Digital Commons Network^™

Longitudinal Assessment Of Health-Related Quality Of Life In Adults With Ckd, Owen Ng, Teixeira-Pinto, Anh Kieu, Anita Van Zwieten, Anoushka Krishnan, Kirsten Howard, Wai H. Lim, Jeremy R. Chapman, Simon D. Roger, Michael J. Bourke, Shaundeep Sen, Steven J. Chadban, Carol A. Pollock, Allison Jaure, Jonathan C. Craig, Jean Yang, Germaine Wong

Research outputs 2022 to 2026

Key Points: Dialysis linked with poorer quality of life compared with transplant patients and patients with CKD. Quality of life trends were similar in both domain-specific and overall quality-of-life measures. Background: There are sparse data about the change in health-related quality of life (HRQoL) with the temporal progression of CKD. In this study, we assessed the association between change in CKD stages, overall and domain-specific quality of life and determined the factors that were associated with this change. Methods: Data were sourced from a multicenter study that included 1290 adult patients aged 18 years and older across six centers in …

Mood Monitoring In Schools: A Promising Alternative To Single-Time-Point Screening, Shane L. Rogers, Brown, Kathryn Campbell, Matthew Goulding

Research outputs 2022 to 2026

School-based mental health screening typically relies on single-time-point assessments, which assume that students’ emotional well-being is sufficiently stable for classification based on a single measurement. The present study examined this assumption by evaluating the stability of emotional well-being classifications under repeated mood monitoring. Students from two secondary schools (United Kingdom, n = 413; Australia, n = 354) completed the Brief Emotional Experience Scale weekly across six to seven weeks. Emotional well-being classifications were examined relative to a predefined low well-being threshold to assess stability across time, and a post-monitoring survey examined students’ self-reported perceptions of the monitoring experience. Most students …

Rapid Isometric Hamstring Strength Scores From Professional Soccer Players At Pre-Season: Positional Differences And Relationship To Peak Force, Nicholas Joel Ripley, Ross, Jack Fahey, Christopher Bramah, Paul Jones, Paul Comfort

Research outputs 2022 to 2026

The assessment of rapid force within a single joint assessment is becoming common practice within elite sport environments. Recent observations have highlighted that rapid force maybe more sensitive to fatigue than peak force within the hamstrings. Yet limited information exists on rapid force production in elite male soccer players. Eighty-nine senior professional men’s soccer players (age; 24.2±5.1 years, height; 1.83±0.05 m, mass; 78.95±7.53 kg) participated within the present study they performed two isometric assessments at joint angles of 30° and 90° of hip flexion and knee. They performed three trials with mean and standard deviation determined differences between soccer positions …

Space-Time Analysis Of Burgeoning Us Atrial Septal Defect Rates Driven By Cannabis, Albert Stuart Reece, Kenneth Hulse

Research outputs 2022 to 2026

Atrial septal defect (ASD) has become increasingly common in the USA and now affects 1 in 11.3 children in some places, but space–time analysis has not been applied to this emerging trend. ASD rate (ASDR) data were obtained from the National Birth Defects Prevention Network 2003–2020. Substance (cigarettes, alcohol, cannabis, analgesics, cocaine) use data were obtained from the National Survey of Drug Use and Health. Income data were obtained from the US Census. Analysis was limited to the Non-Hispanic White population by technical factors. Time-sequential univariate and bivariate maps were prepared for both covariates and outcomes and their combinations. Spatial …

The Age Of Activewear: Understanding Women’S Casualized Athletic Apparel Habits Through Associations With Psychosocial And Body Image Factors, Ross C. Hollett, R. Sharman, Domenic D’Adamo

Research outputs 2022 to 2026

Activewear has become a common component of women’s everyday clothing, yet emerging evidence suggests that exposure to activewear imagery may adversely affect body image. This study aimed to describe women’s activewear engagement across contexts and to investigate how different markers of engagement correspond with positive outcomes such as fitness behavior, body appreciation, and self-esteem, as well as negative outcomes including media pressure, idealized appearance aspirations, and self-objectification. We collected survey data from student (N = 455) and community (N = 374) samples to assess activewear-related behaviors, including online browsing, social media following, purchasing, and wearing, as well as measures of …

The Effect Of Midwife-Led Continuous Labor Support Care On Delivery Mode And Timely Initiation Of Breastfeeding In Primigravida Women In Northwest Ethiopia: A Hybrid Type I Implementation Study, Mengstu Melkamu Asaye, Aragaw, Eden Bishaw Taye, Kihinetu Gelaye Wudineh, Sara Bayes

