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Practices And Perceptions Of Family-Centered Care: A Cross-Sectional Survey Of Secondary School Athletic Trainers, Zachary K. Winkelmann, Nancy A. Uriegas, James M. Mensch, Conner E. Montgomery, Toni M. Torres-Mcgehee Mar 2023

Practices And Perceptions Of Family-Centered Care: A Cross-Sectional Survey Of Secondary School Athletic Trainers, Zachary K. Winkelmann, Nancy A. Uriegas, James M. Mensch, Conner E. Montgomery, Toni M. Torres-Mcgehee

Faculty Publications

Family-centered care (FCC) includes collaboration between families and healthcare providers, the creation of flexible policies, and the family taking an active role in the delivery of care. Secondary school athletic trainers provide care for underage patients in school-based health systems, making them responsible for maintaining communication with parents, guardians, and/or caregivers. This cross-sectional survey investigated the extent to which athletic trainers (n = 205) include aspects of FCC in their daily secondary school clinical practice (current practices = CP) and whether they believe that aspect of care is necessary for FCC to be provided in athletic training (perceived necessary = …


V.Viii.B; 30-12 School Of Social Work Field Office.Pdf, Betty L. Brown-Chappell Phd Mar 2023

V.Viii.B; 30-12 School Of Social Work Field Office.Pdf, Betty L. Brown-Chappell Phd

Program and Teaching Materials [Series V]

EMU Transfer Equivalencies


A Pilot Study Of The Association Between Maternal Mid-Pregnancy Cholesterol And Oxysterol Concentrations And Labor Duration., Todd C. Rideout, Jaclyn Wallace, Xiaozhong Wen, Vanessa M. Barnabei, Kai Ling Kong, Richard W. Browne Mar 2023

A Pilot Study Of The Association Between Maternal Mid-Pregnancy Cholesterol And Oxysterol Concentrations And Labor Duration., Todd C. Rideout, Jaclyn Wallace, Xiaozhong Wen, Vanessa M. Barnabei, Kai Ling Kong, Richard W. Browne

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Previous animal model studies have highlighted a role for cholesterol and its oxidized derivatives (oxysterols) in uterine contractile activity, however, a lipotoxic state associated with hypercholesterolemia may contribute to labor dystocia. Therefore, we investigated if maternal mid-pregnancy cholesterol and oxysterol concentrations were associated with labor duration in a human pregnancy cohort.

METHODS: We conducted a secondary analysis of serum samples and birth outcome data from healthy pregnant women (N = 25) with mid-pregnancy fasting serum samples collected at 22-28 weeks of gestation. Serum was analyzed for total-C, HDL-C, and LDL-C by direct automated enzymatic assay and oxysterol profile including …


Ehie And Ruddick Junior Recital, Arkansas State University Department Of Music Mar 2023

Ehie And Ruddick Junior Recital, Arkansas State University Department Of Music

Performance Programs

No abstract provided.


Assessment Of The Eligibility Of Triglyceride;Glucose Index And Triglyceride;High-Density Lipoprotein Cholesterol Ratio As Applicable Insulin Resistance Indices Among Overweight/Obese Egyptians, Ghada A. Omar, Mona A.E A. Hussein, Wafaa S. Hegab Mar 2023

Assessment Of The Eligibility Of Triglyceride;Glucose Index And Triglyceride;High-Density Lipoprotein Cholesterol Ratio As Applicable Insulin Resistance Indices Among Overweight/Obese Egyptians, Ghada A. Omar, Mona A.E A. Hussein, Wafaa S. Hegab

Journal of Medicine in Scientific Research

Background Insulin resistance (IR) means the requirement of a higher insulin concentration to produce the expected biological effect. It was proposed that triglycerides–glucose index (TY G) and triglycerides–high-density lipoprotein cholesterol ratio (TG/HDL) were dependable, applicable, and less-expensive markers of IR. However, their results varied significantly among different ethnic groups. Aim To assess the eligibility of TY G and TG/HDL as IR indices among overweight and/or obese Egyptians. Patients and methods The participants in this cross-sectional study were 328 overweight and/or obese Egyptians. Their fasting blood glucose, TG, HDL, and fasting insulin blood concentrations were estimated. Homeostasis model assessment-insulin resistance (HOMA-IR), …


