Digital Commons Network^™

Keeping Current - Probate [Notes], Claire Hargrove, Paula Moore, William P. Lapiana, Jake W. Villanueva

Articles & Chapters

No abstract provided.

In Utero Exposure To Antiemetic And Risk Of Adult-Onset Colorectal Cancer, Caitlin C Murphy, Piera M Cirillo, Nickilou Y Krigbaum, Amit G Singal, Barbara A Cohn

Faculty, Staff and Student Publications

BACKGROUND: Incidence rates of colorectal cancer (CRC) are increasing among adults born in and after the 1960s, implicating pregnancy-related exposures introduced at that time as risk factors. Dicyclomine, an antispasmodic used to treat irritable bowel syndrome, was initially included in Bendectin (comprising doxylamine, pyridoxine, and dicyclomine), an antiemetic prescribed during pregnancy in the 1960s.

METHODS: We estimated the association between in utero exposure to Bendectin and risk of CRC in offspring of the Child Health and Development Studies, a multigenerational cohort that enrolled pregnant women in Oakland, CA, between 1959 and 1966 (n = 14 507 mothers and 18 751 …

Alzheimer's Disease Genetic Risk, Cognition, And Brain Aging In Midlife, Willa D Brenowitz, Myriam Fornage, Lenore J Launer, Mohamad Habes, Christos Davatzikos, Kristine Yaffe

Faculty, Staff and Student Publications

We examined associations of an AD genetic risk score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI). A higher AD-GRS based on 25 previously identified loci (excluding APOE) was associated with worse Montreal Cognitive Assessment (−0.14 SD[95% CI:−0.26,−0.02]), older machine learning predicted brain age (2.35 years[95%CI:0.01,4.69]), and white matter hyperintensity volume (0.35 SD [95% CI:0.00,0.71), but not with a composite cognitive outcome, total brain, or hippocampal volume. APOE ε4 allele was not associated with any outcomes. AD risk genes beyond APOE may contribute to subclinical differences in cognition and brain health in …

Conformational Rearrangements In The Sensory Rcsf/Omp Complex Mediate Signal Transduction Across The Bacterial Cell Envelope, Sarah Rosemarie Lach Phd

Dissertations and Theses (Open Access)

Timely detection and repair of envelope damage are paramount for bacterial survival. The Regulator of Capsule Synthesis (Rcs) stress response is a complex signaling cascade that monitors gram-negative cell envelope integrity and can transduce the stress signals across the multilayered envelope to regulate gene expression in the cytoplasm. The outer membrane (OM) lipoprotein RcsF is the sensory component, but how RcsF functions remains elusive. RcsF interacts with the β-barrel assembly machinery (Bam) complex, which assembles RcsF in complex with OM proteins (OMPs), resulting in RcsF’s partial cell surface exposure. RcsF can also interact with the periplasmic domain of the negative …

A Means Of Codifying Safety Cross-Training Knowledge Expectations For Biosafety Professionals, Robert J Emery, Scott J Patlovich, Kristin G King, Janelle Rios

Faculty, Staff and Student Publications

INTRODUCTION: The health and safety issues encountered by biosafety professionals in the daily conduct of their work is rarely limited solely to potentially infectious pathogens. A basic understanding of the other types of hazards inherent to laboratories is necessary. As such, management of the health and safety program at an academic health institution sought to ensure crosscutting competency for its technical staff, including staff members within the biosafety program.

METHODS: Using a focus group approach, a team of safety professionals from a variety of specialties developed a list of 50 basic health and safety items that any safety specialist should …

The Risk Of Sars-Cov-2 Omicron Variant Emergence In Low And Middle-Income Countries (Lmics), Kaiming Bi, Jose Luis Herrera-Diestra, Yuan Bai, Zhanwei Du, Lin Wang, Graham Gibson, Maureen Johnson-Leon, Spencer J Fox, Lauren Ancel Meyers

Faculty, Staff and Student Publications

We estimated the probability of undetected emergence of the SARS-CoV-2 Omicron variant in 25 low and middle-income countries (LMICs) prior to December 5, 2021. In nine countries, the risk exceeds 50 %; in Turkey, Pakistan and the Philippines, it exceeds 99 %. Risks are generally lower in the Americas than Europe or Asia.

