Digital Commons Network^™

Effects Of Renin-Angiotensin System Targeting Drugs On Cerebral Amyloid Angiopathy And Related Neuropathology, Anna Maria Weber, Ariana Hernandez, Chana Vogel, Victoria Pulido-Correa, Maria Agustina Paiz, Shaina Binu, Sonakshi Kose, Aayush Doshi, Dylan Kuni, Sylvia Yousef

Undergraduate Student Symposium

Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease characterized by beta-amyloid (Aβ) accumulation in the cerebral vasculature, resulting in vascular cognitive impairment and dementia (VCID) along with other neuropathologies such as inflammation. Given that medications approved to treat CAA currently do not exist, this highlights that there is a pressing need for more innovative approaches to drug discovery. In this study, classical renin-angiotensin system (RAS)-inhibiting antihypertensive drugs were repurposed to investigate their efficacy for mitigating CAA-associated neuropathology and cognitive decline, while additionally evaluating for sex-specific outcomes. Male and female Tg-SwDI mice were treated for 4 months with non-hypotensive doses …

Evaluting Practical Limitations Of Signal Detection Theory In Clinical Behavioral Research, Xinlei Zhang, Prarthana Harikrishnan

Undergraduate Student Symposium

Deficits in inhibitory control - the ability to suppress automatic, impulsive responses - has been widely considered as a potential biomarker for mental health disorders. Signal Detection Theory (SDT) has provided a systematic measurement method for inhibitory control in clinical behavioral assessment. To evaluate the feasibility of inhibitory control as a biomarker, researchers have used meta-analysis to examine its effect size (Hedge's g) in differentiating between individuals with mental health disorders and healthy controls. Values of g>0.8 indicate that inhibitory control may serve as a clinically useful biomarker for distinguishing patients from healthy individuals, whereas g<0.8 suggests limited clinical utility. However, our study found that a limitation of SDT - its lack of reliability when participants show perfect performance - would lead to distorted and misleading results when evaluating the efficacy of inhibitory control as a biomarker. In our computational simulation, we found that when applying SDT to a clinically useful biomarker (for example, true effect size g = …

Sexual Dimorphism In Physiological, Metabolic, And Hypothalamic Alterations In The Tg-Swdi Mouse Model Of Alzheimer's Disease, Yingying Zhu, Ariana Hernandez, Natalia Noto, Victoria Pulido-Correa, Chana Vogel, Julianna Bonetti

Undergraduate Student Symposium

Alzheimer's disease (AD) is a neurodegenerative disorder affecting 55 million people worldwide. Cognitive disruptions, linked to pathology in the hippocampus and cortical areas, are frequently observed in individuals with late manifestation of AD; however, non-cognitive dysfunctions, which contribute to poor quality of life and survival, are often overlooked. The hypothalamus plays a role in regulating homeostatic functions such as hunger, thirst, sleep, and blood pressure. The coordinated activity of hypothalamic regions such as the paraventricular nucleus, arcuate nucleus, ventromedial nucleus, dorsomedial nucleus, and lateral hypothalamus are crucial in maintaining metabolic homeostasis and neuroendocrine processes. Dysregulation of these processes has been …

Discovery And Genome Annotation Of Tuti And Charminar: Two Newly Discovered Gordonia Rubripertincta Bacteriophages, Tracey Alexis, Melissa Bassily, Jayden Courtney, Tamanna Dipen Shah, Javier Estepa, Malak Gadelkarim, Wayne Jean-Baptiste, Elias Leyes, Anushka Malay, Mackenzie Nezat, Mahisvi Vemulapalli

Undergraduate Student Symposium

As the most abundant organisms, bacteria are both beneficial and harmful, highlighting the significance of regulating their growth. Bacteriophages (phages) are ubiquitous viruses that require a host bacterial organism for replication, making them an essential component of the microbial ecosystem and used as tools for killing bacteria. Since their discovery in 1915, phages have been used in real-world applications including alternatives to antibiotics, diagnostic agents, pest control in agriculture, wastewater treatment, and bioremediation. Since bacteriophages remain mostly undiscovered, continued isolation and genetic characterization of novel phages are essential for advancing scientific knowledge and potential applications. Through Nova Southeastern University's SEA-PHAGES …