Research outputs 2022 to 2026

Midwife-led continuous labor and childbirth support reduces the episiotomy rate and increases the rates of vaginal delivery and early initiation of breastfeeding. However, no studies have yet been conducted in Ethiopia. This study aimed to evaluate the effect of midwife-led continuous labor and childbirth support. A quasi-experimental study involving 419 primigravida women compared an intervention given by trained midwives at two hospitals to routine at two others. Data were collected from July to December 2024 through interviews and record reviews. The McNemar test was used to compare changes, with a p-value of less than 0.05. Midwife-led continuous labor support increased …

Self-Management Challenges And Psychosocial Support Needs In Clean Intermittent Catheterization: A Qualitative Study Of Individuals With Neurogenic Bladder And Caregivers, Lianyu Zou, Xiaomei Wu, Shun Chen, Shuluan Feng, Xiaohua Huang, Weiting Liu

Research outputs 2022 to 2026

Background – Clean intermittent catheterization (CIC) is widely regarded as the preferred approach to bladder management for individuals with neurogenic bladder (NB). Nevertheless, a considerable gap persists between evidence and clinical practice: patients and caregivers frequently encounter self-management barriers that compromise clinical outcomes during CIC. This qualitative study explores these barriers to provide an empirical foundation for developing tailored strategies that improve quality of care. Design – A descriptive qualitative study. Methods – From August to October 2025, a convenience sampling method was employed to recruit 16 participants individuals with NB or their long-term caregivers from the Department of Rehabilitation …

Advancing The Understanding Of Palliative Care In Singapore: Knowledge, Attitudes, Receptiveness, And The Moderating Role Of Media Information-Seeking Preferences, Su Lin Yeo, Angel Lee, Raymond Han Lip Ng, May O. Lwin, Yumin Lin

Research Collection Lee Kong Chian School Of Business

Introduction: Despite the growing demand for palliative care, this specialized medical care remains severely underutilized, with almost 50% of countries worldwide lacking access. Given that misperceptions and stigma continue to hinder progress in healthcare policy, this study aims to examine the relationships between palliative care knowledge, attitudes, and receptiveness to better understand how public health communication can enhance awareness and understanding of the topic in Singapore. Applying the adapted knowledge-attitude-practice (KAP) model, it further extends theory by examining the moderating role of media information-seeking between knowledge and receptiveness.Methods: Mixed-mode surveys involving 1,226 participants (926 online and 300 in-person respondents), representing …

Think First, Chatgpt Later: Guiding Human-Ai Collaboration For Learning Gains In Independent Human Creativity, Sarah Shi Hui Wong, Sophia Xuefei Qiu

Research Collection School of Social Sciences

Generative artificial intelligence (AI) tools such as ChatGPT can boost creative performance, but do these boosts translate into learning gains? This study examined whether the benefits of ChatGPT for creativity persist even when its assistance is removed, and how people can effectively use ChatGPT to enhance their learning and independent creativity. University students (N = 196) solved a creative product improvement task either independently (human-only group) or using ChatGPT freely (general-AI group) or using ChatGPT in a guided way (regulated-AI group). Specifically, the regulated-AI group used a novel “think first, ChatGPT later” approach—they first generated their own ideas, then collaborated …

The Citizen And The Smart City: A Global Comparison Of Institutional Logics, Tim Bunnell, Zachary Spicer, Byron Miller, Teresa Abbruzzese, Paolo Cardullo, Sangwon Chae, I-Chun Catherine Chang, Greig Charnock, Ming-Kuang Chung, Kwon Heo, Sue-Ching Jou, Andrew Karvonen, Olga Kordas, Kong, Lily, Ramon Ribera-Fumaz, Haeran Shin, Orlando Woods

Research Collection College of Integrative Studies

Crucial urbanists’ placement of smart city initiatives in Western Europe or North America mostly on the “low” rungs of participatory ladders or scaffolds does not mean that smart urban development necessarily connotes democracy-eroding neoliberalization everywhere. This article offers a more globally variegated and dynamic understanding of the relationship between citizens and smart cities. We apply an institutional logics framework to the citizen-smart city nexus in seven cities spanning three world regions, considering the interplay of citizen-centric logics with techno-innovation-oriented and bureaucratic/managerial logics. Appreciating contextually specific institutional orders helps to explain why similar initiatives and intentions yield different outcomes across time …