The Role Of Gender Inequality And Health Expenditure On The Coverage Of Demand For Family Planning Satisfied By Modern Contraceptives: A Multilevel Analysis Of Cross-Sectional Studies In 14 Lac Countries, Laísa Rodrigues Moreira, Cauane Blumenberg, Beatriz Elena Caicedo Velasquez, Fernanda Ewerling, Alejandra Balandrán, Luis Paulo Vidaletti, Andrea Ramirez Varela, Franciele Hellwig, Rodolfo Gomez Ponce De Leon, Aluisio J D Barros, Mariangela Freitas Silveira, Fernando C Wehrmeister

Faculty, Staff and Student Publications

BACKGROUND: Despite international efforts to improve reproductive health indicators, little attention is paid to the contributions of contextual factors to modern contraceptive coverage, especially in the Latin America and the Caribbean (LAC) region. This study aimed to identify the association between country-level Gender Inequality and Health Expenditure with demand for family planning satisfied by modern contraceptive methods (DFPSm) in Latin American sexually active women.

METHODS: Our analyses included data from the most recent (post-2010) Demographic and Health Survey or Multiple Indicator Cluster Survey from 14 LAC countries. Descriptive analyses and multilevel logistic regressions were performed. Six individual-level factors were included. …

Delphi Initiative For Early-Onset Colorectal Cancer (Direct) International Management Guidelines, Giulia Martina Cavestro, Alessandro Mannucci, Francesc Balaguer, Heather Hampel, Sonia S Kupfer, Alessandro Repici, Andrea Sartore-Bianchi, Toni T Seppälä, Vincenzo Valentini, Clement Richard Boland, Randall E Brand, Tineke E Buffart, Carol A Burke, Riccardo Caccialanza, Renato Cannizzaro, Stefano Cascinu, Andrea Cercek, Emma J Crosbie, Silvio Danese, Evelien Dekker, Maria Daca-Alvarez, Francesco Deni, Mev Dominguez-Valentin, Cathy Eng, Ajay Goel, Josè G Guillem, Britt B S L Houwen, Charles Kahi, Matthew F Kalady, Fay Kastrinos, Florian Kühn, Luigi Laghi, Andrew Latchford, David Liska, Patrick Lynch, Alberto Malesci, Gianluca Mauri, Elisa Meldolesi, Pål Møller, Kevin J Monahan, Gabriela Möslein, Caitlin C Murphy, Karlijn Nass, Kimmie Ng, Cristina Oliani, Enrico Papaleo, Swati G Patel, Marta Puzzono, Andrea Remo, Luigi Ricciardiello, Carla Ida Ripamonti, Salvatore Siena, Satish K Singh, Zsofia K Stadler, Peter P Stanich, Sapna Syngal, Stefano Turi, Emanuele Damiano Urso, Laura Valle, Valeria Stella Vanni, Eduardo Vilar, Marco Vitellaro, Yi-Qian Nancy You, Matthew B Yurgelun, Raffaella Alessia Zuppardo, Elena M Stoffel, Associazione Italiana Familiarità Ereditarietà Tumori, Collaborative Group Of The Americas On Inherited Gastrointestinal Cancer, European Hereditary Tumour Group, And The International Society For Gastrointestinal Hereditary Tumours

Faculty, Staff and Student Publications

BACKGROUND & AIMS: Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that are not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened to develop the first evidence-based consensus recommendations for eoCRC.

METHODS: After reviewing the published literature, a Delphi methodology was used to draft and respond to clinically relevant questions. Each statement underwent 3 rounds of voting and reached a consensus level of agreement of ≥80%.

RESULTS: The DIRECt group produced 31 statements in 7 areas of interest: diagnosis, risk factors, genetics, pathology-oncology, endoscopy, therapy, and supportive care. There was strong consensus that …

Use Of Contrast Media During Ct-Guided Thermal Ablation Of Colorectal Liver Metastasis For Procedure Planning Is Associated With Improved Immediate Outcomes, Iwan Paolucci, Yuan-Mao Lin, A Kyle Jones, Kristy K Brock, Bruno C Odisio

Faculty, Staff and Student Publications

PURPOSE: The aim of this study was to analyze the impact of using intra-procedural pre-ablation contrast-enhanced CT prior to percutaneous thermal ablation (pre-ablation CECT) of colorectal liver metastases (CLM) on local outcomes.