Role Of Crp In Covid-19 Pneumonia: A Single-Center Experience Of 1000 Cases In A Tertiary Care Setting In India, Manojkumar Bhadake, Shital Patil, Utreshwar Dhumal Mar 2023

Role Of Crp In Covid-19 Pneumonia: A Single-Center Experience Of 1000 Cases In A Tertiary Care Setting In India, Manojkumar Bhadake, Shital Patil, Utreshwar Dhumal

Journal of Medicine in Scientific Research

Introduction Robust data are available for C-reactive protein (CRP) in bacterial infection, and it can be used in this coronavirus disease 2019 (COVID-19) pneumonia pandemic for initial assessment before planning of treatment in indoor settings in comparison with other inflammatory markers and computed tomography (CT) severity. Materials and methods A prospective, observational, follow up study was conducted that included 1000 COVID 19 cases confirmed with RT PCR. All cases were assessed with lung involvement documented and categorized based on high resolution computed tomography (HRCT) thorax, oxygen saturation, and inflammatory markers such as CRP at the entry point and follow up. …


Comparative Study Between Different Types Of Neonatal Sepsis Among Newborns Admitted To The Neonatal Intensive Care Unit In Mataria Teaching Hospital, Cairo, Nada M. Elsayed, Sohaila A. Abd El-Halim, Youssof M. Hassan Mar 2023

Comparative Study Between Different Types Of Neonatal Sepsis Among Newborns Admitted To The Neonatal Intensive Care Unit In Mataria Teaching Hospital, Cairo, Nada M. Elsayed, Sohaila A. Abd El-Halim, Youssof M. Hassan

Journal of Medicine in Scientific Research

Background Sepsis is the most frequent cause of neonatal deaths globally, varying in incidence between different countries. Sepsis is a burden on families and health care resources. Objectives To identify prevalence, type of organism, and outcome of early-onset sepsis (EOS) and late-onset sepsis (LOS). Patients and methods A cross-sectional study was conducted at the neonatal ICU of Mataria Teaching Hospital from November 2018 to October 2019. Demographic, clinical, and laboratory data of proved septic neonates were collected. Classification of cases according to the onset of sepsis: EOS (group I), in which sepsis is presented clinically before the third day of …


The Effect Of Cardiovascular Risk Factors On The Final Outcome In Patients With Covid-19, Emmanuel Louka Aziz, George Ghaly Gerges Mar 2023

The Effect Of Cardiovascular Risk Factors On The Final Outcome In Patients With Covid-19, Emmanuel Louka Aziz, George Ghaly Gerges

Journal of Medicine in Scientific Research

Background Increased cardiovascular risk factors are associated with adverse outcome in patients with coronavirus disease-2019 (COVID-19). In this study, the authors assessed the prevalence of cardiovascular risk factors in patients with COVID-19 and studied the impact of these cardiovascular risk factors on the final outcome in these patients. Aim The authors aimed to study the prevalence of cardiovascular risk factors in patients with COVID-19 as well as the impact of these cardiovascular risk factors on the final outcome in these patients. Patients and methods The study included 200 patients who were admitted in Al-Sahel teaching hospital with COVID- 19-positive PCR. …


Comparative Study Between Minimally Invasive Right Anterior Minithoracotomy Versus Mini-Upper Sternotomy In Isolated Aortic Valve Replacement (Early Outcome), Ashraf Abdelaziz, Hazem G. Bakr, Ibrahim M. Helmi Mar 2023

Comparative Study Between Minimally Invasive Right Anterior Minithoracotomy Versus Mini-Upper Sternotomy In Isolated Aortic Valve Replacement (Early Outcome), Ashraf Abdelaziz, Hazem G. Bakr, Ibrahim M. Helmi

Journal of Medicine in Scientific Research

Background Minimally invasive surgical methods have lately become popular in heart surgery. Ministernotomy and minithoracotomy are the most commonly used incisions in minimally invasive aortic valve replacement. It is still debated if one incision is better than the other. Patients and methods A prospective comparative analysis was used to examine the outcomes of 30 patients who underwent isolated aortic valve replacement. A minimally invasive right anterior minithoracotomy approach was used in group A (n = 15), whereas a mini-upper sternotomy method was used in group B (n = 15). Results The results in both groups reveal no statistical …


