and Students Publications

Peripheral nerve blocks are becoming increasingly used as adjunctive treatment modalities for a variety of conditions refractory to medical management. Right or left stellate ganglion blocks (SGB) are a specific type of peripheral nerve block that target the sympathetic blockade of neuronal impulses using the injection of local anesthetic and steroids into nerve bundles in the cervical area. This review article is intended to summarize the common uses of stellate ganglion blocks and explain the procedural technique, which has evolved with technological advances in ultrasonography. The similarities between these disease processes are centered around sympathetic hyperactivity. This sympathetic overdrive state …

Affare Fatto 2!, Susanna Nocchi, Silvia Bertoni

Books/Book Chapters

Taster. List of contents and first unit of a book for students of Italian as a foreign language.

Affare fatto! 2 is the second volume of a course aimed at learners of Italian who want to reach an intermediate level of competence in the language (B1/B1+ of the CEFR). The book offers material that can be used to attain competences in Italian for Business and for Professional Communication.

Affare fatto! 2 can be used as a textbook in a university course, as a book for professionals who work in Italy or with Italian partners, and as a textbook for those …

Comparison Of Postoperative Outcomes Of Laparoscopic Vs Open Inguinal Hernia Repair, Jennie Meier, Audrey Stevens, Miles Berger, Konstantinos I Makris, Athanasios Bramos, Joan Reisch, C Munro Cullum, Simon C Lee, Celette Sugg Skinner, Herbert Zeh, Cynthia J Brown, Courtney J Balentine

Faculty, Staff and Students Publications

Importance: Advocates of laparoscopic surgery argue that all inguinal hernias, including initial and unilateral ones, should be repaired laparoscopically. Prior work suggests outcomes of open repair are improved by using local rather than general anesthesia, but no prior studies have compared laparoscopic surgery with open repair under local anesthesia.

Objective: To evaluate postoperative outcomes of open inguinal hernia repair under general or local anesthesia compared with laparoscopic repair.

Design, setting, and participants: This retrospective cohort study identified 107 073 patients in the Veterans Affairs Surgical Quality Improvement Program database who underwent unilateral initial inguinal hernia repair from 1998 to 2019. …

Primary Central Nervous System Germ Cell Tumors In Children And Young Adults: A Review Of Controversies In Diagnostic And Treatment Approach, Kee Kiat Yeo, Sumanth Nagabushan, Girish Dhall, Mohamed S Abdelbaki

2020-Current year OA Pubs

Primary central nervous system (CNS) germ cell tumors (GCT) are a rare heterogenous group of cancers, arising most commonly in the second decade of life. Through several clinical trials conducted around the world by various groups, the treatment approach for CNS GCT has advanced substantially with generally improved overall outcomes. In recent years, the goal of clinical trials has been focused on reduction of the radiotherapy burden and minimization of long-term toxicity. This review summarizes the current diagnostic and treatment regimens for CNS GCT, examines the controversies associated with these approaches, gaps in contemporary knowledge, and underscores the challenges we …

Interview No. 1751, Hernandez

Combined Interviews

Hernandez began working at Farah on April of 1972. Everyone at Farah left 2 moths after and she mentioned that those two months were enough for her to know what was right and what was wrong. Hernandez saw and experience many unjust things in those two months. She didn’t know how bad the situation inside the company was until she started to work there and realized that what the people were saying was right and even worse than what they described it as.

The worse part of the Farah company were the managers and their lack of experience in retail …

Interview No. 1753, Sanchez

Combined Interviews

Sanchez began working at Farah on April of 1969. Everyone at Farah hated their job and at first, she didn’t know why but 2 months after entering she realize what was right and what was wrong. As many others Farah workers on Paisano were tired of the unjust treatment and bad wage, Sanchez felt the exact same way in just a week of getting hired.

At first, she thought that it was so easy the hiring process and that Farah hired anyone who was willing to work. Soon after Sanchez realized that Farah hired many people, because of the amount …

Interview No. 1755, Gandara

Combined Interviews

He says that he stared working with his father after returning from the ARMY. He says that when he was working, they had a union that sometimes will fire people for nothing and they will have to legally open a case against that and he says that in order to get a response you needed to wait a long time. He says that one of his duties in the job was cutting ropes into different sizes. There is another woman interview that is his wife and she says that women were a minority in their job and they had to …

Interview No. 1757, Carrillo

Combined Interviews

Her last name is Carrillo and she was born in Mexico, and she arrived at Cuidad Juarez when she was 5 years old when she turned 12, she moved to, El Paso Texas. She was a home stay person and she helped with all the duties in the house, she is the middle child she has 3 older brothers and 3 younger brothers. Before she was married, she was working at a factory where they packed eggs and she worked in the fields picking pecans. She got married at the age of 22, with her husband that she met in …

Interview No. 1758, Saucido

Combined Interviews

Her last name is Saucido and she was working at Farah and she was part of the strike. Some of her duties at Farah was cutting and cleaning which was a very demanding job. She says that before the union there was no one that could help them and they thought that the union was going to make things better for them, but it wasn’t that way. When they were working, they will have supervisors that were making sure you did your job correctly, but sometimes they were extremely demanding and they will fire many people for either taking long …

Interview No. 1749, Jesse Muñoz Rev.