MATERIALS AND METHODS: This retrospective analysis of a prospectively collected liver ablation registry included 144 consecutive patients (median age 57 years IQR [49, 65], 60% men) who underwent 173 CT-guided ablation sessions for 250 CLM between October 2015 and March 2020. In addition to oncologic outcomes, technical success was retrospectively evaluated using a biomechanical deformable image registration software for 3D-minimal ablative margin (3D-MAM) quantification. Bayesian regression was used …

Metabolomic Markers Of Ultra-Processed Food And Incident Ckd, Donghan Su, Jingsha Chen, Shutong Du, Hyunju Kim, Bing Yu, Kari E Wong, Eric Boerwinkle, Casey M Rebholz

Faculty, Staff and Student Publications

BACKGROUND: High ultra-processed food consumption is associated with higher risk of CKD. However, there is no biomarker for ultra-processed food, and the mechanism through which ultra-processed food is associated with CKD is not clear. Metabolomics can provide objective biomarkers of ultra-processed food and provide important insights into the mechanisms by which ultra-processed food is associated with risk of incident CKD. Our objective was to identify serum metabolites associated with ultra-processed food consumption and investigate whether ultra-processed food-associated metabolites are prospectively associated with incident CKD.

METHODS: We used data from 3751 Black and White men and women (aged 45-64 years) in …

Sustainability Considerations For Consumables Used In Microbiological And Biomedical Laboratories, Autumn Cerda, Robert Emery, Scott Patlovich

Faculty, Staff and Student Publications

Introduction: The 6th edition of the Biosafety in Microbiological and Biomedical Laboratories includes Appendix L on sustainability that describes a series of considerations for biocontainment facilities. But many biosafety practitioners may not be familiar with sustainability options that are available, feasible, and safe for laboratory settings as training in this realm is not common.

Methods: With a particular focus on consumable products used in containment laboratory operations, a comparative assessment was made regarding sustainability activities employed in the healthcare setting, where significant advances have been achieved.

Results: Table 1 has been created that describes various consumables that result in waste …

The Anniversary Of The Unea Nexus Resolution, Andrew N. Rowan

WellBeing News

On March 2, 2022, the United Nations Environment Assembly (the world’s environment parliament) passed a landmark resolution calling on the United Nations Environment Program to produce a report on the Nexus between animal welfare, the environment, and sustainable development. This Resolution offers enormous potential for a significant reset in how humanity approaches, values, and interacts with our world moving towards a more holistic global approach (including humans, animals, and the environment).

Bird Flu: Highly Pathogenic Avian Influenza – An Update, Andrew N. Rowan

WellBeing News

In the last few years, a highly pathogenic H5N1 avian influenza (HPAI) virus has caused the deaths of millions of seabirds and waterfowl worldwide, and many more millions of factory-farmed poultry being culled to halt the spread of the virus. WBI wrote about the emergence of this virus and its potential danger to humans in our last WellBeing News. The virus continues to spread and mutate and has caused the deaths of some mammals and a few humans.

Analysis Of Oregon Multi-Family Housing In Relation To Covid-19 Pandemic, Conor Paterson

University Honors Theses

The purpose of this paper is to examine notable metrics of multi-family housing markets before and since the COVID-19 pandemic. The primary locations for the analysis of this issue were Portland, Oregon and other cities located near Portland. This paper attempts to demonstrate the ways in which the COVID-19 pandemic has affected the landscape of multi-family housing options and affordability since the year 2020. A literature review was first conducted to obtain a better understanding of what the discourse community surrounding housing changes has stated about the pandemic's role in the housing market. After drawing conclusions from the prior literature, …

Promoting Equity Through Equitable Risk Tradeoffs, W. Kip Viscusi, Thomas J. Kniesner

Vanderbilt Law School Faculty Publications

The impact and economic merits of President Biden’s Executive Order 13985 on equity depend on how the executive order is implemented. While policy discussion to date has focused on equitable outcomes, we propose framing risk equity policies in terms of equitable risk tradeoff rates based on six policy guidelines. The starting point for ex ante evaluation of equity for mortality risk policies should be the symmetric application of the value of a statistical life (VSL) to all groups. Because of the substantial heterogeneity in VSLs by income and demographic characteristics, symmetric tradeoff rates generate subsidies and deficits relative to private …

Adult And Regenerating Planarians Respond Differentially To Chronic Drug Exposure, Kevin Bayingana , '23, Danielle Ireland, Elizabeth Rosenthal , '23, Christina Rabeler, Eva-Maria S. Collins