A Rare Case Of Dystrophinopathy: Duchenne Muscular Dystrophy;Becker Muscular Dystrophy Intermediate Complex, Manish S. Ahuja, Neena Katoch, Rachna Gulati, Subhendu Pandit, Tathagata Bose Mar 2023

A Rare Case Of Dystrophinopathy: Duchenne Muscular Dystrophy;Becker Muscular Dystrophy Intermediate Complex, Manish S. Ahuja, Neena Katoch, Rachna Gulati, Subhendu Pandit, Tathagata Bose

Journal of Medicine in Scientific Research

An 18-year-old boy with no significant perinatal history presented with insidious onset of slowly progressive flaccid paraparesis with muscle wasting in thighs. On examination, the patient had flaccid motor quadriparesis and partial atrophy of proximal thigh muscles. This was accompanied by pseudohypertrophy of calf muscles and extensor muscles in the dorsum of foot. Investigations revealed very high levels of creatinine phosphokinase in the patient (6495 IU/l in contrast to normal range of 55–170 IU/l) and in his sister (718 IU/l). Echocardiography showed dilated cardiomyopathy with severe left ventricular dysfunction. The multiplex ligation-dependent probe amplification revealed deletion of exons 3 to …


Erratum: Parents’ Knowledge, Attitude And Practices Toward Oral Health Of Their Children With Primary Dentition: A Cross Sectional Study, Marwa Foad, Mennatallah Helal, Soad Abdel Moneim Mar 2023

Erratum: Parents’ Knowledge, Attitude And Practices Toward Oral Health Of Their Children With Primary Dentition: A Cross Sectional Study, Marwa Foad, Mennatallah Helal, Soad Abdel Moneim

Journal of Medicine in Scientific Research

The Erratum statement can be found in the PDF file.


Interaction Analysis Model Lexicon, Austin Megli, Dayra Fallad-Mendoza, Monica Etsitty-Dorame, Jasmine Desiderio, Yan Chen, Damien Sanchez, Nick Flor, Charlotte Gunawardena Mar 2023

Interaction Analysis Model Lexicon, Austin Megli, Dayra Fallad-Mendoza, Monica Etsitty-Dorame, Jasmine Desiderio, Yan Chen, Damien Sanchez, Nick Flor, Charlotte Gunawardena

Organization, Information, and Learning Sciences Student Publications

No abstract provided.


Syndemics And Social Factors: Infectious Disease Patterns Within The Population Of People Experiencing Homelessness In The United States, Kathleen Berzonsky Mar 2023

Syndemics And Social Factors: Infectious Disease Patterns Within The Population Of People Experiencing Homelessness In The United States, Kathleen Berzonsky

Honors Program: Senior Projects (Public)

Individuals experiencing homelessness are at increased risk of suffering from infectious diseases. This is due to a number of social factors and healthcare disparities, as well as the idea of syndemics, by which diseases cluster together to worsen disease burden. Current intervention strategies approach treatment from a post-infection perspective, but reducing transmission rates of infectious diseases within the population of people experiencing homelessness will require a shift in the healthcare framework. The issue of people experiencing homelessness must be viewed through a biosocial lens, focusing on preventative care and treatment. I provide an overview of the social factors governing infectious …


A Comparative Study On The Effects Of Dextrose Prolotherapy And Local Steroid Injection In Patients With Lateral Epicondylitis: A Randomized Controlled Trial, Abhishek Biswas, Ameed Equebal, Osama Neyaz, Rajkumar Yadav, Suvrat Gupta Mar 2023

A Comparative Study On The Effects Of Dextrose Prolotherapy And Local Steroid Injection In Patients With Lateral Epicondylitis: A Randomized Controlled Trial, Abhishek Biswas, Ameed Equebal, Osama Neyaz, Rajkumar Yadav, Suvrat Gupta

