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Chiral Photocurrent In A Quasi-1d Tis3 (001) Phototransistor, Simeon J. Gilbert, Mingxing Li, Jia-Shiang Chen, Hemian Yi, Alexey Lipatov, Jose Avila, Alexander Sinitskii, Maria C. Asensio, Peter A. Dowben, Andrew J. Yost

Department of Physics and Astronomy: Faculty Publications

The presence of in-plane chiral effects, hence spin–orbit coupling, is evident in the changes in the photocurrent produced in a TiS₃(001) field-effect phototransistor with left versus right circularly polarized light. The direction of the photocurrent is protected by the presence of strong spin–orbit coupling and the anisotropy of the band structure as indicated in NanoARPES measurements. Dark electronic transport measurements indicate that TiS₃ is n-type and has an electron mobility in the range of 1–6 cm²V⁻¹s⁻¹. I–V measurements under laser illumination indicate the photocurrent exhibits a bias directionality dependence, reminiscent of …

In This Issuereview Articleoriginal Articlescare Report

Saudi Medical Journal

No abstract provided.

The Utilization Of Artificial Intelligence Applications To Improve Breast Cancer Detection And Prognosis, Walaa M. Alsharif

Saudi Medical Journal

Breast imaging faces challenges with the current increase in medical imaging requests and lesions that breast screening programs can miss. Solutions to improve these challenges are being sought with the recent advancement and adoption of artificial intelligent (AI)-based applications to enhance workflow efficiency as well as patient-healthcare outcomes. rtificial intelligent tools have been proposed and used to analyze different modes of breast imaging, in most of the published studies, mainly for the detection and classification of breast lesions, breast lesion segmentation, breast density evaluation, and breast cancer risk assessment. This article reviews the background of the Conventional Computer-aided Detection system …

Prevalence Of Pelvic Floor Disorders In The Eastern Mediterranean Region: A Meta-Analysis, Hassan M. Elbiss, Wardah Rafaqat, Khalid S. Khan

Saudi Medical Journal

Objectives: High prevalence of risk factors for pelvic floor disorders (PFD) in the Eastern Mediterranean may result in higher rates of prevalence of PFD in comparison to other regions. Despite individual studies, there are no clear statistics on the cumulative prevalence of PFDs in the East Mediterranean region. The aim of this study was to investigate the prevalence of PFDs in the Eastern Mediterranean region. Methods: A literature search without language restriction was conducted in PubMed, Cochrane database and Web of Science from 2016 to 01 June 2022. Cross-sectional and cohort studies that reported prevalence of urinary incontinence (UI), constipation, …

Bilateral 4-Quadrant Laparoscopic-Assisted Transversus Abdominis Plane Block Reduces Early Postoperative Pain After Laparoscopic Cholecystectomy: A Prospective, Single-Blind, Randomized Study, Eralp Çevikkalp, Mustafa Narmanlı, Halil Özgüç, Gökhan Ocakoğlu

Saudi Medical Journal

Objectives: To investigate the efficacy of bilateral 4-quadrant laparoscopic-assisted transversus abdominis plane (BLTAP) block in laparoscopic cholecystectomy (LC). Methods: This study was carried out at Private Medicabil Hospital, Bursa, Turkey, between September 2021 and March 2022. Patients were randomly divided into 4 groups (n=40, each): i) the standard analgesia (SA) group received the block and port-site infiltration with normal saline (NS); ii) the local anesthetic group received the block with NS and port-site infiltration of bupivacaine; iii) the unilateral laparoscopic-assisted transversus abdominis plane (ULTAP) block group received 2-quadrant block with bupivacaine on the right and NS on the left and …

A Prospective Double-Blinded Randomized Control Trial Comparing Erector Spinae Plane Block To Thoracic Epidural Analgesia For Postoperative Pain In Video-Assisted Thoracic Surgery, Jeong-Min Hong, Eunsoo Kim, Soeun Jeon, Dowon Lee, Jiseok Baik, Ah-Reum Cho, Jeong Su Cho, Hyo Yeong Ahn