Biology Faculty Works

There is a lack of data on the effects of chronic exposure to common drugs and stimulants on the developing nervous system. Freshwater planarians have emerged as a useful invertebrate model amenable to high-throughput behavioral phenotyping to assay chemical safety in adult and developing brains. Here, we leverage the unique strength of the system to test in parallel for effects on the adult and developing nervous system, by screening ten common drugs and stimulants (forskolin, clenbuterol, LRE-1, MDL-12,330A, adenosine, caffeine, histamine, mianserin, fluoxetine and sertraline) using the asexual freshwater planarian Dugesia japonica. The compounds were tested up to 100 …

Morphometric Changes Among Testis Of Autoimmune Mouse Model And Healthy Strains, Zeinab Shouman

Mansoura Veterinary Medical Journal

Objective: to compare morphometrically among testis of the healthy strains (C57BL/6N and MRL/MpJ) and autoimmune mouse model (MRL/MpJ-Faslpr) revealing how the autoimmune disease affect cells lining the seminiferous tubules which in turn cause infertility. Design: Descriptive study. Sample: The testis of both healthy strains (C57BL/6N and MRL/MpJ) and autoimmune mouse model (MRL/MpJ-Faslpr) at early (3 months) and late (6 months) age were used (4 mice from each strain and age). Procedures: The testis were removed, fixed and immunostained by PAX7, CKIT, GATA4 as well as Hoechest to reveal the morphometric changes among them at early (3 months) and late (6 …

Prevalence, Genetic Characterization, And Antibiogram Of Salmonella Enterica Recovered From Buffalo Meat, Takwa Fathy, Amira Zakaria, Samir Abd-Elghany, Khalid Sallam

Mansoura Veterinary Medical Journal

Objective: This study aimed to determine the prevalence, virulence-associated genes and antimicrobial resistance of Salmonella species recovered from buffalo meat at Mansoura city in Egypt. Salmonella virulence genes were detected using polymerase chain reaction targeting invA, stn, and hilA genes.Design: Observational study.Samples: 120 samples.Procedures: A total of 120 buffalo meat samples were bacteriologically analyzed to isolate and characterize the Salmonella spp. and its virulence genes, in addition to their antimicrobial resistance.Results: Thirty (25%) out of 120-samples from buffalo meat were positive Salmonella spp. Out of the 191 phenotypically identified Salmonella isolates, only 58 strains were molecularly confirmed as Salmonella spp. …

Recovering Grammar, Rachel T. Goldberg

Cornell Law Faculty Publications

Three major reasons have been proposed for why legal writing professors do not—or should not—teach grammar. First, the argument goes, teaching grammar would take valuable time away from more important, higher-order writing concerns. Second, some legal writing professors do not feel comfortable teaching grammar because, while they can certainly spot grammar problems in their students’ writing, they never learned technical grammar terms themselves. Third, legal writing professors steer clear of grammar because it is perceived to be associated with remedial writing and “mere” skills teaching—associations that further confine legal writing professors to a lower academic status than their clinical and …

Improving Interventions On Cardiovascular Disease And Diet: A Policy Incentive Analysis, Sandra Hurst

Dissertations

Introduction: Various cardiovascular diseases (CVD) can be catastrophic and can lead to irreversible outcomes. There are limited, improved regulations on awareness of primordial and primary preventions that may decrease CVD progression and mortality. Before policies and recommendations can be set, policymakers should understand CVD and the importance of maintaining a healthy diet to decrease the risk of CVDs and improve patient adherence. Therefore, this project aims to analyze federal healthy food incentive policies to promote healthy diet behaviors that reduce CVD risk.

Method: The method used was existing data for a comparative policy analysis that included a policy proposal process: …

Innovations In Implant Therapy, Catherine Monchik, Isis Marsh

Publications and Research

No abstract provided.

Residential-Scale Stormwater Management Practices, Lisa Loosigian, Julia Peterson

UNH Cooperative Extension

No abstract provided.