Overservice Backfires: The Impact Of High Robot Attentiveness On Tourists' Discontinuous Usage Intentions, Jinwei Wang, Yingzong Tang, Xin Chen, Songshan (Sam) Huang

Research outputs 2022 to 2026

AI-powered robots can meet both functional and emotional consumer service needs through proactive engagement. Yet, excessive attentiveness may produce unintended negative outcomes. Drawing on conservation of resources theory, this research employs four studies and a single-paper meta-analysis to investigate how highly (vs. moderately) attentive robotic service influences tourists' intentions to discontinue use. Results show that highly attentive robotic service increases discontinuous usage intentions, and this effect unfolds sequentially through perceived threat to freedom and emotional exhaustion. Furthermore, information sensitivity and technology anxiety moderate the relationship between robotic attentiveness and discontinuous usage intentions. These findings offer strategic insights for tourism practitioners …

Dynamic Knowledge Practices In Tourism Village Development: An Activity Theory Perspective, Xianyang Hu, Jie Chen, Songshan (Sam) Huang

Research outputs 2022 to 2026

This study investigates why tourism village development models often fail to replicate success despite cultural and geographic similarities. Using activity theory and knowledge management concepts, we analyze two adjacent Chinese villages to trace explicit knowledge flow and examine disrupted tacit and indigenous knowledge practices. Findings show that while surface-level knowledge transfer occurs, contradictions within activity system elements, especially the marginalization of indigenous knowledge and community capacity, hinder effective knowledge application. Knowledge flow is inherently nonlinear and deeply context-dependent. We develop a comparative activity system model that highlights how success hinges less on knowledge transfer and more on the integration of …

High-Resolution Monitoring Of Intra-Seasonal Agricultural Drought Using Sentinel-2 And Machine Learning Across Bimodal Growing Seasons In Kenya, S. Mohammad Mirmazloumi, Harison Kipkulei, Rose Waswa, Tobias Landmann, Tom Dienya, Maximilian Schwarz, Fabrizio Ramoino, Clément Albergel, Gohar Ghazaryan

All Peer-Reviewed Publications

Drought presents significant challenges to agriculture, threatening food security and livelihoods, across many regions. In Kenya, recurrent droughts across diverse agro-ecological zones emphasize the urgent need for reliable and scalable drought assessment methods. Although drought assessment with various datasets has been carried out for this region, many of them often use course or moderate resolution data. This study uses high-resolution Sentinel-2 observations and machine learning to monitor intra-seasonal crop conditions and assess drought impacts across bimodal growing seasons. Using pixel-based supervised random forest models trained with multiple vegetation indices as input, we classify croplands into drought-affected and unaffected areas. The …

Land-Use Changes Shape Mosquito Assemblages, Host-Feeding And Arbovirus Infection In Baringo County, Kenya, Caroline Getugi, Elizabeth Kokwaro, Anthony Nyamache, Inga Slothouwer, Gilbert Rotich, Rosemary Sang, Sandra Junglen, David P. Tchouassi

All Peer-Reviewed Publications

Environmental transformation driven by human activity has profound implications for the ecology of mosquito vectors and the pathogens they transmit. This study investigated the influence of land-use change on mosquito assemblages, host-feeding patterns, and arbovirus infection across sylvatic-rural-peri-urban land-use types in Marigat subcounty, Rift Valley, Kenya. Adult mosquitoes were collected using CO₂-baited CDC light traps and BG-Sentinel traps across three sites: Kiborgoch conservancy (sylvatic), Ntepes village (rural) and Marigat town (peri-urban). Sampling was conducted during three sessions including September 2022, August 2023, and December 2023. The mosquitoes were morphologically identified to species, and indices of abundance, richness and diversity compared …

Polyhydroxybutyrate (Phb) From Biofloc Systems Enhances The Growth And Immune Performance Of Genetically Improved Farmed Tilapia, Menaga Meenakshisundaram, Jimmy B. Mboya, Felix Sugantham

All Peer-Reviewed Publications

This study characterised polyhydroxybutyrate (PHB)-producing bacteria from the culture water of genetically improved farmed tilapia (GIFT) in biofloc ponds and investigated the influence of PHB on the growth and immune performance of GIFT. Out of 40 bacterial isolates, Bacillus infantis, Exiguobacterium profundum, Bacillus subtilis, Bacillus megaterium, Klebsiella pneumoniae and Enterococcus hirae showed positive results for PHB against fluorescent stains. The PHB yield in the range of 5%–95.45% (w/w) was recorded, with the highest from K. pneumoniae (95.45% w/w). The experimental treatments included a basal diet as a control (C), a basal diet with PHB (5 g kg⁻¹) from …