Saudi Medical Journal

Objectives: To compare the analgesic efficacies of erector spinae plane (ESP) block and thoracic epidural analgesia (TEA) in video-assisted thoracic surgery (VATS). Methods: Sixty patients undergoing VATS received patient-controlled TEA with a basal rate of 3 ml/hour (h), a bolus of 3 ml (Group E), or ESP block with programmed intermittent bolus infusions of 15 mL/3 h and a bolus of 5 ml (Group ES) for 2 postoperative days. The primary outcome was to compare pain scores at rest 24 h postoperatively between the 2 groups. Secondary outcomes included NRS score for 48 h, procedural time, dermatomal spread, use of …

The Clinical Results Of Lower Trapezius Tendon Transfer With The Peroneus Longus Allograft Augmentation Combined With Interpositional Repair With Fascia Lata In Massive Irreparable Rotator Cuff Tears, Muhammet Bozoğlan, Murat Danışman, Tuğcan Demir, Halil Karaca, Cem Zeki Esenyel

Saudi Medical Journal

Objectives: To investigate the clinical results of lower trapezius (LT) tendon transfer and interpositional repair that were performed simultaneously in patients with massive irreparable rotator cuff tears. Methods: Between 2018 and 2020 years, 16 patients with massive irreparable rotator cuff tears that were treated with LT tendon transfer and interpositional repair at the same time were included in this study. The mean follow-up period was 29±3 months (24-39 months) and the mean age of patients was 62±9 years (42-73 years). The acromio-humeral distance, active range of motions, Visual Analog Scale (VAS) scores, University of California-Los Angeles (UCLA) scores and Constant-Murley …

Does The Preoperative Fasting Period Affect The Liver In A Distant Organ Model Of Renal Ischaemia Reperfusion?, Yasemin Akcaalan, Ersin Gurkan Dumlu, Ebru Menekse, Mustafa Cem Yilmaz, Ezgi Erkilic, Betul Ogut, Aylin Sepıcı Dıncel

Saudi Medical Journal

Objectives: To experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury. Methods: This is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-α), interleukin (IL) …

Real Time Endobronchial Ultrasound Transbronchial Needle Aspiration For The Diagnosis Of Tuberculous Intrathoracic Lymphadenopathy: Saudi Arabian Western Region Experience, Ahmed A. Aljohaney

Saudi Medical Journal

Objectives: To assess the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for presumptive tuberculosis (TB) patients with intrathoracic enlarged lymph nodes in a country with low to moderate TB incidence. Methods: Thirty-one patients with clinical features of TB and intrathoracic lymphadenopathy, who had EBUS-TBNA sampling and final confirmation of intrathoracic TB lymphadenopathy, were retrospectively reviewed over an 8-year period. Routine clinical and laboratory evaluations including computerized tomography scans were performed before the EBUS-TBNA. Sociodemographic characteristics, clinical profile, pathological, and microbiological findings were collected. Results: The EBUS-TBNA confirmed TB diagnosis in 26 (83.9%) subjects with a consistent pathological finding or …

Presentations Of Active Substance Use In The Emergency Department: A Single Center’S Perspective Study In Riyadh, Saudi Arabia, Mohammed K. Alageel, Alshamoos A. Alwassel, Hamad A. Almohsen

Saudi Medical Journal

Objectives: To explore the most common clinical presentations of active substance users in our institution’s Emergency Department (ED). Methods: This was a retrospective chart review of all patients that were brought to the ED of King Saud University Medical City in Riyadh, Saudi Arabia thought to be actively using illicit substances, between January 2019 and December 2021. Those with incomplete data were excluded. Results: A total of 582 patients were included in the study, 532 (91.4%) males, the majority were in the age group 21-30 years old (53.1%). Most patients were fully alert (n=405, 69.6%). Overall, cannabis was used by …

Assessing The Adverse Effects Of Covid-19 Vaccine In Different Scenarios In Saudi Arabia: A Cross-Sectional Study, Ahad Amer Alsaiari, Mamdouh Allahyani, Abdulelah Aljuaid, Alaa Shafie, Ayman Al-Hazmi, Haytham A. Dahlawi, Osama Abdulaziz, Ebtisam Alosimi, Albatool Alzaidi, Mazen Almehmadi

Saudi Medical Journal

Objectives: To assess the different side effects of COVID-19 vaccines at different scenarios in Saudi Arabia. Methods: This cross-sectional study sought to investigate the side effects of COVID-19 vaccines through an online survey of 2,718 participants in Saudi Arabia. Results: People can manage their expectations about vaccine side effects and deal with symptoms better by knowing beforehand that they are likely to experience mild side effects for a short period, symptoms that are manifested regardless of age, and infection before or after vaccination. There are certain uncommon side effects that affect more people who got infected, and not before vaccination; …

