Digital Commons Network^™

Final Results From A Phase 2b Randomized, Placebo-Controlled Clinical Trial Of Rbx2660: A Microbiota-Based Drug For The Prevention Of Recurrent Clostridioides Difficile Infection, Erik R Dubberke, Robert Orenstein, Sahil Khanna, Beth Guthmueller, Christine Lee

2020-Current year OA Pubs

INTRODUCTION: Effective treatments for recurrent Clostridioides difficile infection (rCDI) are urgently needed. RBX2660 is an investigational microbiota-based live biotherapeutic to reduce CDI recurrence following standard-of-care antibiotic treatment in individuals with rCDI. Here we report the final safety data through 24 months of follow-up as well as final efficacy data, reflecting alignment of the pre-specified statistical analysis plan definitions with the data presented.

METHODS: The PUNCH CD2 clinical trial was a prospective, multicenter, randomized, double-blinded, placebo-controlled, three-arm phase 2b study conducted to evaluate the efficacy and safety of RBX2660 for the reduction of rCDI compared to placebo. Eligible patients were at …

Missed Opportunities In The Diagnosis Of Tuberculosis Meningitis, Niamh Simmons, Margaret A Olsen, Joanna Buss, Thomas C Bailey, Carlos Mejia-Chew

2020-Current year OA Pubs

BACKGROUND: Tuberculosis meningitis (TBM) has high mortality and morbidity. Diagnostic delays can impact TBM outcomes. We aimed to estimate the number of potentially missed opportunities (MOs) to diagnose TBM and determine its impact on 90-day mortality.

METHODS: This is a retrospective cohort of adult patients with a central nervous system (CNS) TB

RESULTS: Of 893 patients with TBM, median age at diagnosis was 50 years (interquartile range, 37-64), 61.3% were male, and 35.2% had Medicaid as primary payer. Overall, 407 (45.6%) had a prior hospital or ED visit with an MO code. In-hospital 90-day mortality was not different between those …

Knockout Of Tsc2 In Nav1.8+ Neurons Predisposes To The Onset Of Normal Weight Obesity, Jennifer M Brazill, David Shin, Kristann Magee, Anurag Majumdar, Ivana R Shen, Valeria Cavalli, Erica L Scheller

2020-Current year OA Pubs

OBJECTIVE: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effects, limiting options for therapeutic intervention. The objective of this study was to isolate the role of constitutive mTOR activation in Nav1.8-expressing peripheral neurons in the onset of diet-induced obesity, bone loss, and metabolic disease.

METHODS: In humans, loss of function mutations in tuberous sclerosis complex 2 (TSC2) lead to maximal constitutive activation of mTOR. To mirror this in …

The Futures Of Learning 3: What Kind Of Pedagogies For The 21st Century?, Cynthia Luna Scott

International Journal for Business Education

Since the emergence of a global movement that calls for a new model of learning for the twenty first century, it has been argued that formal education must be transformed to enable new forms of learning that are needed to tackle complex global challenges. Literature on this topic offers compelling arguments for transforming pedagogy to better support acquisition of twenty-first century skills.

What Kind Of Pedagogies For The 21st Century?, Cynthia Luna Scott

International Journal for Business Education

Since the emergence of a global movement that calls for a new model of learning for the twenty first century, it has been argued that formal education must be transformed to enable new forms of learning that are needed to tackle complex global challenges.

Reflective Journals, Tony Shannon Am

International Journal for Business Education

A reflective journal helps to think honestly about one’s actual thinking. This can be uncomfortable at first!