Repetitive Mild Traumatic Brain Injury Exacerbates Cognitive Deficits In A Mouse Model Of Cerebral Amyloid Angiopathy, Lauren Rosenberg, Victoria Pullido-Correa, Ariana Hernandez, Chana Vogel, Bianca Echeverria, Iliana Uribe

Undergraduate Student Symposium

Traumatic brain injury (TBI) affects around 69 million people each year, with mild TBIs (mTBIs) making up the majority of cases. These injuries, often sustained during contact sports, military service, or incidents of domestic violence, typically involve brief or no loss of consciousness and few immediate symptoms. However, repeated occurrences significantly elevate the risk for long-term complications, including dementia. While repetitive in mTBI is strongly linked to chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD), the relationship with cerebral amyloid angiopathy (CAA), characterized by the accumulation of amyloid peptides in the cerebral vasculature, remains understudied. Given that CAA significantly contributes …

Addressing Burnout In Medical Education: A Meta-Analysis Of Florida Medical School, Riddhi Banjeree

Undergraduate Student Symposium

Burnout and mental health issues in medical students in the United States have become increasingly prominent -- posing challenges for student well-being, patient care, and the future of the physician workforce. Burnout is characterized by emotional exhaustion, depersonalization, and a loss of personal accomplishment. These traits can develop early in med school, perpetuate throughout their training years, and are reinforced by demanding academic workloads, competitive exams, and emotionally taxing clinical experiences. The purpose of this project is to examine mental health, counseling, and wellness resources offered across eight medical schools in Florida - U Miami, UCF, UF, USF, FAU, FIU, …

Virtual Reefscapes: Modeling Fish Abundance On Artificial And Natural Reefs In Broward County, Jesse Caruana Snachkus

Undergraduate Student Symposium

This project involved constructing a VR simulation of fish abundance on artificial and natural reefs in Broward County. Two environments, SS Tracey, and a section of the Florida Reef Tract, were created to highlight ecological differences between artificial and natural reef habitats. All environments and species models were designed in Blender, a 3D modeling software, and each fish species was animated to showcase naturalistic behavior. The completed assets were then assembled in VR using the Open Brush application. This project integrates art, technology, and ecology to make marine environments more accessible and engaging for a wide audience. A combination of …

Gathering College Students' Interests In Bone Health By Promoting Vitamin K2 Consumption, Nida Haider

Undergraduate Student Symposium

The human skeleton requires constant sources of nutrients (calcium, vitamin D3, vitamin K) for bone remodeling, maintaining bone mass, and bone density. While there is existing evidence regarding the benefits of calcium and vitamin D3 on bone health, there have been recent studies of the effects of vitamin K derivatives (vitamins K1 and K2) on bone maintenance. The growing popularity of the new over-the-counter supplement named "Vitamin D3 + K2" has initiated our interest in a deeper understanding of the mechanisms of the vitamin K derivatives' roles in bone health regulation. Vitamin K is a fat-soluble vitamin that naturally exists …

Bison Health Network Newsletter, April 2026, Bison Health Network

Bison Health Network News

Newsletter Contents:

Updates
Network Demographics
Health Highlight: Ruminal Acidosis

Investigating The Structural And Functional Roles Of Transcriptionally Active Rice Transposons, Eimaan Admad

Undergraduate Student Symposium

Transposable elements (TEs) are crucial contributors to genome dynamics, evolution, gene structure, and regulation of gene expression. Once considered "junk DNA," TEs are now recognized for their significant roles in genome function and organization. TEs are epigenetically regulated through chromatin modifications, genomic imprinting, and the production of small RNAs and long non-coding RNAs (lncRNAs), which in turn can influence gene expression. Despite a wealth of data from sequencing projects advancing TE research, their large size—often exceeding the read lengths of many sequencing platforms—has limited comprehensive analysis. Moreover, the high copy number and sequence similarity (often >80%) within TE families can …

Environmental Exposure And Neighborhood Change: A Longitudinal Study Of Little Haiti, Miami, Joshua Dumond

