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A Molecular Signature Defining Exercise Adaptation With Ageing And In Vivo Partial Reprogramming In Skeletal Muscle, Ronald G. Jones Iii, Andrea Dimet-Wiley, Amin Haghani, Francielly Morena Da Silva, Camille R. Brightwell, Seongkyun Lim, Sabin Khadgi, Yuan Wen, Corey M. Dungan, Robert T. Brooke, Nicholas P. Greene, Charlotte A. Peterson, John J. Mccarthy, Steve Horvath, Stanley J. Watowich, Christopher S. Fry, Kevin A. Murach

Health, Human Performance and Recreation Faculty Publications and Presentations

Exercise promotes functional improvements in aged tissues, but the extent to which it simulates partial molecular reprogramming is unknown. Using transcriptome profiling from (1) a skeletal muscle-specific in vivo Oct3/4, Klf4, Sox2 and Myc (OKSM) reprogramming-factor expression murine model; (2) an in vivo inducible muscle-specific Myc induction murine model; (3) a translatable high-volume hypertrophic exercise training approach in aged mice; and (4) human exercise muscle biopsies, we collectively defined exercise-induced genes that are common to partial reprogramming. Late-life exercise training lowered murine DNA methylation age according to several contemporary muscle-specific clocks. A comparison of the murine soleus transcriptome …

Contextualizing Corruption: Foreign Financing Bans And Campaign Finance Law, Lori A. Ringhand

Cardozo Law Review

No abstract provided.

Colorblind Nationalism And The Limits Of Citizenship, Ming Hsu Chen

Cardozo Law Review

Policymakers and lawyers posit formal citizenship as the key to inclusion. Rather than presume that formal citizenship will necessarily promote equality, this Article examines the relationship between citizenship, racial equality, and nationalism. It asks: What role does formal citizenship play in excluding noncitizens and Asian, Latinx, and Muslim citizens racialized as foreigners? What effects does it have on the meaning of being American as a non-White citizen? The Article argues that commitments to colorblind equality and democratic self-governance of the nation stand in contradiction to aspirations to protect all persons within the nation. Consequently, individual rights designed to remedy racial …

Right For Any Reason, Jeffrey M. Anderson

Cardozo Law Review

The chances of winning an appeal in federal court are slim. One reason for that is an array of rules of appellate review that “stack the deck” in favor of the appellee and the lower court’s judgment. One such rule of review is “right for any reason,” the rule that an appellee may defend a lower court’s judgment on any grounds supported by the record—even grounds that the lower court rejected or ignored. The judgment may be right, even if the reasons are wrong. In 1924, the Supreme Court described the rule as “settled”—and felt no need to cite authority …

Foreseeability Conventions, John Fabian Witt, Morgan Savige

Cardozo Law Review

How has the foreseeability standard survived its critics? Law relies on foreseeability to solve hard legal problems in a vast array of doctrinal fields. But for a century and more, critics have pilloried the standard as hopelessly indeterminate. Decisionmakers, observe the critics, can characterize virtually any consequence as either foreseeable or unforeseeable. It all depends on how one tells the story. This Article explains the conundrum of foreseeability’s puzzling persistence by offering a novel account of how foreseeability has flourished in fields like tort, contract, and crime. Foreseeability has survived and flourished, the Article proposes, not because it carries determinate …

Can Artists Recapture Their Copyrights In Musical Compositions That Have Been Lost To The Public Domain? Skidmore V. Led Zeppelin Applied, Brianna Bell

Cardozo Law Review

No abstract provided.

The Art World Of Digital Assets: How Non-Fungible Tokens Create A Loophole In Anti-Money Laundering Regulations, Sofia Aizenman

Cardozo Law Review

No abstract provided.

Lindenwood Digest, February 1, 2023, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Navigating Care For Rare Diseases: Caregiver And Patient Advice For Families And Clinicians Managing Care For Vascular Malformations, Anna M Kerr, Christine Bereitschaft, Kayla M Duty, Bryan A Sisk

2020-Current year OA Pubs

OBJECTIVE: Families affected by rare diseases face many challenges finding adequate care and often report poor communication with clinicians. In the current study, we explore patient and caregiver advice for families and clinicians in the context of complex vascular malformations (VMs), a condition that is frequently misunderstood and misdiagnosed.