The Perceived Value Of Using A Team Charter In Business Education, Maureen Snow Andrade, Jonathan Westover, Letty Workman

International Journal for Business Education

Schools of business seek to prepare students for the workplace with employer-valued skills such as communication, teamwork, and application of knowledge. As such, a common practice for business and management educators is to involve students in collaborative team-based assignments and community projects. To facilitate the development of teamwork skills, faculty members may have students create a team charter, which involves student teams identifying goals, roles, and norms. However, empirical evidence of the value of team charters is limited. This study examined student perceptions of team charters to determine if they played a role in effective teamwork or if other variables …

Patient-Mediated Interventions In Hospital: A Systematic Review, Georgia Tobiano, Shelley Roberts, Rachel Muir, Teresa Jerofke-Owen, Christine Ting, Sarah Thorning, Daren K. Heyland, Andrea P. Marshall

College of Nursing Faculty Research and Publications

Aims

To describe the characteristics of hospital-based, patient-mediated interventions and their impact on patient, clinician and organization outcomes.

Design

Systematic review.

Data Sources

Health literature databases (MEDLINE, CINAHL and EMBASE) were searched in August 2021. Backward and forward citation searching was conducted.

Review Methods

Studies investigating patient-mediated interventions, targeted at adult hospitalized patients were eligible. Data were extracted related to study and intervention characteristics. Narrative synthesis was used to understand intervention impact on patient, clinician and organization outcomes (as per a framework). Methodological quality was assessed using the Mixed Methods Assessment Tool.

Results

Thirty-three studies, reporting 18 interventions, were included. …

Laser Powder Bed Fusion Of Molybdenum And Mo-0.1sic Studied By Positron Annihilation Lifetime Spectroscopy And Electron Backscatter Diffraction Method, Nathan E. Ellsworth, Joshua R. Machacek, Ryan A. Kemnitz, Cayla C. Eckley, Brianna M. Sexton, Joel S. Gearhart, Larry W. Burggraf

Faculty Publications

Positron annihilation lifetime spectroscopy (PALS) has been used for the first time to investigate the microstructure of additively manufactured molybdenum. Despite the wide applicability of positron annihilation spectroscopy techniques to the defect analysis of metals, they have only been used sparingly to monitor the microstructural evolution of additively manufactured metals. Molybdenum and molybdenum with a dilute addition (0.1 wt%) of nano-sized silicon carbide, prepared via laser powder bed fusion (LPBF) at four different scan speeds: 100, 200, 400, and 800 mm/s, were studied by PALS and compared with electron backscatter diffraction analysis. The aim of this study was to clarify …

Ads-B Classification Using Multivariate Long Short-Term Memory–Fully Convolutional Networks And Data Reduction Techniques, Sarah Bolton, Richard Dill, Michael R. Grimaila, Douglas Hodson

Faculty Publications

Researchers typically increase training data to improve neural net predictive capabilities, but this method is infeasible when data or compute resources are limited. This paper extends previous research that used long short-term memory–fully convolutional networks to identify aircraft engine types from publicly available automatic dependent surveillance-broadcast (ADS-B) data. This research designs two experiments that vary the amount of training data samples and input features to determine the impact on the predictive power of the ADS-B classification model. The first experiment varies the number of training data observations from a limited feature set and results in 83.9% accuracy (within 10% of …

Immunotherapeutic Targets In Non-Small Cell Lung Cancer, Habib Sadeghirad, Tayyeb Bahrami, Sepideh M. Layeghi, Hassan Yousefi, Meysam Rezaei, Seyed R. Hosseini-Fard, Payar Radfar, Majid E. Warkiani, Ken O'Byrne, Arutha Kulasinghe

School of Medicine Faculty Publications

Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and has a 5-year survival rate of ~20%. Immunotherapies have shown promising results leading to durable responses, however, they are only effective for a subset of patients. To determine the best therapeutic approach, a thorough and in-depth profiling of the tumour microenvironment (TME) is required. The TME is a complex network of cell types that form an interconnected network, promoting tumour cell initiation, growth and dissemination. The stroma, immune cells and endothelial cells that comprise the TME generate a plethora of cytotoxic or …

Extended Training Improves The Accuracy And Efficiency Of Goal-Directed Reaching Guided By Supplemental Kinesthetic Vibrotactile Feedback, Valay A. Shah, Ashiya Thomas, Leigh A. Mrotek, Maura Casadio, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