Undergraduate Student Symposium

Urban development trends in coastal cities are increasingly impacted by environmental characteristics like elevation. As individuals and businesses residing near the coast move inland to escape rising sea levels, climate-resilient communities may begin to experience increased housing market trends and real estate investment. This longitudinal, retrospective study investigates how elevation influences the housing market in higher-ground communities, with a focus on the Little Haiti neighborhood in Miami, Florida, while also describing changes in demographic characteristics over time. Census tracts within Little Haiti were used as the unit of analysis for this study while using the U.S. Geological Survey Data to …

Evaluating Item Discrimination And Gender-Based Differential Item Functioning In Safe Sex Behavior Questionnaire (Ssbq), Prarthana Harikrishnan, Xinlei Zhang, Hannah Scheffer

Undergraduate Student Symposium

Risky sexual behavior can increase rates of sexually transmitted infections (STIs), posing a danger to the health of young adults. The Safe Sex Behavior Questionnaire (SSBQ; Dilorio et al., 1992) is a widely used measure to assess risky sexual behaviors among young adults. However, few studies have evaluated the psychometric properties of the SSBQ, such as how well the survey items discriminate between individuals who engage in safer versus riskier sexual behaviors (discrimination), and whether the items function equivalently for men versus women (differential item functioning). In the current study, we applied psychometric modeling to a dataset of 1,094 young …

Ketone Bodies As Regulators Of Cardiac Energy Metabolism And Cardiovascular Signaling, Eera Mehrota, Anika Singh, Meghana Divi, Cynthia Chamoun, Samiksha Chemukula

Undergraduate Student Symposium

The heart has a high and continuous energy demand and depends on metabolic flexibility to maintain function under both physiological and pathological conditions. Ketone bodies, particularly β-hydroxybutyrate, have emerged as important alternative fuels for the myocardium and as biologically active signaling molecules. This review examines how ketone bodies support cardiac energy metabolism and regulate vascular and myocardial biology through intracellular signaling pathways. A narrative synthesis of peer-reviewed literature was conducted, focusing on ketone utilization in healthy and diseased hearts, metabolic remodeling in heart failure, and the non-energetic signaling roles of ketone bodies in cardiovascular tissues. Evidence indicates that ketone bodies …

Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye

Faculty Publications

Inorganic–organic hybrid materials have been widely investigated for their applications in catalysis, optics, magnetism, and biomedicine. Copper halide complexes are of particular interest due to their structural diversity and physicochemical properties. Conventional crystal growth approaches, such as slow evaporation and hydro(solvo)thermal synthesis, typically require extended reaction times and often favor thermodynamically stable phases. In this study, we prepared ten copper-phenanthroline halide (X = Cl, Br, and I) complexes using both traditional hydrothermal reactions and microwave-assisted hydrothermal methods and obtained [CuI(C₁₂H₈N₂)₂][I₃], [C₁₂H₉N₂][CuI₂]·(H_{2 …}

Cover Page Vol. 65 Issue 1

Reading Horizons: A Journal of Literacy and Language Arts

No abstract provided.

Data Siloing As A Solution To Google’S Illegal Monopoly, Derek Polson, Victoria Wood

Brigham Young University Prelaw Review

While the court-issued remedies prescribed in United States of America v. Google LLC (2024) aim to curb Google’s use of anticompetitive practices, they fail to address the structural mechanisms that sustain its monopoly. Antitrust remedies in the U.S. traditionally seek to (1) end anticompetitive practices and (2) reopen competitive market conditions. The court’s approach in this case does neither. By leaving intact Google’s ability to leverage significant barriers to entry and its unparalleled big data advantage, the court’s remedies preserve the very conditions that entrench Google’s dominance in the digital advertising and search engine markets. This note argues that data …

Reconsidering The Take It Down Act, Cate Thorpe

Brigham Young University Prelaw Review

In the past decade, there has been an increase in digital forgeries leading to the phenomena many have called “revenge porn.” This form of Nonconsensual Intimate Imagery (NCII) has been facilitated by AI-models that allow users to create false images or videos of someone’s likeness, often referred to as deepfakes. In an attempt to combat the dissemination of such forged NCIIs, Congress enacted the TAKE IT DOWN Act. The Act institutes a notice-and-removal procedure for victims to request the removal of  NCIIs depicting their likeness on covered platforms. While the TAKE IT DOWN Act sufficiently addresses some concerns, certain aspects …

The Inapplicability Of Government Speech Doctrine In School Libraries, Dallyn Edmunds