METHODS: We performed semi-structured interviews with 21 adult patients with complex VMs and 24 caregivers of children with VMs. We analyzed the transcripts using thematic analysis.

RESULTS: Participants advised patients and caregivers to advocate for care, address mental and emotional well-being, seek social support, and promote self-management and self-care. Participants advised …

Dsrc Versus Lte-V2x: Empirical Performance Analysis Of Direct Vehicular Communication Technologies, Ehsan Moradi-Pari, Danyang Tian, Mojtaba Bahramgiri, Samer Rajab, Sue Bai

Michigan Tech Publications, Part 1

Vehicle-to-Vehicle (V2V) communication systems have an eminence potential to improve road safety and optimize traffic flow by broadcasting Basic Safety Messages (BSMs). Dedicated Short-Range Communication (DSRC) and LTE Vehicle-to-Everything (V2X) are two candidate technologies to enable V2V communication. DSRC relies on the IEEE 802.11p standard for its PHY and MAC layer while LTE-V2X is based on 3GPP’s Release 14 and operates in a distributed manner in the absence of cellular infrastructure. There has been considerable debate over the relative advantages and disadvantages of DSRC and LTE-V2X, aiming to answer the fundamental question of which technology is most effective in real-world …

Automated In Vivo High-Resolution Imaging To Detect Human Papillomavirus-Associated Anal Precancer In Persons Living With Hiv, David Brenes, Alex Kortum, Jennifer Carns, Tinaye Mutetwa, Richard Schwarz, Yuxin Liu, Keith Sigel, Rebecca Richards-Kortum, Sharmila Anandasabapathy, Michael Gaisa, Elizabeth Chiao

Faculty, Staff and Students Publications

INTRODUCTION: In the United States, the effectiveness of anal cancer screening programs has been limited by a lack of trained professionals proficient in high-resolution anoscopy (HRA) and a high patient lost-to-follow-up rate between diagnosis and treatment. Simplifying anal intraepithelial neoplasia grade 2 or more severe (AIN 2+) detection could radically improve the access and efficiency of anal cancer prevention. Novel optical imaging providing point-of-care diagnoses could substantially improve existing HRA and histology-based diagnosis. This work aims to demonstrate the potential of high-resolution microendoscopy (HRME) coupled with a novel machine learning algorithm for the automated, in vivo diagnosis of anal precancer. …

Association Of Lifestyle Behaviors With Non-Alcoholic Fatty Liver Disease And Advanced Fibrosis Detected By Transient Elastography Among Hispanic/Latinos Adults In The Us, Natalia I Heredia, Xiaotao Zhang, Maya Balakrishnan, Jessica P Hwang, Aaron P Thrift

Faculty, Staff and Students Publications

OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent liver disease, with the highest prevalence observed in the U.S. among Hispanic/Latino adults. While physical activity and dietary behaviors have established protective associations with NAFLD and its severity, these associations have not been well-characterized in Hispanic/Latino adults. The purpose of this study was to assess the association of lifestyle behaviors with NAFLD and advanced fibrosis in US Hispanic/Latino adults.

DESIGN: We selected all Hispanic/Latino adults from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). NAFLD was defined as CAP ≥285 dB/m, and advanced fibrosis as liver stiffness measurements ≥8.6 …

Rates Of Antimicrobial Resistance In Helicobacter Pylori Isolates From Clinical Trial Patients Across The Us And Europe, Francis Mégraud, David Y Graham, Colin W Howden, Ernest Trevino, Alice Weissfeld, Barbara Hunt, Neila Smith, Eckhard Leifke, William D Chey

Faculty, Staff and Students Publications

INTRODUCTION: Guidelines recommend that proton pump inhibitor-based triple regimens with clarithromycin not be used for Helicobacter pylori infection in areas where clarithromycin resistance is ≥15%, or in patients with prior macrolide use. Up-to-date information on local resistance patterns is limited, especially in the US. Here, we report resistance rates to antibiotics commonly used to treat H. pylori from a large study conducted in the US and Europe (pHalcon-HP).