Prior studies have shown that the accuracy and efficiency of reaching can be improved using novel sensory interfaces to apply task-specific vibrotactile feedback (VTF) during movement. However, those studies have typically evaluated performance after less than 1 h of training using VTF. Here, we tested the effects of extended training using a specific form of vibrotactile cues—supplemental kinesthetic VTF—on the accuracy and temporal efficiency of goal-directed reaching. Healthy young adults performed planar reaching with VTF encoding of the moving hand's instantaneous position, applied to the non-moving arm. We compared target capture errors and movement times before, during, and after approximately …

Gender Inequality Against Women Fishers In Indonesia, Ani Purwanti, Dyah Wijaningsih, Muh. Afif Mahfud, Aga Natalis

Indonesia Law Review

This study explores whether or not Law No. 7 of 2016 for the Protection and Empowerment of Fishermen, Fish Cultivators, and Salt Farmers discriminates against women. This law supports small fishermen since it requires the government to provide them with financial stability through harvest season output guarantees. On the other hand, we discovered that Law No. 7 of 2016, about the Protection and Empowerment of Fishermen, Fish Cultivators, and Salt Farmers, has discriminatory consequences damaging the welfare of female fishermen. Because of sociological and cultural bias, female fishermen are the most neglected segment in the fishing sector. This is in …

Kasus Wang Renshu: Sebuah Kegagalan Diplomasi Rrc Terhadap Indonesia, Tuty Enoch Muas

Paradigma: Jurnal Kajian Budaya

The Chinese-Indonesian relations in 1951 was in tension due the actions of Ambassador Wang Renshu. As China was not favored in the international arena for its communist stand, the Chinese citizens in Indonesia became important factor in the relations between China and Indonesia where they were divided into taking side with either the communists or the capitalists. Wang Renshu, a senior member in the China Communist Party, has recruited between six and seven hundred thousand Indonesians of Chinese ancestry to adopt Chinese citizenship, of which it became a threat to the Chinese-Indonesian diplomatic relations. The withdrawal of Ambassador Wang Renshu …

Administrative Appeal Decision - Young, Scott (2022-11-14)

Parole Administrative Appeal Decisions

No abstract provided.

Administrative Appeal Decision - Donis, Enrico (2022-07-18)

Parole Administrative Appeal Decisions

No abstract provided.

Decision In Art. 78 Proceeding - Donis, Enrico (2022-11-30)

Decisions in Art. 78 Proceedings

No abstract provided.

Slamdance Film Festival 2023 Introduction, William L. Blizek

Journal of Religion & Film

Introduction to the 2023 Slamdance Film Festival

Slide List, Sui-Kang Zhao 赵穗康

Zhou Documents

This is a brief description of the artist's fifteen slides. The slides' names, date of shooting, way of being perceived, type of installation involved, material, size are included. Some of the descriptions also include the background information of the work. (He Zhang 25')

Improved Process For The Preparation Of (±) 4-Amino-5-Hexenoic Acid, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; M. Kishore; M. Ramakrishna; Jillepalli Suresh

Defensive Publications Series

Abstract:

The present invention relates to an improved process for the preparation of (±) 4-amino-5-hexenoic acid, represented by the following structural formula.

Formula-1

High Precision Programmable Delay In Networking Switches, N/A

Defensive Publications Series

Fairness in computer networks used in application domains such as financial markets, prediction markets, etc., can be achieved by ensuring that all participants receive the same multicast information at the same time. However, in practice, due to factors such as differing processing delays at network nodes, differing optical fiber lengths, etc., some participants may receive data sooner than others. This disclosure describes techniques to reduce timing variance and unfairness in multicast networks. Since multicasting works by replicating information to destination nodes, the replication engine at a node of a given network layer is programmed to delay retransmission of information received …

Irewards, Mrudul Uchil, Shakti Nilesh

Defensive Publications Series

The present disclosure relates to providing a single platform (107) to communicate offers/promotions to users (101). The platform receives payment cards details and associated issuer information from a user (101). The platform further receives information related to at least one merchant (105) and favorite brand of the user (101). The information related to the merchant or brand may be a name or an identity number. The platform (107) uses machine learning and/or data analytics and dynamically fetches current offers/promotions associated with the cards that can be availed at the at least one merchant (105) and favorite brand of the user …