Brigham Young University Prelaw Review

Since 2021, the number of books removed from school libraries has risen dramatically. These removals have led to lawsuits and questions surrounding the control a state may exercise over the school library. In almost every current case, the government has argued these cases should be dismissed because of the government speech doctrine. A fairly recent creation, the government speech doctrine is the understanding that the government, in order to accomplish its purposes, may at times exercise viewpoint discrimination and regulate speech in ways that perhaps seem prohibited by the First Amendment. Evaluation in government speech cases has typically undergone a …

The Implication Of Permanence: Indigenous Water Rights In The State Of Arizona V. Navajo Nation, Collin Powell

Brigham Young University Prelaw Review

In the State of Arizona v. Navajo Nation, the Supreme Court asked the Navajo to accept a contradiction. In light of disagreements over water rights between Arizona and the Navajo Tribe, members of the Navajo pointed to the Treaty of Bosque Redondo. The Treaty was a compromise between the Navajo and US Officials to reparate the Navajo after “The Long Walk”: a series of forced relocations against the Natives that resulted in over 2,500 deaths. Among these reparations was the guarantee of a “permanent home” on US federal lands. For over a century, case law defined a “permanent home” to …

Full Issue

Brigham Young University Prelaw Review

No abstract provided.

Bringing Order To Chaos: Hearsay Rules In Immigration Courts, Joseph Romano

Immigration Law Blog

This Article examines the admission of hearsay evidence in immigration courts, where judges apply a flexible “probative and fundamentally fair” standard rather than the Federal Rules of Evidence. The Article identifies a lack of clear doctrinal guidance and resulting disparities across cases. To address this gap, the Article proposes a structured four-factor framework focusing on reliability, corroboration, opportunity for rebuttal, and outcome centrality to better ensure consistent and fair adjudication.

Fluctuating Hallucinations: On The Boundaries Of Immigration Judges’ Discretion In The Determination Of Asylum Based On Political Opinions, Yan Zhang

Immigration Law Blog

This article examines the enigmatic nature and blurred boundaries of the discretionary power exercised by immigration judges in asylum cases, highlighting how the scope of such discretion—whether broad or narrow—proves decisive for the applicants and their families. Through a comparative analysis of specific cases, the article underscores the critical importance of immigration judges seeking to discern and follow the true intent of the law—specifically, by deeply understanding and defining the threshold of “persecution,” delineating the boundaries of “political opinion,” and appropriately weighing and prioritizing immigration policies within their specific historical contexts. Furthermore, it is essential that judges conduct a comprehensive …

Book Clubs And Young Adult Literature: Preparing Preservice Special Educators In Inclusive Literacy Practices, Marie Tejero Hughes, Juana Abarca, Marta Mohammad

Reading Horizons: A Journal of Literacy and Language Arts

The study presented in this article explored how book clubs centered on young adult (YA) literature supported 67 preservice special educators (PSEs) in developing inclusive literacy practices. The study examined PSEs’ reflections on social, cultural, and personal themes in YA narratives and how these informed their planning for students with disabilities. Using a qualitative descriptive approach, researchers analyzed online discussion posts collected over a 6-week book club course component. Findings reveal that PSEs engaged with themes such as identity, resilience, systemic inequities, and disability representation, often connecting literature to their own positionalities and future teaching roles. PSEs also identified a …

Home Visits As Culturally Sustaining Pedagogy: A First-Grade Classroom Community Learns From Families’ Shared Assets And Challenges, Jen Mccreight

Reading Horizons: A Journal of Literacy and Language Arts

This article builds on existing scholarship by analyzing the use of home visits as a tool to learn about families’ funds of knowledge—their viewpoints, beliefs, and critical understandings—while also examining families’ own complex views of their linguistic and cultural assets. Through the lens of culturally sustaining pedagogy, the article discusses how home visits were used as a family/school partnership practice that celebrated and built on first grade students’ unique cultural and linguistic assets, as well as how families’ insights were shared with and taken up by first-grade students through classroom activities and projects.