Prevalence Of Microvascular Complications Among Patients With Type 2 Diabetes Mellitus Who Visited Diabetes Clinics In Saudi Arabia, Mounther M. Alnaim, Abdullah Alrasheed, Abdullah A. Alkhateeb, Mohammed M. Aljaafari, Abdulrahman Alismail

Saudi Medical Journal

Objectives: To determine the microvascular complications prevalence in patients with type 2 diabetes mellitus (DM) in the eastern province of the Kingdom of Saudi Arabia. Methods: The participants in this retrospective, cross-sectional study included patients with type 2 DM who visited the diabetes clinics of primary health care centers of 2 National Guard Hospitals, Eastern Province, Saudi Arabia. Results: This study included 935 patients with type 2 diabetes (54.1% women versus 45.9% men). Oral hypoglycemic medication was the most common treatment (90.3%). Overall, 55.1% of patients visited the ophthalmology clinic for retinopathy screening. The last glycated hemoglobin A1c result (mean: …

Do Certain Jobs Increase A Woman’S Risk Of Pregnancy Loss?

Saudi Medical Journal

No abstract provided.

Does Self-Stigma Impact Blood Glucose Control In People With Type 1 Diabetes?

Saudi Medical Journal

No abstract provided.

Five Billion People Unprotected From Trans Fat Leading To Heart Disease

Saudi Medical Journal

No abstract provided.

One Size Does Not Fit All: A Comparison Of White, Latinx, And Black Student's Unadjusted And Adjusted Gpas In A College Of Business And Public Administration Of A Hispanic Serving Institution, Francisca Beer, Daniel Macdonald

International Journal for Business Education

Because higher education creates more informed individuals, healthier citizens, social prestige, job satisfaction, and numerous other non-economic benefits, it is important that all members of society have opportunities for successful educational achievement. Using data for undergraduate students enrolled in a business college of a large Hispanic Serving Institution (HSI), this study documents the existence of an unadjusted GPA gap between White students and ethnic minority students. This study also shows that the unadjusted GPA gaps decrease when socio-economic indicators are introduced in the analysis. The gaps continue to decrease when units-taken, transfer status, age, and student status are added to …

Borderplex Business Barometer, Volume 7, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

Development Of A Porous Layer-By-Layer Microsphere With Branched Aliphatic Hydrocarbon Porogens, Farah Shahjin, Milankumar Patel, Mahmudul Hasan, Jacob D. Cohen, Farhana Islam, Md Ashaduzzaman, Mohammad Ullah Nayan, Mahadevan Subramaniam, You Zhou, Irene Andreu, Howard E. Gendelman, Bhavesh D. Kevadiya

Nebraska Center for Biotechnology: Faculty and Staff Publications

Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms.

Planning And Learning For Non-Markovian Negative Side Effects Using Finite State Controllers, Aishwarya Srivastava, Sandhya Saisubramanian, Praveen Paruchuri, Akshat Kumar, Shlomo Zilberstein

Research Collection School Of Computing and Information Systems

Autonomous systems are often deployed in the open world where it is hard to obtain complete specifications of objectives and constraints. Operating based on an incomplete model can produce negative side effects (NSEs), which affect the safety and reliability of the system. We focus on mitigating NSEs in environments modeled as Markov decision processes (MDPs). First, we learn a model of NSEs using observed data that contains state-action trajectories and severity of associated NSEs. Unlike previous works that associate NSEs with state-action pairs, our framework associates NSEs with entire trajectories, which is more general and captures non-Markovian dependence on states …

Flexible Job-Shop Scheduling Via Graph Neural Network And Deep Reinforcement Learning, Wen Song, Xinyang Chen, Qiqiang Li, Zhiguang Cao

Research Collection School Of Computing and Information Systems

Recently, deep reinforcement learning (DRL) has been applied to learn priority dispatching rules (PDRs) for solving complex scheduling problems. However, the existing works face challenges in dealing with flexibility, which allows an operation to be scheduled on one out of multiple machines and is often required in practice. Such one-to-many relationship brings additional complexity in both decision making and state representation. This article considers the well-known flexible job-shop scheduling problem and addresses these issues by proposing a novel DRL method to learn high-quality PDRs end to end. The operation selection and the machine assignment are combined as a composite decision. …