METHODS: Gastric mucosal biopsies were collected from adult participants with H. pylori infection during screening. Minimum inhibitory concentrations were determined via agar dilution for clarithromycin, amoxicillin, and metronidazole, with breakpoints ≥1 μg/mL, …

The Performance Of Afp, Afp-3, Dcp As Biomarkers For Detection Of Hepatocellular Carcinoma (Hcc): A Phase 3 Biomarker Study In The United States, Nabihah Tayob, Fasiha Kanwal, Abeer Alsarraj, Ruben Hernaez, Hashem B El-Serag

Faculty, Staff and Students Publications

BACKGROUND & AIMS: α-fetoprotein (AFP), AFP Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP) in combination or in GALAD (Gender, Age, AFP-L3, AFP, and DCP) were tested for hepatocellular carcinoma (HCC) surveillance in retrospective cohort and case-control studies. However, there is a paucity of prospective data and no phase III biomarker studies from North American populations.

METHODS: We conducted a prospective specimen collection, retrospective blinded evaluation (PRoBE) cohort study in patients with cirrhosis enrolled in a 6-monthly surveillance with liver imaging and AFP. Blood samples were prospectively collected every 6 months and analyzed in a retrospective blinded …

Preschool-Aged Household Contacts As A Risk Factor For Viral Respiratory Infections In Healthcare Personnel, Zachary M Most, Ann-Christine Nyquist, Lewis J Radonovich, Maria C Rodriguez-Barradas, Connie Savor Price, Michael S Simberkoff, Mary T Bessesen, Derek A T Cummings, Susan M Rattigan, Charlotte Warren-Gash, Charlotte A Gaydos, Cynthia L Gibert, Geoffrey J Gorse, Trish M Perl

Faculty, Staff and Students Publications

BACKGROUND: Viral respiratory infections (VRIs) are common and are occupational risks for healthcare personnel (HCP). VRIs can also be acquired at home and other settings among HCPs. We sought to determine if preschool-aged household contacts are a risk factor for VRIs among HCPs working in outpatient settings.

METHODS: We conducted a secondary analysis of data from a cluster randomized trial at 7 medical centers in the United States over 4 influenza seasons from 2011-2012 to 2014-2015. Adult HCPs who routinely came within 6 feet of patients with respiratory infections were included. Participants were tested for respiratory viruses whenever symptomatic and …

Transeuntis Mundi, A Nomadic Artistic Practice, Cândida Luiza Borges Da Silva

School of Law, Humanities and Social Sciences Theses

In this practice-led Ph.D. research, I investigate how an artistic practice can respond to the migration phenomena performed by human beings across the planet over millennia ¬– what I refer to as the millennial global human journey. Based on the idea of mobility, I chose to frame this research in the articulation of concepts deriving from the prefix trans: transculture, transhumance and transmediality. This research contributes to studies in art composition by developing the processes and concept of transmedial composition, mainly contributing to the field of New Media Art. This investigation resulted in the work Transeuntis Mundi (TM) Project – …

Phenomics Enables Measurement Of Complex Responses Of Developing Animals To Global Environmental Drivers, Oliver Tills, Luke A. Holmes, Elliot Quinn, Tony Everett, Manuela Truebano, John I. Spicer

School of Biological and Marine Sciences

Phenomics offers technological advances for high-dimensional phenotyping, facilitating rapid, high-throughput assessment of physiological performance and has proven invaluable in global research challenges including drug discovery and food security. However, this rapidly growing discipline has remained largely inaccessible to the increasingly urgent challenge of assessing organismal functional sensitivity to global change drivers. Here, we investigate the response of an ecologically important marine invertebrate to multiple environmental drivers using Energy Proxy Traits (EPTs), a new approach for measuring complex phenotypes captured on video as a spectrum of energy levels across different temporal frequencies in fluctuating pixel values. We imaged three developmental stages …

Shoreline Modelling On Timescales Of Days To Decades, Emily Hunt, Mark Davidson, Edward C. C. Steele, Jessica D. Amies, Timothy Scott, Paul Russell