Journal of Medicine in Scientific Research

Background Lateral epicondylitis (LE) is the most common condition of elbow pain. Multiple intralesional steroid injections help in the treatment. Prolotherapy is a traditional injection method recently categorized as regenerative treatment. However, there is scarcity of literature that compares its effectiveness with steroids. Objective The aim was to compare the effectiveness of dextrose prolotherapy (DP) against local steroid injection in patients with LE in relieving pain and improving dysfunction. Participants and methods This parallel, randomized controlled trial was conducted at Outpatient Department, National Institute for Locomotor Disabilities (Divyangjan), (erstwhile National Institute for the Orthopaedically Handicapped) Kolkata, from January 2016 to …


Could Vitamin D3 Be Effective In Prevention Of Risk Of Preeclampsia Among Pregnant Women?, Adel G. Allam, Ibrahim M. El-Maghraby Mar 2023

Could Vitamin D3 Be Effective In Prevention Of Risk Of Preeclampsia Among Pregnant Women?, Adel G. Allam, Ibrahim M. El-Maghraby

Journal of Medicine in Scientific Research

Background Preeclampsia, a pregnancy disease marked by high blood pressure and proteinuria, affects 2–8% of all pregnancies. Preeclampsia can be life-threatening for both the mother and the fetus and is still a significant cause of maternal and neonatal morbidity and mortality. The goal of this study was to assess if there was a link between maternal serum vitamin D3 levels and the severity of preeclampsia. Patients and methods A case–control study was conducted on 70 pregnant women at Shebin El Kom Teaching Hospital. All pregnant women were divided into two groups: group A included 30 apparently healthy pregnant women (control …


Correlation Between Neutrophil-To-Lymphocyte Ratio After Percutaneous Coronary Intervention And The Size Of Infarction In Patients With Acute Myocardial Infarction, Mohamed R. Badran Mar 2023

Correlation Between Neutrophil-To-Lymphocyte Ratio After Percutaneous Coronary Intervention And The Size Of Infarction In Patients With Acute Myocardial Infarction, Mohamed R. Badran

Journal of Medicine in Scientific Research

Background Inflammatory processes have a role in the pathogenesis of acute myocardial infarction (AMI), left ventricular remodeling, and repair. Infarct size (IS) is a strong predictor of prognosis following AMI. Several tools are used to predict IS, but most of them are expensive and inaccessible all the time. So, neutrophil-to-lymphocyte ratio (NLR) as a marker of inflammation is an easy and cheap tool to predict IS. Aim To assess if post-percutaneous coronary intervention (PCI) NLR can predict IS in patients with AMI. Patients and methods The study included 11 125 patients with AMI treated with primary PCI. We used cardiovascular …


Comparative Study Between Right-Sided Minithoracotomy Versus Upper Partial Ministernotomy In Isolated Mitral Valve Replacement (Early Outcome), Ashraf Abdelaziz, Emmanuel L. Aziz, Hazem G. Bakr Mar 2023

Comparative Study Between Right-Sided Minithoracotomy Versus Upper Partial Ministernotomy In Isolated Mitral Valve Replacement (Early Outcome), Ashraf Abdelaziz, Emmanuel L. Aziz, Hazem G. Bakr

Journal of Medicine in Scientific Research

Background In recent years, minimally invasive surgical techniques have become increasingly popular in heart surgery. The most common incisions used in minimally invasive mitral valve replacement are ministernotomy and minithoracotomy. It is still up for dispute whether one incision is superior to the other. Patients and methods The results of 60 patients who had solitary mitral valve replacement were studied using a prospective comparative analysis. In group A (n = 30), a minimally invasive right anterior minithoracotomy technique was performed, whereas in group B (n = 30), a partial upper ministernotomy procedure was used. Results The results in …


Conversations With Chatgpt About C Programming: An Ongoing Study, James C. Davis, Yung-Hsiang Lu, George K. Thiruvathukal Mar 2023

Conversations With Chatgpt About C Programming: An Ongoing Study, James C. Davis, Yung-Hsiang Lu, George K. Thiruvathukal

Computer Science: Faculty Publications and Other Works

AI (Artificial Intelligence) Generative Models have attracted great attention in recent years. Generative models can be used to create new articles, visual arts, music composition, even computer programs from English specifications. Among all generative models, ChatGPT is becoming one of the most well-known since its public announcement in November 2022. GPT means {\it Generative Pre-trained Transformer}. ChatGPT is an online program that can interact with human users in text formats and is able to answer questions in many topics, including computer programming. Many computer programmers, including students and professionals, are considering the use of ChatGPT as an aid. The quality …