Physiological Correlates Of Health-Related Anxiety - An Investigation Between Heart Rate Variability (Hrv) And Blood Pressure Reactivity In Clinical Settings, Alvaro Villarreal, Sarah Headapohl, Chase Parks, Melanie Gonzalez, Sage Olsson, Mounyjwok Odhong

SPARK Symposium Presentations

White coat syndrome – also known as white coat hypertension –  consists in a sharp increase in blood pressure as a result of increased underlying anxiety (Mancia et al. 1677) in clinical and health settings. White coat syndrome has had conflicting results surrounding it, with early research suggesting it requires no serious clinical attention or diagnosis, while more recent research suggests the contrary, that white coat syndrome is clinically problematic and associated with increased cardiovascular risk, metabolic abnormalities, cardiovascular fatalities, and asymptomatic organ damage. This study aims to fill a gap in literature by investigating the impact of induced white …

Preservice Teachers’ Knowledge, Skills, And Perceptions Related To Data-Based Decision Making In Elementary Reading Instruction, Erin K. Washburn, Samantha A. Gesel, Miranda S. Fitzgerald, Corinne R. Kingsbery

Reading Horizons: A Journal of Literacy and Language Arts

Teachers’ knowledge of and ability to use reading assessments and assessment data to inform instruction has long been recognized as a core teaching competency. Data-based decision making (DBDM) is a process by which educators examine assessment data to identify student strengths and needs and apply those findings to their practice. DBDM has been linked to student achievement/engagement and positive teacher self-efficacy. However, DBDM, specifically in reading, is a complex process for teachers. Preservice teacher preparation has been deemed a space for the introduction of DBDM in reading. However, few studies have explored how targeted instruction in reading-related DBDM may impact …

Mobility Without Retention: Reforming The Compact Of Free Association To Address Human Capital Flight, Ellery Miller, Porter O'Reilly

Brigham Young University Prelaw Review

In the aftermath of United States nuclear testing in the Republic of the Marshall Islands (RMI), which rendered several atolls uninhabitable, the country now confronts a different threat: sustained human capital flight. To compensate the RMI for nuclear damages, the United States signed into law the Compact of Free Association (COFA), a treaty structured around three core commitments: (1) defense and security, (2) economic assistance, and (3) unrestricted migration rights. Under COFA, Marshallese citizens may live and work in the United States without a visa, which has resulted in large-scale outmigration of the working-age and educated population. This Note argues …

Thinking Ahead: Ranking Substantive Canons To Protect Loper Bright, Tanner Macdonald

Brigham Young University Prelaw Review

After forty-two years, the Supreme Court overturned Chevron deference in their decision Loper Bright Enterprises v. Raimondo (2024). The decision suggested a rising inclination towards legal formalism in cases of statutory interpretation. This Note argues that if the Court intends statutes to be interpreted in accordance with formalism, clarification is needed. Loper Bright was not sufficient to clear up the inconsistencies in statutory interpretation that the Court used to overrule Chevron. Without a strong prescription, Loper Bright will eventually collapse on itself. A formal ranking of substantive canons is one type of structure that would support Loper Bright and enable …

Rethinking Antitrust In The Age Of Fintech, Quaid Knell, Olivia Mossman

Brigham Young University Prelaw Review

In cases involving large technology firms, current antitrust laws are proving difficult to enforce when applied through the traditional framework of price-centered metrics. Financial technology (fintech) companies are firms that integrate digital technology into financial services and operate through multi-sided platforms, and they are growing in number. This increased number of firms introduces the next challenge for antitrust enforcement, as traditional definitions of market dominance and monopolistic behavior are ill-suited to the realities of the digital landscape. Although there are no current antitrust lawsuits against major fintech firms, their existing structures and business models, if left unexamined, allow these firms …

“Loophole Of The Century”: Routine Use And The Privacy Act Of 1974, Joslynn Jensen

Brigham Young University Prelaw Review

This Note examines structural weaknesses in the Privacy Act of 1974 and argues that the statute no longer provides meaningful safeguards for personal information held by federal agencies. Enacted in the aftermath of the Watergate scandal, the Act was designed to ensure transparency, accountability, and individual control over government recordkeeping systems. However, two core features—the routine-use exception and the Act’s narrow remedial structure—have undermined these protections. The routine-use provision permits agencies to disclose personal records without individualized consent so long as the disclosure is deemed “compatible” with the purpose of collection and published in the Federal Register, a form of …