Combined Interviews

Jesse Munoz was an El Paso priest from Our Lady of the Light Church. He was born in Ciudad Juarez, Mexico, in 1940 during the depression years. When he turned eleven him and his family moved to El Paso, Texas in hopes of a better life and education. At the age of fourteen he took a bus to New York and worked there for over a year. He then had enough money to go to Spain and pay for an education and many years later he came back to El Paso, Texas.

At the time Rev. Munoz came back to …

Interview No. 1752, Valenzuela

Combined Interviews

Her last name is Valenzuela and she was born and raised in El Paso, Texas. After she graduated from high school, she got her first fulltime job at Farah. She was working in setting pockets, that involved a lot of hard work and many hours of work. The training that she was, was how to use the machine but like her many other people wants trained well. She says that many supervisors where over them all day long. She says that thru out the day they get 2 breaks from their job and they can rest on site and can …

Interview No. 1762, Leyva Bustamante

Combined Interviews

In April of 1970, Leyva started working at Farah. Everyone at Farah despised their job, and she didn't understand why at first, but after two months, she realized what was right and what was wrong. Leyva, like many other Farah employees on Paisano, was fed up with the unfair treatment and low pay after only a week on the job.

She initially assumed that the hiring process was simple and that Farah employed anyone who was willing to work. Soon after, Leyva recognized that Farah had employed a large number of individuals, and that they needed to balance the number …

Interview No. 1756, Eva Valdez

Combined Interviews

Eva was offered to join the strike during her time working at Farah Manufacturing Company, she first felt kind of scared because she didn’t want to be part of a strike. Eva didn’t understand what the union strike was about but she would later find out.

Eva’s first days at the Farah Manufacturing Company were filled with patches and jeans. She mentioned that she had to put patches in clothing items all day for long periods of time. For her work she would get pay less than $1.60 an hour. Some of her women coworkers had been working there for …

Interview No. 1768, Arieta

Combined Interviews

When Arieta initially started working there, she said that everyone at Farah detested their jobs. She didn't get the issues at Farah in Paisano that made every employee dread reporting to work each day. After a few days had passed, she received her first check and found she had been paid very little before the manager informed her that her pay would be increasing. She came to the realization that the contract she signed when she first started working there was also a complete fabrication that the bosses didn't regard.

She initially believed that Farah employed anyone who was willing …

Interview No. 1761, Rios

Combined Interviews

Everyone at Farah hated their job, that’s how Rios described it when she first started working there. She didn’t understand the problems happening at Farah at Paisano that made every worker hate going to work every day. A couple of days pass, she received her first check and realized that she got payed very little, when the manager told her that she would be getting payed more. She realized that she started her work there as a lie and that the contract that she sign was also a total lie that the managers didn’t respect.

At first, she thought that …

Interview No. 1765, Garcia

Combined Interviews

Garcia has lived and worked in El Paso, Texas. She mentioned that poverty in Mexico is worse than the poverty in the United States. Garcia left Mexico 5 years ago to get a better life in the USA. She left her children with her mother and got on the train to get to El Paso, Texas. She first arrived to Ciudad Juarez, Mexico and stayed with a family during a couple of weeks, while she gathered her papers to get a passport. After she got her passport she went to El Paso and started working and sending money back to …

Interview No. 1777, Tarango

Combined Interviews

Tarangos fathers’ parents were from Mexico and they passed away when she was very little. She never got to meet them. Her grandparent where from Leon Guanajuato, Mexico as well as his dad. Tarango mentioned that most of his family on her dads’ side were shoe makers back in Mexico, which was all he talked about to Tarango about. Sometimes he would talk about God or the Bible, but mostly about the shoe repair shop they had in Mexico. When Tarango’s dad came to the United States in the 1911 and he didn’t know English very well, but he managed …

Interview No. 1770, Del Hierro

Combined Interviews

Nearly all of Farah's employees were exhausted and tired of work. That was when Del Hierro started working there. She didn’t understand the problem in Farah of Paisano that was causing all workers to be reluctant to go to work every day. A few days went by and she received her first check and when the manager told her she would be paid more, she realized she had barely been paid, and realized that the contract she signed was also a complete lie and not respected by her manager.

At first, she thought the hiring process would be so easy …

Interview No. 1780, Arieta

Combined Interviews

Arieta started off her interview by mentioning that she had always wanted to study to be a nurse. Her husband didn’t believe in her because she was 30 when she began trying to get into nursing. She even mentioned that she felt old to be studying, but she really wanted to be somebody and have a life other than just being a housewife.