Effect Of Different Modalities Of Noninvasive Respiratorys Upport In Preterm Infants With Respiratory Distress Syndrome: A Prospective Multicenter Study, Abeer E. S. Hamed, Alaa A. Rashad, Heba Allah M. Sherief, Magued A. Iskandar, Mahmoud H. Dawabah, Manar A. Eldesouky, Mohamed A. Ibrahim, Sohaila A. Abd El-Halim Mar 2023

Effect Of Different Modalities Of Noninvasive Respiratorys Upport In Preterm Infants With Respiratory Distress Syndrome: A Prospective Multicenter Study, Abeer E. S. Hamed, Alaa A. Rashad, Heba Allah M. Sherief, Magued A. Iskandar, Mahmoud H. Dawabah, Manar A. Eldesouky, Mohamed A. Ibrahim, Sohaila A. Abd El-Halim

Journal of Medicine in Scientific Research

Background The first few hours after birth are very critical for newborns to adapt to the extrauterine environment. However, respiratory distress syndrome (RDS) is very common in newborns, particularly in those with shorter gestation ages, sepsis, and fewer platelet counts. The evaluation of respiratory management with current noninvasive ventilation (NIV) support strategies in preterm infants present within the neonatal intensive care unit, as well as drawbacks of NIV modes including nasal continuous positive airway pressure, nasal intermittent positive pressure ventilation, and high-flow nasal cannula, is also critical for those patients. This study aimed to compare different modes of NIV to …


The Role Of Myocardial Mechanical And Qtc Dispersion In Detecting Significant Coronary Artery Disease, Mohamed R. Badran Mar 2023

The Role Of Myocardial Mechanical And Qtc Dispersion In Detecting Significant Coronary Artery Disease, Mohamed R. Badran

Journal of Medicine in Scientific Research

Background Prolonged myocardial contraction and QT interval duration may be found in ischemic viable myocardium, yet it is unclear if noninvasive examination of regional nonhomogeneous myocardial mechanics and QT duration may detect patients with significant coronary artery disease (CAD). Aim To assess the ability of cardiac mechanical and QTc dispersions to identify significant CAD in patients having chest pain with no prior myocardial infarction. Patients and methods We examined 125 patients who had chest pain and evaluated by coronary angiography. They are divided into two groups. CAD group included 75 patients with significant CAD, and control group included 50 patients …


Early Versus Late Intervention In Patients With High-Risk Non-St;-Elevation Myocardial Infarction, Emmanuel Louka Aziz, Mohamed Abbas Morsy Mar 2023

Early Versus Late Intervention In Patients With High-Risk Non-St;-Elevation Myocardial Infarction, Emmanuel Louka Aziz, Mohamed Abbas Morsy

Journal of Medicine in Scientific Research

Introduction With improvements in percutaneous coronary intervention and the advent of novel adjunctive pharmacotherapy agents (such as GP 2b/3a inhibitors, new antiplatelet agents, and intensive statin regimens), the safety and efficacy of early Percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) has improved significantly (1). Therefore, the current guidelines recommend a routine invasive strategy (angiography and revascularization if applicable) (2) in high-risk patients with non-'ST'-elevation ACS (NSTE-ACS). Aim The aim was to compare the results of early versus late intervention in patients with high-risk NSTE myocardial infarction (MI). Patients and methods This study was carried out on 60 patients …


Individualized Precision Targeting Of Dorsal Attention And Default Mode Networks With Rtms In Traumatic Brain Injury-Associated Depression, Shan H Siddiqi, Sridhar Kandala, Carl D Hacker, Nicholas T Trapp, Eric C Leuthardt, Alexandre R Carter, David L Brody Mar 2023

Individualized Precision Targeting Of Dorsal Attention And Default Mode Networks With Rtms In Traumatic Brain Injury-Associated Depression, Shan H Siddiqi, Sridhar Kandala, Carl D Hacker, Nicholas T Trapp, Eric C Leuthardt, Alexandre R Carter, David L Brody