School of Biological and Marine Sciences

Climate change is resulting in global changes to sea level and wave climates,which in many locations significantly increasethe probability of erosion, floodingand damage to coastal infrastructure and ecosystems.Therefore, there isa pressing societal need to be able to forecast themorphological evolution of our coastlines over a broad range of timescales, spanningdays-to-decades, facilitating more focussed, appropriate,and cost-effective management interventions and data informed planning to support thedevelopment of coastal environments. A wide range of modelling approaches have been used with varying degrees of success to assess both the detailed morphological evolution and/or simplified indicators of coastal erosion/accretion.This paper presents an overview of these …

When Bias Contributes To Variance: True Limit Theory In Functional Coefficient Cointegrating Regression, Peter C. B. Phillips, Ying Wang

Research Collection School Of Economics

Limit distribution theory in the econometric literature for functional coefficient cointegrating regression is incorrect in important ways, influencing rates of convergence, distributional properties, and practical work. The correct limit theory reveals that components from both bias and variance terms contribute to variability in the asymptotics. The errors in the literature arise because random variability in the bias term has been neglected in earlier research. In stationary regression this random variability is of smaller order and can be ignored in asymptotic analysis but not without consequences for finite sample performance. Implications of the findings for rate efficient estimation are discussed. Simulations …

The Study Of Followers In Leadership Research: A Systematic And Critical Review, Burak Oc, Kraivin Chintakananda, Michael R. Bashshur, David V. Day

Research Collection Lee Kong Chian School Of Business

Despite the significant amount of existing research examining the relationship of follower-related factors with leadership outcomes, there is no systematic, critical review that integrates and helps leadership scholars make sense of this rapidly growing body of research. To address this gap in the literature, we first briefly discuss the leading perspectives explaining the role of followers in leadership. Next, we identify and discuss the most frequently studied theoretical narratives explaining the relationship between follower-related predictors and leadership outcomes. Because theoretical arguments generally make causal claims, we identify and examine how methodological concerns including power analysis, multicollinearity, and endogeneity might prevent …

Diagnosing Housing Fever With An Econometric Thermometer, Shuping Shi, Peter C. B. Phillips

Research Collection School Of Economics

Housing fever is a popular term to describe an overheated housing market or housing price bubble. Like other financial asset bubbles, housing fever can inflict harm on the real economy, as indeed the U.S. housing bubble did in the period following 2006 leading up to the general financial crisis and great recession. One contribution that econometricians can make to minimize the harm created by a housing bubble is to provide a quantitative “thermometer” for diagnosing ongoing housing fever. Early diagnosis can enable prompt and effective policy action that reduces long-term damage to the real economy. This paper provides a selective …

Covariate Adjustment In Experiments With Matched Pairs, Yuehao Bai, Liang Jiang, Joseph P. Romano, Azeem M. Shaikh, Yichong Zhang

Research Collection School Of Economics

This paper studies inference on the average treatment effect in experiments in which treatment status is determined according to “matched pairs” and it is additionally desired to adjust for observed, baseline covariates to gain further precision. By a “matched pairs” design, we mean that units are sampled i.i.d. from the population of interest, paired according to observed, baseline covariates and finally, within each pair, one unit is selected at random for treatment. Importantly, we presume that not all observed, baseline covariates are used in determining treatment assignment. We study a broad class of estimators based on a “doubly robust” moment …

Fully Modified Least Squares Cointegrating Parameter Estimation In Multicointegrated Systems, Igor L. Kheifets, Peter C. B. Phillips

Research Collection School Of Economics

Multicointegration is traditionally defined as a particular long run relationship among variables in a parametric vector autoregressive model that introduces additional cointegrating links between these variables and partial sums of the equilibrium errors. This paper departs from the parametric model, using a semiparametric formulation that reveals the explicit role that singularity of the long run conditional covariance matrix plays in determining multicointegration. The semiparametric framework has the advantage that short run dynamics do not need to be modeled and estimation by standard techniques such as fully modified least squares (FM-OLS) on the original system is straightforward. The paper derives FM-OLS …

中小企业如何更上一层楼？, You Ren Chen, Da An Yun, Swee Liang Tan

Research Collection School Of Economics

No abstract provided.