Exploring The Effect Of Counterstereotype And Perspective Taking In Reducing Bias And Promoting Empathy In Police, Sydney C. Timmer-Murillo, Keara Kangas, Nakia Gordon

Psychology Faculty Research and Publications

Racism in policing continues to be a serious issue in the United States (U.S.). While most efforts to reduce racism, focus on changing implicit (i.e., nonconscious) racial biases, other factors may also influence behavior. Intergroup emotion theory posits that emotions, especially empathy, may play a powerful role in changing behavior. In this study, using community-based participatory research design we created and tested a virtual reality (VR) experience designed to reduce implicit racial bias through perspective taking and counter-stereotypical information. Fifty-six police officers from a large city took part in the study. They completed questionnaires and an implicit association task (IAT) …

Hypersiniel: Guaranteed Output Delivery Comes (Almost) Free In Private Delegation Of Zksnarks, Yunbo Yang, Yuejia Cheng, Junkai Liang, Kailun Wang, Xuanming Liu, Xiaoguo Li, Jianfei Sun, Jiachen Shen, Xiaolei Dong, Zhenfu Cao, Meng Hao, Guomin Yang, Deng, Robert H., Kui Ren

Research Collection School Of Computing and Information Systems

Zero-knowledge Succinct Non-interactive Argument of Knowledge (zkSNARK) is a powerful cryptographic primitive that enables a prover to convince a verifier that something is true without leaking the private witness.Current zkSNARKs face significant computational costs in generating proofs, which restricts their use in areas like private payments, confidential smart contracts, and anonymous credentials. Private delegation offers a practical solution by outsourcing the heavy computation to powerful external workers without leaking any private information. In this work, we propose HyperSiniel, an efficient private delegation framework for general zkSNARKs that achieves a new feature called guaranteed output delivery (GOD). HyperSiniel is designed to …

Semat: Semantic Enhanced Natural Image Interactive Matting, Ruihao Xia, Yu Liang, Peng-Tao Jiang, Hao Zhang, Qianru Sun, Yang Tang, Bo Li, Pan Zhou

Research Collection School Of Computing and Information Systems

Recent approaches attempt to adapt powerful interactive segmentation models, such as SAM, to interactive matting and fine-tune the models based on synthetic matting datasets. However, models trained on synthetic data fail to generalize to complex and occlusion scenes. We address this challenge by proposing a new matting dataset based on the COCO dataset, namely COCO-Matting. It selects real-world complex images from COCO and converts semantic segmentation masks to matting labels. The built COCO-Matting comprises an extensive collection of 36,980 human instance-level alpha mattes in complex natural scenarios. Furthermore, existing SAM-based matting methods extract intermediate features and masks from a frozen …

Dragging With Geometry: From Pixels To Geometry-Guided Image Editing, Xinyu Pu, Hongsong Wang, Jie Gui, Pan Zhou

Research Collection School Of Computing and Information Systems

Interactive point-based image editing serves as a controllable editor, enabling precise and flexible manipulation of image content. However, most drag-based methods operate primarily on the 2D pixel plane with limited use of 3D cues. As a result, they often produce imprecise and inconsistent edits, particularly in geometry-intensive scenarios such as rotations and perspective transformations. To address these limitations, we propose a novel geometry-guided drag-based image editing method—GeoDrag, which addresses three key challenges: 1) incorporating 3D geometric cues into pixel-level editing, 2) mitigating discontinuities caused by geometry-only guidance, and 3) resolving conflicts arising from multi-point dragging. Built upon a unified displacement …

Agentspec: Customizable Runtime Enforcement For Safe And Reliable Llm Agents, Haoyu Wang, Christopher M. Poskitt, Jun Sun

Research Collection School Of Computing and Information Systems

Agents built on LLMs are increasingly deployed across diverse domains, automating complex decision-making and task execution. However, their autonomy introduces safety risks, including security vulnerabilities, legal violations, and unintended harmful actions. Existing mitigation methods, such as model-based safeguards and early enforcement strategies, fall short in robustness, interpretability, and adaptability. To address these challenges, we propose AgentSpec, a lightweight domain-specific language for specifying and enforcing runtime constraints on LLM agents. With AgentSpec, users define structured rules that incorporate triggers, predicates, and enforcement mechanisms, ensuring agents operate within predefined safety boundaries. We implement AgentSpec across multiple domains, including code execution, embodied agents, …