2020-Current year OA Pubs

At the group level, antidepressant efficacy of rTMS targets is inversely related to their normative connectivity with subgenual anterior cingulate cortex (sgACC). Individualized connectivity may yield better targets, particularly in patients with neuropsychiatric disorders who may have aberrant connectivity. However, sgACC connectivity shows poor test-retest reliability at the individual level. Individualized resting-state network mapping (RSNM) can reliably map inter-individual variability in brain network organization. Thus, we sought to identify individualized RSNM-based rTMS targets that reliably target the sgACC connectivity profile. We used RSNM to identify network-based rTMS targets in 10 healthy controls and 13 individuals with traumatic brain injury-associated depression …


Social Media And Women Empowerment In Nigeria: A Study Of The #Breakthebias Campaign On Facebook, Deborah Osaro Omontese Mar 2023

Social Media And Women Empowerment In Nigeria: A Study Of The #Breakthebias Campaign On Facebook, Deborah Osaro Omontese

USF Tampa Graduate Theses and Dissertations

This paper examines how the March 2022 #BreakTheBias campaign on Facebook was used as an empowerment platform in Nigeria, where women experience gender disparity. Research on the role of social media in women’s empowerment in Nigeria is an area that has not been fully studied. Previous studies have looked at women’s empowerment mainly through an educational or political lens, neglecting how social media have also been effective in empowering women. Other researchers have studied how women utilize social media platforms for leisure, entertainment, and media sharing. In the present study, non-probability sampling was used to identify 20 posts that convey …


What Is The Future Of Suicide Genetics?, Salahudeen Mirza, Gabriel R Fries Mar 2023

What Is The Future Of Suicide Genetics?, Salahudeen Mirza, Gabriel R Fries

Faculty, Staff and Student Publications

No abstract provided.


Performance Of Six Clinical Physiological Scoring Systems In Predicting In-Hospital Mortality In Elderly And Very Elderly Patients With Acute Upper Gastrointestinal Bleeding In Emergency Department, Po-Han Wu, Shang-Kai Hung, Chien-An Ko, Chia-Peng Chang, Cheng-Ting Hsiao, Jui-Yuan Chung, Hao-Wei Kou, Wan-Hsuan Chen, Chiao-Hsuan Hsieh, Kai-Hsiang Ku, Kai-Hsiang Wu Mar 2023

Performance Of Six Clinical Physiological Scoring Systems In Predicting In-Hospital Mortality In Elderly And Very Elderly Patients With Acute Upper Gastrointestinal Bleeding In Emergency Department, Po-Han Wu, Shang-Kai Hung, Chien-An Ko, Chia-Peng Chang, Cheng-Ting Hsiao, Jui-Yuan Chung, Hao-Wei Kou, Wan-Hsuan Chen, Chiao-Hsuan Hsieh, Kai-Hsiang Ku, Kai-Hsiang Wu

Faculty, Staff and Student Publications

Background and Objectives: The aim of this study is to compare the performance of six clinical physiological-based scores, including the pre-endoscopy Rockall score, shock index (SI), age shock index (age SI), Rapid Acute Physiology Score (RAPS), Rapid Emergency Medicine Score (REMS), and Modified Early Warning Score (MEWS), in predicting in-hospital mortality in elderly and very elderly patients in the emergency department (ED) with acute upper gastrointestinal bleeding (AUGIB). Materials and Methods: Patients older than 65 years who visited the ED with a clinical diagnosis of AUGIB were enrolled prospectively from July 2016 to July 2021. The six scores were calculated …


Hypomorphic Brca2 And Rad51c Double Mutant Mice Display Fanconi Anemia, Cancer And Polygenic Replication Stress, Karl-Heinz Tomaszowski, Sunetra Roy, Carolina Guerrero, Poojan Shukla, Caezaan Keshvani, Yue Chen, Martina Ott, Xiaogang Wu, Jianhua Zhang, Courtney D Dinardo, Detlev Schindler, Katharina Schlacher Mar 2023

Hypomorphic Brca2 And Rad51c Double Mutant Mice Display Fanconi Anemia, Cancer And Polygenic Replication Stress, Karl-Heinz Tomaszowski, Sunetra Roy, Carolina Guerrero, Poojan Shukla, Caezaan Keshvani, Yue Chen, Martina Ott, Xiaogang Wu, Jianhua Zhang, Courtney D Dinardo, Detlev Schindler, Katharina Schlacher