Arieta was tired of being at home and not knowing anything about the world. She ended up not being a nurse because at that time they started to ask for people to have a high school degree …

Interview No. 1775, Jaramillo De Palacio

Combined Interviews

She mentions that the companies were demanding the same quality of work and they were not realizing the amount of work they were giving to the workers, and it was an excessive amount of it. She says that the strikes separated people because it was a movement that had different opinions, but in the end they were fighting for the same thing. The union was created to support employees but the workers realized that that wasn’t true at all. When the strike first started she couldn’t ever imagine that the strike was going to be as big as it was, …

Interview No. 1774, Jaramillo

Combined Interviews

Jaramillo was born in San Antonio after her parents cross the border thru Laredo when immigration wasn’t very strict. After a year they moved to El Paso, Texas where all of her other siblings were born.. One of the things that she admires about growing up in El Paso is that almost everyone knew each other or knows someone who knows them. Her mother owned a restaurant and her father a tailoring shop in which Jaramillo and her siblings grew up. After a couple of years her father passed away. Her mother then decided to sell the tailoring shop and …

Interview No. 1779, Del Palacio

Combined Interviews

Del Palacio was a worker at Farah during the 1970’s. She first started to work for the company when the working conditions were not as bad. Soon things in the company starting to go South. Her quota became higher and higher every week and she was not able to meet the quota many times. Her boss didn’t care if it was literally impossible to complete that many tasks in a short period of time, he just wanted the work done no matter what.

Many of the workers at Farah during that time lived in Ciudad Juarez, Mexico. Those workers had …

Interview No. 1783, Avalos

Combined Interviews

Avalos grandmother is from Mexico. Her father was always on duty and her mother passed away when Avalos was four years old. After her mother passing, her grandmother adopted them and she became their mother. Avalos considers her grandmother her real mother, because she did everything for them. Avalos thanks her grandmother for everything she did for them even when she was an older woman struggling with her health. During her childhood before living with her grandmother she was at an orphanage for a couple of months. Once Avalos and her siblings went to stay with her grandmother their lives …

Interview No. 1784, Hernandez

Combined Interviews

She was born in Alamogordo, New Mexico, May 12, 1929. She had a very big family and she got to meet her grandmother and she was living in Ciudad Juarez, so they moved from Alamogordo to Juarez to be with her. Her grandmother used to have a son that had an accident in a mine, and they got a lot of money for compensation, but the son of her uncle spent everything. She was only 6 years old, and her grandmother died when she was 10 years old, they weren’t living with her, but they lived close, so they visit …

Interview No. 1785, Telles

Combined Interviews

Audio Unintelligible

Myostatin And Follistatin As Monitoring And Prognostic Biomarkers In Dysferlinopathy, Ursula Moore, Alan Pestronk, Et Al.

2020-Current year OA Pubs

Myostatin is a myokine which acts upon skeletal muscle to inhibit growth and regeneration. Myostatin is endogenously antagonised by follistatin. This study assessed serum myostatin and follistatin concentrations as monitoring or prognostic biomarkers in dysferlinopathy, an autosomal recessively inherited muscular dystrophy. Myostatin was quantified twice with a three-year interval in 76 patients with dysferlinopathy and 38 controls. Follistatin was quantified in 62 of these patients at the same timepoints, and in 31 controls. Correlations with motor function, muscle fat fraction and contractile cross-sectional area were performed. A regression model was used to account for confounding variables. Baseline myostatin, but not …

Final Findings From The Control Trial: Strategies To Reduce The Incidence And Severity Of Neratinib-Associated Diarrhea In Patients With Her2-Positive Early-Stage Breast Cancer, Arlene Chan, Ron Bose, Et Al.

2020-Current year OA Pubs

BACKGROUND: Neratinib is an irreversible pan-HER tyrosine kinase inhibitor approved for HER2-positive early-stage and metastatic breast cancer. Diarrhea is the most frequent side effect and the most common reason for early discontinuation. The phase II CONTROL trial investigated antidiarrheal prophylaxis or neratinib dose escalation (DE) for prevention of diarrhea. We present complete study results including final data for two DE strategies.

METHODS: Patients who completed trastuzumab-based adjuvant therapy received neratinib 240 mg/day for 1 year. Early cohorts investigated mandatory prophylaxis with loperamide, then additional budesonide or colestipol. Final cohorts assessed neratinib DE over the first 2 (DE1) or 4 weeks …

Relationship Between Electrode Position And Temporal Modulation Sensitivity In Cochlear Implant Users: Are Close Electrodes Always Better?, Ning Zhou, Xuyang Shi, Omkar Dixit, Jill B Firszt, Timothy A Holden

2020-Current year OA Pubs

Temporal modulation sensitivity has been studied extensively for cochlear implant (CI) users due to its strong correlation to speech recognition outcomes. Previous studies reported that temporal modulation detection thresholds (MDTs) vary across the tonotopic axis and attributed this variation to patchy neural survival. However, correlates of neural health identified in animal models depend on electrode position in humans. Nonetheless, the relationship between MDT and electrode location has not been explored. We tested 13 ears for the effect of distance on modulation sensitivity, specifically targeting the question of whether electrodes closer to the modiolus are universally beneficial. Participants in this study …