Platelets Cause Microvascular Occlusion And Delayed Neurological Deficits After Subarachnoid Hemorrhage In Mice., Ari Dienel, Sung-Ha Hong, Kiara Torres, Kanako Matsumura, Jose Guzman, Peeyush Thankamani Pandit, Bibek Samal, Harveen Kaur, Samitha Nemirajaiah, Angelica Bernal, H Alex Choi, Louise D Mccullough, Spiros L Blackburn, Jaroslaw Aronowski, Devin W Mcbride

Faculty, Staff and Student Publications

After subarachnoid hemorrhage (SAH), some patients develop delayed neurological deficits (DND). Microthrombi are considered a contributing factor to DND, but clinical trials of antiplatelets had mixed results. Existing research suggests that platelets play a role in the etiology of DND, but no comprehensive study has tested causality between platelets and DND after SAH. Here we hypothesize that after SAH, platelet activation promotes microthrombi formation, occlusion of the brain microvasculature and contributes to DND, and that inhibiting platelet aggregation is a therapeutic strategy. Mice experiencing SAH were administered various interventions. The animals were subjected to stimulation of platelets, platelet depletion, or …

Leveraging Section 208 Water Quality Planning To Mitigate Pfas Contamination In Watersheds Across The Waccamaw Region, Anna Dimatteo

Goal 6: Clean Water and Sanitation

No abstract provided.

Upgrades To Carvers Bay Water System To Improve Safety And Water Quality, Samantha Stollenmaier

Goal 6: Clean Water and Sanitation

No abstract provided.

Bridging Gaps: Enhancing Sleep And Health Disparities In Latino Families With Young Adults With Autism Using A Culturally Adapted Intervention, Antonio F Pagán, Alejandro L Pagán, Linda Hernandez, Matthew R Cribbet, Katherine A Loveland, Ron Acierno

Faculty, Staff and Student Publications

The present study examined the effects of a culturally adapted intervention, ¡Iniciando! la Adultez, on sleep and health-related quality of life (HRQoL) in Latino young adults with autism spectrum disorder (ASD) and their Spanish-speaking parents. The intervention targeted the transition to adulthood, a period associated with increased challenges in sleep and HRQoL, particularly for underserved Latino populations. Participants included 26 young adults and 38 parents who completed assessments at baseline and post-treatment. The results indicated significant improvements in several HRQoL domains for both groups, with young adults reporting enhanced emotional well-being, social functioning, and general health. Parents experienced notable improvements …

Preoperative First-Line Amlodipine In Phaeochromocytoma/Paraganglioma: Perioperative Haemodynamic Instability And Its Predictors, Chandramouli L, Saba Samad Memon, Anurag Ranjan Lila, Manjiri Karlekar, Aditya Phadte, Vijaya Sarathi, Rohit Barnabas, Sailaja Pramod Bijani, Sameer Rege, Yogesh Prabhakar Takalkar, Amala Kudalkar, Aarti Kulkarni, Nalini Shah, Tushar R Bandgar

Faculty, Staff and Student Publications

Objectives: Preoperative alpha blockade is recommended for phaeochromocytomas and paragangliomas (PPGLs), whereas evidence for calcium channel blockers remains limited. This study evaluated perioperative haemodynamic outcomes with first-line amlodipine for preoperative blockade and identified predictors of intraoperative haemodynamic instability (iHDI).

Methods/design: In this monocentric retrospective study, 35 operated PPGL patients who received preoperative first-line amlodipine (July 2021-March 2024) were analysed. Continuous intraoperative arterial pressure recordings were analysed for episodes and duration of hypertension, hypotension, and iHDI. Biochemical phenotype and tumour characteristics were assessed as predictors.

Results: The cohort (median age: 32 years; 60% female) included 32 phaeochromocytomas and 3 sympathetic paragangliomas. …

Probability Of Fentanyl Adulteration In Cocaine Selectively Decreases Cocaine Demand, Cecilia Nunez, Jin H Yoon, James Mackillop, Margaret C Wardle

Faculty, Staff and Student Publications

Fentanyl-related, cocaine-overdose deaths have drastically increased, yet research on how people who use cocaine perceive fentanyl adulteration is limited. This study developed the novel Adulterated Cocaine Purchasing Task (ACocPT), a modification of the original Cocaine Purchasing Task, to quantify how people respond to fentanyl adulteration in cocaine. In the ACocPT, participants indicated how much cocaine they would purchase when cocaine had no (0%) vs. some (10%) probability of fentanyl adulteration. Study aims were: 1) determine how possible fentanyl adulteration affects cocaine demand, and 2) determine which individual characteristics predict continued demand for cocaine despite fentanyl adulteration. This Amazon Mechanical Turk …