Method And System For True Random Number Generation Using Brownian Motion., Gokul Anand Manimaran

Defensive Publications Series

The present disclosure relates to a method and system for generation of true random numbers using Brownian motion without any external inputs. The method creates true random numbers utilizing the random movement of colloidal particles in the colloidal solution. Rotor mechanism used in mechanical watches and heat from the system are used to introduce kinetic energy into this colloidal solution. The present disclosure generates sequence of true random numbers using either picture or video of the colloidal particles in the colloidal medium holder. Using the picture, the method counts the number of colloidal particles in area of any shape. Using …

Basic Idea Of My Works, Sui-Kang Zhao 赵穗康

Zhou Documents

This is a brief explanation of the artist's creative art approach and the meaning behind. (He Zhang 25')

The Home & Tomb Of President Lincoln Presented By The Sangamo Ins. Co....Springfield, Ill., C. W. Hotchkiss, Ehrgott, Forbriger And Co., Lithographers, Sangamo Insurance Company

Posters

The commemorative lithograph/advertisement was published by the Sangamo Insurance Company shortly after the death of Abraham Lincoln. It advertises six illustrations of areas of interest in Illinois, including Lincoln's tomb, his Springfield home, and other sites of interest. After the death of Lincoln, the nation took interest in Lincoln's life, and many companies were quick to capitalize on this newfound curiosity. This broadside is an example of the commodification of such tourism.

Letting Go Of Pilot Stigma: A Commentary On Hubbard (2016), Timothy G. Rosser

International Journal of Aviation Sciences (IJAS)

No abstract provided.

Icao Commentary On Hubbard (2016): Stigma And Pilots With Mental Health Issues, Ansa Jordaan

International Journal of Aviation Sciences (IJAS)

No abstract provided.

Stigma And Pilots With Mental Health Issues, Todd P. Hubbard

International Journal of Aviation Sciences (IJAS)

What makes the stigma surrounding pilots with mental health issues an important issue? Until recently, stigma was of minor concern. There were plenty of pilots without issues. Pilots with weaknesses had their careers cut short, if they let it be known that they had a psychological condition. So the numbers of pilots reporting psychological conditions were few. It was simple. Refrain from telling on yourself and you are allowed to fly. Tell on yourself and you suffer the consequences of stigma and maybe a shortened career. Stigma is similar to bullying. It creates a hostile work environment for those affected. …

Training For Warfighter Decision Making: A Survey Of Simulation-Based Training Technologies, Nina Rothstein

International Journal of Aviation Sciences (IJAS)

Training warfighters requires the establishment, enhancement, and assessment of decision making (DM) skills at various levels. This review seeks to identify DM training technologies at the tactical and operational levels of war. Simulation based training (SBT) provides learning experiences for improved cognitive abilities and retention of complex skills. Here, seven SBTs will be evaluated for their situational awareness (SA) training abilities for decision making. Valuation of the included SBTs examine the modifiability (scenario customization), data availability (physiological and behavioral), assessment methods (feedback and after action reviews), validity (team training), and fidelity (2D or 3D environments) for tactical and operational warfighter …

Integration Of Unmanned Aircraft Systems In Public Higher Education, John Mott, Ardyth M. Williams, Darcy M. Bullock

International Journal of Aviation Sciences (IJAS)

It is estimated that there are over one million unmanned aircraft systems (UAS) that, if operated incorrectly, can pose a significant threat to individuals, property, and other aircraft. Many of these systems are now finding their ways into universities, where they are operated by nonaviation professionals with an overall objective of exploring new research opportunities. While these initiatives hold significant promise for technical advancements, some employ relatively primitive operational and safety protocols. This article reviews FAA rules and reports on a university effort that has developed a formal partnership between an established aviation center utilizing licensed pilots and an engineering …