Faculty, Staff and Student Publications

The prototypic cancer-predisposition disease Fanconi Anemia (FA) is identified by biallelic mutations in any one of twenty-three FANC genes. Puzzlingly, inactivation of one Fanc gene alone in mice fails to faithfully model the pleiotropic human disease without additional external stress. Here we find that FA patients frequently display FANC co-mutations. Combining exemplary homozygous hypomorphic Brca2/Fancd1 and Rad51c/Fanco mutations in mice phenocopies human FA with bone marrow failure, rapid death by cancer, cellular cancer-drug hypersensitivity and severe replication instability. These grave phenotypes contrast the unremarkable phenotypes seen in mice with single gene-function inactivation, revealing an unexpected synergism between Fanc mutations. Beyond …


Grace Huff Williams Mar 2023

Grace Huff Williams

African American Funeral Programs

No abstract provided.


Smad2/3 Signaling In The Uterine Epithelium Controls Endometrial Cell Homeostasis And Regeneration, Maya L Kriseman, Suni Tang, Zian Liao, Peixin Jiang, Sydney E Parks, Dominique I Cope, Fei Yuan, Fengju Chen, Ramya P Masand, Patricia D Castro, Michael M Ittmann, Chad J Creighton, Zhi Tan, Diana Monsivais Mar 2023

Smad2/3 Signaling In The Uterine Epithelium Controls Endometrial Cell Homeostasis And Regeneration, Maya L Kriseman, Suni Tang, Zian Liao, Peixin Jiang, Sydney E Parks, Dominique I Cope, Fei Yuan, Fengju Chen, Ramya P Masand, Patricia D Castro, Michael M Ittmann, Chad J Creighton, Zhi Tan, Diana Monsivais

Faculty, Staff and Students Publications

The regenerative potential of the endometrium is attributed to endometrial stem cells; however, the signaling pathways controlling its regenerative potential remain obscure. In this study, genetic mouse models and endometrial organoids are used to demonstrate that SMAD2/3 signaling controls endometrial regeneration and differentiation. Mice with conditional deletion of SMAD2/3 in the uterine epithelium using Lactoferrin-iCre develop endometrial hyperplasia at 12-weeks and metastatic uterine tumors by 9-months of age. Mechanistic studies in endometrial organoids determine that genetic or pharmacological inhibition of SMAD2/3 signaling disrupts organoid morphology, increases the glandular and secretory cell markers, FOXA2 and MUC1, and alters the genome-wide distribution …


The Nairobi Declaration-Reducing The Burden Of Dementia In Low- And Middle-Income Countries (Lmics): Declaration Of The 2022 Symposium On Dementia And Brain Aging In Lmics, Gladys E. Maestre, Maria Carrillo, Raj N. Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Upal Roy, Noe Garza, Jennifer Cahn, Deepa Roy Mar 2023

The Nairobi Declaration-Reducing The Burden Of Dementia In Low- And Middle-Income Countries (Lmics): Declaration Of The 2022 Symposium On Dementia And Brain Aging In Lmics, Gladys E. Maestre, Maria Carrillo, Raj N. Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Upal Roy, Noe Garza, Jennifer Cahn, Deepa Roy

School of Medicine Publications

Delegates of the 2022 Symposium on Dementia and Brain Aging in Low- and Middle-Income Countries, representing over 40 countries, met in Nairobi, Kenya, December 5–9 to highlight advances in dementia prevention, diagnosis, care, and research, as well as explore the future needs of the global community.


Molecular Mechanism Of Biased Signaling At The Kappa Opioid Receptor, Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che Mar 2023

Molecular Mechanism Of Biased Signaling At The Kappa Opioid Receptor, Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che

2020-Current year OA Pubs

The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular pathways of KOR may be key to maintaining this benefit while minimizing side-effect liabilities. As for most G protein-coupled receptors (GPCRs), however, the molecular mechanisms of ligand-specific signaling at KOR have remained unclear. To better understand the molecular determinants of KOR signaling bias, we apply structure determination, atomic-level molecular dynamics (MD) simulations, and functional assays. We determine a crystal structure of KOR bound to the G protein-biased agonist nalfurafine, the first approved KOR-targeting drug. We also identify an arrestin-biased …