Student Affairs Newletter, Georgia Southern University

Division of Student Affairs Newsletter (2020-2023)

A Message from our VP

Eagle Engage

True Blue Campaign

Office of Student Conduct

Counseling Center

Office of Student Activities

Office of Leadership & Community Engagement

Campus Recreation and Intramurals

Office of Student Wellness & Health Promotion

Eagles Call

Announcements

The Octofoil, January/February/March 2023, Ninth Infantry Division Association

The Octofoil

The Octofoil is the offical publication of the Ninth Infantry Division Association, Inc., an organization formed by the officers and men of the 9th Infantry Division in order to perpetuate the memory of fallen comrades, preserve the esprit de corps of the Division, promote peace and serve as an information bureau about the 9th Infantry Division. The Association is made up of 9th Infantry veterans from WWII and Vietnam, spouses, widows and lineal descendants.

The Rise Of Antisemitism In Germany, Susan M. Watts

Ballard Brief

Antisemitism has been rising in Germany since the country's reunification in the 1990s. In the modern day, antisemitism takes many forms, including hate speech, violent attacks, and anti-Jewish conspiracy theories. Although antisemitism has been rising in many parts of the world, Germany's history during the Holocaust causes its rise to be especially alarming to the Jewish community. The rise in antisemitism has been caused by the internet, current events like the pandemic and the Israel-Palestine conflict, and rightwing political extremism. Due to the rise in antisemitism, the fear of harassment and violence among Jews in Germany has risen, along with …

Design And Synthesis Of New Acyl Urea Analogs As Potential Σ1r Selective Ligands, R. Thapa, R. Flores, Kwan H. Cheng, Bereket Mochona, Donald Sikazwe

Physics and Astronomy Faculty Research

In search of synthetically accessible open-chain analogs of PD144418 or 5-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-3-(p-tolyl)isoxazole, a highly potent sigma-1 receptor (σ1R) ligand, we herein report the design and synthesis of sixteen arylated acyl urea derivatives. Design aspects included modeling the target compounds for drug-likeness, docking at σ1R crystal structure 5HK1, and contrasting the lower energy molecular conformers with that of the receptor-embedded PD144418—a molecule we opined that our compounds could mimic pharmacologically. Synthesis of our acyl urea target compounds was achieved in two facile steps which involved first generating the N-(phenoxycarbonyl) benzamide intermediate and then coupling it with the appropriate amines—weakly to strongly …

Two Decades After Salini V Morocco: The Case For Retaining The Salini Test With Modifications, Darius Chan, Justin Lai

Research Collection Yong Pung How School Of Law

The definition of an investment under Article 25 of the ICSID Convention continues to attract a divergence of views. Ever since its use in 2001, the Salini Test, in its various forms, has become the predominant method that tribunals use to determine whether there is an investment. However, the Salini Test is hardly free from controversy, and suffers from two significant issues. First, its criteria are often subject to differing interpretations, leading to confusion over how the test should actually be applied. Second, the Salini Test has lost its legal force over time, as it has been relegated to factors …

The Coming Central Bank Digital Currency Revolution And The E-Cny, Heng Wang, Ross Buckley

Research Collection Yong Pung How School Of Law

The only central bank money individuals and businesses have today is cash. Everything else they use as money is commercial bank promises. Central bank digital currencies (“CBDC”) will likely change all this by putting central bank money into everyone’s hands. China is a front runner in this revolution, and its CBDC, the e-CNY, may well in time profoundly affect the international economic order. This article analyses the major considerations around the e-CNY, its ramifications, in particular for trade, and its possible challenges.

Beijing’S Regulatory Crackdown Is Unlikely To End Any Time Soon, Henry S. Gao

Research Collection Yong Pung How School Of Law

China’s incomplete transition to a market economy means regulations often lag behind the demands of the market.

Sensitivity Of A Preanaesthesia Screening And Triage Tool In Identifying High-Risk Patients Attending The Preanaesthesia Assessment Clinic In A Tertiary Referral Hospital In Sub-Saharan Africa: A Diagnostic Accuracy Study, Brian Misoi, Vitalis Mung’Ayi, Rajpreet Bal, Shamshudin Mohammedali

General Surgery, East Africa

Objectives: The use of preoperative triage questionnaires is an innovative way to mitigate the shortage of anaesthesiologists and to identify and refer high-risk patients early for evaluation. This study evaluates the diagnostic accuracy of one such questionnaire in identifying high-risk patients in a Sub-Saharan population.

Design: Diagnostic accuracy study

Setting: The study was conducted in a preanaesthesia assessment clinic in a tertiary referral hospital in SubSaharan Africa. Participants The study had a sample size of 128, including all patients above the age of 18 scheduled for elective surgery under any modality of anaesthesia other than local anaesthesia presenting to the …