Learning Comprehensive Global Features In Person Re-Identification: Ensuring Discriminativeness Of More Local Regions, Jiali Xia, Jianqiang Huang, Shibao Zheng, Qin Zhou, Bernt Schiele, Xian-Sheng Hua, Qianru Sun

Research Collection School Of Computing and Information Systems

Person re-identification (Re-ID) aims to retrieve person images from a large gallery given a query image of a person of interest. Global information and fine-grained local features are both essential for the representation. However, global embedding learned by naive classification model tends to be trapped in the most discriminative local region, leading to poor evaluation performance. To address the issue, we propose a novel baseline network that learns strong global feature termed as Comprehensive Global Embedding (CGE), ensuring more local regions of global feature maps to be discriminative. In this work, two key modules are proposed including Non-parameterized Local Classifier …

Effective Graph Kernels For Evolving Functional Brain Networks, Xinlei Wang, Jinyi Chen, Bing Tian Dai, Junchang Xin, Yu Gu, Ge Yu

Research Collection School Of Computing and Information Systems

The graph kernel of the functional brain network is an effective method in the field of neuropsychiatric disease diagnosis like Alzheimer's Disease (AD). The traditional static brain networks cannot reflect dynamic changes of brain activities, but evolving brain networks, which are a series of brain networks over time, are able to seize such dynamic changes. As far as we know, the graph kernel method is effective for calculating the differences among networks. Therefore, it has a great potential to understand the dynamic changes of evolving brain networks, which are a series of chronological differences. However, if the conventional graph kernel …

Generalization Bounds For Inductive Matrix Completion In Low-Noise Settings, Antoine Ledent, Rodrigo Alves, Yunwen Lei, Yann Guermeur, Marius Kloft

Research Collection School Of Computing and Information Systems

We study inductive matrix completion (matrix completion with side information) under an i.i.d. subgaussian noise assumption at a low noise regime, with uniform sampling of the entries. We obtain for the first time generalization bounds with the following three properties: (1) they scale like the standard deviation of the noise and in particular approach zero in the exact recovery case; (2) even in the presence of noise, they converge to zero when the sample size approaches infinity; and (3) for a fixed dimension of the side information, they only have a logarithmic dependence on the size of the matrix. Differently …

Remediating System Neglect In Judgmental Demand Forecasting, Srikant Vinakota

Dissertations and Theses Collection (Open Access)

Prior research has shown that individuals tasked with judgmental forecasting of demand based on time-series data overreact in stable environments and underreact in unstable environments. Kremer et al. (2011) attributed this to the system neglect hypothesis, which claims that forecasters emphasize forecast errors over the system parameters.

The present research investigates interventions that mitigate system neglect and address the causal factors for overreaction and underreaction. Given the desire by organizations to move towards touchless planning and automated decision-making, minimizing human judgment and understanding its drivers is of significant practical importance.

We tested four different interventions on an online subject pool …

Empirical Study Of Esg Ratings In China’S A-Share Market: A Focus On The Csi 800 Stocks, Wenqing Tan

Dissertations and Theses Collection (Open Access)

In this study, we focus on the Chinese A-share market, and particularly on the CSI 800 stocks. Our aim is to conduct a comparison analysis of the prominent environmental, social, and governance (ESG) rating agencies in an effort to reflect the growing importance of ESG investment, social responsibility, and sustainable development. We mainly use three mainstream rating agencies’ rating data (i.e., the China Securities Index [CSI], Wind, and SynTao Green Finance) to conduct descriptive statistics and comparative analysis. Furthermore, we conduct grouping tests on the ESG scores in the CSI 800 and across various sectors to explore their effectiveness in …

Caribbean Partnership Expands, Sarah Schaier

UNH Today Archive

No abstract provided.