Factors Associated With Venous Complications In Lower Extremity Free Flap Reconstruction: A Multivariate Analysis, Bora Kahramangil, Ellen Wang, Imran Rizvi, Jessica R Nye, Kylie Swiekatowski, Alexandra Dunker, Kate Liao, Michael H Haydon, Jeffrey G Trost, Mohin A Bhadkamkar

Faculty, Staff and Student Publications

Background: Due to their dependent location, lower extremity (LE) free flaps (FFs) are at increased risk for venous complications. This study analyzes risk factors of venous complications in LE FFs.

Methods: A single-center retrospective review was conducted of adult patients undergoing LE FF reconstruction from 2016 to 2025. Variables included demographics, wound and operative characteristics, and the number of venous anastomoses. The primary outcome was venous complications, defined as a composite variable encompassing venous congestion, flap loss due to venous causes, and flap hematoma.

Results: The cohort consisted of 370 patients undergoing LE FF reconstructions. Single venous anastomosis was used …

A Treat-To-Target Approach For Obesity Management: A Post Hoc Analysis Of The Surmount-5 Trial., Carel W Le Roux, Luca Busetto, Louis Aronne, Deborah Bade Horn, Georgios K Dimitriadis, Beverly Falcon, Luis-Emilio Garcia-Perez, Elisa Gomez Valderas, Theresa Hunter Gibble, Cagri Senyucel, Julia P Dunn

Faculty, Staff and Student Publications

Introduction: With new advancements in obesity medicine, clarity on goals and expectations for successful disease management is limited. This post hoc analysis assessed application of proposed treat-to-target (TtT) thresholds for obesity to the outcome measures of SURMOUNT-5, which randomised participants with obesity to tirzepatide or semaglutide.

Methods: The proportion of participants in each treatment group reaching proposed TtT thresholds for waist to height ratio (WHtR) < 0.53, body mass index (BMI) < 27 kg/m2, or a combination was evaluated. The associations between the thresholds and achieving low disease activity to remission (meeting goals for at least four of five defined cardiometabolic risk parameters) and normalisation or improvement in SF-36v2 physical component score (PCS) from baseline to week 72 were explored.

Results: About 23.1%-33.9% of participants treated with tirzepatide and 14.2%-20.7% treated with semaglutide reached the TtT thresholds, with greater weight reduction than the overall population. About 77% of participants who reached WHtR < 0.53 achieved low disease activity to remission, with an odds ratio of 2.31 (p < 0.001) compared to those who did not reach this target. The BMI threshold was not statistically associated with the assessed outcomes for SF-36v2 PCS.

Conclusion: In this …

Correction: Prospective Trial Of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage Via Lumbar Catheter Extension (Pillar-Xt), Spiros L Blackburn, Marc A Babi, Andrew W Grande, Omar A Choudhri, Erik F Hauck, Christopher P Kellner, Michael C Giordano, Shivanand P Lad, Aaron R Mccabe

Faculty, Staff and Student Publications

This corrects the article "Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage via Lumbar Catheter Extension (PILLAR-XT)" in volume 43 on page 934.

Distinct Effects Of Complement C4a And C4b Copy Numbers In Systemic Sclerosis Serological And Clinical Subtypes, Javier Martínez-López, Carlos Rangel-Peláez, Inmaculada Rodriguez-Martin, Alfredo Guillen-Del-Castillo, Carmen P Simeón-Aznar, José L Callejas, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K De Vries-Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E Alarcon-Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta-Herrera, Martin Kerick

Faculty, Staff and Student Publications

Objective: Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. The variable copy number (CN) of C4 genes and retroviral human endogenous retrovirus K (HERV-K) element influence its function. Given the relationship of C4 CN with systemic sclerosis (SSc) risk, we assessed associations with SSc clinical and serologic subtypes.

Methods: We compared imputed C4 CNs across SSc subgroups (4,049 anticentromere positive [ACA+]; 2,200 anti-topoisomerase I [ATA+]; 577 anti-RNA polymerase [ARA+]; 1,078 triple-negative [TN] patients; 6,295 limited cutaneous SSc [lcSSc]; and 2,946 diffuse cutaneous …