Child Opportunity Index And Hospital Utilization In Children With Traumatic Brain Injury Admitted To The Picu, Monica M. Gray, Kurt C. Stange, Elaine A. Borawski, Steven L. Shein, Katherine N. Slain

Faculty Scholarship

IMPORTANCE: The need to understand how Community-based disparities impact morbidity and mortality in pediatric critical illness, such as traumatic brain injury. Test the hypothesis that ZIP code-based disparities in hospital utilization, including length of stay (LOS) and hospital costs, exist in a cohort of children with traumatic brain injury (TBI) admitted to a PICU using the Child Opportunity Index (COI). DESIGN: Multicenter retrospective cohort study. SETTING: Pediatric Health Information System (PHIS) database. PATIENTS: Children 0-18 years old admitted to a PHIS hospital with a diagnosis of TBI from January 2016 to December 2020 requiring PICU care. To identify the most …

Patient-Mediated Interventions In Hospital: A Systematic Review, Georgia Tobiano, Shelley Roberts, Rachel Muir, Teresa Jerofke-Owen, Christine Ting, Sarah Thorning, Daren K. Heyland, Andrea P. Marshall

College of Nursing Faculty Research and Publications

Aims

To describe the characteristics of hospital-based, patient-mediated interventions and their impact on patient, clinician and organization outcomes.

Design

Systematic review.

Data Sources

Health literature databases (MEDLINE, CINAHL and EMBASE) were searched in August 2021. Backward and forward citation searching was conducted.

Review Methods

Studies investigating patient-mediated interventions, targeted at adult hospitalized patients were eligible. Data were extracted related to study and intervention characteristics. Narrative synthesis was used to understand intervention impact on patient, clinician and organization outcomes (as per a framework). Methodological quality was assessed using the Mixed Methods Assessment Tool.

Results

Thirty-three studies, reporting 18 interventions, were included. …

A Super-Ensemble Approach To Map Land Cover Types With High Resolution Over Data-Sparse African Savanna Landscapes, Lei Song, Anna Bond Estes, Lyndon Despard Estes

Geography

Accurate and timely land cover products are critical inputs for landscape planning, and provide key information for biodiversity conservation and food security. However, poor mapping quality and low resolution are considerable issues in existing land cover maps over the African savanna, where land use is complex and changing rapidly, and necessary ground-truth data are sparse and hard to obtain. To overcome this problem, to make optimal use of existing maps, and to minimize manual training data collection, we developed a three-stage ensemble method to make land cover maps. In the first stage, we extracted the consensus of multiple existing land …

Delay: The Next "D" Factor In Travel Behavior?, Reza Sardari, Jianling Li, Raha Pouladi

SAGE Open Access Agreement Publications-Archive

Empirical research on the impact of congestion on travel behavior remains limited. This study fills this gap using a comprehensive analytical framework, an improved time-related travel delay measure, structure equation modeling, and the disaggregated household survey data for the Puget Sound Region. The results indicate that travel time delay is associated with fewer household vehicles, fewer vehicle trips, and lower vehicle miles traveled. The findings confirm the intricate impacts of the travel time delay, reinforce the importance of the “D” factors in travel behavior, and point to the need for comprehensive solutions to travel demand management.

Rationale And Design Of The Proactive-Hf Trial For Managing Patients With Nyha Class Iii Heart Failure By Using The Combined Cordella Pulmonary Artery Sensor And The Cordella Heart Failure System, Sandra Chaparro

All Publications

Background: Optimizing guideline-directed medical therapy (GDMT) and monitoring congestion in patients with heart failure (HF) are key to disease management and preventing hospitalizations. A pulmonary artery pressure (PAP)-guided HF management system providing access to body weight, blood pressure, heart rate, blood oxygen saturation, PAP, and symptoms, may provide new insights into the effects of patient engagement and comprehensive care for remote GDMT titration and congestion management.

Methods: The PROACTIVE-HF study was originally approved in 2018 as a prospective, randomized, controlled, single-blind, multicenter trial to evaluate the safety and effectiveness of the Cordella PAP Sensor in patients with HF and with …

Potential And Pitfalls Of Pharmacovigilance Databases In Oncology, Ilana Schlam, Michael S Ewer, Sandra M Swain

Duncan NRI Faculty and Staff Publications

No abstract provided.