Beyond Varices: Complications Of Cirrhotic Portal Hypertension In Pediatrics, Anna M Banc-Husu, Henry Shiau, Peace Dike, Benjamin L Shneider

Faculty, Staff and Students Publications

Complications of cirrhotic portal hypertension (PHTN) in children are broad and include clinical manifestations ranging from variceal hemorrhage, hepatic encephalopathy (HE), ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS) to less common conditions such as hepatopulmonary syndrome, portopulmonary hypertension, and cirrhotic cardiomyopathy. The approaches to the diagnosis and management of these complications have become standard of practice in adults with cirrhosis with many guidance statements available. However, there is limited literature on the diagnosis and management of these complications of PHTN in children with much of the current guidance available focused on variceal hemorrhage. The aim of this review …

Current Challenges And Future Direction In Surveillance For Hepatocellular Carcinoma In Patients With Nonalcoholic Fatty Liver Disease, George Cholankeril, Hashem B El-Serag

Faculty, Staff and Students Publications

The burden for hepatocellular carcinoma (HCC) attributed to nonalcoholic fatty liver disease (NAFLD) continues to grow in parallel with rising global trends in obesity. The risk of HCC is elevated among patients with NAFLD-related cirrhosis to a level that justifies surveillance based on cost-effectiveness argument. The quality of current evidence for HCC surveillance in all patients with chronic liver disease is poor, and even lower in those with NAFLD. For a lack of more precise risk-stratification tools, current approaches to defining a target population in noncirrhotic NAFLD are limited to noninvasive tests for liver fibrosis, as a proxy for liver-related …

Genetic Variants In Arhgef6 Cause Congenital Anomalies Of The Kidneys And Urinary Tract In Humans, Mice, And Frogs, Verena Klämbt, Florian Buerger, Chunyan Wang, Thomas Naert, Karin Richter, Theresa Nauth, Anna-Carina Weiss, Tobias Sieckmann, Ethan Lai, Dervla M Connaughton, Steve Seltzsam, Nina Mann, Amar J Majmundar, Chen-Han W Wu, Ana C Onuchic-Whitford, Shirlee Shril, Sophia Schneider, Luca Schierbaum, Rufeng Dai, Mir Reza Bekheirnia, Marieke Joosten, Omer Shlomovitz, Asaf Vivante, Ehud Banne, Shrikant Mane, Richard P Lifton, Karin M Kirschner, Andreas Kispert, Georg Rosenberger, Klaus-Dieter Fischer, Soeren S Lienkamp, Mirjam M P Zegers, Friedhelm Hildebrandt

Faculty, Staff and Students Publications

Background: About 40 disease genes have been described to date for isolated CAKUT, the most common cause of childhood CKD. However, these genes account for only 20% of cases. ARHGEF6, a guanine nucleotide exchange factor that is implicated in biologic processes such as cell migration and focal adhesion, acts downstream of integrin-linked kinase (ILK) and parvin proteins. A genetic variant of ILK that causes murine renal agenesis abrogates the interaction of ILK with a murine focal adhesion protein encoded by Parva , leading to CAKUT in mice with this variant.

Methods: To identify novel genes that, when mutated, result in …

Lumasiran For Advanced Primary Hyperoxaluria Type 1: Phase 3 Illuminate-C Trial, Mini Michael, Jaap W Groothoff, Hadas Shasha-Lavsky, John C Lieske, Yaacov Frishberg, Eva Simkova, Anne-Laure Sellier-Leclerc, Arnaud Devresse, Fitsum Guebre-Egziabher, Sevcan A Bakkaloglu, Chebl Mourani, Rola Saqan, Richard Singer, Richard Willey, Bahru Habtemariam, John M Gansner, Ishir Bhan, Tracy Mcgregor, Daniella Magen

Faculty, Staff and Students Publications

Rationale & objective: Lumasiran reduces urinary and plasma oxalate (POx) in patients with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function. ILLUMINATE-C evaluates the efficacy, safety, pharmacokinetics, and pharmacodynamics of lumasiran in patients with PH1 and advanced kidney disease.

Study design: Phase 3, open-label, single-arm trial.

Setting & participants: Multinational study; enrolled patients with PH1 of all ages, estimated glomerular filtration rate ≤45 mL/min/1.73 m2 (if age ≥12 months) or increased serum creatinine level (if age < 12 months), and POx ≥20 μmol/L at screening, including patients with or without systemic oxalosis.

Intervention: Lumasiran administered subcutaneously; 3 monthly doses followed by monthly or quarterly weight-based dosing.

Outcome: Primary end point: percent change in POx …